Selective changes of retroelement expression in human prostate cancer.

abstract：:The possible roles of cytochrome P450 (P450) enzymes in the metabolic activation of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) by rat liver microsomes have been examined in a system containing the bacterial tester strain Salmonella typhimurium NM2009, a newly developed strain showing high O-acetylt...

journal_title：Carcinogenesis

authors： Yamazaki H,Oda Y,Funae Y,Imaoka S,Inui Y,Guengerich FP,Shimada T

更新日期：1992-06-01 00:00:00

abstract：:The HBL100 cell line, established in vitro from milk of an apparently healthy woman, expresses SV40 large T antigen defective in some of its functions. Here we demonstrate that the HBL100 genomic DNA possesses transforming activity in NIH3T3 cells and that this activity is associated with the viral information. ...

journal_title：Carcinogenesis

authors： Vanhamme L,Szpirer C

更新日期：1988-04-01 00:00:00

abstract：:Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling u...

journal_title：Carcinogenesis

authors： Rogers KR,Kikawa KD,Mouradian M,Hernandez K,McKinnon KM,Ahwah SM,Pardini RS

更新日期：2010-09-01 00:00:00

abstract：:Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...

journal_title：Carcinogenesis

authors： Hacker HJ,Steinberg P,Bannasch P

更新日期：1998-01-01 00:00:00

abstract：:In order to explore a possibility that the custom of drinking green tea infusion is efficacious for reducing the carcinogenic risk of environmental exposure to pentachlorophenol (PCP), we examined the effects in a hepato- and cholangiocarcinogenesis model in mice exposed to diethylnitrosamine (DEN). In the first exper...

journal_title：Carcinogenesis

authors： Umemura T,Kai S,Hasegawa R,Kanki K,Kitamura Y,Nishikawa A,Hirose M

更新日期：2003-06-01 00:00:00

abstract：:Occupational exposure to styrene was studied in nine workers of a hand lamination plant in Bohemia. Personal dosimeters were used to monitor the styrene workplace exposure, and the levels of styrene in blood and mandelic acid in urine were measured. Blood samples were taken at four occasions during a 7 month period to...

journal_title：Carcinogenesis

authors： Vodicka P,Bastlová T,Vodicková L,Peterková K,Lambert B,Hemminki K

更新日期：1995-07-01 00:00:00

abstract：:Weanling male F344 rats were fed either a semi-purified diet low in methionine and lacking in choline and folic acid (folate/methyl deficient) or a supplemented control diet for periods of 2, 5, 7 days, 3 weeks, and 9 weeks. Two days after initiating the folate/methyl deficient diet in weanling F344 rats, the incidenc...

journal_title：Carcinogenesis

authors： James SJ,Miller BJ,Basnakian AG,Pogribny IP,Pogribna M,Muskhelishvili L

更新日期：1997-02-01 00:00:00

abstract：:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobi...

journal_title：Carcinogenesis

authors： Osterman-Golkar S,Bergmark E

更新日期：1988-11-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), the most abundant heterocyclic amine produced during the cooking of meats and fish, is suspected to be a human carcinogen. Metabolic activation of PhIP is primarily mediated by the enzyme cytochrome P450 (CYP) 1A2. Metabolism of PhIP by CYP1A2 differs considerabl...

journal_title：Carcinogenesis

authors： Cheung C,Loy S,Li GX,Liu AB,Yang CS

更新日期：2011-02-01 00:00:00

abstract：:Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistan...

journal_title：Carcinogenesis

authors： Rossman TG,Wang Z

更新日期：1999-02-01 00:00:00

abstract：:Epidemiological evidence has been supporting a relationship between dietary aflatoxin B1 (AFB1) exposure, development of human primary hepatocellular carcinoma (HCC) and mutations in the p53 tumor suppressor gene. However, the correlation between the observed p53 mutations, the AFB1 DNA adducts and their activation pa...

journal_title：Carcinogenesis

authors： Macé K,Aguilar F,Wang JS,Vautravers P,Gómez-Lechón M,Gonzalez FJ,Groopman J,Harris CC,Pfeifer AM

