Ellagic acid induces transcription of the rat glutathione S-transferase-Ya gene.

abstract：:Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pre...

journal_title：Carcinogenesis

authors： Beguin Y,Bours V,Delbrouck JM,Robaye G,Roelandts I,Bury J,Fillet G,Weber G

更新日期：1989-11-01 00:00:00

abstract：:As rat tracheal epithelial cells progress from a normal to a neoplastic phenotype there are systematic changes in their ability to produce and activate latent transforming growth factor type beta (TGF-beta) as well as systematic changes in their response to this growth factor. Using a TGF-beta radioreceptor binding co...

journal_title：Carcinogenesis

authors： Terzaghi-Howe M

更新日期：1989-06-01 00:00:00

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:We previously characterized a clone of CHO cells, clone B, that displayed tolerance to the cytotoxic effects of N-methylnitrosourea (MNU) and 6-thioguanine (6-TG). To determine whether this phenotype affected the mutagenic response of the cells, MNU-induced mutation to 8-azaadenine resistance (8-AAr) was measured in t...

journal_title：Carcinogenesis

authors： Aquilina G,Biondo R,Dogliotti E,Bignami M

更新日期：1993-10-01 00:00:00

abstract：:Isolated trout liver cells were treated with lysolecithin to produce an in situ system for characterizing DNA repair in teleosts. In this preparation, the integrity of the plasma membrane is altered, nuclei remain intact, and the concentrations of dNTPs and nucleotide analogs, which normally do not penetrate intact pl...

journal_title：Carcinogenesis

authors： Miller MR,Blair JB,Hinton DE

更新日期：1989-06-01 00:00:00

abstract：:Adult rat hepatocytes in primary culture were used to study the effect of tryptophan pyrolysis products on the transcriptional process. Hepatocytes were treated with 1, 5 and 10 micrograms/ml of 3-amino-1,4-dimethyl-5H-pyrido-[4,3-b]-indole (Trp-P-1) or 3-amino-1-methyl-5H-pyrido-[4,3-b]-indole (Trp-P-2) for 2 and 4 h...

journal_title：Carcinogenesis

authors： Thybaud-Lambay V,Decloitre F,Moulé Y,Florentin Y

更新日期：1983-01-01 00:00:00

abstract：:The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed...

journal_title：Carcinogenesis

authors： Kandaswami C,Kumar S,Dubey SK,Sikka HC

更新日期：1987-12-01 00:00:00

abstract：:A 25mer oligonucleotide containing a single N-(deoxyguanosin-8-yl-)-1-aminopyrene (dGAP), the major DNA adduct formed by reductively activated 1-nitropyrene, was synthesized. The adduct was located at nucleotide 21 from the 3' end. DNA synthesis on this template by human DNA polymerases alpha and beta, HIV reverse tra...

journal_title：Carcinogenesis

authors： Vyas RR,Basu AK

更新日期：1995-04-01 00:00:00

abstract：:The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...

journal_title：Carcinogenesis

authors： Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

更新日期：2006-09-01 00:00:00

abstract：:The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene tran...

journal_title：Carcinogenesis

authors： Capaccione KM,Pine SR

更新日期：2013-07-01 00:00:00

abstract：:The transforming potential of acrylonitrile epoxide (ANO) was tested in a modified NIH3T3 transfection-transformation assay. This involves a new ras construct obtained by ligating a human c-Ha-ras-1 proto-oncogene to the pSV2neo mammalian vector. The new plasmid was allowed to react with ANO or an established carcinog...

journal_title：Carcinogenesis

authors： Yuan B,Wong JL

更新日期：1991-05-01 00:00:00

abstract：:The formation of thioether conjugates is an important pathway for inactivation of certain carcinogens. This study assessed the mechanism by which the bladder carcinogen 2-amino-4-(5-nitro-2-furyl)-thiazole (ANFT) forms a glutathione conjugate (ANFT-SG). Peroxidatic metabolism of ANFT, in the presence of glutathione, r...

journal_title：Carcinogenesis

authors： Lakshmi VM,Zenser TV,Sohani S,Davis BB

更新日期：1992-11-01 00:00:00

abstract：:Whole-body autoradiography of [3H]aflatoxin B1 ([3H]AFB1) in lamb showed a localization of bound labelling, in addition to the liver, in the nasal olfactory and respiratory mucosa, in the mucosa of the nasopharynx, pharynx, oesophagus, larynx, trachea, bronchi and bronchioles and in the palpebral and bulbar conjunctiv...

journal_title：Carcinogenesis

authors： Larsson P,Busk L,Tjälve H

更新日期：1994-05-01 00:00:00

abstract：:In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of independent techniques. A fraction of DNA treated briefly with either of the...

journal_title：Carcinogenesis

authors： Kubinski H,Kubinski ZO,Fiandt M,Konopa G

更新日期：1981-01-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:The incidence and mortality statistics for oral squamous cell carcinoma (OSCC) were 10th and 12th, respectively, in human cancers diagnosed worldwide in 2008. In this study, to identify novel tumor-suppressive microRNAs (TS-miRNAs) and their direct targets in OSCC, we performed methylation-based screening for 43 miRNA...

