HIF-2alpha-mediated activation of the epidermal growth factor receptor potentiates head and neck cancer cell migration in response to hypoxia.

abstract：:EphB2, a receptor tyrosine kinase regulated by the beta-catenin/Tcf4 complex, is expressed in the proliferative compartment of mouse intestine and regulates bidirectional migration of intestinal precursor cells in the crypt-villus axis through repulsive interaction with Ephrin-B ligands. Recently, it has been shown th...

journal_title：Carcinogenesis

authors： Guo DL,Zhang J,Yuen ST,Tsui WY,Chan AS,Ho C,Ji J,Leung SY,Chen X

更新日期：2006-03-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:The modifying effects of the phenolic antioxidant catechol (CC) and its analogs hydroquinone (HQ) and resorcinol (RN) on pancreatic carcinogenesis were evaluated in 146 female Syrian golden hamsters. Groups of animals received either saline or 70 mg/kg body wt N-nitrosobis(2-oxopropyl)amine (BOP) s.c. injections, twic...

journal_title：Carcinogenesis

authors： Maruyama H,Amanuma T,Nakae D,Tsutsumi M,Kondo S,Tsujiuchi T,Denda A,Konishi Y

更新日期：1991-07-01 00:00:00

abstract：:The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-...

journal_title：Carcinogenesis

authors： Takeda K,Shudo K,Okamoto T,Nagao M,Wakabayashi K,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:Mutagenicity assays were carried out in the Salmonella/microsome test, using five S. typhimurium his(-) strains (TA1535, TA1537, TA1538, TA98 and TA100), both in the presence and absence of post-mitochondrial preparations from Aroclor-induced rat livers and suitable co-factors. Seven oil dispersants showed a wide rang...

journal_title：Carcinogenesis

authors： Petrilli FL,De Renzi GP,De Flora S

更新日期：1980-01-01 00:00:00

abstract：:Continuous dietary administration of the hepatocarcinogen 2-acetylaminofluorene (AAF) to rats produces a gradual increase in hepatic DNA adducts until a plateau is reached after approximately 2 weeks. The rate of DNA adduct formation remains constant through 1 month of AAF feeding, while adduct removal profiles are bi...

journal_title：Carcinogenesis

authors： Poirier MC,Fullerton NF,Patterson ED,Beland FA

更新日期：1990-08-01 00:00:00

abstract：:Although the human O6-alkylguanine-DNA alkyltransferase (AGT) is very sensitive to inactivation by O6-benzylguanine (BG) or 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (5-nitroso-BP), the equivalent protein formed by the carboxyl terminal domain of the product of the Escherichia coli ada gene (Ada-C) is unaffected by ...

journal_title：Carcinogenesis

authors： Crone TM,Kanugula S,Pegg AE

更新日期：1995-08-01 00:00:00

abstract：:We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]a...

journal_title：Carcinogenesis

authors： Shoji Y,Takahashi M,Takasuka N,Niho N,Kitamura T,Sato H,Maruyama T,Sugimoto Y,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2005-12-01 00:00:00

abstract：:The fluorescent 12-O-tetradecanoylphorbol-13-acetate (TPA) analogue dansyl-TPA allowed the distribution of fluorescent molecules to be visualized in living mouse fibroblasts. The entry of dansyl-TPA into cells occurred within millisecond time scale and was found largely energy independent. Dansyl-TPA was shown to stai...

journal_title：Carcinogenesis

authors： Tran PL,Deugnier MA

更新日期：1985-03-01 00:00:00

abstract：:Gene-environment interactions play an important role in folate metabolism, with a potential impact on human health. Deficiencies in the uptake of key micronutrients and variant genotypes can affect the folic acid cycle, modulating methyl group transfer in key processes and leading to increased cancer risk and Down syn...

journal_title：Carcinogenesis

authors： Zijno A,Andreoli C,Leopardi P,Marcon F,Rossi S,Caiola S,Verdina A,Galati R,Cafolla A,Crebelli R

更新日期：2003-06-01 00:00:00

abstract：:The genes that are involved in estrogen biosynthesis, cellular binding and metabolism may contribute to breast cancer susceptibility. We examined the effect of the CYP17 promoter T --> C polymorphism and its interactions with the reproductive history, exogenous hormone use and selected lifestyle risk factors on breast...

journal_title：Carcinogenesis

authors： Chen Y,Gammon MD,Teitelbaum SL,Britton JA,Terry MB,Shantakumar S,Eng SM,Wang Q,Gurvich I,Neugut AI,Santella RM,Ahsan H

更新日期：2008-04-01 00:00:00

abstract：:Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases....

journal_title：Carcinogenesis

authors： Tebbi A,Levillayer F,Jouvion G,Fiette L,Soubigou G,Varet H,Boudjadja N,Cairo S,Hashimoto K,Suzuki AM,Carninci P,Carissimo A,di Bernardo D,Wei Y

更新日期：2016-01-01 00:00:00

abstract：:The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...

journal_title：Carcinogenesis

authors： Dragani TA,Sozzi G,Della Porta G

更新日期：1983-01-01 00:00:00

abstract：:The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lac...

journal_title：Carcinogenesis

authors： Yang J,Yoshizawa K,Nandi S,Tsubura A

更新日期：1999-04-01 00:00:00

abstract：:The present study was designed to evaluate the tolerance and cancer chemopreventive activity of triphenylselenonium chloride in female Sprague-Dawley rats. No information is available in the literature on the anticarcinogenic efficacy of a lipophilic cationic selenium compound as exemplified by the triphenylselenonium...

