Abstract:
:Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Limiting zinc supply by means such as reduced zinc intake should negatively modulate mammary tumorigenesis. Our objective was to determine the effects of zinc status on MNU-induced mammary tumorigenesis in sexually mature female rats. Twenty-one-day-old Sprague-Dawley rats were assigned to low-zinc (3 mg zinc/kg diet) or adequate-zinc (12 mg zinc/kg diet) ad libitum or pair-fed control group (n = 25-33 rats/group). On day 50 of age, all rats were intraperitoneally injected with MNU (50 mg/kg body wt) to induce mammary tumorigenesis. Rats were further maintained on their assigned diet until 14 weeks post-MNU injection. Total food intake and overall body weight gain were lower in low-zinc rats than in adequate-zinc ad libitum control rats, but were similar to adequate-zinc pair-fed control rats. Plasma zinc concentration was lower in low-zinc rats than in adequate-zinc ad libitum and pair-fed control rats, confirming moderately low-zinc status in low-zinc rats. Tumor incidence (46 versus 84 and 80%; P < 0.05) and tumor multiplicity (0.8 versus 5.0 and 2.6 tumors/rat; P < 0.05) and tumor number (28 versus 123 and 66 tumors) were reduced in low-zinc rats compared with that in adequate-zinc ad libitum and pair-fed control rats, respectively. Tumor latency in low-zinc and adequate-zinc pair-fed control rats was not significantly different, but was longer than in adequate-zinc ad libitum control rats (P < 0.05), suggesting that reduced food intake associated with low-zinc intake prolonged tumor latency. Tumor burden and size were not affected by zinc intake. Overall, our observations showed that moderately low-zinc status suppressed MNU-induced rat mammary tumorigenesis.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Lee S,Simpson M,Nimmo M,Xu Zdoi
10.1093/carcin/bgh214keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
1879-85issue
10eissn
0143-3334issn
1460-2180pii
bgh214journal_volume
25pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enz...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.747
更新日期:1982-01-01 00:00:00
abstract::Previous studies have shown that platinum-DNA adduct level in leukocyte DNA (measured by antibody methodology) is directly related to disease response in ovarian cancer and testicular cancer. To determine if this principle could be more broadly applied, platinum-DNA damage was studied in a blinded fashion in leukocyte...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章
doi:10.1093/carcin/12.7.1253
更新日期:1991-07-01 00:00:00
abstract::Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.12.2563
更新日期:1996-12-01 00:00:00
abstract::4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), a major metabolite of the tobacco-specific pulmonary carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has a chiral center but the tumorigenicity of the NNAL enantiomers has not been previously examined. In this study, we assessed the relative tumori...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.8.1577
更新日期:1999-08-01 00:00:00
abstract::Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.7.1335
更新日期:1991-07-01 00:00:00
abstract::Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy135
更新日期:2019-03-12 00:00:00
abstract::Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.9
更新日期:1983-01-01 00:00:00
abstract::Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear. One of the reasons for this is due, at least in part, to a lack of a suitable animal model which can closely mimic the breast ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.6.1069
更新日期:1999-06-01 00:00:00
abstract::Genomic alterations affecting components of the mechanistic target of rapamycin (mTOR) pathway are found rather frequently in cancers, suggesting that aberrant pathway activity is implicated in oncogenesis of different tumor types. mTOR functions as the core catalytic kinase of two distinct complexes, mTOR complex 1 (...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgy086
更新日期:2018-07-30 00:00:00
abstract::The GTPase activating proteins (GAP) stimulate the intrinsic GTPase activity of ras-p21 thus converting the protein into its inactive form. We have now analyzed carcinogen-induced mouse liver tumors for the possible occurrence of mutational changes in one of the two known GAP genes, namely p120-GAP. RNA from a total o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.10.1903
更新日期:1992-10-01 00:00:00
abstract::The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.6.1061
更新日期:1988-06-01 00:00:00
abstract::Our previous report demonstrated that RSK2 plays an important role in cell proliferation and transformation induced by tumor promoters such as epidermal growth factor mediated through the N-terminal kinase domain of RSK2 in JB6 Cl41 mouse skin epidermal cells in vitro. However, no direct evidence has been reported reg...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs271
更新日期:2012-12-01 00:00:00
abstract::The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.12.2957
更新日期:1995-12-01 00:00:00
abstract::We have shown that parathyroid hormone-related protein (PTHrP) is a survival factor for human renal cell carcinoma (RCC) and that its expression is negatively regulated by the von Hippel-Lindau (VHL) tumor suppressor gene at the level of messenger RNA (mRNA) stability, as observed for tumor growth factors (TGFs). Our ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn275
