Expression of cytochrome P450 in yeast after different chemical treatments.

abstract：:Catechol (1,2-dihydroxybenzene) is a major phenolic compound present in the co-carcinogenic fraction of cigarette tar. It has been shown to be a potent co-carcinogen with benzo[a]pyrene (BaP) in mouse skin. In this study we have examined the co-carcinogenic and co-initiating activities of catechol with racemic and ena...

journal_title：Carcinogenesis

authors： Melikian AA,Jordan KG,Braley J,Rigotty J,Meschter CL,Hecht SS,Hoffmann D

更新日期：1989-10-01 00:00:00

abstract：:Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...

journal_title：Carcinogenesis

authors： Birek C,Pawson T,McCulloch CA,Tenenbaum HC

更新日期：1988-10-01 00:00:00

abstract：:In this communication, we investigate the preventive effect of a flavonoid antioxidant, silymarin, on free radical-generating skin tumor promoting agent benzoyl peroxide (BPO)-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin. Topical application of silymarin at a dose of 6 mg p...

journal_title：Carcinogenesis

authors： Zhao J,Lahiri-Chatterjee M,Sharma Y,Agarwal R

更新日期：2000-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...

journal_title：Carcinogenesis

authors： Narayanapillai SC,Han YH,Song JM,Kebede ME,Upadhyaya P,Kassie F

更新日期：2020-11-13 00:00:00

abstract：:Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characteri...

journal_title：Carcinogenesis

authors： Chen HZ,Zhao BX,Zhao WX,Li L,Zhang B,Wu Q

更新日期：2008-11-01 00:00:00

abstract：:Sulforaphane (SFN), an isothiocyanate first isolated from broccoli, exhibits chemopreventive properties in prostate cancer cells through mechanisms that are poorly understood. We recently reported on a novel mechanism of chemoprotection by SFN in human colon cancer cells, namely the inhibition of histone deacetylase (...

journal_title：Carcinogenesis

authors： Myzak MC,Hardin K,Wang R,Dashwood RH,Ho E

更新日期：2006-04-01 00:00:00

abstract：:In order to study the oncogenesis of melanocytes, transgenic mouse lines were established that express a mutated human Ha-ras (TPras) gene in pigment producing cells. The ras transgenic mice exhibit an altered phenotype, including melanocytic hyperplasia and a muted agouti coat, indicative of hyperproliferative melano...

journal_title：Carcinogenesis

authors： Broome Powell M,Gause PR,Hyman P,Gregus J,Lluria-Prevatt M,Nagle R,Bowden GT

更新日期：1999-09-01 00:00:00

abstract：:The resistant hepatocyte model was used to study expression of tumor-associated aldehyde dehydrogenase (ALDH) activity during the course of rat hepatocarcinogenesis. The hepatic ALDH phenotype was determined at intervals over 280 days by histochemical analysis, total ALDH activity assays and gel electrophoresis, using...

journal_title：Carcinogenesis

authors： Jones DE Jr,Evces S,Lindahl R

更新日期：1984-12-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified b...

journal_title：Carcinogenesis

authors： Slattery ML,Sweeney C,Murtaugh M,Ma KN,Potter JD,Levin TR,Samowitz W,Wolff R

更新日期：2005-08-01 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...

journal_title：Carcinogenesis

authors： Calabrese C,Rizzello F,Gionchetti P,Calafiore A,Pagano N,De Fazio L,Valerii MC,Cavazza E,Strillacci A,Comelli MC,Poggioli G,Campieri M,Spisni E

更新日期：2016-06-01 00:00:00

abstract：:It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...

journal_title：Carcinogenesis

authors： Volate SR,Davenport DM,Muga SJ,Wargovich MJ

更新日期：2005-08-01 00:00:00

abstract：:Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions in the body. Presently, there are markedly conflicting findings in the literature regarding NO and its role in carcinogenesis and tumor progression. NO has been shown to have dichotomous effects on cellular proliferation,...

journal_title：Carcinogenesis

authors： Burke AJ,Sullivan FJ,Giles FJ,Glynn SA

更新日期：2013-03-01 00:00:00

abstract：:Dose-response relationships in the induction of urinary bladder cancer in male C57BL/6 x DBA/2-F1 (BDF) mice by intragastric instillation of N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) were studied. Administration of a total dose of 0 to 80 mg OH-BBN in 10 weekly fractions to groups of 25 mice resulted in a linear ...

journal_title：Carcinogenesis

authors： McCormick DL,Ronan SS,Becci PJ,Moon RC

更新日期：1981-01-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Male Leeds strain rats were given a diet containing either 0.06% 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) or 0.05% 2-acetylaminofluorene (2-AAF), alone or together with 0.0067% 3-methylcholanthrene (MeCh). MeCh both reduced the incidence of hepatic neoplasms induced by 3'-MeDAB and delayed their development. Wit...

