Abstract:
:Oreochromis mossambicus, commonly known as tilapia, is a freshwater teleost with a wide tolerance to environmental conditions. Multiple focal lesions in the liver were observed 2 months after cessation of a one-month long treatment with 100 p.p.m. diethylnitrosamine. Cells were small and compact and arranged in sheets. Ultrastructurally, these cells have abundant endoplasmic reticulum, round mitochondria, less conspicuous golgi apparatus and fat droplets. Other organs like the intestines, spleen, kidneys, ovaries and pituitary appeared normal. Two liver inducible enzymes, gamma-glutamyl transferase and tyrosine aminotransferase were elevated by 5- and 3-fold respectively. Aggressive migration of hepatocytes was observed in tumorigenic liver explants. Vitellogenesis and early embryological development appeared unaffected as the female fish spawned during hepatocarcinogenesis. However, their fry were stunted and short-lived. To compare the susceptibility of tilapia to another hepatocarcinogen, the fish were also treated with methylazoxymethanol acetate at 10 p.p.m. for 0.5-1 h. However, methylazoxymethanol acetate was too toxic and 75% of the fish succumbed 1 day after treatment. Moreover, after 2 months post-treatment, neither tumors nor change in enzyme activities were observed in any organ. These results suggest that tilapia could be a useful model for screening and differentiating carcinogens since they could develop liver tumors within only 2 months after treatment with diethylnitrosamine.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Ding JL,Hee PL,Lam TJdoi
10.1093/carcin/10.3.493subject
Has Abstractpub_date
1989-03-01 00:00:00pages
493-9issue
3eissn
0143-3334issn
1460-2180journal_volume
10pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The aims of this study were to examine the anti-proliferative effects of different concentrations of a commercial preparation of conjugated linoleic acids (CLA) mixture of isomers [cis-9, trans-11 CLA (c9,t11 CLA): trans-10, cis-12 CLA (50:50)] and their constituent isomers on PC-3, a human prostatic carcinoma cell li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh116
更新日期:2004-07-01 00:00:00
abstract::Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA met...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr181
更新日期:2011-10-01 00:00:00
abstract::The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.12.2335
更新日期:1989-12-01 00:00:00
abstract::Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh065
更新日期:2004-05-01 00:00:00
abstract::The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.7.805
更新日期:1982-01-01 00:00:00
abstract::Oxidative DNA damage may be implicated in ageing, carcinogenesis and other degenerative diseases. Oxidative DNA damage can be assessed in humans in vivo from the urinary excretion of the DNA-repair product 8-hydroxydeoxyguanosine (8OHdG). We investigated factors influencing the excretion of 8OHdG in 24 h urine from 83...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.12.2241
更新日期:1992-12-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgv108
更新日期:2015-10-01 00:00:00
abstract::Phorbol ester-sensitive EL4 murine thymoma cells respond to phorbol 12-myristate 13-acetate with activation of ERK mitogen-activated protein kinases, synthesis of interleukin-2, and death, whereas phorbol ester-resistant variants of this cell line do not exhibit these responses. Additional aspects of the resistant phe...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.9.1817
更新日期:1997-09-01 00:00:00
abstract::The faecal concentration of substances responding to the chemical test for N-nitroso compounds (apparent total N-nitroso compounds, ATNC) was investigated in human subjects consuming their normal free-choice diet. Concentrations ranged from 40 to 590 micrograms (N-NO)/kg faeces. To ascertain the likely relative contri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.8.1395
更新日期:1991-08-01 00:00:00
abstract::Little is known about the longitudinal course of hepatitis B virus (HBV) load and its relationship with the development of hepatocellular carcinoma (HCC). We conducted a case-cohort study nested within a cohort of 2874 HBV surface antigen-positive male Taiwanese government employees aged 30 years or older. HBV genotyp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm252
更新日期:2008-01-01 00:00:00
abstract::For a group of nine hydrocarbon and halogenated hydrocarbon epoxides, there is shown to be a good correlation between their abilities to inhibit epoxide hydrase and the quantity Vmin /Es, where Vmin is the most negative value of the molecule's electrostatic potential in the neighborhood of the epoxide oxygen and Es is...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.6.845
更新日期:1984-06-01 00:00:00
abstract::DNA strand breage in response to damage produced by UV (254 nm) radiation was characterized after permeabilization of diploid normal and xeroderma pigmentosum variant fibroblasts. The breakage reaction required ATP, Mg2+ and sucrose for maximal activity and was inhibited by 150 mM Na+ or K+ and 1 mM N-ethylmaleimide. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.1.15
更新日期:1990-01-01 00:00:00
