Abstract:
:The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics of the tumour promoter [3H]phorbol-12,13-dibutyrate to particulate skin preparations. The mouse strains tested were Swiss albino, Balb/c, C3H, LACA and AKR/J. Although some differences were apparent, Swiss albino, LACA and C3H mice were generally sensitive to skin carcinogenesis by both benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene, either with or without promotion with croton oil. AKR/J mice were sensitive to both carcinogens with promotion but relatively insensitive in the absence of promotion. Balb/c mice had low sensitivity except when exposed to repeated low doses of benzo[a]pyrene. The [3H]phorbol-12,13-dibutyrate binding characteristics of particulate skin preparations from all strains were indistinguishable.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Wheldrake JF,Marshall J,Ramli J,Murray AWdoi
10.1093/carcin/3.7.805subject
Has Abstractpub_date
1982-01-01 00:00:00pages
805-7issue
7eissn
0143-3334issn
1460-2180journal_volume
3pub_type
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