Induction of high incidence of mammary tumour in female Noble rats with a combination of 17beta-oestradiol and testosterone.

abstract：:The human homolog of the Drosophila headcase (HECA) belongs to a new class of cell differentiation regulators. In Drosophila, the HECA protein regulates the proliferation and differentiation of cells during adult morphogenesis. There is growing evidence that HECA plays an important role in human carcinogenesis. In dif...

journal_title：Carcinogenesis

authors： Dowejko A,Bauer RJ,Müller-Richter UD,Reichert TE

更新日期：2009-10-01 00:00:00

abstract：:The inbred DRH rats are highly resistant to the induction of hepatocellular carcinoma (HCC) by feeding of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). Previously, we found that two quantitative trait loci (QTLs), Drh1 and Drh2, significantly reduced the number, size and area of glutathione S-transferase-placental ...

journal_title：Carcinogenesis

authors： Yan Y,Zeng ZZ,Higashi S,Denda A,Konishi Y,Onishi S,Ueno H,Higashi K,Hiai H

更新日期：2002-01-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant heterocyclic amine produced during the cooking of meats and fish, is suspected to be a human carcinogen. Metabolic activation of PhIP is primarily mediated by the enzyme cytochrome P450 (CYP) 1A2. Metabolism of PhIP by CYP1A2 differs considerabl...

journal_title：Carcinogenesis

authors： Cheung C,Loy S,Li GX,Liu AB,Yang CS

更新日期：2011-02-01 00:00:00

abstract：:Genetically based differences in metabolism, related to MspI restriction site and Ile-Val polymorphisms of the cytochrome P450 (CYP) 1A1 gene and the null genotype of glutathione transferase class mu (GSTM1), have been reported to be associated with lung cancer susceptibility. The present study was set up to establish...

journal_title：Carcinogenesis

authors： Alexandrie AK,Sundberg MI,Seidegård J,Tornling G,Rannug A

更新日期：1994-09-01 00:00:00

abstract：:Twist1 is an essential transcription factor required to initiate epithelial-mesenchymal transition (EMT) and promote tumor metastasis. PAQR3 is a newly found tumor suppressor that is frequently downregulated in many types of human cancers. Downregulation of PAQR3 is associated with accelerated metastasis and poor prog...

journal_title：Carcinogenesis

authors： Guo W,You X,Xu D,Zhang Y,Wang Z,Man K,Wang Z,Chen Y

更新日期：2016-04-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative genomic analyses and ...

journal_title：Carcinogenesis

authors： Zhang C,Cao P,Yang A,Xia X,Li Y,Shi M,Yang Y,Wei X,Yang C,Zhou G

更新日期：2019-05-14 00:00:00

abstract：:Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...

journal_title：Carcinogenesis

authors： Flaks A,Flaks B

更新日期：1983-01-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:The effects of retinol and retinoic acid on cytotoxicity and mutation expression at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus in Chinese hamster ovary (CHO) cells with or without exogenous metabolic activation were studied in the presence and absence of known chemical mutagens. Neither retinol ...

journal_title：Carcinogenesis

authors： Budroe JD,Schol HM,Shaddock JG,Casciano DA

更新日期：1988-07-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), a major adrenal secretory product in men and women, is a potent inhibitor of mammalian glucose-6-phosphate dehydrogenase (G6PDH). Long-term treatment with this steroid has previously been found to suppress spontaneous breast cancer development in C3H mice. DHEA is now shown to inhibit Ep...

journal_title：Carcinogenesis

authors： Henderson E,Schwartz A,Pashko L,Abou-Gharbia M,Swern D

更新日期：1981-01-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:P-glycoprotein (P-gp) mediates the active transport of various substrates including xenobiotics, and it thus has a protective function in various cell types and tissues/organs including the intestinal epithelium. However, whether or not P-gp plays a positive role in the intestinal tumorigenesis is unclear. We have int...

journal_title：Carcinogenesis

authors： Mochida Y,Taguchi K,Taniguchi S,Tsuneyoshi M,Kuwano H,Tsuzuki T,Kuwano M,Wada M

更新日期：2003-07-01 00:00:00

abstract：:Ouabain resistance (ouar) and 6-thioguanine resistance (6-TGr) mutation frequencies were measured in Chinese hamster ovary cells after treatment with N-ethyl-N-nitrosourea (ENU) for varying periods of time. Maximal mutation frequency at the Na+/K+ ATPase gene locus (ouar mutations) was attained within 5 min of exposur...

journal_title：Carcinogenesis

authors： Dogliotti E,Vitelli A,Terlizzese M,Di Muccio A,Calcagnile A,Saffiotti U,Bignami M

更新日期：1987-01-01 00:00:00

abstract：:The survival of transfected simian virus (SV) 40 DNA is acutely sensitive to damage in a 302-bp regulatory region that governs viral gene expression and the initiation of viral DNA replication. We investigated whether the lethal effect of damage in this region is due to the disruption of gene expression or to the inhi...

journal_title：Carcinogenesis

authors： Brown TC,Cerutti P

更新日期：1987-08-01 00:00:00

abstract：:The fetus and neonate are sensitive targets for chemically induced carcinogenesis. Few studies have examined the risk/benefit of chemoprotective phytochemicals, given in the maternal diet, against transplacental carcinogenesis. In this study, B6129 SF1/J (AHR(b-1/d)) and 129Sv/ImJ (AHR(d/d)) mice were cross-bred. The ...

