Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells.

abstract：:Aberrant crypt foci (ACF) are microscopic surface abnormalities that are putative precursors to colorectal cancer (CRC). ACF exhibit similar histological and molecular abnormalities to adenomas and CRC and potentially represent useful biomarkers of cancer risk. Microsatellite instability (MSI) is one molecular abnorma...

journal_title：Carcinogenesis

authors： Greenspan EJ,Cyr JL,Pleau DC,Levine J,Rajan TV,Rosenberg DW,Heinen CD

更新日期：2007-04-01 00:00:00

abstract：:DNAs from fourteen fibrosarcomas induced by 3-methylcholanthrene (MCA) in BALB/c mice were analyzed for the presence of transforming oncogenes following transfection on NIH3T3 cells. Six transfection-positive DNAs contained an activated ras gene: four c-K-ras and two c-N-ras. These results demonstrate that c-K-ras is ...

journal_title：Carcinogenesis

authors： Borrello MG,Carbone G,Pierotti MA,Molla A,Della Porta G

更新日期：1988-08-01 00:00:00

abstract：:Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...

journal_title：Carcinogenesis

authors： Otori K,Yano Y,Takada N,Lee CC,Hayashi S,Otani S,Fukushima S

更新日期：1997-08-01 00:00:00

abstract：:Purified DNA was modified in vitro by 3H-labelled O-acetyl or O,O'-diacetyl-4-hydroxyaminoquinoline-1-oxide (Ac4HAQO or di Ac-4HAQO). It was then subjected to the action of the single-stranded DNA specific nuclease S1 and the digested fractions were analysed. For both types of modified DNA, the release of non-modified...

journal_title：Carcinogenesis

authors： Galiègue S,Bailleul B,Loucheux-Lefebvre MH,Laval J

更新日期：1982-01-01 00:00:00

abstract：:Trabectedin is a marine-derived antineoplastic drug. Besides targeting the cancer cells, trabectedin has a peculiar activity on the tumor microenvironment with marked effects on the vasculature and the immune response. Because a favorable microenvironment is a key factor in the progression of cutaneous melanoma, we hy...

journal_title：Carcinogenesis

authors： Carminati L,Pinessi D,Borsotti P,Minoli L,Giavazzi R,D'Incalci M,Belotti D,Taraboletti G

更新日期：2019-04-29 00:00:00

abstract：:Effects of tamoxifen (TAM) on development of uterine endometrial carcinogenesis were studied in intact and ovariectomized (OVX) mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). In experiment I, animals were implanted with cholesterol (ChL, controls) or TAM (5% w/w) and/or 17beta-oestradiol (E(2), 0.5% w...

journal_title：Carcinogenesis

authors： Takahashi M,Shimomoto T,Miyajima K,Iizuka S,Watanabe T,Yoshida M,Kurokawa Y,Maekawa A

更新日期：2002-09-01 00:00:00

abstract：:Cancer testis antigens (CTAs) are promising targets for T cell-based immunotherapy and studies have shown that certain CT genes are epigenetically depressed in cancer cells through DNA demethylation. Melanoma-associated antigen A11 (MAGE-A11) is a CTA that is frequently expressed in esophageal cancer and is correlated...

journal_title：Carcinogenesis

authors： Wu Y,Sang M,Liu F,Zhang J,Li W,Li Z,Gu L,Zheng Y,Li J,Shan B

更新日期：2020-07-14 00:00:00

abstract：:Caucasian renal transplant recipients from Queensland, Australia have the highest non-melanoma skin cancer (NMSC) risk worldwide. Although ultraviolet light (UVR) exposure is critical, genetic factors also appear important. We and others have shown that polymorphism in the glutathione S-transferases (GST) is associate...

journal_title：Carcinogenesis

authors： Fryer AA,Ramsay HM,Lovatt TJ,Jones PW,Hawley CM,Nicol DL,Strange RC,Harden PN

更新日期：2005-01-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present wo...

