Expression of mutant thyroid hormone nuclear receptors is associated with human renal clear cell carcinoma.

abstract：:4-Hydroxyphenylretinamide (4-HPR) is a synthetic retinoid with minimal toxicity and favorable pharmacokinetics during long-term administration to patients in clinical trials. Since 4-HPR binds poorly to the retinoic acid receptors, the issue of whether 4-HPR exerts its biological actions via classical retinoid recepto...

journal_title：Carcinogenesis

authors： Giandomenico V,Andreola F,Rodriguez de la Concepcion ML,Collins SJ,De Luca LM

更新日期：1999-06-01 00:00:00

abstract：:In order to understand the possible role of reactive intermediates in the formation of tissue-specific DNA damage by chromium(VI), electron paramagnetic resonance spectroscopy was used to study the in vivo formation of chromium(V) in the liver and red blood cells of 14 day chick embryos following treatment with chromi...

journal_title：Carcinogenesis

authors： Liebross RH,Wetterhahn KE

更新日期：1992-11-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining ...

journal_title：Carcinogenesis

authors： Zhu J,Zhang S,Gu L,Di W

更新日期：2012-12-01 00:00:00

abstract：:Remodeling or deregulation of the calcium signaling pathway is a relevant hallmark of cancer including cutaneous melanoma (CM). In this study, using data from a published genome-wide association study (GWAS) from The University of Texas M.D. Anderson Cancer Center, we assessed the role of 41,377 common single-nucleoti...

journal_title：Carcinogenesis

authors： Wang X,Liu H,Xu Y,Xie J,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Song Y,Wei Q

更新日期：2019-04-29 00:00:00

abstract：:Comparisons of aromatic amine activation were made by using intact cells or cell homogenates (S-9) from bovine bladder urothelium and liver. Since both liver and bladder are thought to contribute carcinogenic metabolites for bladder cancer initiation, comparisons of these two organs' relative ability to activate aroma...

journal_title：Carcinogenesis

authors： Hix C,Oglesby L,MacNair P,Sieg M,Langenbach R

更新日期：1983-11-01 00:00:00

abstract：:The modifying effects of oltipraz on induction of glandular stomach carcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in a total of 120 male 6-week-old Wistar rats, divided into six groups. Groups 1-3 (30 animals each) were given 100 p.p.m. MNNG in their drinking water for 10 weeks as an ...

journal_title：Carcinogenesis

authors： Nishikawa A,Tanakamura Z,Furukawa F,Lee IS,Kasahara K,Ikezaki S,Takahashi M

更新日期：1998-02-01 00:00:00

abstract：:4-Oxo-4-(3-pyridyl)butanal (OPB) is an aldehyde formed during the activation of the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Using the DNA alkaline elution technique, the properties of DNA alkali-labile sites induced in the isolated rat hepatocytes by NNK and OPB were compar...

journal_title：Carcinogenesis

authors： Demkowicz-Dobrzanski K,Castonguay A

更新日期：1991-11-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:Testosterone, testosterone propionate, 17 beta-trenbolone and progesterone, which represent the main endogenous and synthetic androgens and a progestin, were evaluated for possible cell transformation and genetic effects in Syrian hamster embryo (SHE) cells. Cell growth was reduced by treatment with the steroids at 10...

journal_title：Carcinogenesis

authors： Tsutsui T,Komine A,Huff J,Barrett JC

更新日期：1995-06-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly among white males, over the past few decades in the USA. However, the etiology of EA and the striking male predominance is not fully explained by known risk factors. To identify susceptible genes for EA risk, we conducted a pathw...

journal_title：Carcinogenesis

authors： Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DC

更新日期：2010-07-01 00:00:00

abstract：:Recent studies indicate that cytochrome P450 (P450) 3A4 plays important roles in the activation of procarcinogens such as aflatoxin B1 and sterigmatocystin, as well as in the oxidation of a number of structurally diverse chemicals and endogenous compounds. Since P450 3A5 has been reported to be present at significant ...

journal_title：Carcinogenesis

authors： Yamazaki H,Inui Y,Wrighton SA,Guengerich FP,Shimada T

更新日期：1995-09-01 00:00:00

abstract：:Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O(6)-guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin and etoposide. Recently, it has been demonstrated that overexpression of the MSH3 protein is associated with depletion of the mismatch b...

journal_title：Carcinogenesis

authors： Pepponi R,Graziani G,Falcinelli S,Vernole P,Levati L,Lacal PM,Pagani E,Bonmassar E,Jiricny J,D'Atri S

更新日期：2001-08-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:Thymidine kinase (TK), the enzyme in the pyrimidine salvage pathway, and its isozymes were examined in 15 specimens of normal mucosa, 14 polyps and 14 carcinomas in human colon. The average TK activities in colon polyps and carcinomas were about 1.6 and 2.9 times that in normal colon mucosa, respectively. The colon TK...

journal_title：Carcinogenesis

authors： Sakamoto S,Sagara T,Iwama T,Kawasaki T,Okamoto R

更新日期：1985-06-01 00:00:00

abstract：:This study was undertaken to investigate the hypothesis linking peroxisome proliferation with the production of reactive oxygen species and subsequent DNA damage. Hepatic peroxisomal proliferation was induced in male Wistar-derived rats by the administration of clofibrate, methyl clofenapate, di(2-ethylhexyl)phthalate...

