Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis.

abstract：:Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinoma...

journal_title：Carcinogenesis

authors： Lee JS,Grisham JW,Thorgeirsson SS

更新日期：2005-06-01 00:00:00

abstract：:Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats are resistant to hepatocar...

journal_title：Carcinogenesis

authors： Wood GA,Korkola JE,Lee VM,Sarma DS,Archer MC

更新日期：1997-09-01 00:00:00

abstract：:Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as gene regulators controlling diverse biological processes, including car...

journal_title：Carcinogenesis

authors： Wang H,Wu J,Meng X,Ying X,Zuo Y,Liu R,Pan Z,Kang T,Huang W

更新日期：2011-07-01 00:00:00

abstract：:Oxidative stress has consistently been linked to breast carcinogenesis, and mitochondria play a significant role in regulating reactive oxygen species generation. In our previous study, we found that increased levels of mitochondrial DNA (mtDNA) copy number and the presence of mitochondrial length heteroplasmies in th...

journal_title：Carcinogenesis

authors： Shen J,Wan J,Song R,Zhao H

更新日期：2015-11-01 00:00:00

abstract：:Formation of O6-ethylguanine (O6EG) in trachea DNA was measured 12 h after acute i.p. administration of 50, 100 and 200 mg diethylnitrosamine (DEN)/kg body wt to Syrian golden hamsters. Purine bases were fractionated by h.p.l.c., and ethylated guanines were quantified optically by fluorescence spectrophotometry. Signi...

journal_title：Carcinogenesis

authors： Fong AT,Rasmussen RE

更新日期：1986-09-01 00:00:00

abstract：:Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...

journal_title：Carcinogenesis

authors： Vredeveld LC,Rowland BD,Douma S,Bernards R,Peeper DS

更新日期：2010-02-01 00:00:00

abstract：:Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of these compounds have either marginal or no modulating effect, some have been identified as effective inhibitors. The strong inhibit...

journal_title：Carcinogenesis

authors： Bhattacharya RK,Firozi PF,Aboobaker VS

更新日期：1984-10-01 00:00:00

abstract：:Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...

journal_title：Carcinogenesis

authors： Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

更新日期：2015-10-01 00:00:00

abstract：:Several previous in vitro studies have indicated that ascorbate and glutathione are the major reductants of Cr(VI) in cells. In order to evaluate the in vivo effects of ascorbate and glutathione on Cr(VI)-induced carcinogenesis, Cr uptake and the formation of Cr(V), Cr-DNA adducts and 8-hydroxy-2'-deoxyguanosine (8-OH...

journal_title：Carcinogenesis

authors： Yuann JM,Liu KJ,Hamilton JW,Wetterhahn KE

更新日期：1999-07-01 00:00:00

abstract：:To elucidate the mechanism of metabolic activation of 3'-methyl-N,N-dimethyl-4-aminoazobenzene (3'-Me-DAB), the mutagenicity of its metabolites and some related azo compounds towards Salmonella typhimurium TA-98 and TA-100 was investigated. Mutagenicity of the metabolites, either N-demethylated or oxidized at the 3'-m...

journal_title：Carcinogenesis

authors： Mori Y,Niwa T,Hori T,Toyoshi K

更新日期：1980-02-01 00:00:00

abstract：:Estrogen plays an important role in breast cancer development. While the mechanism of the estrogen effects is not fully elucidated, one possible route is by increasing the stem cell-like properties in the tumors. Tocopherols are known to reduce breast cancer development and progression. The aim of the present study is...

journal_title：Carcinogenesis

authors： Bak MJ,Furmanski P,Shan NL,Lee HJ,Bao C,Lin Y,Shih WJ,Yang CS,Suh N

更新日期：2018-07-30 00:00:00

abstract：:The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...

journal_title：Carcinogenesis

authors： Chen W,Wang X,Zhuang J,Zhang L,Lin Y

更新日期：2007-10-01 00:00:00

abstract：:Twist1 is an essential transcription factor required to initiate epithelial-mesenchymal transition (EMT) and promote tumor metastasis. PAQR3 is a newly found tumor suppressor that is frequently downregulated in many types of human cancers. Downregulation of PAQR3 is associated with accelerated metastasis and poor prog...

journal_title：Carcinogenesis

authors： Guo W,You X,Xu D,Zhang Y,Wang Z,Man K,Wang Z,Chen Y

更新日期：2016-04-01 00:00:00

abstract：:Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...

journal_title：Carcinogenesis

authors： Brooks G,Evans AT,Aitken A,Evans FJ

更新日期：1989-02-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:gamma-Glutamyl transpeptidase (gamma GT) positive hepatocytes were isolated from F344 male rats fed 2-acetylaminofluorene. The isolation procedure is rapid and highly selective for cells exhibiting gamma GT on their surface. Suspensions of liver cells obtained from perfusion in situ with a collagenase solution were in...

journal_title：Carcinogenesis

authors： Hanigan HM,Pitot HC

更新日期：1982-01-01 00:00:00

abstract：:The breast cancer gene BRCA1 has previously been cloned from both human and mouse. We cloned a fragment of the rat Brca1 homologue in order to map it and explore its biological function. Partial cDNA fragments of the rat Brca1 homologue were isolated by RT-PCR. Sequence analysis revealed that the RING-finger domain is...