journal_title：Carcinogenesis

authors： Banerjee S,Panda CK,Das S

更新日期：2006-08-01 00:00:00

abstract：:Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...

journal_title：Carcinogenesis

authors： Plna K,Segerbäck D,Schweda EK

更新日期：1996-07-01 00:00:00

abstract：:TMPRSS4 is a novel type II transmembrane serine protease that is highly expressed on the cell surface in pancreatic, thyroid and other cancer tissues, although its oncogenic significance and molecular mechanisms are unknown. Previously, we have shown that TMPRSS4 promotes invasion, migration and metastasis of human tu...

journal_title：Carcinogenesis

authors： Kim S,Kang HY,Nam EH,Choi MS,Zhao XF,Hong CS,Lee JW,Lee JH,Park YK

更新日期：2010-04-01 00:00:00

abstract：:It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsib...

journal_title：Carcinogenesis

authors： Yokota J

更新日期：2000-03-01 00:00:00

abstract：:Xanthorrhizol is an active component isolated from Curcuma xanthorrhiza Roxb. (Zingiberaceae) that is traditionally used in Indonesia for medicinal purposes. In the present study, we found that the topical application of xanthorrhizol before 12-O-tetradecanoylphorbol-13-acetate (TPA) treatment significantly inhibits T...

journal_title：Carcinogenesis

authors： Chung WY,Park JH,Kim MJ,Kim HO,Hwang JK,Lee SK,Park KK

更新日期：2007-06-01 00:00:00

abstract：:A number of distinct subtypes of neuroblastoma exist with different genetic abnormalities that are predicative of outcome. Whole chromosome gains are usually associated with low stage disease and favourable outcome, whereas loss of 1p, 3p and 11q, unbalanced gain of 17q and MYCN amplification (MNA) are indicative of h...

journal_title：Carcinogenesis

authors： McArdle L,McDermott M,Purcell R,Grehan D,O'Meara A,Breatnach F,Catchpoole D,Culhane AC,Jeffery I,Gallagher WM,Stallings RL

更新日期：2004-09-01 00:00:00

abstract：:Changes in lipid metabolism were monitored in rat hepatocyte nodules at certain time points over 9 months. Tissue obtained from partially hepatectomized rats, collected over a period of 7 days, were included as a control for normal hepatocyte cell proliferation. Two important features regarding the lipid profiles of h...

journal_title：Carcinogenesis

authors： Abel S,Smuts CM,de Villiers C,Gelderblom WC

更新日期：2001-05-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Inbred strains of mice with differential response to known tumor promoters were compared with respect to their susceptibility to modulation of hepatic antioxidant enzymes by long-term treatment with high fat diet (HF) and phenobarbital (PB). Mice of the C57BL/6J (C57), C3H/HeOuJ (C3H) and DBA/2J (DBA) strains were fed...

journal_title：Carcinogenesis

authors： Ahotupa M,Bereziat JC,Mäntylä E,Bartsch H

更新日期：1993-06-01 00:00:00

abstract：:The landscape of HPV infection in racial/ethnic subgroups of head and neck cancer (HNC) patients has not been evaluated carefully. In this study, a meta-analysis examined the prevalence of HPV in HNC patients of African ancestry. Additionally, a pooled analysis of subject-level data was also performed to investigate H...

journal_title：Carcinogenesis

authors： Ragin C,Liu JC,Jones G,Shoyele O,Sowunmi B,Kennett R,Groen HJ,Gibbs D,Blackman E,Esan M,Brandwein MS,Devarajan K,Bussu F,Chernock R,Chien CY,Cohen MA,Samir EM,Mikio S,D'Souza G,Funchain P,Eng C,Gollin SM,Hong

更新日期：2017-02-01 00:00:00

abstract：:The rates of reaction and the products formed when two vicinal diol-epoxides derived from benz(a)anthracene, anti-BA-3,4-diol 1,2-oxide (t-3,r-4-dihydroxy-t-1,2-oxy-1,2,3,4-tetrahydrobenz(a) anthracene)* and anti-BA-8,9-diol 10,11-oxide (r-8,t-9-dihydroxy-t-10,11-oxy-8,9,10,11-tetrahydrobenz(a)anthracene) reacted with...