journal_title：Carcinogenesis

authors： Elliott BM,Elcombe CR

更新日期：1987-09-01 00:00:00

abstract：:The effects of five non-mutagenic carcinogens--Aroclor 1260, benzoyl peroxide (BP), phenobarbital (PB), 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and 1,1'-(2,2,2-trichloroethylidene)bis[4-chlorobenzene] (DDT)--on gap junctional intercellular communication (GJIC) were tested in a cell line consisting of initiated cel...

journal_title：Carcinogenesis

authors： Jansen LA,Jongen WM

更新日期：1996-02-01 00:00:00

abstract：:A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...

journal_title：Carcinogenesis

authors： Brenner AV,Butler MA,Wang SS,Ruder AM,Rothman N,Schulte PA,Chanock SJ,Fine HA,Linet MS,Inskip PD

更新日期：2007-12-01 00:00:00

abstract：:Oxidative stress has consistently been linked to breast carcinogenesis, and mitochondria play a significant role in regulating reactive oxygen species generation. In our previous study, we found that increased levels of mitochondrial DNA (mtDNA) copy number and the presence of mitochondrial length heteroplasmies in th...

journal_title：Carcinogenesis

authors： Shen J,Wan J,Song R,Zhao H

更新日期：2015-11-01 00:00:00

abstract：:High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...

journal_title：Carcinogenesis

authors： Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

更新日期：2000-10-01 00:00:00

abstract：:A single i.p. injection of diethylnitrosamine (DEN) or benzo[a]pyrene (BAP) in 1-day-old female rats produced a high incidence of gamma-glutamyltranspeptidase-(GGT)-positive hepatocyte foci within 4 weeks after the rats were weaned onto a 0.05% phenobarbital diet; the injection of benzo[e]pyrene did not produce foci u...

journal_title：Carcinogenesis

authors： Peraino C,Staffeldt EF,Ludeman VA

更新日期：1981-01-01 00:00:00

abstract：:Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...

journal_title：Carcinogenesis

authors： Cho K,Mabasa L,Bae S,Walters MW,Park CS

更新日期：2012-05-01 00:00:00

abstract：:Folate and vitamin D have been shown to be influenced by ultraviolet (UV) radiation. UVA radiation can break down plasma folate, whereas vitamin D can be synthesized in UVB-exposed skin. Folate metabolism is involved in DNA synthesis and repair, and vitamin D processes anti-proliferative effects. The functions of both...

journal_title：Carcinogenesis

authors： Han J,Colditz GA,Hunter DJ

更新日期：2007-02-01 00:00:00

abstract：:Alterations of epigenetic modifications are promising targets for cancer therapy, and several epigenetic drugs are now being clinically utilized. At the same time, individual epigenetic modifications have physiological functions in normal cells, and cancer cell specificity is considered difficult to achieve using a dr...

journal_title：Carcinogenesis

authors： Takeshima H,Wakabayashi M,Hattori N,Yamashita S,Ushijima T

更新日期：2015-02-01 00:00:00

abstract：:It has been demonstrated that nuclear factor-kappa B (NF-κB), which is overactivated in hepatocellular carcinoma (HCC), plays important roles in the development of HCC. Recently, a group of dysregulated micro RNAs were reported to be involved in HCC progression. Further understanding of micro RNA-mediated regulation o...

journal_title：Carcinogenesis

authors： Li HP,Zeng XC,Zhang B,Long JT,Zhou B,Tan GS,Zeng WX,Chen W,Yang JY

更新日期：2013-11-01 00:00:00

abstract：:The objective was to study the relationship between cyclin D1 gene (CCND1) polymorphism and lung cancer in the Chinese population. Blood samples of 182 cases and 185 controls were collected from a hospital based case-control study. PCR-SSCP was used to examine the G/A polymorphism in exon 4 of CCND1. The results showe...

journal_title：Carcinogenesis

authors： Qiuling S,Yuxin Z,Suhua Z,Cheng X,Shuguang L,Fengsheng H

更新日期：2003-09-01 00:00:00

abstract：:This study was conducted to investigate the modifying effect of glutathione S-transferase (GST) M1 and T1 polymorphisms on aflatoxin-induced hepatocarcinogenesis among chronic hepatitis B virus surface antigen (HBsAg) carriers. A total of 79 HBsAg-positive cases of hepatocellular carcinoma (HCC) diagnosed between 1991...

journal_title：Carcinogenesis

authors： Sun CA,Wang LY,Chen CJ,Lu SN,You SL,Wang LW,Wang Q,Wu DM,Santella RM

更新日期：2001-08-01 00:00:00

abstract：:O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic clearance of these steroids. However, the metabolic clearance rate of 4-hydroxyestradiol (4-OH-E2) is considerably lower than that of 2-hydroxyestradiol, although 2- and 4-hydroxycatecholestrogen...

journal_title：Carcinogenesis

authors： Roy D,Weisz J,Liehr JG

更新日期：1990-03-01 00:00:00

abstract：:Nitrosododecamethyleneimine (NDMI) was given to NZR/Gd rats by gavage in olive oil solution, confirming its hepatocarcinogenic activity. Twenty male and 20 female rats received 2.5 mg NDMI twice a week for 52 weeks; a further 10 male rats received 25.0 mg twice a week for 12 weeks. Two-thirds of the animals survived m...

journal_title：Carcinogenesis

authors： Goodall CM,Lijinsky W

更新日期：1984-04-01 00:00:00