abstract::Inhalation of diesel exhaust (DE), which contains soot particles with adsorbed mutagenic organic compounds, and its virtually mutagen-free soot particle analog, carbon black (CB), produce similar types and prevalences of pulmonary neoplasms in chronically exposed F344 rats. This result suggests that DE-induced neoplas...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.5.1215
更新日期:1995-05-01 00:00:00
abstract::Extracts of human urine were shown to contain substances that strongly inhibited the liver S9-mediated mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Salmonella typhimurium TA98 strain in a liquid incubation assay. The inhibitory effect was unrelated to cytotoxicity and was similar with urin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.12.2317
更新日期:1992-12-01 00:00:00
abstract::Complementary DNA of marmoset CYP1A2 was isolated by means of screening the cDNA library and reverse-transcriptase polymerase chain reaction. The deduced amino acid sequence of marmoset CYP1A2 consisted of 516 residues and showed 88.2 and 90.0% identities to corresponding forms in human and cynomolgus monkey, respecti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.10.1985
更新日期:1997-10-01 00:00:00
abstract::There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh174
更新日期:2004-09-01 00:00:00
abstract::Nitric oxide donating aspirin (NO-ASA), consisting of a traditional ASA to which a NO-releasing moiety is covalently attached, is a promising chemopreventive agent against colon cancer. Its mechanism of action is not fully delineated. Here we examined its effect on the expression of the nuclear receptor PPARdelta, who...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi221
更新日期:2006-02-01 00:00:00
abstract::O6-Methylguanine-DNA methyltransferase (O6-MT) has been described as a DNA repair enzyme that reverses alkylation damage at the O6 position of guanine in DNA. We demonstrate that the concentration of this protein decreases immediately prior to DNA synthesis in cultured chick hepatocytes. If intracellular levels are ex...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.1.33
更新日期:1992-01-01 00:00:00
abstract::Human fibroblasts were embedded in microscopic-sized agarose beads and lysed in situ to produce chromosome-sized DNA trapped inside the beads. Conventional alkaline agarose gel electrophoresis of trapped DNA from cells damaged by X-rays before embedding gave mol. wts similar to those obtained with alkaline sucrose gra...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.9.1691
更新日期:1989-09-01 00:00:00
abstract::Reactive oxygen species (ROS) have been implicated in skin tumor promotion. Earlier, we showed that porphyrin-mediated cutaneous photosensitization results in the in situ generation of ROS. Recently, we have provided the first in situ evidence for the involvement of ROS in stage I tumor promotion. In this study we fur...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.9.2023
更新日期:1996-09-01 00:00:00
abstract::It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi089
更新日期:2005-08-01 00:00:00
abstract::The measurement of oxidative damage to cellular DNA is a challenging analytical problem requiring highly sensitive and specific methods. In addition, artefactual DNA oxidation during its extraction and subsequent work-up may give rise to overestimated levels of oxidized DNA bases. In the present study, we have used (1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/23.11.1911
更新日期:2002-11-01 00:00:00
abstract::Although the human O6-alkylguanine-DNA alkyltransferase (AGT) is very sensitive to inactivation by O6-benzylguanine (BG) or 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (5-nitroso-BP), the equivalent protein formed by the carboxyl terminal domain of the product of the Escherichia coli ada gene (Ada-C) is unaffected by ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.8.1687
更新日期:1995-08-01 00:00:00
abstract::Groups of male and female IF strain mice were fed a diet containing either 0.5% or 1.0% paracetamol for up to 18 months. Among male mice fed the higher dose, the total liver cell tumour incidence was 87%, 21.7% developing hepatocellular carcinomas: both yields were statistically significant. The corresponding incidenc...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.4.363-a
更新日期:1983-01-01 00:00:00
abstract::MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs020
更新日期:2012-04-01 00:00:00
abstract::The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.3.383
更新日期:1998-03-01 00:00:00
abstract::The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.8.1437
更新日期:1998-08-01 00:00:00
abstract::Gestational trophoblastic diseases (GTD) are group of pregnancy-related tumors characterized by abnormal levels of 'β-hCG' with higher incidence in South-East Asia, especially India. Our laboratory has reported that wild-type BRCA1 transcriptionally regulates β-hCG in triple negative breast cancers (TNBCs). These fact...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz117
更新日期:2020-07-10 00:00:00
abstract::Female inbred C3H/St mice infected with the Bittner Milk Particle, develop mammary adenocarcinoma with 27% incidence if maintained on a Torula Yeast diet supplemented with 1 ppm of selenium (organically bound, in yeast). Animals switched from the 1 ppm Se diet to a diet containing only 0.15 ppm Se after reaching the a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.2.199
更新日期:1980-02-01 00:00:00
abstract::Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.8.1895
更新日期:1995-08-01 00:00:00