Metabolism of benzo[f]quinoline by rat liver microsomes.

abstract：:Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats are resistant to hepatocar...

journal_title：Carcinogenesis

authors： Wood GA,Korkola JE,Lee VM,Sarma DS,Archer MC

更新日期：1997-09-01 00:00:00

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:The phylogenetically distant F344 and BN rat strains and their (BN x F344) F1 hybrids were compared for susceptibility to hepatocarcinogenesis using the 'resistant hepatocyte' model. Quantitative stereological analysis of frequency (number/liver) and size (mean volume and volume fraction) of placental form glutathione...

journal_title：Carcinogenesis

authors： Pascale RM,Simile MM,DeMiglio MR,Muroni MR,Gaspa L,Dragani TA,Feo F

更新日期：1996-08-01 00:00:00

abstract：:Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models. The molecular basis of its action is far less characterized. We investigated the effects of RSVL on activity of adenylate- and guanylate-cyclase (AC, GC) enzymes; two known cytostatic cascades in MCF-7 breast cancer cells. RS...

journal_title：Carcinogenesis

authors： El-Mowafy AM,Alkhalaf M

更新日期：2003-05-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. The expression of CYP1A1 protein appears not to be constit...

journal_title：Carcinogenesis

authors： Drahushuk AT,McGarrigle BP,Larsen KE,Stegeman JJ,Olson JR

更新日期：1998-08-01 00:00:00

abstract：:Cultured human epidermal cells which require no feeder layer were used to study metabolism of benzo[a]pyrene (BP) and DNA adduct formation. The cultures were prepared from a single cell suspension and maintained at a pH of 5.9--6.2. At 2 microM BP some cell toxicity was observed, and substantial cell death occurred at...

journal_title：Carcinogenesis

authors： Theall G,Eisinger M,Grunberger D

更新日期：1981-01-01 00:00:00

abstract：:Adipocytokines are a group of adipocyte-secreted proteins that have significant effects on the metabolism of lipids and carbohydrates, as well as numerous other processes. A number of recent studies have indicated that some adipocytokines may significantly influence the proliferation of malignant cells in vitro, where...

journal_title：Carcinogenesis

authors： Miyamoto S,Yasui Y,Tanaka T,Ohigashi H,Murakami A

更新日期：2008-05-01 00:00:00

abstract：:Oxidative DNA modifications such as 7,8-dihydro-8-oxoguanine (8-oxoG) are generated endogenously in apparently all living cells. The defect of the repair of 8-oxoG in Csb(m/m)Ogg1⁻(/)⁻ mice results in elevated basal levels of these lesions and increased frequencies of spontaneous mutations, which initiate tumorigenesi...

journal_title：Carcinogenesis

authors： Fusser M,Nesse GJ,Khobta A,Xia N,Li H,Klungland A,Epe B

更新日期：2011-01-01 00:00:00

abstract：:The levels of S-adenosylmethionine (AdoMet) and of S-adenosylhomocysteine (AdoHcy) as well as the ratio of AdoMet/AdoHcy were determined in the liver, lungs, testes and kidneys of weanling male rats fed a commercial chow diet or 5 different amino acid-defined diets for 1-5 weeks. The amino acid-defined diets used were...

journal_title：Carcinogenesis

authors： Shivapurkar N,Poirier LA

更新日期：1983-08-01 00:00:00

abstract：:Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effect of underfeeding. In the present experiment the effect of food rest...

journal_title：Carcinogenesis

authors： Pashko LL,Schwartz AG

更新日期：1996-02-01 00:00:00

abstract：:Treatment of SV40-infected CV-1 cells with the ultimate carcinogen anti-benzo[a]pyrene diol epoxide (BPDE) at 1 X 10(-4) mg/ml or higher reduced the rate of viral DNA synthesis to an extent dependent on the BPDE concentration; similar reductions in cellular DNA synthesis were produced in infected and uninfected cells....

journal_title：Carcinogenesis

authors： Lockhart ML,Rosenberg BH

更新日期：1983-01-01 00:00:00

abstract：:The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts deriv...

journal_title：Carcinogenesis

authors： Smith PJ,Greene MH,Adams D,Paterson MC

更新日期：1983-01-01 00:00:00

abstract：:It is estimated that one-third of Americans use dietary herbal supplements on a regular basis. Diets rich in bioactive phytochemicals are associated with reduced risk of certain cancers, notably, colon cancer. Herbal supplements have not been directly tested as sources of bioactive cancer preventives. Hence, this stud...

journal_title：Carcinogenesis

authors： Volate SR,Davenport DM,Muga SJ,Wargovich MJ

更新日期：2005-08-01 00:00:00

abstract：:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...

journal_title：Carcinogenesis

authors： Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

更新日期：1988-03-01 00:00:00

abstract：:We compared the frequencies of mutation and morphological transformation in relation to the repair of potentially lethal damage (PLD) and sublethal damage (SLD) in X-irradiated golden hamster embryo (GHE) cells. The repair of PLD induced in GHE cells by X-rays was shown to be an error-free process which reduced the fr...

