当前位置： SCI文献检索 > CARCINOGENESIS期刊下所有文献 > Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation.

Phenobarbital reduces EGF receptors and the ability of physiological concentrations of calcium to suppress hepatocyte proliferation.

Abstract：

:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital (PB, 0.1% in the drinking water) reduced significantly the ability of physiological levels of calcium to suppress hepatocyte proliferation. An increased relative ability of hepatocytes to proliferate at physiological calcium concentrations versus that at 0.4 mM calcium was first seen after 3 days of in vivo PB treatment and this effect was maintained during 2 months of exposure. Hepatocytes from short-term PB-exposed animals (i.e. 3-28 days) proliferated at physiological Ca2+ concentrations 2-3 times better than those from control animals. However, after 2 months of continuous PB exposure, cell growth was reduced significantly at all extracellular Ca2+ concentrations investigated. EGF binding studies demonstrated that the biphasic kinetic effect of PB on hepatocyte proliferation was not correlated directly with the steady decline in EGF receptor number or the lack of significant change in receptor binding affinity with duration of PB exposure. These results imply that the effectiveness of PB in tumour promotion may result from its ability to reduce the absolute magnitude of normal hepatocyte proliferation and to alter the growth regulatory effect of extracellular calcium. Further, the results argue that PB effects on hepatocyte proliferation are not mediated simply through regulation of EGF surface receptor number or binding affinity. Additional events of the EGF-induced cascade necessary for hepatocyte proliferation appear to be modified by PB.

journal_name

Carcinogenesis

journal_title

Carcinogenesis

authors

Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

doi

10.1093/carcin/9.3.479

subject

Has Abstract

pub_date

1988-03-01 00:00:00

pages

479-83

issue

3

eissn

0143-3334

issn

1460-2180

journal_volume

9

pub_type

杂志文章

相关文献

CARCINOGENESIS文献大全
  • Intestinal metabolism of nitrosamines. 1. Transport and metabolism of six nitrosamines in isolated perfused rat small intestinal segments.

    abstract：:Possible relationships between structure and metabolism of nitrosamines have been investigated in the rat small intestine. Isolated segments of jejunum and ileum were perfused from the luminal side for 2 h with a Tyrode solution containing one of four symmetrical dialkylnitrosamines with 2-5 carbon atoms per side chai...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/7.7.1207

    authors： Richter E,Richter-Cooberg U,Feng X,Schulze J,Wiessler M

    更新日期：1986-07-01 00:00:00

  • Ascorbic acid and beta-carotene as modulators of oxidative damage.

    abstract：:Naturally occurring antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxygen reactive species. In fact, oxidative stress is considered a cause of aging, degenerative disease and cancer. We have focused our attention on two agents, ascorbic acid and beta-carot...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/18.1.223

    authors： Cozzi R,Ricordy R,Aglitti T,Gatta V,Perticone P,De Salvia R

    更新日期：1997-01-01 00:00:00

  • Organ-specific oxidative DNA damage associated with normal birth in rats.

    abstract：:Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/17.12.2563

    authors： Randerath E,Zhou GD,Randerath K

    更新日期：1996-12-01 00:00:00

  • Tumor-initiating activity and carcinogenicity of dibenzo[a,l]pyrene versus 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene at low doses in mouse skin.

    abstract：:Dibenzo[a,l]pyrene (DB[a,l]P) is an extremely potent carcinogen that may be present in environmental samples. Dose-response studies were conducted at low doses in mouse skin by initiation-promotion and repeated application to compare its activity to that of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (B[a]P)...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/14.5.875

    authors： Higginbotham S,RamaKrishna NV,Johansson SL,Rogan EG,Cavalieri EL

    更新日期：1993-05-01 00:00:00

  • gamma-Glutamyltranspeptidase-positive rat hepatocytes are protected from GSH depletion, oxidative stress and reversible alterations of collagen receptors.

    abstract：:The aim of this study has been to define cytotoxic mechanisms that may cause clonal expansion in the liver of pre-carcinogenic cells. An in vitro model, which has been described previously, was used. Hepatocytes were isolated from carcinogen-treated rats and a high proportion of the cells were gamma-glutamyltranspepti...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/11.1.69

    authors： Stenius U,Rubin K,Gullberg D,Högberg J

    更新日期：1990-01-01 00:00:00

  • Requirement for human AP endonuclease 1 for repair of 3'-blocking damage at DNA single-strand breaks induced by reactive oxygen species.

    abstract：:The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As an AP endonuclease, it initiates repair of AP sites in DNA produced either spontaneously or after removal of uracil and alkylated bases in DNA by monofunctional...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：

    authors： Izumi T,Hazra TK,Boldogh I,Tomkinson AE,Park MS,Ikeda S,Mitra S

    更新日期：2000-07-01 00:00:00

  • Polyphenol-rich sweet potato greens extract inhibits proliferation and induces apoptosis in prostate cancer cells in vitro and in vivo.

