Metabolic cooperation in SK-HEP-1 human hepatoma cells following treatment with benzodiazepine tranquilizers.

Abstract:

:The ability of three benzodiazepine tranquilizers, diazepam, oxazepam and chlordiazepoxide chlorhydrate to block metabolic cooperation between human hepatoma cells was analysed using autoradiographical monitoring. Independent tests were performed with compound concentrations varying from 1 to 50 micrograms/ml. The results showed that at a toxic dose of 50 micrograms/ml diazepam and oxazepam markedly inhibited metabolic cooperation and that oxazepam remained effective at a lower, non-toxic, dose (10 micrograms/ml). Chlordiazepoxide chlorhydrate was found to be less toxic than diazepam and oxazepam and did not interfere with metabolic cooperation at any concentration up to 50 micrograms/ml.

journal_name

Carcinogenesis

journal_title

Carcinogenesis

authors

Rolin-Limbosch S,Moens W,Szpirer C

doi

10.1093/carcin/8.7.1013

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

1013-6

issue

7

eissn

0143-3334

issn

1460-2180

journal_volume

8

pub_type

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