Abstract:
:The ability of three benzodiazepine tranquilizers, diazepam, oxazepam and chlordiazepoxide chlorhydrate to block metabolic cooperation between human hepatoma cells was analysed using autoradiographical monitoring. Independent tests were performed with compound concentrations varying from 1 to 50 micrograms/ml. The results showed that at a toxic dose of 50 micrograms/ml diazepam and oxazepam markedly inhibited metabolic cooperation and that oxazepam remained effective at a lower, non-toxic, dose (10 micrograms/ml). Chlordiazepoxide chlorhydrate was found to be less toxic than diazepam and oxazepam and did not interfere with metabolic cooperation at any concentration up to 50 micrograms/ml.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Rolin-Limbosch S,Moens W,Szpirer Cdoi
10.1093/carcin/8.7.1013subject
Has Abstractpub_date
1987-07-01 00:00:00pages
1013-6issue
7eissn
0143-3334issn
1460-2180journal_volume
8pub_type
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