MicroRNA-423 promotes cell growth and regulates G(1)/S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma.

abstract：:Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were studied in human buccal mucosa in vitro. Microautoradiographic analysis of [5-3H]NNK-exposed explant cultures demonstrated a uniform distribution of bound radioactivity in the mucosal ...

journal_title：Carcinogenesis

authors： Liu Y,Sundqvist K,Belinsky SA,Castonguay A,Tjälve H,Grafström RC

更新日期：1993-11-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospi...

journal_title：Carcinogenesis

authors： Brenner AV,Butler MA,Wang SS,Ruder AM,Rothman N,Schulte PA,Chanock SJ,Fine HA,Linet MS,Inskip PD

更新日期：2007-12-01 00:00:00

abstract：:The inhibitory effects of three phenolic compounds (ferulic, chlorogenic and ellagic acids) on benzo[a]pyrene- and 7,12-dimethylbenz[a]anthracene-induced neoplasia have been investigated in mice. Ellagic acid was the most potent antagonist of tumorigenesis since this compound is active, by i.p. administration or added...

journal_title：Carcinogenesis

authors： Lesca P

更新日期：1983-12-01 00:00:00

abstract：:Radioactive methylnitrosourea, epichlorohydrin, styrene oxide, and N-acetoxy-2-acetylaminofluorene were reacted with 14 different polyamino acids in vitro, to determine the relative reactivity of the functional groups in amino acids. All the carcinogens reacted preferentially with polycysteine and much less with polyh...

journal_title：Carcinogenesis

authors： Hemminki K

更新日期：1983-01-01 00:00:00

abstract：:Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...

journal_title：Carcinogenesis

authors： Tilby MJ,McCartney H,Cordell J,Frank AJ,Dean CJ

更新日期：1995-08-01 00:00:00

abstract：:Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...

journal_title：Carcinogenesis

authors： Kato T,Ohgaki H,Hasegawa H,Sato S,Takayama S,Sugimura T

更新日期：1988-01-01 00:00:00

abstract：:Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...

journal_title：Carcinogenesis

authors： Babson JR,Russo-Rodriguez SE,Rastetter WH,Wogan GN

更新日期：1986-06-01 00:00:00

abstract：:Insulin-like growth factor 1 receptor (IGF-1R) activation is required for prostate cell proliferation. Prostate cancer is one of the most commonly diagnosed malignant tumors in Western countries. Overexpression of IGF-1R in prostate cancer is associated with tumor growth. These suggest that IGF-1R inhibitory agents ma...

journal_title：Carcinogenesis

authors： Fang J,Zhou Q,Shi XL,Jiang BH

更新日期：2007-03-01 00:00:00

abstract：:Oral squamous cell carcinoma (SCC) is among the most prevalent cancers in the world and is characterized by high morbidity and few therapeutic options. Like most cancers, oral SCC arises from a multistep process involving alterations of genes responsible for balancing proliferation and differentiation. Among these, Kr...

journal_title：Carcinogenesis

authors： Abrigo M,Alvarez R,Paparella ML,Calb DE,Bal de Kier Joffe E,Gutkind JS,Raimondi AR

更新日期：2014-03-01 00:00:00

abstract：:Induction of glutathione S-transferase (GST) enzymes can increase detoxification of carcinogens and reduce carcinogen-induced mutagenesis and tumorigenesis. To determine if the anticarcinogen ellagic acid induces cellular enzymes which detoxify carcinogens, we examined the effect of ellagic acid on the expression of g...

journal_title：Carcinogenesis

authors： Barch DH,Rundhaugen LM,Pillay NS

更新日期：1995-03-01 00:00:00

abstract：:The incidence of esophageal adenocarcinoma (EA) has been increasing rapidly, particularly among white males, over the past few decades in the USA. However, the etiology of EA and the striking male predominance is not fully explained by known risk factors. To identify susceptible genes for EA risk, we conducted a pathw...

journal_title：Carcinogenesis

authors： Liu CY,Wu MC,Chen F,Ter-Minassian M,Asomaning K,Zhai R,Wang Z,Su L,Heist RS,Kulke MH,Lin X,Liu G,Christiani DC

更新日期：2010-07-01 00:00:00

abstract：:Colorectal cancer (CRC) is the fourth leading cause of cancer mortality worldwide. Genome-wide association studies (GWAS) identified more than 50 CRC loci. However, most of the previous studies were conducted in European population, and host genetic factors among Japanese population are largely remained to be identifi...

journal_title：Carcinogenesis

authors： Tanikawa C,Kamatani Y,Takahashi A,Momozawa Y,Leveque K,Nagayama S,Mimori K,Mori M,Ishii H,Inazawa J,Yasuda J,Tsuboi A,Shimizu A,Sasaki M,Yamaji T,Sawada N,Iwasaki M,Tsugane S,Naito M,Wakai K,Koyama T,Takezaki T

更新日期：2018-05-03 00:00:00

abstract：:An antibody (anti-EH) specific for microsomal epoxide hydrolase (mEH) from rhesus monkey liver has been used to test the immunochemical relationship between human liver mEH and the serum EH levels in human patients with hepatocellular carcinoma (HCC). Immunoblots of separated rhesus monkey and human liver microsomal p...

journal_title：Carcinogenesis

authors： Moody DE,Hammock BD,Ruebner BH,Hillman DW,Hillman JH

更新日期：1989-02-01 00:00:00

abstract：:In the previous 500 2-year chemical bioassays within the National Toxicology Program, large intestinal tumors (cecal carcinomas) related to chemical exposure have not been observed in B6C3F1 mice. The recently completed o-nitrotoluene study provided the first cecal tumor response and an opportunity to evaluate the mor...

