Spontaneous mutagenesis in Csb(m/m)Ogg1⁻(/)⁻ mice is attenuated by dietary resveratrol.

abstract：:The oncoprotein ErbB3 is overexpressed in several human cancers, for example in pancreatic adenocarcinoma and in ovarian cancers, and ErbB3-containing heterodimers have been demonstrated to be potent signaling units in carcinogenesis. This especially applies to ErbB2-ErbB3 and epidermal growth factor receptor (EGFR)-E...

journal_title：Carcinogenesis

authors： Sak MM,Breen K,Rønning SB,Pedersen NM,Bertelsen V,Stang E,Madshus IH

更新日期：2012-05-01 00:00:00

abstract：:An enhancement of the cellular cAMP level has been shown to protect against phorbol ester-induced inhibition of gap junctional intercellular communication (GJIC) and induction of morphological transformation in Syrian hamster embryo (SHE) cells. Cholera toxin, forskolin, 3-isobutyl-1-methylxanthine (IBMX) and theophyl...

journal_title：Carcinogenesis

authors： Roseng LE,Rivedal E,Sanner T

更新日期：1992-10-01 00:00:00

abstract：:The p53 gene was examined for point mutations in archived, alpha-radiation-associated lung and liver cancers. Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of min...

journal_title：Carcinogenesis

authors： Hollstein M,Bartsch H,Wesch H,Kure EH,Mustonen R,Mühlbauer KR,Spiethoff A,Wegener K,Wiethege T,Müller KM

更新日期：1997-03-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:We have previously reported the disposition of benzo[a]pyrene (B[a]P) and its metabolites in male Sprague-Dawley rats following intratracheal instillation of [3H]B[a]P [Weyand, E.H. and Bevan, D.R. (1986) Cancer Res., 46, 5655-5661]. In some experiments, cannulas were implanted in the bile duct of the animals prior to...

journal_title：Carcinogenesis

authors： Bevan DR,Weyand EH

更新日期：1988-11-01 00:00:00

abstract：:Colorectal cancer (CRC) displays a predilection for metastasis to liver. Although stromal cell-derived factor-1 (SDF-1)/CXCR4 plays an important role in the liver metastasis, the molecular mechanism still remains obscure. We previously reported that integrin αvβ6 was implicated in the progression of CRC. However, no d...

journal_title：Carcinogenesis

authors： Wang B,Wang W,Niu W,Liu E,Liu X,Wang J,Peng C,Liu S,Xu L,Wang L,Niu J

更新日期：2014-02-01 00:00:00

abstract：:To determine the contribution of susceptibility loci in explaining the genetic basis of acute lymphoblastic leukemia (ALL), we genotyped 29 high-potential candidate genes with 672 tagged single-nucleotide polymorphisms (SNPs) in a sample (163 cases and 251 healthy controls) of Caucasian children. Fifty SNPs in 15 gene...

journal_title：Carcinogenesis

authors： Beuten J,Gelfond JA,Piwkham D,Pollock BH,Winick NJ,Collier AB 3rd,Tomlinson GE

更新日期：2011-09-01 00:00:00

abstract：:Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models. The molecular basis of its action is far less characterized. We investigated the effects of RSVL on activity of adenylate- and guanylate-cyclase (AC, GC) enzymes; two known cytostatic cascades in MCF-7 breast cancer cells. RS...

journal_title：Carcinogenesis

authors： El-Mowafy AM,Alkhalaf M

更新日期：2003-05-01 00:00:00

abstract：:In the present study the modulating effects of dietary fish oil (MaxEPA) on unsaturated fat-promoted pancreatic carcinogenesis in azaserine-treated rats were investigated. Three groups of 20 rats (each group comprised five saline-treated and 15 azaserine-treated animals) were fed an AIN76-based purified diet containin...

journal_title：Carcinogenesis

authors： Appel MJ,Woutersen RA

更新日期：1994-10-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Given our recent observation of the dehydro-epiandrosterone-mediated inhibition of protein isoprenylation and the fact that 99% of the circulating dehydro-epiandrosterone is sulfated, with less than 1...

journal_title：Carcinogenesis

authors： Schulz S,Nyce JW

更新日期：1994-11-01 00:00:00

abstract：:The metabolism of zymosterol and mevalonic acid was studied in vitro using the skin homogenates of 3-methylcholanthrene (3MC), diazacholesterol-treated and untreated mice. In normal mouse skin only lathosterol was a major metabolite and the other metabolites, cholesta-5,7,24-trien-3 beta-ol, desmosterol, cholesterol a...

