Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis.

abstract：:Carcinogenicity of catechol, a naturally occurring and industrial chemical which has been shown to have strong cell proliferating potential on rat glandular stomach epithelium, was investigated in male and female F344 rats and B6C3F1 mice. Groups of 30 male and female F344 rats and B6C3F1 mice were treated with 0.8% c...

journal_title：Carcinogenesis

authors： Hirose M,Fukushima S,Tanaka H,Asakawa E,Takahashi S,Ito N

更新日期：1993-03-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:Orotic acid, a precursor of pyrimidine nucleotide biosynthesis and a promoter for liver carcinogenesis, when fed at 1% level in a diet for 5 weeks resulted in liver DNA damage. The damage can be monitored as alkali-labile lesions using alkaline sucrose gradients as well as alkaline elution technique. Furthermore, the ...

journal_title：Carcinogenesis

authors： Rao PM,Rajalakshmi S,Alam A,Sarma DS,Pala M,Parodi S

更新日期：1985-05-01 00:00:00

abstract：:Two new mouse epidermal cell lines have been isolated and characterized as target cells for three chemical carcinogens. The ability to grow these cells at low density (approximately 5 clonogenic cells/cm2) has permitted more precise quantitation of chemical carcinogen-induced changes in epidermal differentiation. The ...

journal_title：Carcinogenesis

authors： Kulesz-Martin M,Yoshida MA,Prestine L,Yuspa SH,Bertram JS

更新日期：1985-09-01 00:00:00

abstract：:Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have repor...

journal_title：Carcinogenesis

authors： Xue H,Aziz RM,Sun N,Cassady JM,Kamendulis LM,Xu Y,Stoner GD,Klaunig JE

更新日期：2001-02-01 00:00:00

abstract：:Alternative splicing regulators have emerged as new players in cancer development, modulating the activities of many tumor suppressors and oncogenes and regulating the signaling pathways. However, little is known about the mechanisms by which these oncogenic splicing factors lead to cellular transformation. We have sh...

journal_title：Carcinogenesis

authors： Shimoni-Sebag A,Lebenthal-Loinger I,Zender L,Karni R

更新日期：2013-11-01 00:00:00

abstract：:Previous studies have demonstrated that O6-methylguanine-DNA methyltransferase (MGMT) is a major contributor to tumor cellular resistance toward chloroethylnitrosoureas. To further clarify the effect of MGMT gene expression on cellular chemosensitivity to 1-(4-amino-2-methyl-5-pyrimidinyl)-3-(2-chloroethyl)-3-nitrosou...

journal_title：Carcinogenesis

authors： Yang J,Chen JM,Zhang YP

更新日期：1995-09-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...

journal_title：Carcinogenesis

authors： Hertzog PJ,Lindsay Smith JR,Garner RC

更新日期：1980-09-01 00:00:00

abstract：:Inflammatory tumor microenvironments play pivotal roles in the development of cancer. Inflammatory cytokines such as CXCL1/GROα exert cancer-promoting activities by increasing tumor angiogenesis. However, whether CXCL1/GROα also plays a role in the progression of prostate cancer, particularly in highly invasive castra...

journal_title：Carcinogenesis

authors： Kuo PL,Shen KH,Hung SH,Hsu YL

更新日期：2012-12-01 00:00:00

abstract：:In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...

journal_title：Carcinogenesis

authors： van den Goorbergh JA,de Wit H,Tijdens RB,Mulder GJ,Meerman JH

更新日期：1987-02-01 00:00:00

abstract：:Phosphorylation of proteins on serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase Pin1 and is a central signaling mechanism in cell proliferation and transformation. Although Pin1 is frequently overexpressed in hepatocellula...

journal_title：Carcinogenesis

authors： Lee NY,Choi HK,Shim JH,Kang KW,Dong Z,Choi HS

更新日期：2009-04-01 00:00:00

abstract：:Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...

journal_title：Carcinogenesis

authors： Iversen OH,Thorud E,Volden G

更新日期：1981-01-01 00:00:00

abstract：:Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20-40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have...

journal_title：Carcinogenesis

authors： Thun MJ,DeLancey JO,Center MM,Jemal A,Ward EM

更新日期：2010-01-01 00:00:00

abstract：:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...

journal_title：Carcinogenesis

authors： Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

更新日期：1988-03-01 00:00:00

abstract：:Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at significantly increased risk of developing cancer. Although the increased risk of breast cancer is often highlighted, cancer at several other sites is also considerably more common in these individuals. Here, we discuss existing k...

