Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.

abstract：:The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not...

journal_title：Carcinogenesis

authors： Goldman PR,Vogel WH

更新日期：1984-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:58 MCA Cl 16 is an oncogenic methylcholanthrene-transformed variant of the non-transformed mouse embryo fibroblast cell line, C3H/10T1/2 Cl 8. Using two different protocols, we have isolated six temperature-sensitive mutants from N-methyl-N'-nitro-N-nitrosoguanidine treated cultures of 58 MCA Cl 16. C3H/10T1/2 Cl 8, 5...

journal_title：Carcinogenesis

authors： Boreiko C,Heidelberger C

更新日期：1980-01-01 00:00:00

abstract：:The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...

journal_title：Carcinogenesis

authors： DiGiovanni J,Kruszewski FH,Coombs MM,Bhatt TS,Pezeshk A

更新日期：1988-08-01 00:00:00

abstract：:Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced oxidative stress. Lipid peroxidation (LPO)-induced etheno-DNA adducts in nuclear- and mitochondrial-DNA along with apoptosis was measured in LEC rat liver. Levels o...

journal_title：Carcinogenesis

authors： Nair J,Strand S,Frank N,Knauft J,Wesch H,Galle PR,Bartsch H

更新日期：2005-07-01 00:00:00

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00

abstract：:Mutant RAS (RAS(V12)) is known to transform most immortal cells but to induce premature senescence in primary cells. RAS(V12)-induced senescence in murine cells depends on the induction of the ARF/p53 and the retinoblastoma (Rb) family tumor suppressor pathways. We and others have shown previously that oncogene-induce...

journal_title：Carcinogenesis

authors： Vredeveld LC,Rowland BD,Douma S,Bernards R,Peeper DS

更新日期：2010-02-01 00:00:00

abstract：:Reprogrammed metabolism has been identified as an emerging hallmark in cancer cells. It has been demonstrated that fructose-1, 6-bisphosphatase 1 (FBP1) as a rate-limiting enzyme in gluconeogenesis plays critical roles in tumor initiation and progression in several cancer types. However, function of FBP1 in hepatocell...

journal_title：Carcinogenesis

authors： Yang J,Wang C,Zhao F,Luo X,Qin M,Arunachalam E,Ge Z,Wang N,Deng X,Jin G,Cong W,Qin W

更新日期：2017-02-01 00:00:00

abstract：:We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]a...

journal_title：Carcinogenesis

authors： Shoji Y,Takahashi M,Takasuka N,Niho N,Kitamura T,Sato H,Maruyama T,Sugimoto Y,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2005-12-01 00:00:00

abstract：:Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...

journal_title：Carcinogenesis

authors： Cho K,Mabasa L,Bae S,Walters MW,Park CS

更新日期：2012-05-01 00:00:00

abstract：:Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...

journal_title：Carcinogenesis

authors： Gupta RC,Dighe NR

更新日期：1984-03-01 00:00:00

abstract：:The present study was conducted to clarify the cooperative significance of epigenomic and genomic abnormalities during gastric carcinogenesis. Using 21 samples of normal control gastric mucosa (C), 109 samples of non-cancerous gastric mucosa (N) and 105 samples of cancerous tissue (T) from 109 patients with primary ga...

journal_title：Carcinogenesis

authors： Yang M,Arai E,Takahashi Y,Totsuka H,Chiku S,Taniguchi H,Katai H,Sakamoto H,Yoshida T,Kanai Y

更新日期：2020-11-13 00:00:00

abstract：:Previous studies have shown that polycyclic aromatic hydrocarbons (PAHs) mobilize intracellular Ca2+ in human T cells by inositol trisphosphate-dependent mechanisms resulting from activation of phospholipase C-gamma by SRC-related protein tyrosine kinases, thereby mimicking antigen-receptor activation. Ca2+ appears to...

journal_title：Carcinogenesis

authors： Tannheimer SL,Barton SL,Ethier SP,Burchiel SW

更新日期：1997-06-01 00:00:00

abstract：:It is now unanimously accepted that neoplastic cells tend to become less susceptible to the growth regulatory effects of transforming growth factor-beta1 (TGF-beta1), mainly because of reduced expression and/or activity of TGF-beta1-specific receptors, as reported for many human cancers including colon cancer. Consequ...

journal_title：Carcinogenesis

authors： Biasi F,Mascia C,Poli G

更新日期：2008-05-01 00:00:00

abstract：:When hepatocytes isolated from mouse liver are cultivated in vitro, a small fraction of cells can survive, forming colonies, while most cells die within a few weeks. We compared the colony forming capacity of hepatocytes in three mouse strains; two strains susceptible for hepatocarcinogenesis, C3H/HeJ (C3) and DBA/2J ...

journal_title：Carcinogenesis

authors： Yoshie M,Nishimori H,Lee GH,Ogawa K

更新日期：1998-06-01 00:00:00

abstract：:Epithelial cells derived from 46 human breast tissue samples of patients suffering from breast cancer have been cultivated. Twenty-five of these cell cultures stemmed from normal and 21 from tumor tissues. Moderate to large variations of protein levels of three protein kinase C (PKC) isoenzymes (alpha, delta and epsil...

