Abstract:
:In order to study the oncogenesis of melanocytes, transgenic mouse lines were established that express a mutated human Ha-ras (TPras) gene in pigment producing cells. The ras transgenic mice exhibit an altered phenotype, including melanocytic hyperplasia and a muted agouti coat, indicative of hyperproliferative melanocytes. These mice and their wild-type littermates have been subjected to a variety of carcinogenesis protocols, including 7, 12-dimethylbenz-[a]anthracene (DMBA), 12-O-tetradecanoylphorbol-13-acetate (TPA) and UV radiation exposure. Topical DMBA treatment of TPras mice resulted in a high incidence of melanomas. Metastatic lesions were observed in skin, lungs and lymph nodes. TPA treatment of TPras mice induced a small number of papillomas but no nevi or melanomas. UV light exposures induced papillomas in negative littermate and melanomas in some albino TPras mice. These results show that melanocytes expressing an activated Ha-ras in the TPras transgenic mice are susceptible to induction of melanoma by DMBA.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Broome Powell M,Gause PR,Hyman P,Gregus J,Lluria-Prevatt M,Nagle R,Bowden GTdoi
10.1093/carcin/20.9.1747keywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
1747-53issue
9eissn
0143-3334issn
1460-2180journal_volume
20pub_type
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