journal_title：Carcinogenesis

authors： Sowter HM,Ashworth A

更新日期：2005-10-01 00:00:00

abstract：:Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...

journal_title：Carcinogenesis

authors： Denissova NG,Nasello CM,Yeung PL,Tischfield JA,Brenneman MA

更新日期：2012-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...

journal_title：Carcinogenesis

authors： Khaleghpour K,Li Y,Banville D,Yu Z,Shen SH

更新日期：2004-02-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...

journal_title：Carcinogenesis

authors： Alexandrie AK,Sundberg MI,Seidegård J,Tornling G,Rannug A

更新日期：1994-09-01 00:00:00

abstract：:The polysubstituted benzamide derivative metoclopramide (MCA) has previously been shown to enhance the effect of cisplatin and ionizing radiation treatment of xenografted human squamous cell carcinomas from the head and neck region. In the present work we show that MCA decreases the nucleoid sedimentation rate, indica...

journal_title：Carcinogenesis

authors： Lybak S,Pero RW

更新日期：1991-09-01 00:00:00

abstract：:We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this fo...

journal_title：Carcinogenesis

authors： Pierre F,Perrin P,Bassonga E,Bornet F,Meflah K,Menanteau J

更新日期：1999-10-01 00:00:00

abstract：:One hundred forty-seven female Sprague-Dawley rats were divided into 5 groups and at 60 days of age were treated i.g. with 5 mg of 7,12-dimethylbenzanthracene (DMBA) suspended in 1.0 ml of sesame oil. Selenium (Se), as selenium dioxide (SeO2), was administered in the drinking water to 4 of the 5 groups (30 rats/group)...

journal_title：Carcinogenesis

authors： Welsch CW,Goodrich-Smith M,Brown CK,Greene HD,Hamel EJ

更新日期：1981-01-01 00:00:00

abstract：:The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I (AAI) and aristolochic acid II (AAII), was investigated. Under anaerobic conditions the major metabolites were the corresponding aristolactams for both AAI and AAII. In contrast under aerob...

journal_title：Carcinogenesis

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:Telomerase contributes to the infinite replicative potential of cancer cells by conferring proliferation and survival through the regulation of growth factors and apoptotic proteins. Although it is generally known that the phytoestrogen, genistein, has telomerase-repressing and anti-proliferative effects on various ca...

journal_title：Carcinogenesis

authors： Chau MN,El Touny LH,Jagadeesh S,Banerjee PP

更新日期：2007-11-01 00:00:00

abstract：:Monoclonal or affinity-purified antibodies specific to Novikoff hepatoma cytokeratin p39 were employed to study the origin and fate of p39-containing cell types during hepatocarcinogenesis induced with N,N-dimethyl-p(m-tolylazo)aniline. Frozen sections were obtained from the livers of animals autopsied temporally duri...

journal_title：Carcinogenesis

authors： Schmidt WN,Page DL,McKusick K,Hnilica LS

更新日期：1985-08-01 00:00:00

abstract：:Pretreatment of Fischer 344 rats with the antioxidant ethoxyquin (EQ), followed by administration of aflatoxin B1 (AFB1) in the continuing presence of EQ was used to examine the effect of the antioxidant on liver and kidney. EQ (0.5% in diet) completely prevented the formation of AFB1-induced preneoplastic liver lesio...

journal_title：Carcinogenesis

authors： Manson MM,Green JA,Driver HE

更新日期：1987-05-01 00:00:00

abstract：:I-compounds are endogenous bulky DNA modifications which are detected by nuclease P1-enhanced 32P-post-labeling in tissue DNA of animals not knowingly exposed to carcinogens. Their profiles and levels depend inter alia on animal age, species, strain, tissue, gender, diet and exposure to chemicals such as cytochrome P4...

journal_title：Carcinogenesis

authors： Zhou GD,Vulimiri SV,Randerath E,Randerath K

更新日期：1998-10-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:Glycyrrhizin (GL) is widely used in Japan as a therapeutic agent for chronic active liver diseases. However, its action on hepatocarcinogenesis remains to be elucidated. To clarify its effect, mice treated with diethylnitrosamine (NDEA) with or without GL were analyzed. Five-week-old male BALB/c mice were divided into...

journal_title：Carcinogenesis

authors： Shiota G,Harada K,Ishida M,Tomie Y,Okubo M,Katayama S,Ito H,Kawasaki H

更新日期：1999-01-01 00:00:00