Abstract:
:Initiation with the carcinogen 7,12-dimethylbenz[a]anthracene followed by promotion with the hyperplasiogenic phorbol ester 12-O-tetradecanoylphorbol-13-acetate carried out on the dorsal skin of European hamsters (Cricetus cricetus L.) led to the formation of a broad spectrum of skin tumors in terms of a two-stage principle. Tumor formation involved the epidermis and its appendages, the connective tissue, and the vascular and pigmentary system. With regard to the sensitivity to initiation with DMBA alone and initiation with DMBA and promotion with TPA the European hamster occupies a special position since all of the DMBA-TPA sensitive two-stage target organs known from the mouse, rabbit, Syrian golden hamster and rat are combined in this animal.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Goerttler K,Loehrke H,Hesse B,Schweizer Jdoi
10.1093/carcin/5.4.521subject
Has Abstractpub_date
1984-04-01 00:00:00pages
521-4issue
4eissn
0143-3334issn
1460-2180journal_volume
5pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Several previous in vitro studies have indicated that ascorbate and glutathione are the major reductants of Cr(VI) in cells. In order to evaluate the in vivo effects of ascorbate and glutathione on Cr(VI)-induced carcinogenesis, Cr uptake and the formation of Cr(V), Cr-DNA adducts and 8-hydroxy-2'-deoxyguanosine (8-OH...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.7.1267
更新日期:1999-07-01 00:00:00
abstract::Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disorder, and prophylactic colectomy has been shown to decrease the incidence of colorectal cancer (CRC). Duodenal cancer and desmoids are now the leading causes of death in FAP. We evaluate whether 3 months of oral supplementation with a patented...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章
doi:10.1093/carcin/bgw041
更新日期:2016-06-01 00:00:00
abstract::The relationship between urinary metabolites and DNA damage in the urinary bladder epithelium of male and female rats was tested by alkaline elution assay after an intravesical injection of OPP or its urinary metabolites. 2-Phenyl-1,4-benzoquinone (PBQ) revealed a weak DNA-damaging activity in both sexes at 0.05-0.1%....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.10.1823
更新日期:1989-10-01 00:00:00
abstract::Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.493
更新日期:1989-03-01 00:00:00
abstract::Here we report that colorectal cancer patients show a markedly higher frequency (3-fold) of wild-type NAT2*4 allele homozygotes than the control population. However, a marked difference in NAT2*4/NAT2*4 genotype frequency associated with the patients gender was observed pointing to a male-specific effect of this genot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.1.37
更新日期:1998-01-01 00:00:00
abstract::The high incidence of oesophageal cancer in Northern Iran has been associated with opium. N-Nitrosamines are the only carcinogens known to induce oesophageal cancer in animals. Ethanol, which is the major influence on oesophageal cancer incidence in the West, inhibits the first pass clearance of N-nitrosodimethylamine...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.2.365
更新日期:1997-02-01 00:00:00
abstract::Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.1.99
更新日期:1998-01-01 00:00:00
abstract::A reduction in the ratio of tetraploid to diploid liver nuclei has been investigated as an early indicator of hepatocarcinogenesis in the rat using the liver carcinogen 3'-methyl-4-dimethylaminoazobenzene (3'M). In a dose ranging study 3'M was administered by gavage to rats at 5, 12.5 and 25 mg/kg for up to 10 weeks a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.1.21
更新日期:1985-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer has been thoroughly investigated, and although many miRNAs are identified as cancer related, little is known about their involvement in benign ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt333
更新日期:2014-01-01 00:00:00
abstract::Isothiocyanates are anticarcinogenic phytochemicals found in cruciferous vegetables that both induce and are substrates for the gluthatione S-transferases (GSTs). The GSTs are phase II metabolizing enzymes involved in metabolism of various bioactive compounds. Functional polymorphisms in GST genes have been identified...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm141
更新日期:2007-09-01 00:00:00
abstract::Marked inter-individual variation in lung cancer risk cannot be accounted for solely by cigarette smoke and other environmental exposures. Evidence suggests that variation in bronchial epithelial cell expression of key DNA repair genes plays a role. Variation in these genes correlates with variation in expression of C...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm214
更新日期:2007-12-01 00:00:00
abstract::We have previously demonstrated that the active dihydrofolate reductase (DHFR) gene is efficiently repaired in Chinese hamster ovary (CHO) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. Preferential DNA repair of essential genes may explain why the u.v. resistance o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1333