journal_title：Carcinogenesis

authors： Tanimoto Y,Fukao K,Yoshiga K,Takada K,Ohyama Y,Okuda K

更新日期：1990-09-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00

abstract：:Gangliosides from liver parenchymal and non-parenchymal cells were isolated from Fischer 344 rats that had been fed normal diet or a diet supplemented with 0.03% N-2-acetylaminofluorene (AAF) for 4 weeks. Gangliosides from liver cell fractions were characterized by an induction of both II3NeuAcIV3 alpha GalIV2FucGg4 a...

journal_title：Carcinogenesis

authors： Holmes EH

更新日期：1990-01-01 00:00:00

abstract：:A mouse monoclonal antibody (Mab) was prepared which showed high specificity for a potential marker of exposure to methylating carcinogens such as 3-methyladenine (3-MeAde). In a low-temperature (4 degrees C) ELISA a linear calibration curve was obtained between 3 and 50 fmol/well. In combination with an immunoaffinit...

journal_title：Carcinogenesis

authors： Prevost V,Shuker DE,Bartsch H,Pastorelli R,Stillwell WG,Trudel LJ,Tannenbaum SR

更新日期：1990-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is the third most common cancer worldwide. Chronic inflammation appears to enhance the risk of CRC. Emerging evidence has suggested that epigenetic mechanisms play an important role in CRC. Aspirin [acetylsalicylic acid (ASA)] has been shown to prevent CRC; however, the epigenetic mechanisms of...

journal_title：Carcinogenesis

authors： Guo Y,Liu Y,Zhang C,Su ZY,Li W,Huang MT,Kong AN

更新日期：2016-06-01 00:00:00

abstract：:The natural flavonoid quercetin has been suggested by epidemiological studies to have preventive activity against lung cancer; however, the mechanism of which has not been well elucidated. In this report, we demonstrate that quercetin significantly enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAI...

journal_title：Carcinogenesis

authors： Chen W,Wang X,Zhuang J,Zhang L,Lin Y

更新日期：2007-10-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF) was administered i.p. to male Wistar rats 17 h after partial hepatectomy. Hepatocytes were analyzed for the presence of micronuclei 7 h, 1, 2, 3 and 4 days after injection. N-OH-AAF treatment resulted in a high frequency of micronucleated hepatocytes at days 3 and 4 (19.5% an...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Mulder GJ,Meerman JH

更新日期：1989-04-01 00:00:00

abstract：:Carcinomas of the ethmoidal region of the nose are observed relatively frequently in cattle in several countries in tropical and subtropical latitudes. Viruses have been implicated as causative agents, but it has been observed that affected animals sometimes suffer from aflatoxicosis, and a role of aflatoxin B1 (AFB1)...

journal_title：Carcinogenesis

authors： Larsson P,Pettersson H,Tjälve H

更新日期：1989-06-01 00:00:00

abstract：:3-Methylcholanthrene (3-MC) pretreatment induces the liver microsomal 2-acetylaminofluorene (2-AAF) N-hydroxylase activity of C57BL6 responsive mice. The same pretreatment modifies this enzyme by significantly increasing its apparent Km value which, moreover, becomes protein concentration dependent. After 3-MC inducti...

journal_title：Carcinogenesis

authors： Razzouk C,Batardy-Grégoire M,Roberfroid M

更新日期：1982-01-01 00:00:00

abstract：:Fifty-five types of commercial cigarettes on the West German market were analyzed for tobacco-specific nitrosamines (TSNA) in mainstream smoke. The cigarettes included filter and nonfilter cigarettes with very high, high, medium, low and ultra-low tar and nicotine yields. The observed range for N'-nitrosonornicotine w...

journal_title：Carcinogenesis

authors： Fischer S,Spiegelhalder B,Preussmann R

更新日期：1989-01-01 00:00:00

abstract：:To compare mutagenesis by O6-methylguanine (m6G), O4-methylthymine (m4T) and O6-ethylguanine (e6G), and assess their genotoxicity in Escherichia coli, double-stranded and gapped plasmids were constructed containing a single m6G, e6G or m4T in the initiation codon (ATG) of a lacZ' gene. Modified base induced mutations ...

