Polymorphisms in glutathione S-transferases and non-melanoma skin cancer risk in Australian renal transplant recipients.

abstract：:Abnormalities in the expression of DMBT1 (deleted in malignant brain tumors 1) have been implicated in the development of esophageal, gastric and colorectal cancers of the alimentary tract, but the underlying mechanism remains unclear. In the present study, using the gastric cell line AGS, we identified two intracellu...

journal_title：Carcinogenesis

authors： Kang W,Nielsen O,Fenger C,Leslie G,Holmskov U,Reid KB

更新日期：2005-06-01 00:00:00

abstract：:Telomeres are critical in maintaining chromosome and genomic stability. Arsenic, a human carcinogen as well as an anticancer agent, is known for its clastogenicity. To better understand molecular mechanisms of arsenic actions, we investigated arsenite effects on telomere and telomerase and determined cell growth and a...

journal_title：Carcinogenesis

authors： Zhang TC,Schmitt MT,Mumford JL

更新日期：2003-11-01 00:00:00

abstract：:Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as...

journal_title：Carcinogenesis

authors： Kim DJ,Lee MH,Liu K,Lim DY,Roh E,Chen H,Kim SH,Shim JH,Kim MO,Li W,Ma F,Fredimoses M,Bode AM,Dong Z

更新日期：2017-10-26 00:00:00

abstract：:This study presents the physical characterization of mutants induced in mammalian cells by high linear energy transfer alpha-particle radiation that simulates exposure to radon daughters. Alpha-Particles from accelerated 4He at 150 keV/microns were used to induce 20 Chinese hamster ovary mutants that are deficient in ...

journal_title：Carcinogenesis

authors： Jin Y,Yie TA,Carothers AM

更新日期：1995-08-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:Although the alternative splicing of various genes is a common event in human tumors, the mechanisms behind it have not been characterized. We hypothesized that the expression of splicing regulatory factors would be changed during cellular transformation. Gene expression of three splicing regulatory factors, alternati...

journal_title：Carcinogenesis

authors： Maeda T,Hiranuma H,Jikko A

更新日期：1999-12-01 00:00:00

abstract：:CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be...

journal_title：Carcinogenesis

authors： Cheng M,Yang L,Yang R,Yang X,Deng J,Yu B,Huang D,Zhang S,Wang H,Qiu F,Zhou Y,Lu J

更新日期：2013-10-01 00:00:00

abstract：:To test the hypothesis that nucleotide excision repair (NER) plays a protective role in chemical carcinogenesis in internal organs, xeroderma pigmentosum group A gene-deficient (XPA(-/-)) mice, heterozygous (XPA(+/-)) and wild-type (XPA(+/+)) mice were orally administered 0.001% 4-nitroquinoline 1-oxide (4NQO) in thei...

journal_title：Carcinogenesis

authors： Ide F,Oda H,Nakatsuru Y,Kusama K,Sakashita H,Tanaka K,Ishikawa T

更新日期：2001-04-01 00:00:00

abstract：:Purified DNA was modified in vitro by 3H-labelled O-acetyl or O,O'-diacetyl-4-hydroxyaminoquinoline-1-oxide (Ac4HAQO or di Ac-4HAQO). It was then subjected to the action of the single-stranded DNA specific nuclease S1 and the digested fractions were analysed. For both types of modified DNA, the release of non-modified...

journal_title：Carcinogenesis

authors： Galiègue S,Bailleul B,Loucheux-Lefebvre MH,Laval J

更新日期：1982-01-01 00:00:00

abstract：:Untreated and Aroclor 1254-pretreated male Wistar rats were given a single dose of 1.0 mg/kg body weight of randomly tritium-labelled 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (3H-PhIP) by oral intubation. Urine and faeces were collected at 24, 48 and 72 hours after dosing, and total radioactivity determined. A...

journal_title：Carcinogenesis

authors： Dragsted LO,Frandsen H,Reistad R,Alexander J,Larsen JC

更新日期：1995-11-01 00:00:00

abstract：:Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...

journal_title：Carcinogenesis

authors： Poirier MC,Fullerton NF,Patterson ED,Beland FA

更新日期：1990-08-01 00:00:00

abstract：:1,3-Butadiene (BD) is an indirect alkylating agent that has greater cancer potency in the mouse than in the rat. The purpose of the present study was to compare the mutagenic potency of BD at the hprt locus of T-lymphocytes of exposed mice and rats and to determine whether mutations induced in this marker gene can be ...

journal_title：Carcinogenesis

authors： Meng Q,Recio L,Reilly AA,Wong BA,Bauer M,Walker VE

更新日期：1998-06-01 00:00:00

abstract：:Alternative pre-messenger RNA (mRNA) splicing is a key molecular event that allows for protein diversity and plays important roles in development and disease. Alternative pre-mRNA splicing regulations during spermatogenesis and alternative pre-mRNA splicing etiology in testicular tumorigenesis are yet to be characteri...

journal_title：Carcinogenesis

authors： He C,Zuo Z,Chen H,Zhang L,Zhou F,Cheng H,Zhou R

更新日期：2007-12-01 00:00:00

abstract：:A diet that is deficient in methionine, choline, folic acid and vitamin B12 has been found to induce alterations rapidly in liver tRNA methylation in male Fischer rats. In vitro assays indicated that activity of N2-guanine tRNA methyltransferase II (NMG2) was increased to 150% of controls levels in 1 week and 300% of ...