更新日期:2009-03-01 00:00:00
abstract::Amarogentin, a secoiridoid glycoside, is an active component of the medicinal plant Swertia chirata. In this study, chemopreventive and chemotherapeutic actions of amarogentin were evaluated in a carbon tetrachloride (CCl(4))/N-nitrosodiethylamine (NDEA)-induced liver carcinogenesis mouse model system during continuou...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs276
更新日期:2012-12-01 00:00:00
abstract::Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we report the clinical significance of the serum cathepsin E (CatE) activ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt373
更新日期:2014-03-01 00:00:00
abstract::Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1555
更新日期:1987-10-01 00:00:00
abstract::Plant chlorophylls and carotenoids are highly colored, conjugated polyenes that play central roles in photosynthesis. Other porphyrins (tetrapyrroles), such as cytochromes, which are structurally related to chlorophyll, participate in redox reactions in many living systems. An unexpected new property of tetrapyrroles,...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi068
更新日期:2005-07-01 00:00:00
abstract::Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs174
更新日期:2012-09-01 00:00:00
abstract::The lymphocyte response to u.v. radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The u.v.-induced DNA synthesis was determined as the increase in incorporation of [3H]thymidine in irradiated cells compared with nonirradiated cells after incubation f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.6.843
更新日期:1985-06-01 00:00:00
abstract::The metabolism of 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene (BP) and benz[a]anthracene (BA) by epithelial cell aggregates and fibroblasts in culture has been investigated using mammary tissue obtained from female Wistar rats. The results show that: (a) both types of mammary cells metabolise all three hydro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.2.203
更新日期:1982-01-01 00:00:00
abstract::Hydrazine sulfate is a genotoxic hepatocarcinogen for the hamster. A study was conducted to follow changes in DNA maintenance methylation in selected genes in liver DNA during the 21-month induction of liver adenomas and hepatocellular carcinomas by demonstrating changes in restriction fragment length polymorphism. Ma...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.12.2711
更新日期:1996-12-01 00:00:00
abstract::A topical application of a chalcone derivative, 4,2',4'-trihydroxychalcone (isoliquiritigenin) inhibited epidermal ornithine decarboxylase (ODC) induction and ear edema formation, i.e. inflammation, caused by a topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) in CD-1 mice. In addition, isoliquiritigen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.2.317
更新日期:1991-02-01 00:00:00
abstract::Fish or vegetable oils were fed during the promotion stage of a mouse skin carcinogenesis model in order to investigate the effects of dietary fat on tumor development. Two weeks after initiation with 10 nmol dimethylbenz[a]anthracene, SENCAR mice were divided into five groups and maintained on one of the following se...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1023
更新日期:1991-06-01 00:00:00
abstract::A mismatch between metabolic demand and oxygen delivery leads to microenvironmental changes in solid tumors. The resulting tumor hypoxia is associated with malignant progression, therapy resistance and poor prognosis. However, the molecular mechanisms underlying therapy resistance in hypoxic tumors are not fully under...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn231
更新日期:2008-12-01 00:00:00
abstract::S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.7.1533
更新日期:1996-07-01 00:00:00
abstract::The repair kinetics and sensitivity to inhibitors of DNA strand breaks caused by superoxide anion, hydrogen peroxide, benzoyl peroxide and anthralin have been studied and compared with strand breaks caused by well-studied agents such as ionizing radiation and bleomycin. The latter two agents are generally believed to ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.9.1511
更新日期:1986-09-01 00:00:00
abstract::We have shown previously that apoptosis induction by diallyl trisulfide (DATS), a constituent of processed garlic, in PC-3 and DU145 human prostate cancer cells is associated with c-Jun N-terminal kinase and extracellular signal-regulated kinase-mediated phosphorylation of Bcl-2. However, pharmacological inhibition of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi228
更新日期:2006-03-01 00:00:00
abstract::In recent years, considerable emphasis has been placed on identifying new cancer chemopreventive agents which could be useful for human populations. Silymarin, an anti-oxidant flavonoid isolated from artichoke, has been shown to possess significant activity against hepatotoxicity and other pharmacological and physiolo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.6.1099
更新日期:1994-06-01 00:00:00
abstract::Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr078
更新日期:2011-07-01 00:00:00