journal_title：Carcinogenesis

authors： Yu Z,Mahadevan B,Löhr CV,Fischer KA,Louderback MA,Krueger SK,Pereira CB,Albershardt DJ,Baird WM,Bailey GS,Williams DE

更新日期：2006-10-01 00:00:00

abstract：:Propylene oxide, a widely used monofunctional alkylating agent, has been shown to be genotoxic in in vitro test systems and induces tumors in the nasal tissues of experimental animals. Propylene oxide, like related alkylating agents, forms several different adducts with DNA bases, but predominantly at the 7-position o...

journal_title：Carcinogenesis

authors： Plna K,Nilsson R,Koskinen M,Segerbäck D

更新日期：1999-10-01 00:00:00

abstract：:Caffeine is sequentially metabolized by cytochrome P4501A2 (CYP1A2), N-acetyltransferase (NAT) and/or xanthine oxidase (XO). In the present study the activity of these three enzymes was estimated from ratios of the metabolites formed from dietary caffeine and excreted into the urine collected as spot samples. In the u...

journal_title：Carcinogenesis

authors： Vistisen K,Poulsen HE,Loft S

更新日期：1992-09-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose....

journal_title：Carcinogenesis

authors： Bellamri M,Wang Y,Yonemori K,White KK,Wilkens LR,Le Marchand L,Turesky RJ

更新日期：2018-12-31 00:00:00

abstract：:We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...

journal_title：Carcinogenesis

authors： Bolognesi C,Mariani MR,Boffa LC

更新日期：1988-08-01 00:00:00

abstract：:Compounds of nickel(II) and cadmium(II) are carcinogenic to humans and to experimental animals. One frequently discussed mechanism involved in tumor formation is an increase in reactive oxygen species by both metals with the subsequent generation of oxidative DNA damage. In the present study we used human HeLa cells t...

journal_title：Carcinogenesis

authors： Dally H,Hartwig A

更新日期：1997-05-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:A remodeling of calcium homeostasis has been identified as a characterizing feature of some cancers. Possible consequences of this include alterations in many pivotal physiological responses including apoptosis, proliferation and gene transcription. An alteration in calcium homeostasis can occur via changes in the exp...

journal_title：Carcinogenesis

authors： Aung CS,Ye W,Plowman G,Peters AA,Monteith GR,Roberts-Thomson SJ

更新日期：2009-11-01 00:00:00

abstract：:Fish or vegetable oils were fed during the promotion stage of a mouse skin carcinogenesis model in order to investigate the effects of dietary fat on tumor development. Two weeks after initiation with 10 nmol dimethylbenz[a]anthracene, SENCAR mice were divided into five groups and maintained on one of the following se...

journal_title：Carcinogenesis

authors： Locniskar M,Belury MA,Cumberland AG,Patrick KE,Fischer SM

更新日期：1991-06-01 00:00:00

abstract：:To study the relationship between epidermal DNA synthesis and carcinogenesis, hairless mice of both sexes were given a single topical application of 1 mg N-methyl-N-nitrosourea (MNU) in acetone. A control group received only MNU, whereas other groups were injected i.p. with 5 mg hydroxyurea (HU), 1 h, 45 min and 15 mi...

journal_title：Carcinogenesis

authors： Iversen OH

更新日期：1982-01-01 00:00:00

abstract：:Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...

journal_title：Carcinogenesis

authors： Brooks G,Evans AT,Aitken A,Evans FJ

更新日期：1989-02-01 00:00:00

abstract：:Cells from patients with genomic instability syndromes have high predisposition to cancer. However, little is known about whether these mutant cells have high susceptibility to oncogenic transformation. We have tested the hypothesis that a defect in maintaining genome integrity is necessary but not sufficient alone fo...

journal_title：Carcinogenesis

authors： Li J,Sejas DP,Burma S,Chen DJ,Pang Q

更新日期：2007-06-01 00:00:00

abstract：:The effect of co-administration of diethylnitrosamine (DEN) and Clophen A 50, a commercial mixture of polychlorinated biphenyls (PCB), on pre-neoplastic enzyme-altered islands in livers of female Sprague-Dawley rats was studied. The islands were identified by the loss of adenosine-5'-triphosphatase (ATPase), emergence...

journal_title：Carcinogenesis

authors： Deml E,Oesterle D

更新日期：1986-10-01 00:00:00

abstract：:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...

journal_title：Carcinogenesis

authors： Stitzel KA,Horn PA,Ezra MF

更新日期：1990-12-01 00:00:00

abstract：:Wnt/β-Catenin signaling dysregulation is involved in tumorigenesis. Furthermore, epigenetic modification of the Dickkopf (DKK) family (DKK1-DKK4) has been shown to be important in Wnt signaling regulation. In this study, the role of DKK2, a Wnt antagonist, in epithelial ovarian cancer (EOC) was evaluated by examining ...

journal_title：Carcinogenesis

authors： Zhu J,Zhang S,Gu L,Di W

更新日期：2012-12-01 00:00:00

abstract：:Cisplatin alone or in combination with 5FU (5-fluorouracil) and docetaxel (TPF) are common regimen chemotherapeutics for treatment of advanced oral squamous cell carcinoma (OSCC). Despite the initial positive response, several patients experience relapse due to chemoresistance. The potential role of Bcl-2 antiapoptoti...

journal_title：Carcinogenesis

authors： Maji S,Shriwas O,Samal SK,Priyadarshini M,Rath R,Panda S,Das Majumdar SK,Muduly DK,Dash R

更新日期：2019-03-12 00:00:00