A novel onco-miR-365 induces cutaneous squamous cell carcinoma.

abstract：:Antibodies specific for u.v.-induced DNA damage were raised in rabbits, and used to study damage and repair of nuclear DNA in nude mouse and human skin in vivo by immuno-fluorescence and immunoperoxidase techniques. Purification of the antibodies by affinity chromatography strongly reduced unspecific background staini...

journal_title：Carcinogenesis

authors： Eggset G,Volden G,Krokan H

更新日期：1983-01-01 00:00:00

abstract：:We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...

journal_title：Carcinogenesis

authors： Bolognesi C,Mariani MR,Boffa LC

更新日期：1988-08-01 00:00:00

abstract：:The O6-alkylguanine-DNA alkyltransferase (ATase) is known to overcome the effects of promutagenic, precarcinogenic O6-alkylguanine induced in DNA by exposure to environmental, chemotherapeutic and dietary alkylating agents. Within an organ, the cell type-specific responses to these agents may be attributed, in part, t...

journal_title：Carcinogenesis

authors： Wani G,Wani AA,D'Ambrosio SM

更新日期：1993-04-01 00:00:00

abstract：:The influence of the smoking parameters (puff profile, puff duration, puff volume, puff frequency) on the delivery of tobacco-specific nitrosamines (TSNAs) in mainstream smoke was investigated for six different cigarette brands, including filter cigarettes with very low to medium smoke yields and non-filter cigarettes...

journal_title：Carcinogenesis

authors： Fischer S,Spiegelhalder B,Preussmann R

更新日期：1989-06-01 00:00:00

abstract：:In order to establish an animal model for studying the cause and prevention of esophageal adenocarcinoma (EAC) and its frequent precursor, Barrett's esophagus (BE), factors affecting the pathogenic processes were investigated in an esophagoduodenal anastomosis model with rats. Experiments by us and others have shown t...

journal_title：Carcinogenesis

authors： Goldstein SR,Yang GY,Curtis SK,Reuhl KR,Liu BC,Mirvish SS,Newmark HL,Yang CS

更新日期：1997-11-01 00:00:00

abstract：:The inbred DRH rats are highly resistant to the induction of hepatocellular carcinoma (HCC) by feeding of 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB). Previously, we found that two quantitative trait loci (QTLs), Drh1 and Drh2, significantly reduced the number, size and area of glutathione S-transferase-placental ...

journal_title：Carcinogenesis

authors： Yan Y,Zeng ZZ,Higashi S,Denda A,Konishi Y,Onishi S,Ueno H,Higashi K,Hiai H

更新日期：2002-01-01 00:00:00

abstract：:Breast cancer is a leading cause of cancer-related mortality in women. Triple-negative breast cancer (TNBC; HER2-, ER-/PR-) is an aggressive subtype prone to drug resistance and metastasis, which is characterized by high intratumor microvascular density (iMVD) resulting from angiogenesis. However, the mechanisms contr...

journal_title：Carcinogenesis

authors： Kumar N,Prasad P,Jash E,Jayasundar S,Singh I,Alam N,Murmu N,Somashekhar SP,Goldman A,Sehrawat S

更新日期：2018-10-08 00:00:00

abstract：:Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were studied in human buccal mucosa in vitro. Microautoradiographic analysis of [5-3H]NNK-exposed explant cultures demonstrated a uniform distribution of bound radioactivity in the mucosal ...

journal_title：Carcinogenesis

authors： Liu Y,Sundqvist K,Belinsky SA,Castonguay A,Tjälve H,Grafström RC

更新日期：1993-11-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC), one of the most prevalent and lethal cancers, has shown an alarming rise in the USA. Without effective therapy for HCC, novel chemopreventive strategies may effectively circumvent the current morbidity and mortality. Oxidative stress predisposes to hepatocarcinogenesis and is the major ...

journal_title：Carcinogenesis

authors： Bishayee A,Bhatia D,Thoppil RJ,Darvesh AS,Nevo E,Lansky EP

更新日期：2011-06-01 00:00:00

abstract：:In recent years, considerable emphasis has been placed on identifying new cancer chemopreventive agents which could be useful for human populations. Silymarin, an anti-oxidant flavonoid isolated from artichoke, has been shown to possess significant activity against hepatotoxicity and other pharmacological and physiolo...

journal_title：Carcinogenesis

authors： Agarwal R,Katiyar SK,Lundgren DW,Mukhtar H

更新日期：1994-06-01 00:00:00

abstract：:Previous reports showed that skin fibroblasts or peripheral blood lymphocytes from individuals with hereditary cancer or with a genetic disorder predisposing to cancer show an abnormally high frequency of chromatid damage after X-irradiation in G2 phase. The reproducibility of this response suggested that it could pro...

journal_title：Carcinogenesis

authors： Takai S,Price FM,Sanford KK,Tarone RE,Parshad R

更新日期：1990-08-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:The effect of a deoxycholic acid instillation on colonic epithelium was investigated and compared with the effect of an intervention scheme in which deoxycholic acid (DCA) treated mice received oral supplements of calcium lactate. The morphology of colonic tissue exposed to DCA was markedly affected when compared to t...

journal_title：Carcinogenesis

authors： Wargovich MJ,Eng VW,Newmark HL,Bruce WR

更新日期：1983-09-01 00:00:00

abstract：:We have previously demonstrated that betel quid containing safrole induced DNA adducts are highly associated with the development of oral squamous cell carcinoma (OSCC) in Taiwan. Sulfotransferase (SULT) is essential for the formation of these adducts. To elucidate the effects of SULT1A1 haplotypes on OSCC susceptibil...

