Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes.

abstract：:The in vivo formation of specific 7,12-dimethylbenz[a]-anthracene (DMBA)-DNA adducts in the mammary gland of the female Sprague-Dawley rat was studied in response to dietary butylated hydroxytoluene (BHT). Dietary BHT concentrations of 0.4 and 0.8% significantly inhibited total DMBA-DNA binding by 41.5 and 35.6% respe...

journal_title：Carcinogenesis

authors： Singletary KW,Nelshoppen JM

更新日期：1991-10-01 00:00:00

abstract：:The aim of this study has been to define cytotoxic mechanisms that may cause clonal expansion in the liver of pre-carcinogenic cells. An in vitro model, which has been described previously, was used. Hepatocytes were isolated from carcinogen-treated rats and a high proportion of the cells were gamma-glutamyltranspepti...

journal_title：Carcinogenesis

authors： Stenius U,Rubin K,Gullberg D,Högberg J

更新日期：1990-01-01 00:00:00

abstract：:Proliferation, apoptosis and angiogenesis are critical biologic processes altered during carcinogenesis. Surrogate biomarkers of these processes represent potential intermediate endpoints for short-term intervention studies with preventive and therapeutic agents. We examined the interrelationships among these processe...

journal_title：Carcinogenesis

authors： Liao Z,Boileau TW,Erdman JW Jr,Clinton SK

更新日期：2002-10-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling u...

journal_title：Carcinogenesis

authors： Rogers KR,Kikawa KD,Mouradian M,Hernandez K,McKinnon KM,Ahwah SM,Pardini RS

更新日期：2010-09-01 00:00:00

abstract：:Drug resistance is one of the main obstacles to the successful treatment of cancer. The availability of agents that are highly effective against drug-resistant cancer cells is therefore essential. The present study was performed to examine the anticancer effects of evodiamine, a major constituent of the Chinese herb E...

journal_title：Carcinogenesis

authors： Liao CH,Pan SL,Guh JH,Chang YL,Pai HC,Lin CH,Teng CM

更新日期：2005-05-01 00:00:00

abstract：:Asphalt fume condensate (AFC) and chromatographically separated fractions have been shown to cause cancer in mouse skin. The levels of known carcinogenic initiators in these complex mixtures, however, are considered too low to account for their carcinogenic potency. It has been proposed that AFC may contain co-carcino...

journal_title：Carcinogenesis

authors： Wey HE,Breitenstein MJ,Toraason MA

更新日期：1992-06-01 00:00:00

abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common childhood leukemia, with a cure rate of 80%. Nevertheless, disease relapse is the most important prognostic factor for the disease outcome. We aimed to elucidate the role of Wnt secretion-regulating protein, Wntless (Wls)/GPR177, on disease out...

journal_title：Carcinogenesis

authors： Chiou SS,Wang LT,Huang SB,Chai CY,Wang SN,Liao YM,Lin PC,Liu KY,Hsu SH

更新日期：2014-10-01 00:00:00

abstract：:Chemopreventive agents are compounds that inhibit carcinogenesis when administered prior or subsequent to a course of carcinogen administration. The effects of dietary administration of crocin dyes on the hepatic damage induced by aflatoxin B1 (AFB1) and dimethylnitrosamine (DMN) in rats were investigated. Female Spra...

journal_title：Carcinogenesis

authors： Lin JK,Wang CJ

更新日期：1986-04-01 00:00:00

abstract：:The expression of cyclooxygenase-2 (COX-2) has been reported as an indicator of poor prognosis in a wide variety of human tumors, including colon, breast and uveal melanoma (UM). COX-2 inhibitors have shown promise in controlling the malignancy of several types of tumors. Previous studies have demonstrated the efficac...

journal_title：Carcinogenesis

authors： Marshall JC,Fernandes BF,Di Cesare S,Maloney SC,Logan PT,Antecka E,Burnier MN Jr

更新日期：2007-09-01 00:00:00

abstract：:Pulmonary adenocarcinoma (PAC) is the leading type of lung cancer in smokers and non-smokers that arises in most cases from small airway epithelial cells. PAC has a high mortality due to its aggressive behavior and resistance to cancer therapeutics. We have shown previously that the proliferation of human PAC cells NC...

journal_title：Carcinogenesis

authors： Schuller HM,Al-Wadei HA,Majidi M

更新日期：2008-10-01 00:00:00

abstract：:The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...

journal_title：Carcinogenesis

authors： DiGiovanni J,Kruszewski FH,Coombs MM,Bhatt TS,Pezeshk A

更新日期：1988-08-01 00:00:00

abstract：:Extracts of human urine were shown to contain substances that strongly inhibited the liver S9-mediated mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Salmonella typhimurium TA98 strain in a liquid incubation assay. The inhibitory effect was unrelated to cytotoxicity and was similar with urin...

journal_title：Carcinogenesis

authors： Malaveille C,Hautefeuille A,Brun G,Vineis P,Bartsch H

更新日期：1992-12-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...

journal_title：Carcinogenesis

authors： Li WQ,Zhang L,Ma JL,Zhang Y,Li JY,Pan KF,You WC

更新日期：2009-03-01 00:00:00

abstract：:Genome-wide DNA hypomethylation was one of the first epigenetic alterations described in cancer cells. However, the cause of this hypomethylation is still poorly understood. We have previously developed a line of primary mesenchymal stem cells (MSC, the putative origin of various types of sarcoma) in which five oncoge...