journal_title：Carcinogenesis

authors： Imber R,Haberthür F,Meier F,Filipuzzi I,Almendral AC

更新日期：1994-02-01 00:00:00

abstract：:To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...

journal_title：Carcinogenesis

authors： Schaaper RM,Koffel-Schwartz N,Fuchs RP

更新日期：1990-07-01 00:00:00

abstract：:Phenobarbital and clofibrate, two non-genotoxic carcinogens, have been investigated regarding the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis in primary cultures of rat hepatocytes. Low toxicity concentrations, 200 and 100 microg/ml for phenobarbital and clofibrate respect...

journal_title：Carcinogenesis

authors： Díez-Fernández C,Sanz N,Alvarez AM,Wolf A,Cascales M

更新日期：1998-10-01 00:00:00

abstract：:The role of aflatoxin B1 (AFB1) in the induction of rearrangements affecting minisatellite sequences was studied in an in vitro yeast model. The Saccharomyces cerevisiae strain used expresses human cytochrome P450 1A2 and NADPH-cytochrome P450 oxidoreductase and has previously been used to study genetic recombination ...

journal_title：Carcinogenesis

authors： Kaplanski C,Wild CP,Sengstag C

更新日期：1998-09-01 00:00:00

abstract：:Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addres...

journal_title：Carcinogenesis

authors： Robey RB,Weisz J,Kuemmerle NB,Salzberg AC,Berg A,Brown DG,Kubik L,Palorini R,Al-Mulla F,Al-Temaimi R,Colacci A,Mondello C,Raju J,Woodrick J,Scovassi AI,Singh N,Vaccari M,Roy R,Forte S,Memeo L,Salem HK,Amedei A,

更新日期：2015-06-01 00:00:00

abstract：:[3H]Benzo[a]pyrene (B[a]P) was administered to male Sprague-Dawley rats via intratracheal instillation, and bile was collected over a period of 6 h. Conjugated metabolites of B[a]P in bile were separated by paper chromatography or reversed-phase ion-pair HPLC and quantified by liquid scintillation spectrometry. In pap...

journal_title：Carcinogenesis

authors： Bevan DR,Sadler VM

更新日期：1992-03-01 00:00:00

abstract：:Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...

journal_title：Carcinogenesis

authors： Shahin MM,Bugaut A,Junino A,Kalopissis G

更新日期：1982-01-01 00:00:00

abstract：:Calpains are cysteine proteases comprising members ubiquitously expressed in human tissues and other tissue-specific isoforms. Alterations of calpain 3 (p94), the muscle-specific isoform that contains three peculiar sequences (NS, IS1 and IS2), are strictly associated to the limb-girdle muscular dystrophy type 2A, in ...

journal_title：Carcinogenesis

authors： Moretti D,Del Bello B,Cosci E,Biagioli M,Miracco C,Maellaro E

更新日期：2009-06-01 00:00:00

abstract：:The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a possible increased CRC risk from (higher) dietary fat intake. Therefore, ...

journal_title：Carcinogenesis

authors： van Kranen HJ,van Iersel PW,Rijnkels JM,Beems DB,Alink GM,van Kreijl CF

更新日期：1998-09-01 00:00:00

abstract：:Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...

journal_title：Carcinogenesis

authors： Fu PY,Hu B,Ma XL,Tang WG,Yang ZF,Sun HX,Yu MC,Huang A,Hu JW,Zhou CH,Fan J,Xu Y,Zhou J

更新日期：2020-07-14 00:00:00

abstract：:We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...

journal_title：Carcinogenesis

authors： Preet R,Mohapatra P,Das D,Satapathy SR,Choudhuri T,Wyatt MD,Kundu CN

更新日期：2013-02-01 00:00:00

abstract：:Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...

journal_title：Carcinogenesis

authors： Poirier MC,Fullerton NF,Patterson ED,Beland FA

更新日期：1990-08-01 00:00:00

abstract：:Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. We have used human hepatoma HepG2 cells to examine the regulation of TrxRs by isothiocyanate ...

journal_title：Carcinogenesis

authors： Zhang J,Svehlíková V,Bao Y,Howie AF,Beckett GJ,Williamson G

更新日期：2003-03-01 00:00:00

abstract：:To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...

journal_title：Carcinogenesis

authors： Tang H,Dong X,Day RS,Hassan MM,Li D

更新日期：2010-04-01 00:00:00

abstract：:The 32P-postlabeling method has been adapted for the analysis of thymidine-cis-glycol-3'-phosphate (cis-dTGp,cis-5,6-dihydroxy-5,6-dihydrothymidine-3'-phosphat e). Cis-dTGp was isolated and purified from normal nucleotides by phenylboronate affinity chromatography and phosphorylated by T4 polynucleotide kinase in pres...

journal_title：Carcinogenesis

authors： Hegi ME,Sagelsdorff P,Lutz WK

更新日期：1989-01-01 00:00:00