Gene expression rather than the initiation of DNA replication is the principal target of lethal u.v.-induced damage in a regulatory region of SV40 DNA.

abstract：:Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...

journal_title：Carcinogenesis

authors： Lee JJ,Natsuizaka M,Ohashi S,Wong GS,Takaoka M,Michaylira CZ,Budo D,Tobias JW,Kanai M,Shirakawa Y,Naomoto Y,Klein-Szanto AJ,Haase VH,Nakagawa H

更新日期：2010-03-01 00:00:00

abstract：:The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3 [Ex8-280C>A (rs6948) and Ex8+567T>C (rs1049216)], CASP8 Ex14-271A>T (rs13113), CASP9 Ex5+32G>A (rs1052576) and CASP10 Ex3...

journal_title：Carcinogenesis

authors： Lan Q,Zheng T,Chanock S,Zhang Y,Shen M,Wang SS,Berndt SI,Zahm SH,Holford TR,Leaderer B,Yeager M,Welch R,Hosgood D,Boyle P,Rothman N

更新日期：2007-04-01 00:00:00

abstract：:An important difference between chemical agents that induce oxidative damage in DNA and ionizing radiation is that radiation-induced damage is clustered locally on the DNA. Both modelling and experimental studies have predicted the importance of clustering of lesions induced by ionizing radiation and its dependence on...

journal_title：Carcinogenesis

authors： Prise KM,Pullar CH,Michael BD

更新日期：1999-05-01 00:00:00

abstract：:Zinc has been shown to be accumulated in N-methyl-N-nitrosourea (MNU)-induced rat mammary tumors. Zinc is required for cell proliferation and tumorigenesis is characterized by dysregulation of cell proliferation. An accumulation of zinc in mammary tumors perhaps indicates a reliance on zinc to sustain tumor growth. Li...

journal_title：Carcinogenesis

authors： Lee S,Simpson M,Nimmo M,Xu Z

更新日期：2004-10-01 00:00:00

abstract：:Recent evidence demonstrates the existence of diversified microbiota in the lung. However, the effect of lung carcinogenesis on the flora in lung microenvironment has yet not been well investigated. In this study, we surveyed the microbial composition and diversity in lung tumor and paired adjacent normal tissues obta...

journal_title：Carcinogenesis

authors： Mao Q,Ma W,Wang Z,Liang Y,Zhang T,Yang Y,Xia W,Jiang F,Hu J,Xu L

更新日期：2020-08-12 00:00:00

abstract：:Ovarian cancer is developed from a single layer of thin epithelial cells covering the surface of ovary, named human ovarian surface epithelial cells. Like all primary human cells, human ovarian surface epithelial cells have a finite life span and will go into senescence and eventually die when cultured in vitro. Immor...

journal_title：Carcinogenesis

authors： Yang G,Rosen DG,Mercado-Uribe I,Colacino JA,Mills GB,Bast RC Jr,Zhou C,Liu J

更新日期：2007-01-01 00:00:00

abstract：:Mevastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis. Butyrate, a short-chain fatty acid, reduces proliferation and induces differentiation of human colon cancer cells. The aim of our study was to determine the effect of mevastatin, ...

journal_title：Carcinogenesis

authors： Wächtershäuser A,Akoglu B,Stein J

更新日期：2001-07-01 00:00:00

abstract：:Ouabain resistance (ouar) and 6-thioguanine resistance (6-TGr) mutation frequencies were measured in Chinese hamster ovary cells after treatment with N-ethyl-N-nitrosourea (ENU) for varying periods of time. Maximal mutation frequency at the Na+/K+ ATPase gene locus (ouar mutations) was attained within 5 min of exposur...

journal_title：Carcinogenesis

authors： Dogliotti E,Vitelli A,Terlizzese M,Di Muccio A,Calcagnile A,Saffiotti U,Bignami M

更新日期：1987-01-01 00:00:00

abstract：:Hydrazine sulfate is a genotoxic hepatocarcinogen for the hamster. A study was conducted to follow changes in DNA maintenance methylation in selected genes in liver DNA during the 21-month induction of liver adenomas and hepatocellular carcinomas by demonstrating changes in restriction fragment length polymorphism. Ma...

journal_title：Carcinogenesis

authors： Zheng H,Shank RC

更新日期：1996-12-01 00:00:00

abstract：:Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...

journal_title：Carcinogenesis

authors： Huang WY,Gao YT,Rashid A,Sakoda LC,Deng J,Shen MC,Wang BS,Han TQ,Zhang BH,Chen BE,Rosenberg PS,Chanock SJ,Hsing AW