journal_title：Carcinogenesis

authors： Wild L,Funes JM,Boshoff C,Flanagan JM

更新日期：2010-10-01 00:00:00

abstract：:We have shown previously that (NOHA) an intermediate in the nitric oxide (NO) synthetic pathway and an inhibitor of arginase significantly reduced intracellular polyamines, activated caspase-3 and induced apoptosis in the human breast cancer cell line MDA-MB-468. These actions of NOHA were abolished in the presence of...

journal_title：Carcinogenesis

authors： Singh R,Pervin S,Wu G,Chaudhuri G

更新日期：2001-11-01 00:00:00

abstract：:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...

journal_title：Carcinogenesis

authors： Iversen OH

更新日期：1982-01-01 00:00:00

abstract：:In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...

journal_title：Carcinogenesis

authors： Del Carratore R,Morichetti E,Cecchini E,Bronzetti G,Gallo E,Galeotti CL

更新日期：1992-11-01 00:00:00

abstract：:Chemical carcinogenesis in mouse skin has been divided into the process of initiation, promotion and progression. Recently we have shown that ionizing radiation acts as an initiator in this model system. In this paper we describe a three-stage experiment using ionizing radiation in the third stage of mouse skin carcin...

journal_title：Carcinogenesis

authors： Jaffe DR,Williamson JF,Bowden GT

更新日期：1987-11-01 00:00:00

abstract：:Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that molecularly and phenotypically resembles human TNBC to study the effects of exo...

journal_title：Carcinogenesis

authors： Peeney D,Jensen SM,Castro NP,Kumar S,Noonan S,Handler C,Kuznetsov A,Shih J,Tran AD,Salomon DS,Stetler-Stevenson WG

更新日期：2020-05-14 00:00:00

abstract：:Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...

journal_title：Carcinogenesis

authors： Wang K,Tu Y,Wan JB,Chen M,He C

更新日期：2020-07-10 00:00:00

abstract：:The hedgehog pathway plays a critical role in the development of the foregut. Recent studies indicate that the hedgehog pathway activation occurs in the stomach and other gastrointestinal cancers. However, the association of hedgehog pathway activation with tumor stage, differentiation and tumor subtype is not well do...

journal_title：Carcinogenesis

authors： Ma X,Chen K,Huang S,Zhang X,Adegboyega PA,Evers BM,Zhang H,Xie J

更新日期：2005-10-01 00:00:00

abstract：:Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are produced in DNA via monoadduct formation at the guanine-O6 position, followed by a delayed reaction with the opposite DNA strand. Human cells are known to differ in their capacity to repair...

journal_title：Carcinogenesis

authors： Zlotogorski C,Erickson LC

更新日期：1983-01-01 00:00:00

abstract：:The nasal passages are a common portal of entry and are a prime site for toxicant-induced pathology. Sustained increases in regenerative cell proliferation can be a significant driving force in chemical carcinogenesis. The atmosphere in Mexico City contains a complex mixture of air pollutants and its residents are exp...

journal_title：Carcinogenesis

authors： Calderón-Garcidueñas L,Rodriguez-Alcaraz A,Garcia R,Barragan G,Villarreal-Calderón A,Madden MC

更新日期：1999-03-01 00:00:00

abstract：:To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...

journal_title：Carcinogenesis

authors： Schaaper RM,Koffel-Schwartz N,Fuchs RP

更新日期：1990-07-01 00:00:00

abstract：:The aim of this work was to optimize the ionic strength (tau) in the liver microsomal assay (LMA) in performing short-term genotoxicity tests. tau optimization would increase the sensitivity (i.e. decrease false negatives) and at the same time increase the specificity (decrease false positives). Such optimization depe...

journal_title：Carcinogenesis

authors： Paolini M,Mesirca R,Pozzetti L,Silingardi P,Grilli S,Cantelli-Forti G

更新日期：1992-08-01 00:00:00

abstract：:In order to detect any protective agent against tumor formation, we examined the anti-tumor-promoting effect of a Japanese traditional soybean fermented food, Natto. Dye transfer was employed as an assay method. When fluorescent dye was microinjected into cultured BALB/3T3 cells, the dye was transformed into the neigh...

journal_title：Carcinogenesis

authors： Takahashi C,Kikuchi N,Katou N,Miki T,Yanagida F,Umeda M

更新日期：1995-03-01 00:00:00

abstract：:Telomere dynamics are a critical component of both aging and cancer. Telomeres progressively shorten in almost all dividing cells and most human cells do not express or maintain sufficient telomerase activity to fully maintain telomeres. There is accumulating evidence that when only a few telomeres are short, they for...

journal_title：Carcinogenesis

authors： Shay JW,Wright WE

更新日期：2005-05-01 00:00:00

abstract：:Despite their individual key roles in promoting head and neck squamous cell carcinoma (HNSCC) progression and treatment resistance, little is known about the impact of intratumoral hypoxia on the activity of the epidermal growth factor receptor (EGFR) signaling pathway in this cancer type. Here, we show that in highly...

journal_title：Carcinogenesis

authors： Wang X,Schneider A

更新日期：2010-07-01 00:00:00