Abstract:
:Covalent binding to haemoglobin, plasma proteins and DNA was determined after intraperitoneal administration of radiolabelled diethylnitrosamine to mice. The level of alkylation of DNA in liver--the main site of activation--was found to be about two orders of magnitude higher than the level of alkylation of haemoglobin, if compared per unit weight of macromolecule. A high reactivity towards nucleophilic oxygen atoms was characteristic of the reaction pattern. Carboxylic acid ethyl esters, ethylserine and ethylthreonine are important reaction products in the proteins.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Osterman-Golkar S,Bergmark Edoi
10.1093/carcin/9.11.1915subject
Has Abstractpub_date
1988-11-01 00:00:00pages
1915-7issue
11eissn
0143-3334issn
1460-2180journal_volume
9pub_type
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