Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study Project.

abstract：:The lipoxygenase catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol) was examined. Epoxidation of the BP-7,8-diol was catalyzed by 5- and 15-lipoxygenase in the presence of either arachidonic acid, gamma-linolenic acid, or 15-hydroperoxyeicosatetraenoic acid (15-HPETE). The anti-9,10-epoxy-7...

journal_title：Carcinogenesis

authors： Hughes MF,Chamulitrat W,Mason RP,Eling TE

更新日期：1989-11-01 00:00:00

abstract：:As renal cell carcinomas are characterized by the disappearance of the transcription factor LFB1, which is known to be primarily involved in gene regulation in the liver, we have measured the presence of LFB1 in rat hepatocellular carcinomas induced by diethylnitrosamine. The level of LFB1 binding activity in adenoid-...

journal_title：Carcinogenesis

authors： Stumpf H,Senkel S,Rabes HM,Ryffel GU

更新日期：1995-01-01 00:00:00

abstract：:We investigated possible mechanisms associated with promotion of hepatocarcinogenesis by the synthetic estrogens mestranol (M) and ethinyl estradiol (EE). Our first objective was to determine whether chronic EE treatment was associated with hepatotoxicity accompanied by regenerative hyperplasia. Female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Yager JD,Roebuck BD,Paluszcyk TL,Memoli VA

更新日期：1986-12-01 00:00:00

abstract：:Formaldehyde (FA) is a widely produced industrial chemical. Sufficient evidence exists to consider FA as an animal carcinogen. In humans the evidence is not conclusive. DNA-protein crosslinks (DPC) may be one of the early lesions in the carcinogenesis process in cells following exposures to carcinogens. It has been sh...

journal_title：Carcinogenesis

authors： Shaham J,Bomstein Y,Meltzer A,Kaufman Z,Palma E,Ribak J

更新日期：1996-01-01 00:00:00

abstract：:Previous results in a number of laboratories have demonstrated that epidermal papillomas and carcinomas induced by the two-stage protocol of initiation and promotion contain a point mutation in the 61st codon of the c-Ha-ras oncogene when the initiating agent used is 7,12-dimethylbenz[a]anthracene (DMBA). In the prese...

journal_title：Carcinogenesis

authors： Pelling JC,Neades R,Strawhecker J

更新日期：1988-04-01 00:00:00

abstract：:Mouse ovarian surface epithelial cells (MOSEC) were obtained from virgin, mature mice by mild trypsinization and were repeatedly passaged in vitro. Early passage cells (<20 passages) exhibited a cobblestone morphology and contact inhibition of growth. After approximately 20 passages in vitro, cobblestone morphology an...

journal_title：Carcinogenesis

authors： Roby KF,Taylor CC,Sweetwood JP,Cheng Y,Pace JL,Tawfik O,Persons DL,Smith PG,Terranova PF

更新日期：2000-04-01 00:00:00

abstract：:We have recently shown that the prostaglandin E(2) (PGE(2)) receptor EP(3) plays an important role in suppression of colon cancer cell proliferation and that its deficiency enhances late stage colon carcinogenesis. Here we examined the effects of EP(3)-deficiency on two-stage skin carcinogenesis. 7,12-Dimethylbenz[a]a...

journal_title：Carcinogenesis

authors： Shoji Y,Takahashi M,Takasuka N,Niho N,Kitamura T,Sato H,Maruyama T,Sugimoto Y,Narumiya S,Sugimura T,Wakabayashi K

更新日期：2005-12-01 00:00:00

abstract：:Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive ag...

journal_title：Carcinogenesis

authors： Kensler TW,Ng D,Carmella SG,Chen M,Jacobson LP,Muñoz A,Egner PA,Chen JG,Qian GS,Chen TY,Fahey JW,Talalay P,Groopman JD,Yuan JM,Hecht SS

更新日期：2012-01-01 00:00:00

abstract：:The administration of 4-hydroxybutyl(butyl)nitrosamine (OH-BBN) to male B6D2F1 mice yielded a high incidence of large palpable urinary bladder cancers. Since prior studies demonstrated chemopreventive effects of non-steroidal anti-inflammatory drugs (NSAIDs), we further explored the efficacy of the NSAID indomethacin ...