journal_title：Carcinogenesis

authors： Chen KS,Shepel LA,Haag JD,Heil GM,Gould MN

更新日期：1996-08-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:The ability of three benzodiazepine tranquilizers, diazepam, oxazepam and chlordiazepoxide chlorhydrate to block metabolic cooperation between human hepatoma cells was analysed using autoradiographical monitoring. Independent tests were performed with compound concentrations varying from 1 to 50 micrograms/ml. The res...

journal_title：Carcinogenesis

authors： Rolin-Limbosch S,Moens W,Szpirer C

更新日期：1987-07-01 00:00:00

abstract：:Carcinogenic tobacco-specific nitrosamines are present in tobacco products and are believed to play a significant role in human cancers associated with tobacco use. Additional amounts of tobacco-specific nitrosamines could be formed endogenously. We tested this hypothesis by treating rats with nicotine and sodium nitr...

journal_title：Carcinogenesis

authors： Carmella SG,Borukhova A,Desai D,Hecht SS

更新日期：1997-03-01 00:00:00

abstract：:The effects of in vivo exposure to DDT on hepatic gap junctional intercellular communication (GJIC) and connexin gene/protein expression in Sprague-Dawley rats were examined by in vivo/in vitro dye-transfer assay, immunohistochemical staining, and by Western and Northern blot analyses. In the dose-response study, thre...

journal_title：Carcinogenesis

authors： Tateno C,Ito S,Tanaka M,Oyamada M,Yoshitake A

更新日期：1994-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of short non-coding, single-stranded RNAs, which perform posttranscriptional regulatory functions as tumor suppressors or oncogenes. Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) genes are currently being identified for contributing to cancer risk, prognosis and survival. ...

journal_title：Carcinogenesis

authors： Du M,Lu D,Wang Q,Chu H,Tong N,Pan X,Qin C,Yin C,Wang M,Zhang Z

更新日期：2014-07-01 00:00:00

abstract：:Dibenzo[a,l]pyrene (DB[a,l]P) is an extremely potent carcinogen that may be present in environmental samples. Dose-response studies were conducted at low doses in mouse skin by initiation-promotion and repeated application to compare its activity to that of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (B[a]P)...

journal_title：Carcinogenesis

authors： Higginbotham S,RamaKrishna NV,Johansson SL,Rogan EG,Cavalieri EL

更新日期：1993-05-01 00:00:00

abstract：:Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive ag...

journal_title：Carcinogenesis

authors： Kensler TW,Ng D,Carmella SG,Chen M,Jacobson LP,Muñoz A,Egner PA,Chen JG,Qian GS,Chen TY,Fahey JW,Talalay P,Groopman JD,Yuan JM,Hecht SS

更新日期：2012-01-01 00:00:00

abstract：:Dysbiosis of oral microbiome may dictate the progression of oral squamous cell carcinoma (OSCC). Yet, the composition of oral microbiome fluctuates by saliva and distinct sites of oral cavity and is affected by risky behaviors (smoking, drinking, and betel quid chewing) and individuals' oral health condition. To chara...

journal_title：Carcinogenesis

authors： Su SC,Chang LC,Huang HD,Peng CY,Chuang CY,Chen YT,Lu MY,Chiu YW,Chen PY,Yang SF

更新日期：2020-07-04 00:00:00

abstract：:Herbacetin is a flavonol compound that is found in plants such as flaxseed and ramose scouring rush herb, it possesses a strong antioxidant capacity, and exerts anticancer effects on colon and breast cancer. However, the effect of herbacetin on skin cancer has not been investigated. Herein, we identified herbacetin as...

journal_title：Carcinogenesis

authors： Kim DJ,Lee MH,Liu K,Lim DY,Roh E,Chen H,Kim SH,Shim JH,Kim MO,Li W,Ma F,Fredimoses M,Bode AM,Dong Z

更新日期：2017-10-26 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:Adduct formation has been considered to be a major causal factor of DNA damage by carcinogenic heterocyclic amines. By means of experiments with an electrochemical detector coupled to a high-performance liquid chromatograph, we revealed that N-hydroxy metabolite of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (Ph...

journal_title：Carcinogenesis

authors： Murata M,Kawanishi S

更新日期：2002-05-01 00:00:00

abstract：:The role of BRCA1 in sporadic breast and ovarian cancers remains elusive. Direct involvement of BRCA1 in the development of breast and ovarian cancer is suggested by the finding that the BRCA1 promoter region CpG island is methylated in a proportion of breast and ovarian cancers. The aim of this study was to compare t...

journal_title：Carcinogenesis

authors： Bianco T,Chenevix-Trench G,Walsh DC,Cooper JE,Dobrovic A

更新日期：2000-02-01 00:00:00

abstract：:A large number of chemical carcinogens require metabolic activation before they are biologically active. The metabolism of a few of these compounds has been investigated in cultured human tissues and cells and the metabolism has been compared with the metabolism in organs from experimental animals in which the compoun...

journal_title：Carcinogenesis

authors： Autrup H

更新日期：1990-05-01 00:00:00