journal_title：Carcinogenesis

authors： Wainfan E,Dizik M,Hluboky M,Balis ME

更新日期：1986-03-01 00:00:00

abstract：:BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transfo...

journal_title：Carcinogenesis

authors： Katoh F,Yamasaki H

更新日期：1991-10-01 00:00:00

abstract：:Lipid peroxidation aldehydes of the 4-hydroxy-alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated aldehyde, acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. In com...

journal_title：Carcinogenesis

authors： Krokan H,Grafstrom RC,Sundqvist K,Esterbauer H,Harris CC

更新日期：1985-12-01 00:00:00

abstract：:Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5...

journal_title：Carcinogenesis

authors： Leung KH,Archer MC

更新日期：1981-01-01 00:00:00

abstract：:Conversion of the 2'-deoxyguanosine (dG) residues in calf thymus DNA to 8-hydroxy-2'-deoxyguanosine (8-OH-dG) was achieved at physiological pH by treating the DNA with hydrogen peroxide (H2O2) in the presence of nickel(II) chloride (NiCl2). The effectiveness of this reaction was enhanced by L-histidine (His) which for...

journal_title：Carcinogenesis

authors： Dutta AK,Misra M,North SL,Kasprzak KS

更新日期：1992-02-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:Benzo(a]pyrene was metabolized in liver cell lines derived from BC-IV and BD-IV rats which included several chemically-transformed lines (IAR-6-1; IAR-19; IAR-28), one spontaneous transformant (IAR-27) as well as one non-malignant line (IAR-20). Cultures were treated with tritiated benzo[a]pyrene over a 5-day period. ...

journal_title：Carcinogenesis

authors： Selkirk JK,MacLeod MC,Kuroki T,Drevon C,Piccoli C,Montesano R

更新日期：1982-01-01 00:00:00

abstract：:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...

journal_title：Carcinogenesis

authors： Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

更新日期：1988-03-01 00:00:00

abstract：:In order to investigate specific DNA damage caused by nitric oxide (NO) induced lipid peroxidation, levels of promutagenic etheno adducts 1,N6-ethenodeoxyadenosine (epsilondA) and 3,N4-ethenodeoxycytidine (epsilondC) were measured in spleen DNA of SJL mice induced to produce high levels of NO by injection of RcsX (pre...

journal_title：Carcinogenesis

authors： Nair J,Gal A,Tamir S,Tannenbaum SR,Wogan GN,Bartsch H

更新日期：1998-12-01 00:00:00

abstract：:The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...

journal_title：Carcinogenesis

authors： Budroe JD,Schol HM,Shaddock JG,Casciano DA

更新日期：1988-07-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:The pyrene-like fluorescence of adducts derived from the covalent binding of (+/-)-trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene [+/-]-anti-BPDE] to DNA increases in intensity by factors of 20 or more as the temperature is lowered from ambient to approximately 100 K. This effect is primarily a...

journal_title：Carcinogenesis

authors： Zhao R,Liu TM,Kim SK,MacLeod MC,Geacintov NE

更新日期：1992-10-01 00:00:00

abstract：:Women who carry the BRCA mutation are at high lifetime risk of breast cancer, but there is no consensus regarding an effective and safe chemoprevention strategy. A large body of evidence suggests that 3,3-diindolylmethane (DIM), a dimer of indole-3-carbinol found in cruciferous vegetables, can potentially prevent carc...

journal_title：Carcinogenesis

authors： Yerushalmi R,Bargil S,Ber Y,Ozlavo R,Sivan T,Rapson Y,Pomerantz A,Tsoref D,Sharon E,Caspi O,Grubsrein A,Margel D

更新日期：2020-10-15 00:00:00

abstract：:In order to explore a possibility that the custom of drinking green tea infusion is efficacious for reducing the carcinogenic risk of environmental exposure to pentachlorophenol (PCP), we examined the effects in a hepato- and cholangiocarcinogenesis model in mice exposed to diethylnitrosamine (DEN). In the first exper...

journal_title：Carcinogenesis

authors： Umemura T,Kai S,Hasegawa R,Kanki K,Kitamura Y,Nishikawa A,Hirose M

更新日期：2003-06-01 00:00:00

abstract：:The E3 ubiquitin ligase EDD is overexpressed in recurrent, platinum-resistant ovarian cancers, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of the prosurvival pro...

journal_title：Carcinogenesis

authors： Bradley A,Zheng H,Ziebarth A,Sakati W,Branham-O'Connor M,Blumer JB,Liu Y,Kistner-Griffin E,Rodriguez-Aguayo C,Lopez-Berestein G,Sood AK,Landen CN Jr,Eblen ST

更新日期：2014-05-01 00:00:00

abstract：:A new sensitive 32P-postlabeling assay for DNA adducts has been developed in which DNA is hydrolyzed initially by nuclease P1 and prostatic acid phosphatase instead of micrococcal nuclease and spleen phosphodiesterase as employed in previous postlabeling procedures. When DNA containing bulky adducts, X1, X2, .....Xn, ...

journal_title：Carcinogenesis

authors： Randerath K,Randerath E,Danna TF,van Golen L,Putman KL

更新日期：1989-07-01 00:00:00