更新日期：2008-01-01 00:00:00

abstract：:Chemopreventive activities of all-trans retinoic acid (AtRA), 9-cis retinoic acid (9cRA), retinol (ROL) and beta-carotene (betaC) were evaluated during hepatocarcinogenesis. Rats received 1 mg/100 g body wt AtRA (AtRA group), 9cRA (9cRA group), ROL (ROL group), 7 mg/100 g body wt betaC (betaC group) or corn oil (CO gr...

journal_title：Carcinogenesis

authors： de Almeida Vasconcelos Fonseca EM,Chagas CE,Mazzantini RP,Heidor R,Ong TP,Moreno FS

更新日期：2005-11-01 00:00:00

abstract：:The H2-receptor antagonist, ranitidine, is among the most widely used pharmaceuticals to treat gastroesophageal reflux disease and peptic ulcers. While previous studies have demonstrated that amines can form N-nitrosamines when exposed to nitrite at stomach-relevant pH, N-nitrosamine formation from ranitidine, an amin...

journal_title：Carcinogenesis

authors： Zeng T,Mitch WA

更新日期：2016-06-01 00:00:00

abstract：:The carcinogenic effects of in utero exposure to 3-methylcholanthrene (MC) have been demonstrated in the tumor-resistant C57BL/6 (B6) and DBA (D2) strains of mice. In this study, we determined the effects of in utero exposure to MC in BALB/c mice, a strain which demonstrates greater susceptibility to lung tumor induct...

journal_title：Carcinogenesis

authors： Gressani KM,Leone-Kabler S,O'Sullivan MG,Case LD,Malkinson AM,Miller MS

更新日期：1999-11-01 00:00:00

abstract：:Formation of O6-ethylguanine (O6EG) in trachea DNA was measured 12 h after acute i.p. administration of 50, 100 and 200 mg diethylnitrosamine (DEN)/kg body wt to Syrian golden hamsters. Purine bases were fractionated by h.p.l.c., and ethylated guanines were quantified optically by fluorescence spectrophotometry. Signi...

journal_title：Carcinogenesis

authors： Fong AT,Rasmussen RE

更新日期：1986-09-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:Malondialdehyde (MDA), a product of lipid peroxidation, causes mutations in bacterial and mammalian cells and cancer in rats. MDA reacts with deoxynucleosides in vitro and the monomeric adduct of MDA with deoxyguanosine (M1G-dR) is the major adduct. M1G-dR has been detected in rat and human liver. Random mutagenesis s...

journal_title：Carcinogenesis

authors： Chaudhary AK,Reddy GR,Blair IA,Marnett LJ

更新日期：1996-05-01 00:00:00

abstract：:Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 overexpression is still unclear. MicroRNAs (miRNA) have been implicated as gene regulators controlling diverse biological processes, including car...

journal_title：Carcinogenesis

authors： Wang H,Wu J,Meng X,Ying X,Zuo Y,Liu R,Pan Z,Kang T,Huang W

更新日期：2011-07-01 00:00:00

abstract：:The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in viv...

journal_title：Carcinogenesis

authors： Zhou M,Liu W,Ma S,Cao H,Peng X,Guo L,Zhou X,Zheng L,Guo L,Wan M,Shi W,He Y,Lu C,Jiang L,Ou C,Guo Y,Ding Z

更新日期：2013-07-01 00:00:00

abstract：:The influence of various dietary constituents--phenethylisothiocyanate (PEITC), oleic acid (OA), triolein (TO), and vitamin A (ROL)--on the genotoxic activity of nitrosamines (NDMA, NDELA, NPYR) was investigated. For this purpose differential DNA repair assays with Escherichia coli K-12 strains were performed in vitro...

journal_title：Carcinogenesis

authors： Knasmüller S,Huber WW,Kienzl H,Schulte-Hermann R

更新日期：1992-09-01 00:00:00

abstract：:To indicate how readily nitrosamines (NAms) diffuse into the esophagus, we measured diffusion rate (flux) through rat esophagus of dialkyl-NAms using side-by-side diffusion apparatuses. Mucosal and serosal flux at 37 degrees C of two NAms, each at 50 microM, was followed for 90 min by gas chromatography-thermal energy...