    abstract：:Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vege...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgr215

    authors： Karna P,Gundala SR,Gupta MV,Shamsi SA,Pace RD,Yates C,Narayan S,Aneja R

    更新日期：2011-12-01 00:00:00

  • Adenylate cyclase activity in crude liver membranes during chemical hepatocarcinogenesis.

    abstract：:Crude plasma membranes were prepared from the liver of control rats or of rats submitted to an initiation by diethyl-nitrosamine and selection with 2-acetylaminofluorene and carbon tetrachloride (group IS) or of rats submitted to an initiation-selection protocol followed by a promotion with phenobarbital (group IS PB)...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/12.4.659

    authors： Marino A,Ravelingien N,De Cannière D,Préat V,Dehaye JP,Pector JC

    更新日期：1991-04-01 00:00:00

  • The principal urinary metabolite of allyl isothiocyanate, N-acetyl-S-(N-allylthiocarbamoyl)cysteine, inhibits the growth and muscle invasion of bladder cancer.

    abstract：:Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgr283

    authors： Bhattacharya A,Li Y,Geng F,Munday R,Zhang Y

    更新日期：2012-02-01 00:00:00

  • Oxidative damage to DNA: levels of thymine glycol and thymidine glycol in neoplastic human urines.

    abstract：:We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.02...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/14.7.1359

    authors： Cao EH,Wang JJ

    更新日期：1993-07-01 00:00:00

  • Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles.

    abstract：:Exposure of rats to diesel emissions results in the development of lung tumors. The objective of this study was to determine whether the polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs or other polycyclic organic matter adsorbed to diesel particles induces the formation of DNA adducts in the lung when compared to ...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/15.7.1291

    authors： Gallagher J,Heinrich U,George M,Hendee L,Phillips DH,Lewtas J

    更新日期：1994-07-01 00:00:00

  • DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.

    abstract：:Alkylation of DNA and hemoglobin was compared in male F344 rats given a single s.c. injection of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), or its major metabolite formed by carbonyl reduction, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). In hepatic DNA, levels of 7...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/9.9.1665

    authors： Hecht SS,Trushin N

    更新日期：1988-09-01 00:00:00

  • The Escherichia coli MutS DNA mismatch binding protein specifically binds O(6)-methylguanine DNA lesions.

    abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/17.9.2085

    authors： Rasmussen LJ,Samson L

    更新日期：1996-09-01 00:00:00

  • Interactions of cytokine gene polymorphisms in prostate cancer risk.

    abstract：:Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgm277

    authors： Zabaleta J,Lin HY,Sierra RA,Hall MC,Clark PE,Sartor OA,Hu JJ,Ochoa AC

    更新日期：2008-03-01 00:00:00

  • Enhanced growth of colorectal aberrant crypt foci in fasted/refed rats involves changes in TGFbeta1 and p21CIP expressions.

    abstract：:We previously demonstrated that fasting/refeeding enhances the initiation phase of liver and colorectal carcinogenesis in rats. The present study was undertaken to establish whether cycles of fasting/refeeding carried out during the promotion phase of carcinogenesis may also affect the formation of aberrant crypt foci...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/23.2.323

    authors： Caderni G,Perrelli MG,Cecchini F,Tessitore L

    更新日期：2002-02-01 00:00:00

  • Effects of dietary indoles and isothiocyanates on N-nitrosodimethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone alpha-hydroxylation and DNA methylation in rat liver.

    abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/6.4.539

    authors： Chung FL,Wang MY,Hecht SS

    更新日期：1985-04-01 00:00:00

  • Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

    abstract：:The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively correlated with tumor progression in multiple neoplasms, being a promising new target for cancer treatment. However, the precise molecular effects of NDRG1 remain unclear. Herein, we summarize recent advances in understanding the impac...

    journal_title：Carcinogenesis

    pub_type： 杂志文章,评审

    doi：10.1093/carcin/bgt163

    authors： Sun J,Zhang D,Bae DH,Sahni S,Jansson P,Zheng Y,Zhao Q,Yue F,Zheng M,Kovacevic Z,Richardson DR

    更新日期：2013-09-01 00:00:00

  • Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine.

    abstract：:DNA-demethylating agents activate tumor suppressor genes that are silenced by DNA methylation in cancer and are therefore emerging as a novel approach to cancer therapy. 5-azacytidine (VIDAZA), the first representative of this class of drugs was approved for treatment of myelodysplastic syndromes and is currently bein...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgt284

    authors： Chik F,Machnes Z,Szyf M

    更新日期：2014-01-01 00:00:00

  • Molecular epidemiology, pathogenesis and prevention of gastric cancer.

    abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

    journal_title：Carcinogenesis

    pub_type： 杂志文章,评审

    doi：10.1093/carcin/20.12.2195

    authors： Stadtländer CT,Waterbor JW

    更新日期：1999-12-01 00:00:00

  • Tumor-initiating activity, mutagenicity, and metabolism of methylated anthracenes.

    abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/6.10.1483

    authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

    更新日期：1985-10-01 00:00:00

  • Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction.

    abstract：:In the present study the role of two families of cytochrome P-450 proteins and the contribution of the cytosolic fraction in the activation of N-nitrosopiperidine to mutagens in the Ames test were investigated. The bioactivation of this nitrosamine was preferentially catalysed by the phenobarbitone-induced cytochromes...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/8.11.1691

    authors： Ayrton AD,Smith JN,Ioannides C

    更新日期：1987-11-01 00:00:00

  • Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice.

    abstract：:3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, pravastatin (Pr) and simvastatin (Si), suppressed 1,2-dimethylhydrazine (DMH)-induced colon cancer development in female ICR mice. All mice received an i.p. injection of 10 mg DMH/kg body wt once weekly for 15 weeks. Pr was administered at 0.01, 0.0...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/15.9.2045

    authors： Narisawa T,Fukaura Y,Terada K,Umezawa A,Tanida N,Yazawa K,Ishikawa C

    更新日期：1994-09-01 00:00:00

  • Monoclonal antibodies for the immunoassay of mutagenic compounds produced by cooking beef.

    abstract：:A family of 2-amino-N-methylimidazoazaarene (AIA) mutagens are produced in meats by cooking, and are of concern as potential carcinogens in the human diet. These are potent genotoxins in bacterial mutation assays, but are present only in trace quantities in cooked foods. Conventional analytical chemistry methods have ...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/9.1.153

    authors： Vanderlaan M,Watkins BE,Hwang M,Knize MG,Felton JS

    更新日期：1988-01-01 00:00:00

  • Apoptosis and proliferation under conditions of deoxynucleotide pool imbalance in liver of folate/methyl deficient rats.

    abstract：:Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/18.2.287

    authors： James SJ,Miller BJ,Basnakian AG,Pogribny IP,Pogribna M,Muskhelishvili L

    更新日期：1997-02-01 00:00:00

  • Partial hepatectomy is a promoter of hepatocarcinogenesis in C57BL/6J male mice but not in C3H/HeJ male mice.

    abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/11.4.589

    authors： Hanigan MH,Winkler ML,Drinkwater NR

    更新日期：1990-04-01 00:00:00

  • von Hippel-Lindau tumor suppressor gene-dependent mRNA stabilization of the survival factor parathyroid hormone-related protein in human renal cell carcinoma by the RNA-binding protein HuR.

    abstract：:We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of messenger RNA (mRNA) stability, as observed for tumor growth factors (TGFs). Our ...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgn275

    authors： Danilin S,Sourbier C,Thomas L,Rothhut S,Lindner V,Helwig JJ,Jacqmin D,Lang H,Massfelder T

    更新日期：2009-03-01 00:00:00

  • The influence of inhibitors on the repair of benzo[a]pyrene-damaged DNA in hamster tracheal epithelial cells.

    abstract：:We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/5.2.187

    authors： Ireland CM,Eastman A,Bresnick E

    更新日期：1984-02-01 00:00:00

  • Morphological correlates of transformation in cultured C3H/10T1/2 mouse embryo cells.

    abstract：:In efforts to determine common and consistent morphological parameters of transformation in C3H/10T1/2 cells, 15 cell lines transformed by different carcinogens were examined with the scanning electron microscope (SEM) and compared to non-transformed cells. Cell lines were studied at different passages, at different c...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/5.7.885

    authors： Narayan KS,Young R,Heidelberger C,Landolph JR

    更新日期：1984-07-01 00:00:00

  • Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells.

    abstract：:Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells and increased in...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/bgu139

    authors： Lin CW,Sun MS,Liao MY,Chung CH,Chi YH,Chiou LT,Yu J,Lou KL,Wu HC

    更新日期：2014-11-01 00:00:00

  • Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up.

    abstract：:The measurement of oxidative damage to cellular DNA is a challenging analytical problem requiring highly sensitive and specific methods. In addition, artefactual DNA oxidation during its extraction and subsequent work-up may give rise to overestimated levels of oxidized DNA bases. In the present study, we have used (1...

    journal_title：Carcinogenesis

    pub_type： 杂志文章

    doi：10.1093/carcin/23.11.1911

    authors： Ravanat JL,Douki T,Duez P,Gremaud E,Herbert K,Hofer T,Lasserre L,Saint-Pierre C,Favier A,Cadet J

    更新日期：2002-11-01 00:00:00