Abstract:
:The relationship between striatal dopamine-stimulated adenylate cyclase (DAC) and 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors was studied. An inverse correlation between activity of this enzyme and the number and growth of tumors was observed in several strains and substrains of rats. Chronic, but not acute, restraint stress inhibited tumor growth and increased DAC activity. No correlation between enzyme activity and the number of tumors was found in the stress study. Increased DAC activity appears to protect or inhibit DMBA mammary tumor development in rats.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Goldman PR,Vogel WHdoi
10.1093/carcin/5.7.971subject
Has Abstractpub_date
1984-07-01 00:00:00pages
971-3issue
7eissn
0143-3334issn
1460-2180journal_volume
5pub_type
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