journal_title：Carcinogenesis

authors： Haorah J,Miller DW,Brand R,Smyrk TC,Wang X,Chen SC,Mirvish SS

更新日期：1999-05-01 00:00:00

abstract：:The bioactivation of cyclopenta[cd]pyrene (CPP) was investigated to determine the major DNA adduct-forming metabolite(s) of this widespread environmental contaminant and suspect carcinogen. DNA adducts were analyzed by 32P-postlabeling. Four major and at least seven minor adducts formed when CPP was incubated with cal...

journal_title：Carcinogenesis

authors： Beach AC,Gupta RC

更新日期：1994-05-01 00:00:00

abstract：:Fish or vegetable oils were fed during the promotion stage of a mouse skin carcinogenesis model in order to investigate the effects of dietary fat on tumor development. Two weeks after initiation with 10 nmol dimethylbenz[a]anthracene, SENCAR mice were divided into five groups and maintained on one of the following se...

journal_title：Carcinogenesis

authors： Locniskar M,Belury MA,Cumberland AG,Patrick KE,Fischer SM

更新日期：1991-06-01 00:00:00

abstract：:The effect of a deoxycholic acid instillation on colonic epithelium was investigated and compared with the effect of an intervention scheme in which deoxycholic acid (DCA) treated mice received oral supplements of calcium lactate. The morphology of colonic tissue exposed to DCA was markedly affected when compared to t...

journal_title：Carcinogenesis

authors： Wargovich MJ,Eng VW,Newmark HL,Bruce WR

更新日期：1983-09-01 00:00:00

abstract：:The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...

journal_title：Carcinogenesis

authors： Loveland PM,Wilcox JS,Pawlowski NE,Bailey GS

更新日期：1987-08-01 00:00:00

abstract：:Zuotin-related factor 1 (ZRF1) is a recently characterized epigenetic factor involved in transcriptional regulation and is highly overexpressed in several malignancies, but it is not known whether it plays a role in gastric cancer (GC). In this study, we investigated whether ZRF1 acts as a cancer-promoting gene throug...

journal_title：Carcinogenesis

authors： Imamura T,Komatsu S,Ichikawa D,Miyamae M,Okajima W,Ohashi T,Kiuchi J,Nishibeppu K,Kosuga T,Konishi H,Shiozaki A,Fujiwara H,Okamoto K,Tsuda H,Otsuji E

更新日期：2018-02-09 00:00:00

abstract：:In vitro exposures of isolated DNA to one of the two carcinogenic and mutagenic chemicals, diethylsulfate or dimethylsulfate, induces several kinds of physicochemical and morphological alterations. These changes are detectable by a variety of independent techniques. A fraction of DNA treated briefly with either of the...

journal_title：Carcinogenesis

authors： Kubinski H,Kubinski ZO,Fiandt M,Konopa G

更新日期：1981-01-01 00:00:00

abstract：:Alterations in the pattern of epidermal cell differentiation and proliferation in mouse skin and benign skin tumors were studied by two-color immunofluorescence using monospecific antibodies. Replicating cells were identified by 5-bromo-deoxyuridine (BrdU) pulse-labeling and differentiating cells by keratins K1 and K1...

journal_title：Carcinogenesis

authors： Huitfeldt HS,Heyden A,Clausen OP,Thrane EV,Roop D,Yuspa SH

更新日期：1991-11-01 00:00:00

abstract：:The modulating effects of dietary feeding of two xanthophylls, astaxanthin (AX) and canthaxanthin (CX) during the postinitiation phase on colon carcinogenesis initiated with azoxymethane (AOM) were investigated in male F344 rats. Animals were initiated with AOM by weekly s.c. injections of 15 mg/kg body wt for 3 weeks...

journal_title：Carcinogenesis

authors： Tanaka T,Kawamori T,Ohnishi M,Makita H,Mori H,Satoh K,Hara A

更新日期：1995-12-01 00:00:00

abstract：:Specific repair endonucleases were used to quantify oxidative modifications in mitochondrial DNA (mtDNA) from rat liver and from porcine liver and kidney by means of a relaxation assay. In rat liver mitochondria the number of modifications sensitive to formamidopyrimidine--DNA glycosylase (FPG protein), which include ...

journal_title：Carcinogenesis

authors： Hegler J,Bittner D,Boiteux S,Epe B

更新日期：1993-11-01 00:00:00

abstract：:The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the dose-response and to establish benzene's internal dosimetry at doses encompassing human environmental exposures. [14C]-Benzene was administered to B6C3F1 male mic...

journal_title：Carcinogenesis

authors： Creek MR,Mani C,Vogel JS,Turteltaub KW

更新日期：1997-12-01 00:00:00