更新日期：1997-07-01 00:00:00

abstract：:There is increasing concern that compounds formed during the chemical or biological transformation of pollutants in the environment may be more detrimental to human and environmental health than the original pollutant. In this study, two bacterial transformation products of polycyclic aromatic hydrocarbons (PAHs), pyr...

journal_title：Carcinogenesis

authors： Zielinska-Park J,Nakamura J,Swenberg JA,Aitken MD

更新日期：2004-09-01 00:00:00

abstract：:The reaction of deoxyadenosine with beta-propiolactone produces two derivatives. One is 1-(2-carboxyethyl)-2'-deoxyadenosine (CEdA) first described by Maté, et al. The proposed structure for the other is 3-(beta-D-2-deoxyribosyl)-7,8-dihydropyrimido-[2,l-i]purine-9-one (dDPP). Spectral characteristics of both compound...

journal_title：Carcinogenesis

authors： Chen R,Mieyal JJ,Goldthwait DA

更新日期：1981-01-01 00:00:00

abstract：:Specific methylated derivatives of anthracene are mutagenic in S. typhimurium and have tumor-initiating activity on mouse skin. In this study, the mutagenic activities of 1-, 2-, and 9-methylanthracene, 2,9- and 9,10-dimethylanthracene, 2,9,-10-trimethylanthracene, 2,3,9,10-tetramethylanthracene, and the photo-oxide o...

journal_title：Carcinogenesis

authors： La Voie EJ,Coleman DT,Rice JE,Geddie NG,Hoffmann D

更新日期：1985-10-01 00:00:00

abstract：:Radioactive methylnitrosourea, epichlorohydrin, styrene oxide, and N-acetoxy-2-acetylaminofluorene were reacted with 14 different polyamino acids in vitro, to determine the relative reactivity of the functional groups in amino acids. All the carcinogens reacted preferentially with polycysteine and much less with polyh...

journal_title：Carcinogenesis

authors： Hemminki K

更新日期：1983-01-01 00:00:00

abstract：:The activity of nuclear transcription factors is often regulated by specific kinase-signaling pathways. We have previously shown that the organochlorine pesticide dichlorodiphenyltrichloroethane (DDT) stimulates activator protein-1 activity through the p38 mitogen-activated protein kinase (MAPK). Here, we show that DD...

journal_title：Carcinogenesis

authors： Bratton MR,Frigo DE,Vigh-Conrad KA,Fan D,Wadsworth S,McLachlan JA,Burow ME

更新日期：2009-01-01 00:00:00

abstract：:Feeding male Wistar rats a choline-deficient diet containing 0.07% DL-ethionine (CDE diet) for up to 5 weeks results in the production of two distinct non-parenchymal cell populations, oval and duct-like cells. These cells can undergo replication and display different patterns of expression of glutathione S-transferas...

journal_title：Carcinogenesis

authors： Tee LB,Kirilak Y,Huang WH,Morgan RH,Yeoh GC

更新日期：1994-12-01 00:00:00

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:There is indirect evidence to suggest that the excision-repair mechanism responsible for the removal of UV-induced thymine dimers may also play a role in the repair of cis-diamminedichloroplatinum(II) (cis-DDP)-induced DNA adducts in both bacteria and mammalian cells. It was hypothesized that UV dimers and cis-DDP add...

journal_title：Carcinogenesis

authors： Swinnen LJ,Fisher SG,Erickson LC

更新日期：1989-08-01 00:00:00

abstract：:Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesi...

journal_title：Carcinogenesis

authors： Fusser M,Nesse GJ,Khobta A,Xia N,Li H,Klungland A,Epe B

更新日期：2011-01-01 00:00:00

abstract：:17beta-estradiol (E2), estrone and diethylstilbestrol (DES) had no effect on nuclear and nucleolar RNA synthesis in vitro. However, after reacting with dimethyldioxirane (DMDO), a versatile epoxide-forming oxidant, these estrogens were able to inhibit and in a dose-dependent manner nuclear and nucleolar RNA synthesis ...