更新日期:1987-09-01 00:00:00
abstract::Liver microsomes from male Syrian golden hamsters and Sprague Dawley rats metabolize the cis and trans isomers of N-nitroso-2,6-dimethylmorpholine (NNDM) to N-nitroso-(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) as the major product detectable by h.p.l.c. The rates of total metabolism are similar for both the cis and tr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.8.1009
更新日期:1984-08-01 00:00:00
abstract::The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/carcin/16.4.955
更新日期:1995-04-01 00:00:00
abstract::Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characterized ALK5 inhibitor,...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq191
更新日期:2010-12-01 00:00:00
abstract::The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh105
更新日期:2004-06-01 00:00:00
abstract::The induction of aberrant crypt foci (ACF) by irradiation of gamma-rays (60Co), and the effect of dietary sugar beet fiber (SBF) on irradiation-induced ACF were examined. We found that abdominal irradiation of gamma-rays could induce ACF in the rat colon. The irradiation was performed once a week at a dose rate of 2 o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.6.1005
更新日期:1999-06-01 00:00:00
abstract::The urinary excretion of dimethylnitrosamine (DMN) was studied in male Sprague-Dawley rats. Animals were given DMN (3, 5, 10, 20, 30 and 50 mg/kg body weight, i.p.) or [3H]DMN (0.1, 1 and 3 mg; 8.7, 1.5 and 0.28 mCi/kg body weight, respectively, i.p.) diluted with sterile 0.9% NaCl. Urine was collected for 24 h after ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/2.7.609
更新日期:1981-01-01 00:00:00
abstract::To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.8.1257
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:Analysis of candidate genes in individual studies has had only limited success in identifying particular gene variants that are conclusively associated with lung cancer risk. In the International Lung Cancer Consortium (ILCCO), we conducted a coordinated genotyping study of 10 common variants selected becaus...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq001
更新日期:2010-04-01 00:00:00
abstract::Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh350
更新日期:2005-03-01 00:00:00
abstract::Phosphoinositide-specific phospholipase Cgamma (PLCgamma) is a key regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain of certain activated receptors and catalyses the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] forming IP3 and diacylglycerol (DAG) in resp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.1.177
更新日期:1998-01-01 00:00:00
abstract::It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsib...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/21.3.497
更新日期:2000-03-01 00:00:00
abstract::Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene located at chromosome 11q22. Since we previously reported amplification of 11q22 region in esophageal squamous cell carcinoma (ESCC), in this study we focused on the clinical signifi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq254
更新日期:2011-03-01 00:00:00
abstract::Although the anticancer properties of oligomeric proanthocyanidins (OPCs) from grape seeds have been well recognized, the molecular mechanisms by which they exert anticancer effects are poorly understood. In this study, through comprehensive RNA-sequencing-based gene expression profiling in multiple colorectal cancer ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy034
更新日期:2018-05-28 00:00:00
abstract::Acutely transforming retrovirus AKT8 in rodent T cell lymphoma (Akt) phosphorylates and regulates the function of many cellular proteins involved in processes such as metabolism, apoptosis and proliferation. However, the precise mechanisms by which Akt promotes cell survival and inhibits apoptosis have been characteri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn197
更新日期:2008-11-01 00:00:00
abstract::Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.3.417
更新日期:2003-03-01 00:00:00
abstract::Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.4.539
更新日期:1985-04-01 00:00:00
abstract::When exogenous [(3)H]retinol (vitamin A) was added to culture medium, normal human epithelial cells from the oral cavity, skin, lung and breast took up and esterified essentially all of the [(3)H]retinol within a few hours. As shown by [(3)H]retinol pulse-chase experiments, normal epithelial cells then slowly hydrolyz...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.11.1925
更新日期:2000-11-01 00:00:00
abstract::The arylamine carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMABP) has been proposed to be metabolically activated to DNA-binding derivatives through the formation of an N-hydroxy intermediate. In this study, the subsequent activation of N-hydroxy-DMABP through acid catalysis or enzymatic esterification was examined. [Rin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.2.251
更新日期:1985-02-01 00:00:00