journal_title：Carcinogenesis

authors： Sills RC,Hong HL,Flake G,Moomaw C,Clayton N,Boorman GA,Dunnick J,Devereux TR

更新日期：2004-04-01 00:00:00

abstract：:Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....

journal_title：Carcinogenesis

authors： Lockhart ML,Rosenberg BH

更新日期：1983-01-01 00:00:00

abstract：:People are constantly being exposed to toxic and carcinogenic aldehydes. However, little is actually known about the mechanisms underlying the toxic and carcinogenic effects of these aldehydes on human cells. The DNA alkylating activities of two of the more toxic and environmentally prominent alpha,beta-unsaturated al...

journal_title：Carcinogenesis

authors： Wilson VL,Foiles PG,Chung FL,Povey AC,Frank AA,Harris CC

更新日期：1991-08-01 00:00:00

abstract：:N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...

journal_title：Carcinogenesis

authors： Wong HL,Murphy SE,Wang M,Hecht SS

更新日期：2003-02-01 00:00:00

abstract：:The Notch pathway plays a key role in the development and is increasingly recognized for its importance in cancer. We demonstrated previously the overexpression of Notch-1 and its ligands in gliomas and showed that their knockdown inhibits glioma cell proliferation and survival. To elucidate the mechanisms downstream ...

journal_title：Carcinogenesis

authors： Purow BW,Sundaresan TK,Burdick MJ,Kefas BA,Comeau LD,Hawkinson MP,Su Q,Kotliarov Y,Lee J,Zhang W,Fine HA

更新日期：2008-05-01 00:00:00

abstract：:A 25mer oligonucleotide containing a single N-(deoxyguanosin-8-yl-)-1-aminopyrene (dGAP), the major DNA adduct formed by reductively activated 1-nitropyrene, was synthesized. The adduct was located at nucleotide 21 from the 3' end. DNA synthesis on this template by human DNA polymerases alpha and beta, HIV reverse tra...

journal_title：Carcinogenesis

authors： Vyas RR,Basu AK

更新日期：1995-04-01 00:00:00

abstract：UNLABELLED:Neurotrophic factors possess an emerging role in the pathophysiology of several gastrointestinal disorders, regulating innervation, pain sensation and disease-associated neuroplasticity. Here, we aimed at characterizing the role of the neurotrophic factor neurturin (NRTN) and its receptor glial-cell-line-der...

journal_title：Carcinogenesis

authors： Wang K,Demir IE,D'Haese JG,Tieftrunk E,Kujundzic K,Schorn S,Xing B,Kehl T,Friess H,Ceyhan GO

更新日期：2014-01-01 00:00:00

abstract：:To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...

journal_title：Carcinogenesis

authors： Tang H,Dong X,Day RS,Hassan MM,Li D

更新日期：2010-04-01 00:00:00

abstract：:B-cell precursor acute lymphoblastic leukemia (BCP ALL) is the most common childhood leukemia, with a cure rate of 80%. Nevertheless, disease relapse is the most important prognostic factor for the disease outcome. We aimed to elucidate the role of Wnt secretion-regulating protein, Wntless (Wls)/GPR177, on disease out...

journal_title：Carcinogenesis

authors： Chiou SS,Wang LT,Huang SB,Chai CY,Wang SN,Liao YM,Lin PC,Liu KY,Hsu SH

更新日期：2014-10-01 00:00:00

abstract：:Mutations or transcriptional silencing of mismatch repair genes have been linked with tumour cell resistance to O(6)-guanine methylating agents, 6-thioguanine, cisplatin, doxorubicin and etoposide. Recently, it has been demonstrated that overexpression of the MSH3 protein is associated with depletion of the mismatch b...

journal_title：Carcinogenesis

authors： Pepponi R,Graziani G,Falcinelli S,Vernole P,Levati L,Lacal PM,Pagani E,Bonmassar E,Jiricny J,D'Atri S

更新日期：2001-08-01 00:00:00

abstract：:Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...

journal_title：Carcinogenesis

authors： Smith CA,Xu YZ,Swann PF

更新日期：1990-05-01 00:00:00

abstract：:Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...

journal_title：Carcinogenesis

authors： Coombs MM

更新日期：1982-01-01 00:00:00

abstract：:Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3'-Me-DAB in the diet). The oral administration of 3'-CH2OH-DAB for 3 months resulted in a high incidence of liver t...

journal_title：Carcinogenesis

authors： Mori Y,Niwa T,Toyoshi K,Nagai H,Koda A,Kawada K,Ojima A,Takahashi Y

更新日期：1980-06-01 00:00:00

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:Inducers of Phase II enzymes, already consumed by humans as food additives, medicines or as constituents of vegetables, can prevent experimental carcinogenesis. Since protection is neither carcinogen- nor organ-specific, clinical trials are already underway to establish the efficacy of 'anticarcinogenic enzyme inducer...

journal_title：Carcinogenesis

authors： Prochaska HJ,Fernandes CL

更新日期：1993-12-01 00:00:00

abstract：:FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in t...

journal_title：Carcinogenesis

authors： Baffa R,Fassan M,Sevignani C,Vecchione A,Ishii H,Giarnieri E,Iozzo RV,Gomella LG,Croce CM

更新日期：2008-04-01 00:00:00