journal_title：Carcinogenesis

authors： Lubet RA,Huebner K,Fong LY,Altieri DC,Steele VE,Kopelovich L,Kavanaugh C,Juliana MM,Soong SJ,Grubbs CJ

更新日期：2005-03-01 00:00:00

abstract：:Well-differentiated squamous cell carcinomas were induced in hamster buccal pouch epithelium by twice weekly topical applications of N-methyl-N-benzylnitrosamine (MBN) or 7,12-dimethylbenz[a]anthracene (DMBA) over a period of 15 weeks. Each of the 22 tumors induced (14 MBN and eight DMBA) were evaluated by single-stra...

journal_title：Carcinogenesis

authors： Chang KW,Lin SC,Koos S,Pather K,Solt D

更新日期：1996-03-01 00:00:00

abstract：:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...

journal_title：Carcinogenesis

authors： Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu L

更新日期：2020-08-12 00:00:00

abstract：:2-Hexenal is an alpha,beta-unsaturated carbonyl compound which is mutagenic, genotoxic and forms cyclic 1,N2-propanodeoxyguanosine adducts like similar propenals for which carcinogenicity was shown, e.g. acrolein or crotonaldehyde. Since humans have a permanent intake of 2-hexenal via vegetarian food this genotoxic co...

journal_title：Carcinogenesis

authors： Schuler D,Eder E

更新日期：1999-07-01 00:00:00

abstract：:The role of parity before and after N-methyl-N-nitrosourea (MNU) treatment in protection against mammary carcinogenesis was investigated. The effect of lactation on reduction in the incidence of mammary carcinoma was also examined. Parous rats were compared with respective age-matched virgins (AMVs). Pregnancy and lac...

journal_title：Carcinogenesis

authors： Yang J,Yoshizawa K,Nandi S,Tsubura A

更新日期：1999-04-01 00:00:00

abstract：:The nicotine-derived nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces lung adenocarcinoma through formation of DNA adducts. Our previous research on susceptibility to tobacco-induced carcinogenesis focused on benzo[a]pyrene diol epoxide (BPDE) as the in vitro mutagen for phenotype measurements ...

journal_title：Carcinogenesis

authors： Wang L,Wei Q,Shi Q,Guo Z,Qiao Y,Spitz MR

更新日期：2007-07-01 00:00:00

abstract：:Previous studies have shown that polycyclic aromatic hydrocarbons (PAHs) mobilize intracellular Ca2+ in human T cells by inositol trisphosphate-dependent mechanisms resulting from activation of phospholipase C-gamma by SRC-related protein tyrosine kinases, thereby mimicking antigen-receptor activation. Ca2+ appears to...

journal_title：Carcinogenesis

authors： Tannheimer SL,Barton SL,Ethier SP,Burchiel SW

更新日期：1997-06-01 00:00:00

abstract：:Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...

journal_title：Carcinogenesis

authors： Baird WM,Zennie TM,Ferin M,Chae YH,Hatchell J,Cassady JM

更新日期：1988-04-01 00:00:00

abstract：:Nucleotide excision repair (NER) removes bulky DNA lesions and is thus crucial for the protection against environmental carcinogens and UV light exposure. Deficiencies in NER cause increased mutation rates and chromosomal aberrations. Current methods for studying NER are mostly based on either quantitation of lesion r...

journal_title：Carcinogenesis

authors： Rubbi CP,Milner J

更新日期：2001-11-01 00:00:00

abstract：:Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Li...

journal_title：Carcinogenesis

authors： Lee S,Simpson M,Nimmo M,Xu Z

更新日期：2004-10-01 00:00:00

abstract：:Occupational nitrosamine exposures from a rubber vehicle seal (VS) curing operation were compared with the peripheral blood lymphocyte concentrations of two nitrosamine-related DNA adducts, N(7)-methylguanine (N(7)mdG) and O(6)-methylguanine (O(6)mdG), and with the activity of the enzyme that repairs O(6)mdG adducts, ...

journal_title：Carcinogenesis

authors： Reh BD,DeBord DG,Butler MA,Reid TM,Mueller C,Fajen JM

更新日期：2000-01-01 00:00:00

abstract：:Effect of nicotine on PDGF AA and PDGF BB interaction with cervical cancer SiHa cells was tested. [125I]PDGF AA was internalized by cells and accumulated in the cytoplasm and nucleus (chromatin). In the absence of nicotine, maximal accumulation of [125I]PDGF AA inside the cells occurred after 1 day of incubation, whic...

