Abstract:
:We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this food may interfere with carcinogenesis due to involvement of mucosal cells in the regulation of tissue homeostasis. In the present experiment, we tested whether T cell status may influence colon tumor formation in Min mice fed a food supplement of short chain fructo-oligosaccharides. Min mice depleted of CD4(+) and CD8(+) lymphocytes developed twice as many tumors as immunocompetent mice (0.8 as compared with 0.4, the mean number in 7-week-old Min mice when food supplementation began; P = 0.02). It is concluded that food supplementation with a substrate (a known prebiotic) fermented in the colon may stimulate a mechanism of immunosurveillance that would otherwise remain inefficient.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Pierre F,Perrin P,Bassonga E,Bornet F,Meflah K,Menanteau Jdoi
10.1093/carcin/20.10.1953keywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
1953-6issue
10eissn
0143-3334issn
1460-2180journal_volume
20pub_type
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