journal_title：Carcinogenesis

authors： Pauly GT,Hughes SH,Moschel RC

更新日期：1998-03-01 00:00:00

abstract：:A method was devised to quantitate N-acetoxy-N-acetyl-2-aminofluorene (N-AcO-AAF) induced crosslinking of the ionic complex between [methyl-3H]thymidine labeled pBR322 DNA and lysozyme. This involved chromatography of the modified complex on Sephadex CM 25 with a high salt buffer that dissociated the non-covalently bo...

journal_title：Carcinogenesis

authors： Rayshell M,Ross J,Werbin H

更新日期：1983-01-01 00:00:00

abstract：:O6-Alkylguanine-DNA alkyltransferase (AGAT) activity was determined in macroscopically normal peripheral lung tissues from 122 patients undergoing lung surgery. AGAT activity of smokers was 1.4-fold higher than that of lifetime non-smokers (P = 0.030). Less than one year of abstinence from smoking did not cause a sign...

journal_title：Carcinogenesis

authors： Drin I,Schoket B,Kostic S,Vincze I

更新日期：1994-08-01 00:00:00

abstract：:We have investigated the role of the signaling intermediate, EPS8, in tumor progression using a model system and in vivo. HN4 primary tumor cells express low levels of EPS8, similar to normal keratinocytes, and show minimal invasion in vitro in response to epidermal growth factor, whereas HN12 cells express high level...

journal_title：Carcinogenesis

authors： Wang H,Patel V,Miyazaki H,Gutkind JS,Yeudall WA

更新日期：2009-01-01 00:00:00

abstract：:Modification of 3,2'-dimethyl-4-aminobiphenyl (DMAB) multi-organ carcinogenesis by simultaneous treatment with butylated hydroxyanisole (BHA) or butylated hydroxytoluene (BHT) was studied using young and old male F344 rats. Animals, 4 or 54 weeks old, were given DMAB (s.c. injection of 50 mg/kg body wt once a week for...

journal_title：Carcinogenesis

authors： Shirai T,Fukushima S,Kawabe M,Shibata M,Iwasaki S,Tada M,Ito N

更新日期：1991-07-01 00:00:00

abstract：:Yes-associated protein (YAP), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene located at chromosome 11q22. Since we previously reported amplification of 11q22 region in esophageal squamous cell carcinoma (ESCC), in this study we focused on the clinical signifi...

journal_title：Carcinogenesis

authors： Muramatsu T,Imoto I,Matsui T,Kozaki K,Haruki S,Sudol M,Shimada Y,Tsuda H,Kawano T,Inazawa J

更新日期：2011-03-01 00:00:00

abstract：:Despite decreases in the cancer death rates in high-resource countries, such as the USA, the number of cancer cases and deaths is projected to more than double worldwide over the next 20-40 years. Cancer is now the third leading cause of death, with >12 million new cases and 7.6 million cancer deaths estimated to have...

journal_title：Carcinogenesis

authors： Thun MJ,DeLancey JO,Center MM,Jemal A,Ward EM

更新日期：2010-01-01 00:00:00

abstract：:Cells from patients with genomic instability syndromes have high predisposition to cancer. However, little is known about whether these mutant cells have high susceptibility to oncogenic transformation. We have tested the hypothesis that a defect in maintaining genome integrity is necessary but not sufficient alone fo...

journal_title：Carcinogenesis

authors： Li J,Sejas DP,Burma S,Chen DJ,Pang Q

更新日期：2007-06-01 00:00:00

abstract：:The dose and time dependence of the cellular phenotype in preneoplastic and neoplastic liver lesions was evaluated quantitatively in groups of male Sprague-Dawley rats exposed for 7 weeks to 0, 12 and 24 mg/kg body wt of N-nitrosomorpholine (NNM) and studied at different time points up to 80 weeks after withdrawal of ...

journal_title：Carcinogenesis

authors： Weber E,Bannasch P

更新日期：1994-06-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...

journal_title：Carcinogenesis

authors： Baraniskin A,Birkenkamp-Demtroder K,Maghnouj A,Zöllner H,Munding J,Klein-Scory S,Reinacher-Schick A,Schwarte-Waldhoff I,Schmiegel W,Hahn SA

更新日期：2012-04-01 00:00:00