journal_title：Carcinogenesis

authors： Rakowicz-Szulczynska EM,McIntosh DG,Perry M,Smith ML

更新日期：1996-09-01 00:00:00

abstract：:Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...

journal_title：Carcinogenesis

authors： Kato T,Ohgaki H,Hasegawa H,Sato S,Takayama S,Sugimura T

更新日期：1988-01-01 00:00:00

abstract：:Caucasian renal transplant recipients from Queensland, Australia have the highest non-melanoma skin cancer (NMSC) risk worldwide. Although ultraviolet light (UVR) exposure is critical, genetic factors also appear important. We and others have shown that polymorphism in the glutathione S-transferases (GST) is associate...

journal_title：Carcinogenesis

authors： Fryer AA,Ramsay HM,Lovatt TJ,Jones PW,Hawley CM,Nicol DL,Strange RC,Harden PN

更新日期：2005-01-01 00:00:00

abstract：:It has been demonstrated that nuclear factor-kappa B (NF-κB), which is overactivated in hepatocellular carcinoma (HCC), plays important roles in the development of HCC. Recently, a group of dysregulated micro RNAs were reported to be involved in HCC progression. Further understanding of micro RNA-mediated regulation o...

journal_title：Carcinogenesis

authors： Li HP,Zeng XC,Zhang B,Long JT,Zhou B,Tan GS,Zeng WX,Chen W,Yang JY

更新日期：2013-11-01 00:00:00

abstract：:The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 2...

journal_title：Carcinogenesis

authors： Manenti G,De Gregorio L,Pilotti S,Falvella FS,Incarbone M,Ravagnani F,Pierotti MA,Dragani TA

更新日期：1997-10-01 00:00:00

abstract：:Benzene is a well-characterized human carcinogen and clastogen still present in both the occupational and general environment. However, the levels of benzene encountered today are, in most cases, relatively low and new methods, more specific and sensitive than classical cytogenetics, are probably needed to assess if c...

journal_title：Carcinogenesis

authors： Surrallés J,Autio K,Nylund L,Järventaus H,Norppa H,Veidebaum T,Sorsa M,Peltonen K

更新日期：1997-04-01 00:00:00

abstract：:Human fibroblasts repair DNA damaged by bleomycin through both short-patch and long-patch pathways, mediated by an aphidicolin-resistant (beta) and aphidicolin-sensitive (delta) DNA polymerase respectively (DiGiuseppe, J.A. and Dresler, S.L. (1989) Biochemistry, 28, 9515-9520). Despite certain similarities, aphidicoli...

journal_title：Carcinogenesis

authors： DiGiuseppe JA,Hunting DJ,Dresler SL

更新日期：1990-06-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a mutagen found in cooked meat, has been shown to induce mammary gland tumors in rats. Our laboratory recently observed that a high fat diet enhances the incidence and severity of PhIP-induced mammary gland cancer in rats. In the current study, reverse transcript...

journal_title：Carcinogenesis

authors： Davis CD,Snyderwine EG

更新日期：1995-12-01 00:00:00

abstract：:The mechanism(s) of tumour promotion in liver by estrogens is not well understood although growth stimulation is known to be one important element of their action. As a basis for studying mechanisms of growth control by estrogens, effects of both natural and synthetic estrogens on DNA synthesis and protooncogene c-fos...

journal_title：Carcinogenesis

authors： Lee CH,Edwards AM

更新日期：2001-09-01 00:00:00

abstract：:Aberrant crypt foci (ACF), putative preneoplastic lesions, are early morphological changes induced by the colon carcinogen azoxymethane (AOM). Although inbred mice differ markedly in their susceptibility to AOM carcinogenesis, we have previously shown that ACF develop in both resistant and sensitive mouse strains afte...

journal_title：Carcinogenesis

authors： Papanikolaou A,Wang QS,Papanikolaou D,Whiteley HE,Rosenberg DW

更新日期：2000-08-01 00:00:00

abstract：:Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G2 phase. The reproducibility of this response suggested that it could pro...

journal_title：Carcinogenesis

authors： Takai S,Price FM,Sanford KK,Tarone RE,Parshad R

更新日期：1990-08-01 00:00:00