journal_title：Carcinogenesis

authors： Yu FL,Bender W

更新日期：1996-09-01 00:00:00

abstract：:Despite recent additions to the armory of chemotherapeutic agents for colorectal cancer (CRC) treatment, the results of chemotherapy remain unsatisfactory. 5-Fluorouracil (5-FU) still represents the cornerstone of treatment and resistance to its actions is a major obstacle to successful chemotherapy. Therefore, new ac...

journal_title：Carcinogenesis

authors： Kodach LL,Bos CL,Durán N,Peppelenbosch MP,Ferreira CV,Hardwick JC

更新日期：2006-03-01 00:00:00

abstract：:In the era of precision oncology, bladder cancer (BlCa) is characterized by generic patient management and lack of personalized prognosis and surveillance. Herein, we have studied the clinical significance of urothelial cancer associated 1 (UCA1) lncRNA in improving patients' risk stratification and prognosis. A scree...

journal_title：Carcinogenesis

authors： Avgeris M,Tsilimantou A,Levis PK,Rampias T,Papadimitriou MA,Panoutsopoulou K,Stravodimos K,Scorilas A

更新日期：2019-08-22 00:00:00

abstract：:Spontaneous and hepatocarcinogen (2-nitropropane, 2-NP)-induced levels of 8-hydroxy-2'-deoxyguanosine (oh8dG) in the nuclear DNA of regenerating liver [24, 48, 72 h and 7 days after partial hepatectomy (PH)] of male Sprague-Dawley rats were analysed for the verification of a hypothesis that the high susceptibility of ...

journal_title：Carcinogenesis

authors： Adachi S,Kawamura K,Takemoto K

更新日期：1994-03-01 00:00:00

abstract：:The catalytic activity of the nuclear enzyme poly(ADP-ribose) polymerase (NAD+ ADP-ribosyl transferase, EC 2,4,2,30) is totally dependent upon the presence of DNA strand breaks. Having isolated a full-length cDNA for the polymerase, we have now evaluated the effect of endogenously and exogenously induced DNA strand br...

journal_title：Carcinogenesis

authors： Bhatia K,Pommier Y,Giri C,Fornace AJ,Imaizumi M,Breitman TR,Cherney BW,Smulson ME

更新日期：1990-01-01 00:00:00

abstract：:Experiments were conducted to determine whether the natural estrogen and an environmental compound with estrogenic action, 4-n-octylphenol (4nOP), could modify tumor development in human c-Ha-ras proto-oncogene transgenic (Tg) rats which are highly susceptible to mammary and skin carcinogens. Female and male Tg and no...

journal_title：Carcinogenesis

authors： Han BS,Fukamachi K,Takasuka N,Ohnishi T,Maeda M,Yamasaki T,Tsuda H

更新日期：2002-07-01 00:00:00

abstract：:The faecal concentration of substances responding to the chemical test for N-nitroso compounds (apparent total N-nitroso compounds, ATNC) was investigated in human subjects consuming their normal free-choice diet. Concentrations ranged from 40 to 590 micrograms (N-NO)/kg faeces. To ascertain the likely relative contri...

journal_title：Carcinogenesis

authors： Rowland IR,Granli T,Bøckman OC,Key PE,Massey RC

更新日期：1991-08-01 00:00:00

abstract：:Dose response studies regarding the cancer initiating potential of fumonisin B1 (FB1) were conducted as a function of time. Feeding studies over 21 days indicated that FB1 induced a feed refusal effect in rats at dietary levels of 250, 500 and 750 mg FB1/kg diet. This effect was overcome after 14 days and the feed int...

journal_title：Carcinogenesis

authors： Gelderblom WC,Cawood ME,Snyman SD,Marasas WF

更新日期：1994-02-01 00:00:00

abstract：:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...

journal_title：Carcinogenesis

authors： Cosma GN,Marchok AC

更新日期：1987-12-01 00:00:00