journal_title：Carcinogenesis

authors： Ip C,Thompson H,Ganther H

更新日期：1994-12-01 00:00:00

abstract：:We have investigated the effect of the soybean isoflavone genistein on 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in calf thymus DNA exposed to either UV irradiation or the Fenton reaction system. Under the conditions used we observed that UV light and the Fenton reaction significantly increase 8-OHdG formation in...

journal_title：Carcinogenesis

authors： Wei H,Cai Q,Rahn RO

更新日期：1996-01-01 00:00:00

abstract：:Heterocyclic aromatics amines (HAAs), such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), are metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2). We examined the relationship between CYP1A2 and NAT2 activity and the excretion of total unconjugated MeIQx in 66 healthy subje...

journal_title：Carcinogenesis

authors： Sinha R,Rothman N,Mark SD,Murray S,Brown ED,Levander OA,Davies DS,Lang NP,Kadlubar FF,Hoover RN

更新日期：1995-11-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...

journal_title：Carcinogenesis

authors： Saad MI,McLeod L,Yu L,Ebi H,Ruwanpura S,Sagi I,Rose-John S,Jenkins BJ

更新日期：2020-06-17 00:00:00

abstract：:The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...

journal_title：Carcinogenesis

authors： Tsuda H,Ogiso T,Hasegawa R,Imaida K,Masui T,Ito N

更新日期：1987-05-01 00:00:00

abstract：:1,3-Butadiene (BD) is a more potent tumor inducer in mice than in rats. BD also shows striking differences in metabolic activation, with substantially higher blood concentrations of 1,2:3,4-diepoxybutane (butadiene diepoxide; BDE) in BD-exposed mice than in similarly exposed rats. The objective of this study was to de...

journal_title：Carcinogenesis

authors： Sweeney LM,Schlosser PM,Medinsky MA,Bond JA

更新日期：1997-04-01 00:00:00

abstract：:We have shown previously that the difference between C57BL/6J and C3H/HeJ male mice in their susceptibilities to chemically-induced liver tumors results predominantly from an allelic difference at the Hepatocarcinogen sensitivity (Hcs) locus. This locus modulates the rate of growth of preneoplastic liver lesions and m...

journal_title：Carcinogenesis

authors： Hanigan MH,Winkler ML,Drinkwater NR

更新日期：1990-04-01 00:00:00

abstract：:We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...

journal_title：Carcinogenesis

authors： Bolognesi C,Mariani MR,Boffa LC

更新日期：1988-08-01 00:00:00

abstract：:Transcripts originating from the transcriptional read through of two adjacent, similarly oriented genes have been identified in normal and neoplastic tissues, but their functional role and the mechanisms that regulate their expression are mostly unknown. Here, we investigated whether the expression of read-through tra...

journal_title：Carcinogenesis

authors： Maspero D,Dassano A,Pintarelli G,Noci S,De Cecco L,Incarbone M,Tosi D,Santambrogio L,Dragani TA,Colombo F

更新日期：2020-07-14 00:00:00

abstract：:Poly(ADP-ribose) polymerase, which catalyzes the formation of poly(ADP-ribose) polymers, is an enzyme involved in cell proliferation, differentiation and transformation as well as in recovery from DNA damage. Poly(ADP-ribose) polymers are rapidly synthesized from the ADP-ribose moieties from intracellular NAD+, which,...

journal_title：Carcinogenesis

authors： Stierum RH,van Herwijnen MH,Hageman GJ,Kleinjans JC

更新日期：1994-04-01 00:00:00

abstract：:BALB/c 3T3 A31-1-13 cells are highly susceptible to chemical-induced cell transformation and their gap-junctional intercellular communication (GJIC) is decreased when these cells become confluent. On the other hand, A31-1-1 cells do not show such a change in GJIC and are more resistant to chemical induction of transfo...

journal_title：Carcinogenesis

authors： Katoh F,Yamasaki H

更新日期：1991-10-01 00:00:00

abstract：:Several purified polychlorinated biphenyl (PCB) congeners with differing toxicity/tumor promotional activities in rat liver in vivo were tested for their effects on gap-junctional intercellular communication (GJIC) in cell strains and lines derived from human liver and skin. This in vitro assay is being developed to d...

journal_title：Carcinogenesis

authors： Swierenga SH,Yamasaki H,Piccoli C,Robertson L,Bourgon L,Marceau N,Fitzgerald DJ

更新日期：1990-06-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:The potential importance of prostaglandin H synthase (PGHS) in the genotoxicity of fecapentaene-12 (fec-12) has been indicated by the finding that non-steroidal anti-inflammatory agents (NSAIDs) block the induction of oxidative DNA base damage by fec-12 in HeLa cells. To further investigate the role of PGHS in the met...

journal_title：Carcinogenesis

authors： Plummer SM,Hall M,Faux SP

更新日期：1995-05-01 00:00:00

abstract：:On the basis of preliminary in vitro experience, we assessed whether an enriched nutritional formulation with estrogen receptor (ER)-beta agonist and anti-inflammatory properties may prevent inflammation-associated colorectal cancer (CRC) in an animal model. Study sample enclosed 110 C57BL/6J male mice. Forty underwen...

journal_title：Carcinogenesis

authors： Girardi B,Principi M,Pricci M,Giorgio F,Iannone A,Losurdo G,Ierardi E,Di Leo A,Barone M

更新日期：2018-10-08 00:00:00