Abstract:
:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 min before, simultaneously with, and 15 min, 30 min and 45 min after MNU application. The production of skin tumors was recorded and the results were assessed with accepted statistical methods. Injection of HU shortly before a single application of MNU enhanced skin carcinogenesis, and when HU is injected 30 min before MNU, the enhancement seems to be most pronounced. HU administered simultaneously with or following MNU application, did not alter the production of tumors. The cell kinetic situation in the epidermis at the time of a carcinogen application, and the modulation of the cell kinetic reaction to the carcinogen by any type of post- or pretreatment, may influence tumorigenesis.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Iversen OHdoi
10.1093/carcin/3.8.891subject
Has Abstractpub_date
1982-01-01 00:00:00pages
891-4issue
8eissn
0143-3334issn
1460-2180journal_volume
3pub_type
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