Abstract:
:Naturally occurring antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxygen reactive species. In fact, oxidative stress is considered a cause of aging, degenerative disease and cancer. We have focused our attention on two agents, ascorbic acid and beta-carotene, commonly considered to be antioxidants, but whose protective activity against cancer is insufficiently known. This paper reports on the ability of these agents to act against damage induced by H2O2 and bleomycin, in Chinese hamster ovary cells cultivated in vitro. Cytogenetic and cytofluorimetric analyses were performed. Both vitamins proved effective in reducing H2O2-induced sister chromatid exchanges, but increased H2O2- and bleomycin-induced chromosomal aberrations. Cytofluorimetric data, in contrast, showed that ascorbic acid and beta-carotene act as scavengers of endogeneous and H2O2-induced oxygen species.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Cozzi R,Ricordy R,Aglitti T,Gatta V,Perticone P,De Salvia Rdoi
10.1093/carcin/18.1.223subject
Has Abstractpub_date
1997-01-01 00:00:00pages
223-8issue
1eissn
0143-3334issn
1460-2180journal_volume
18pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in viv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt097
更新日期:2013-07-01 00:00:00
abstract::Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.6.859
更新日期:1986-06-01 00:00:00
abstract::Thapsigargin (Tg), applied twice weekly to the backs of CD-1 mice initiated with 7,12-dimethylbenz[a]anthracene, promoted papillomas on the skin of approximately 50% of the mice. Tg alone induced papillomas in 10% of the mice. Although Tg and 12-O-tetradecanoylphorbol-13-acetate (TPA) are synergistic in a keratinocyte...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.4.699
更新日期:1996-04-01 00:00:00
abstract::The effect of oral vitamin C supplementation on intragastric ascorbate levels and gastric mucosal DNA damage as measured by the 32P-postlabelling assay was assessed in 43 patients. In patients with normal gastric mucosa, treatment with vitamin C resulted in elevation of intragastric ascorbate levels in all cases. In t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.2.291
更新日期:1994-02-01 00:00:00
abstract::The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.2.265
更新日期:1987-02-01 00:00:00
abstract::Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown clinical results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry superior distribution properties into the tumor micr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt227
更新日期:2013-10-01 00:00:00
abstract::Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.11.1129
更新日期:1981-01-01 00:00:00
abstract::Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.8.1399
更新日期:2002-08-01 00:00:00
abstract::Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh065
更新日期:2004-05-01 00:00:00
abstract::In order to study the oncogenesis of melanocytes, transgenic mouse lines were established that express a mutated human Ha-ras (TPras) gene in pigment producing cells. The ras transgenic mice exhibit an altered phenotype, including melanocytic hyperplasia and a muted agouti coat, indicative of hyperproliferative melano...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.9.1747
更新日期:1999-09-01 00:00:00
abstract::The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.8.1437
更新日期:1998-08-01 00:00:00
abstract::In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.11.2175
更新日期:1992-11-01 00:00:00
abstract::A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.5.463
更新日期:1981-01-01 00:00:00
abstract::The faecal concentration of substances responding to the chemical test for N-nitroso compounds (apparent total N-nitroso compounds, ATNC) was investigated in human subjects consuming their normal free-choice diet. Concentrations ranged from 40 to 590 micrograms (N-NO)/kg faeces. To ascertain the likely relative contri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.8.1395
更新日期:1991-08-01 00:00:00
abstract::This commentary was written to stimulate thoughts on, and consideration of, enzyme expression data in target organs when investigating possible associations between polymorphisms in carcinogen activation enzymes, lifestyle/dietary factors and cancer risk. The lung and breast are taken as examples. There is overwhelmin...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/22.2.209
更新日期:2001-02-01 00:00:00
abstract::The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibitio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.9.1581
更新日期:1986-09-01 00:00:00
abstract::Macrophages and their immortalized cell lines can be activated to form nitrite and nitrate via oxidation of arginine and this is accompanied by the formation of N-nitroso compounds. The mechanism of nitrosamine formation has been investigated through the use of compounds which are known either to inhibit or enhance ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.563
更新日期:1989-03-01 00:00:00
abstract::An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression. We used a beta-carotene 15,15'-monooxygenase 1 (Bcmo1) knockout mouse (Bcmo1(-/-)) model, unable to convert...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq083
更新日期:2010-08-01 00:00:00
abstract::Nitric oxide (NO) has been shown to induce double strand DNA breaks in Barrett's oesophagus (BO) and in other cancers has a role in invasion. The specific aims of this study were to investigate whether NO can induce invasion in cells representative of different stages of Barrett's progression and to determine possible...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq130
更新日期:2010-09-01 00:00:00
abstract::The ability to repair damaged DNA was determined in different cell populations of rabbit lung cells isolated by centrifugal elutriation. DNA excision repair, measured as unscheduled DNA synthesis, was examined in in vitro confluent primary cultures. A dose dependent level of DNA excision repair was observed in alveola...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.4.661
更新日期:1985-04-01 00:00:00
abstract::Currently there is no well-defined biological parameter or marker to help define agents, doses, and dose schedules for human cancer chemoprevention trials. Induction of ornithine decarboxylase, the rate limiting enzyme in the polyamine biosynthetic pathway, has been shown to be an essential aspect of mouse skin tumor ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.11.1589
更新日期:1985-11-01 00:00:00
abstract::We previously reported that 8-hydroxyguanine (7,8-dihydro-8-oxoguanine) at the second position of codon 12 of the c-Ha-ras gene induces many types of mutations in NIH3T3 cells. In this study we incorporated the modified base into the first and second positions of codon 12 in the coding strand and into the first positi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.4.883
更新日期:1995-04-01 00:00:00
abstract::To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.8.1257
更新日期:1986-08-01 00:00:00
abstract::The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.12.1651
更新日期:1983-12-01 00:00:00
abstract::Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl109
更新日期:2006-11-01 00:00:00
abstract::p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr003
更新日期:2011-04-01 00:00:00
abstract::The role of urinary pH and Na+ concentration on the bladder carcinogenesis of o-phenylphenol (OPP) was examined in male F344 rats. The rats were given powdered diet containing 2% sodium o-phenylphenate (OPP-Na, group 1), 1.25% OPP plus 0.64% NaHCO3 (group 2), 1.25% OPP plus 0.32% NaHCO3 (group 3), 1.25% OPP plus 0.16%...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.9.1635
更新日期:1989-09-01 00:00:00
abstract::Although the human O6-alkylguanine-DNA alkyltransferase (AGT) is very sensitive to inactivation by O6-benzylguanine (BG) or 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (5-nitroso-BP), the equivalent protein formed by the carboxyl terminal domain of the product of the Escherichia coli ada gene (Ada-C) is unaffected by ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.8.1687
更新日期:1995-08-01 00:00:00
abstract::Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.10.2515
更新日期:1995-10-01 00:00:00
abstract::We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.1.43
更新日期:1991-01-01 00:00:00