journal_title：Carcinogenesis

authors： Hemminki K,Cooper CS,Ribeiro O,Grover PL,Sims P

更新日期：1980-03-01 00:00:00

abstract：:We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...

journal_title：Carcinogenesis

authors： Yabu K,Warty VS,Gorelik E,Shinozuka H

更新日期：1991-01-01 00:00:00

abstract：:DNA repair after gamma radiation was studied in purified T lymphocytes from young and aged subjects. Two different assays were employed. In the first, T lymphocytes were stimulated with phytohemagglutinin (PHA) for 72 h and then treated with hydroxyurea, irradiated with 30 K rads and pulsed with [3H]thymidine (TdR) fo...

journal_title：Carcinogenesis

authors： Licastro F,Franceschi C,Chiricolo M,Battelli MG,Tabacchi P,Cenci M,Barboni F,Pallenzona D

更新日期：1982-01-01 00:00:00

abstract：:This commentary was written to stimulate thoughts on, and consideration of, enzyme expression data in target organs when investigating possible associations between polymorphisms in carcinogen activation enzymes, lifestyle/dietary factors and cancer risk. The lung and breast are taken as examples. There is overwhelmin...

journal_title：Carcinogenesis

authors： Williams JA

更新日期：2001-02-01 00:00:00

abstract：:The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hepatocytes from males...

journal_title：Carcinogenesis

authors： Andrae U,Homfeldt H,Vogl L,Lichtmannegger J,Summer KH

更新日期：1988-05-01 00:00:00

abstract：:Methylation of the non-carcinogen 15,16-dihydrocyclopenta[a]phenanthren-17-one (CPP-17-one) at the bay region to form 11-CH3-CPP-17-one confers carcinogenic potential. In the present study we have investigated the in vitro metabolism and mutagenicity of the methylated compound by hepatic microsomal preparations from r...

journal_title：Carcinogenesis

authors： Boyd GW,Young RJ,Harvey RG,Coombs MM,Ioannides C

更新日期：1993-09-01 00:00:00

abstract：:Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...

journal_title：Carcinogenesis

authors： Zabaleta J,Lin HY,Sierra RA,Hall MC,Clark PE,Sartor OA,Hu JJ,Ochoa AC

更新日期：2008-03-01 00:00:00

abstract：:The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigated in N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters. Female 5-week-old Syrian golden hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 hamsters, were given BOP by two subcutaneous injections 7 days...

journal_title：Carcinogenesis

authors： Nishikawa A,Furukawa F,Uneyama C,Ikezaki S,Tanakamaru Z,Chung FL,Takahashi M,Hayashi Y

更新日期：1996-06-01 00:00:00

abstract：:Oxidative stress has consistently been linked to breast carcinogenesis, and mitochondria play a significant role in regulating reactive oxygen species generation. In our previous study, we found that increased levels of mitochondrial DNA (mtDNA) copy number and the presence of mitochondrial length heteroplasmies in th...

journal_title：Carcinogenesis

authors： Shen J,Wan J,Song R,Zhao H

更新日期：2015-11-01 00:00:00

abstract：:The magnitude of benefit is variable for advanced non-small cell lung cancer (NSCLC) patients receiving platinum-based chemotherapy. The purpose of this study is to determine whether genetic variations in the transforming growth factor-beta (TGF-β) pathway are associated with clinical outcomes in NSCLC patients receiv...

journal_title：Carcinogenesis

authors： Lin M,Stewart DJ,Spitz MR,Hildebrandt MA,Lu C,Lin J,Gu J,Huang M,Lippman SM,Wu X

更新日期：2011-07-01 00:00:00

abstract：:Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...

journal_title：Carcinogenesis

authors： Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

更新日期：2015-10-01 00:00:00