journal_title：Carcinogenesis

authors： Endo H,Muramatsu T,Furuta M,Uzawa N,Pimkhaokham A,Amagasa T,Inazawa J,Kozaki K

更新日期：2013-03-01 00:00:00

abstract：:Resveratrol is a phytochemical that has been under consideration for use as a prostate cancer chemopreventive agent. However, the efficacy, as well as the mechanisms of action of resveratrol on prostate cancer prevention, remains largely unknown. This study seeks to address these questions and examine the cancer preve...

journal_title：Carcinogenesis

authors： Wang TT,Hudson TS,Wang TC,Remsberg CM,Davies NM,Takahashi Y,Kim YS,Seifried H,Vinyard BT,Perkins SN,Hursting SD

更新日期：2008-10-01 00:00:00

abstract：:Complementary DNA of marmoset CYP1A2 was isolated by means of screening the cDNA library and reverse-transcriptase polymerase chain reaction. The deduced amino acid sequence of marmoset CYP1A2 consisted of 516 residues and showed 88.2 and 90.0% identities to corresponding forms in human and cynomolgus monkey, respecti...

journal_title：Carcinogenesis

authors： Sakuma T,Igarashi T,Hieda M,Ohgiya S,Isogai M,Ninomiya S,Nagata R,Nemoto N,Kamataki T

更新日期：1997-10-01 00:00:00

abstract：:FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in t...

journal_title：Carcinogenesis

authors： Baffa R,Fassan M,Sevignani C,Vecchione A,Ishii H,Giarnieri E,Iozzo RV,Gomella LG,Croce CM

更新日期：2008-04-01 00:00:00

abstract：:Thioredoxin reductases (TrxRs) catalyse the NADPH-dependent reduction of thioredoxin and play an important role in multiple cellular events related to carcinogenesis including cell proliferation, apoptosis and cell signaling. We have used human hepatoma HepG2 cells to examine the regulation of TrxRs by isothiocyanate ...

journal_title：Carcinogenesis

authors： Zhang J,Svehlíková V,Bao Y,Howie AF,Beckett GJ,Williamson G

更新日期：2003-03-01 00:00:00

abstract：:The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...

journal_title：Carcinogenesis

authors： Kulkarni JR,Lalitha VS,Bhide SV

更新日期：1988-11-01 00:00:00

abstract：:Pardaxin, an antimicrobial peptide secreted by the Red Sea flatfish Pardachirus marmoratus, inhibits proliferation and induces apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are only partially understood at present. In this study, we used proteomic approaches and network reconstruct...

journal_title：Carcinogenesis

authors： Huang TC,Chen JY

更新日期：2013-08-01 00:00:00

abstract：:We have recently shown that a variety of human tumor cell lines are capable of preventing chloroethylnitrosourea (CNU)-induced DNA crosslinks, presumably by removing guanine O6-chloroethyl DNA monoadducts before crosslinks can form. Those cells capable of preventing crosslinking were of the Mer+ (Methylation repair) p...

journal_title：Carcinogenesis

authors： Zlotogorski C,Erickson LC

更新日期：1984-01-01 00:00:00

abstract：:Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...

journal_title：Carcinogenesis

authors： Brooks G,Evans AT,Aitken A,Evans FJ

更新日期：1989-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...

journal_title：Carcinogenesis

authors： Schrauzer GN,McGinness JE,Kuehn K

更新日期：1980-02-01 00:00:00

abstract：:Amarogentin, a secoiridoid glycoside, is an active component of the medicinal plant Swertia chirata. In this study, chemopreventive and chemotherapeutic actions of amarogentin were evaluated in a carbon tetrachloride (CCl(4))/N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis mouse model system during continuou...

journal_title：Carcinogenesis

authors： Pal D,Sur S,Mandal S,Das A,Roy A,Das S,Panda CK

更新日期：2012-12-01 00:00:00

abstract：:Modulation of microsome mediated benzo[a]pyrene (BP) metabolism by oleic and linoleic acids was studied. Oleic and linoleic acids did not influence the apparent activity of aryl hydrocarbon hydroxylase or the relative ratios of BP-7,8-dihydrodiol to phenol metabolites on high performance liquid chromatography. The tot...

journal_title：Carcinogenesis

authors： Nemoto N,Takayama S

更新日期：1983-10-01 00:00:00

abstract：:E mu-pim-1 transgenic mice, which overexpress the pim-1 oncogene in lymphoid tissues, have shown increased susceptibility to induction of T cell lymphomas by N-ethyl-N-nitrosourea, a direct-acting chemical carcinogen (Nature, 340, 61-63, 1989). We sought to further evaluate E mu-pim-1 transgenic mice as a potential te...

journal_title：Carcinogenesis

authors： Storer RD,Cartwright ME,Cook WO,Soper KA,Nichols WW

更新日期：1995-02-01 00:00:00

abstract：:The JB6 mouse epidermal cell system has been extensively used as an in vitro model for the study of tumor promotion. The present study aimed to assess the relevance of monolayer measurements to the process of transformation, which is induced more efficiently under anchorage-independent (AI) conditions. Although it wou...

journal_title：Carcinogenesis

authors： Dong Z,Cmarik JL,Wendel EJ,Colburn NH

更新日期：1994-05-01 00:00:00