journal_title：Carcinogenesis

authors： Chung YT,Hsieh LL,Chen IH,Liao CT,Liou SH,Chi CW,Ueng YF,Liu TY

更新日期：2009-02-01 00:00:00

abstract：:Pardaxin, an antimicrobial peptide secreted by the Red Sea flatfish Pardachirus marmoratus, inhibits proliferation and induces apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are only partially understood at present. In this study, we used proteomic approaches and network reconstruct...

journal_title：Carcinogenesis

authors： Huang TC,Chen JY

更新日期：2013-08-01 00:00:00

abstract：:The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promot...

journal_title：Carcinogenesis

authors： Li G,Zhai X,Zhang Z,Chamberlain RM,Spitz MR,Wei Q

更新日期：2006-10-01 00:00:00

abstract：:Cigarette smoking is a major cause of human cancer at a variety of sites, although its carcinogenic mechanisms remains unestablished. Cigarette smoke can be divided into two phases, gas phase and particulate matter (tar). Both phases contain high concentrations of oxidants and free radicals, especially nitric oxide (N...

journal_title：Carcinogenesis

authors： Yoshie Y,Ohshima H

更新日期：1997-07-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases....

journal_title：Carcinogenesis

authors： Tebbi A,Levillayer F,Jouvion G,Fiette L,Soubigou G,Varet H,Boudjadja N,Cairo S,Hashimoto K,Suzuki AM,Carninci P,Carissimo A,di Bernardo D,Wei Y

更新日期：2016-01-01 00:00:00

abstract：:2-Nitrofluorene (NF) is a potent genotoxic substance found in environments where incomplete combustion takes place. NF is a mutagen and a carcinogen in animal models. NF or 7,12-dimethylbenz[a]anthracene (DMBA) was administered once topically to female SENCAR mice followed by promotion by 12-O-tetradecanoylphorbol-13-...

journal_title：Carcinogenesis

authors： Möller L,Zeisig M,Toftgård R

更新日期：1993-08-01 00:00:00

abstract：:The nitrogen heterocycle dibenz[c,h]acridine (DB[c,h]ACR) and the enantiomers of the diastereomeric pair of bay-region 3,4-diol 1, 2-epoxides as well as other bay-region epoxides and dihydrodiol derivatives of this hydrocarbon have been evaluated for tumorigenicity on mouse skin and in the newborn mouse. On mouse skin...

journal_title：Carcinogenesis

authors： Chang RL,Wood AW,Kumar S,Lehr RE,Shirai N,Jerina DM,Conney AH

更新日期：2000-11-01 00:00:00

abstract：:The role of haplotypes and the interaction of haplotypes and smoking in lung cancer risk have not been well characterized. We analyzed data from an Italian population-based, case-control study with 1815 lung cancer patients and 1959 healthy controls in discovery, and performed a validation using a case-control study w...

journal_title：Carcinogenesis

authors： Ji X,Gui J,Han Y,Brennan P,Li Y,McKay J,Caporaso NE,Bertazzi PA,Landi MT,Amos CI

更新日期：2015-11-01 00:00:00

abstract：:Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...

journal_title：Carcinogenesis

authors： Hesterberg TW,Barrett JC

更新日期：1985-03-01 00:00:00

abstract：:Both dehydroepiandrosterone (DHEA) and the synthetic steroid 16 alpha-Br-epiandrosterone (Br-Epi), a more potent inhibitor of glucose-6-phosphate dehydrogenase (G6PDH) than DHEA, inhibit the 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulation of superoxide anion (O2-) formation by human neutrophils. DHEA has previo...

journal_title：Carcinogenesis

authors： Whitcomb JM,Schwartz AG

更新日期：1985-03-01 00:00:00

abstract：:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...

journal_title：Carcinogenesis

authors： Osterman-Golkar S,Bergmark E

更新日期：1988-11-01 00:00:00

abstract：:Overexpression of ectopic mutant p53 represses wild-type p53-stimulated transcription, known as a dominant negative effect. On the other hand, overexpression of wild-type p53 can repress transcription stimulated by several transcription factors, including hypoxia-inducible factor-1 (HIF-1). Using a panel of well-chara...

journal_title：Carcinogenesis

authors： Blagosklonny MV,Giannakakou P,Romanova LY,Ryan KM,Vousden KH,Fojo T

更新日期：2001-06-01 00:00:00

abstract：:Initiation with the carcinogen 7,12-dimethylbenz[a]anthracene followed by promotion with the hyperplasiogenic phorbol ester 12-O-tetradecanoylphorbol-13-acetate carried out on the dorsal skin of European hamsters (Cricetus cricetus L.) led to the formation of a broad spectrum of skin tumors in terms of a two-stage pri...

journal_title：Carcinogenesis

authors： Goerttler K,Loehrke H,Hesse B,Schweizer J

更新日期：1984-04-01 00:00:00

abstract：:XB2 cells, a teratocarcinoma derived cell line of keratinocyte lineage, have been shown to proliferate and differentiate in low calcium medium (0.03 mM Ca2+) at a density of 500 cells/9.6 cm2 without the need for fibroblast feeder layers or conditioned medium. The degree of differentiation can be assessed by measureme...

journal_title：Carcinogenesis

authors： Hewitt SD,Duffy PA,Orton TC,Garner RC

更新日期：1990-03-01 00:00:00