journal_title：Carcinogenesis

authors： Flaks A,Flaks B

更新日期：1982-01-01 00:00:00

abstract：:Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...

journal_title：Carcinogenesis

authors： Poirier MC,Fullerton NF,Patterson ED,Beland FA

更新日期：1990-08-01 00:00:00

abstract：:As rat tracheal epithelial cells progress from a normal to a neoplastic phenotype there are systematic changes in their ability to produce and activate latent transforming growth factor type beta (TGF-beta) as well as systematic changes in their response to this growth factor. Using a TGF-beta radioreceptor binding co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M

更新日期：1989-06-01 00:00:00

abstract：:Proliferation, apoptosis and angiogenesis are critical biologic processes altered during carcinogenesis. Surrogate biomarkers of these processes represent potential intermediate endpoints for short-term intervention studies with preventive and therapeutic agents. We examined the interrelationships among these processe...

journal_title：Carcinogenesis

authors： Liao Z,Boileau TW,Erdman JW Jr,Clinton SK

更新日期：2002-10-01 00:00:00

abstract：:Thioredoxin-1 is a low molecular weight redox protein that protects cells against oxidant damage. Thioredoxin-1 levels are increased in the epidermal layer of sun-damaged human skin. Thioredoxin-1 levels are also increased in several human primary tumors where its expression is associated with increased tumor cell pro...

journal_title：Carcinogenesis

authors： Mustacich D,Wagner A,Williams R,Bair W,Barbercheck L,Stratton SP,Bhattacharyya AK,Powis G

更新日期：2004-10-01 00:00:00

abstract：:Carcinomas of the ethmoidal region of the nose are observed relatively frequently in cattle in several countries in tropical and subtropical latitudes. Viruses have been implicated as causative agents, but it has been observed that affected animals sometimes suffer from aflatoxicosis, and a role of aflatoxin B1 (AFB1)...

journal_title：Carcinogenesis

authors： Larsson P,Pettersson H,Tjälve H

更新日期：1989-06-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picry...

journal_title：Carcinogenesis

authors： Lo AH,Liang YC,Lin-Shiau SY,Ho CT,Lin JK

更新日期：2002-06-01 00:00:00

abstract：:The relationship between urinary metabolites and DNA damage in the urinary bladder epithelium of male and female rats was tested by alkaline elution assay after an intravesical injection of OPP or its urinary metabolites. 2-Phenyl-1,4-benzoquinone (PBQ) revealed a weak DNA-damaging activity in both sexes at 0.05-0.1%....

journal_title：Carcinogenesis

authors： Morimoto K,Sato M,Fukuoka M,Hasegawa R,Takahashi T,Tsuchiya T,Tanaka A,Takahashi A,Hayashi Y

更新日期：1989-10-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:The effect of transplantation of Yoshida sarcoma cells into rats on the concentrations of both the acute-phase proteins (APPs) in the serum and their mRNAs in the liver has been investigated. In rats that responded to transplantation by forming solid tumors, the serum APP levels increased with tumor size. Some of the ...

journal_title：Carcinogenesis

authors： Sevaljević L,Savovski K,Sekularac S

更新日期：1991-09-01 00:00:00

abstract：:Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...

journal_title：Carcinogenesis

authors： Yang R,Frank B,Hemminki K,Bartram CR,Wappenschmidt B,Sutter C,Kiechle M,Bugert P,Schmutzler RK,Arnold N,Weber BH,Niederacher D,Meindl A,Burwinkel B

更新日期：2008-02-01 00:00:00

abstract：:In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the animals were followed ...

journal_title：Carcinogenesis

authors： Jackson PE,Cooper DP,O'Connor PJ,Povey AC

更新日期：1999-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short non-coding, single-stranded RNAs, which perform posttranscriptional regulatory functions as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) genes are currently being identified for contributing to cancer risk, prognosis and survival. ...

journal_title：Carcinogenesis

authors： Du M,Lu D,Wang Q,Chu H,Tong N,Pan X,Qin C,Yin C,Wang M,Zhang Z

更新日期：2014-07-01 00:00:00

abstract：:The effects and mechanisms of action of diepoxybutane (DEB) and mitomycin C (MMC) were investigated on sea urchin embryogenesis, (Sphaerechinus granularis and Paracentrotus lividus). DEB- and MMC-induced toxicity was evaluated by means of selected end-points, including developmental defects, cytogenetic abnormalities ...

journal_title：Carcinogenesis

authors： Korkina LG,Deeva IB,De Biase A,Iaccarino M,Oral R,Warnau M,Pagano G

更新日期：2000-02-01 00:00:00