journal_title：Carcinogenesis

authors： Watanabe M,Suzuki N,Sawada S,Nikaido O

更新日期：1984-10-01 00:00:00

abstract：:The role of bacteria in catalysing intragastric formation of N-nitrosothiazolidine-4-carboxylic acid and N-nitrosomorpholine was investigated in a rat model of omeprazole-induced achlorhydria. Omeprazole-treated rats gavaged with nitrosation-proficient bacteria were treated with nitrosamines and/or precursors and comp...

journal_title：Carcinogenesis

authors： Calmels S,Béréziat JC,Ohshima H,Bartsch H

更新日期：1991-03-01 00:00:00

abstract：:Studies have shown that fisetin, a small phytochemical molecule, has antitumor activity; however, its antiangiogenic activity has not yet been examined. Accordingly, herein, we investigated the antiangiogenic efficacy and associated mechanisms of fisetin in human umbilical vein endothelial cells (HUVECs). Fisetin (10-...

journal_title：Carcinogenesis

authors： Bhat TA,Nambiar D,Pal A,Agarwal R,Singh RP

更新日期：2012-02-01 00:00:00

abstract：:The p53 gene was examined for point mutations in archived, alpha-radiation-associated lung and liver cancers. Lung tumors of 50 uranium miners in Germany were screened by restriction fragment length analysis for the putative hotspot mutation at codon 249 (Arg-->Met) previously detected in a significant fraction of min...

journal_title：Carcinogenesis

authors： Hollstein M,Bartsch H,Wesch H,Kure EH,Mustonen R,Mühlbauer KR,Spiethoff A,Wegener K,Wiethege T,Müller KM

更新日期：1997-03-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00

abstract：:Recent studies have revealed that 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) has anti-tumorigenic activity in vitro. In the present work, we evaluated the in vitro and in vivo antiangiogenic and antitumor activities of PGG and examined its molecular mechanisms. PGG significantly inhibited the proliferation and tub...

journal_title：Carcinogenesis

authors： Huh JE,Lee EO,Kim MS,Kang KS,Kim CH,Cha BC,Surh YJ,Kim SH

更新日期：2005-08-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00

abstract：:Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...

journal_title：Carcinogenesis

authors： Lu GD,Shen HM,Chung MC,Ong CN

更新日期：2007-09-01 00:00:00

abstract：:Monoclonal antibodies were produced that recognized alkali-stabilized modifications of DNA formed by the anticancer drug melphalan in order to permit measurement of melphalan-DNA adducts in individual cells by immunofluorescent staining. Antibody Amp4/42 did not bind to alkali-treated control DNA or to DNA that had be...

journal_title：Carcinogenesis

authors： Tilby MJ,McCartney H,Cordell J,Frank AJ,Dean CJ

更新日期：1995-08-01 00:00:00

abstract：:Previous research suggests that far upstream element-binding protein 1 (FUBP1) plays an important role in various tumors including epatocellular carcinoma (HCC). However, the role of FUBP1 in liver cancer remains controversial, and the regulatory pathway by FUBP1 awaits to be determined. This study aims to identify th...

journal_title：Carcinogenesis

authors： Fu PY,Hu B,Ma XL,Tang WG,Yang ZF,Sun HX,Yu MC,Huang A,Hu JW,Zhou CH,Fan J,Xu Y,Zhou J

更新日期：2020-07-14 00:00:00

abstract：:The carcinogenicity of two commonly used brown and black varieties of masheri, a pyrolysed tobacco product, was studied by feeding the masheri through the diet at a 10% level to three different animal species of both sexes. In Sprague-Dawley rats, only brown masheri was used, while in Swiss mice and Syrian golden hams...

journal_title：Carcinogenesis

authors： Kulkarni JR,Lalitha VS,Bhide SV

更新日期：1988-11-01 00:00:00

abstract：:Mutations in genes important for the preservation of genome stability can increase the frequency of gene amplification, a process relevant to tumor development. To investigate whether telomerase, the enzyme deputed to telomere maintenance, also plays a role in gene amplification, we studied the amplification of the ca...

journal_title：Carcinogenesis

authors： Rebuzzini P,Martinelli P,Blasco M,Giulotto E,Mondello C

更新日期：2007-03-01 00:00:00

abstract：:The metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) was examined in microsomes from uninduced F-344 rats. Even when the conditions were varied, no metabolism of this compound was detected. On the other hand, freshly isolated hepatocytes from F-344 rats metabolized BOP efficiently to CO2. The kinetics of conversion ...

journal_title：Carcinogenesis

authors： Farrelly JG,Saavedra JE,Kupper RJ,Stewart ML

更新日期：1987-08-01 00:00:00

abstract：:The tumor suppressor PTEN antagonizes phosphatidylinositol 3-kinase (PI3K), which contributes to tumorigenesis in many cancer types. While PTEN mutations occur in some melanomas, their precise mechanistic consequences have yet to be elucidated. We sought to identify novel downstream effectors of PI3K using a combinati...

journal_title：Carcinogenesis

authors： Packer L,Pavey S,Parker A,Stark M,Johansson P,Clarke B,Pollock P,Ringner M,Hayward N

更新日期：2006-09-01 00:00:00

abstract：:The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p. administration of 100 mg/kg body wt N-diethyl-nitrosamine, 4 i.p. administrations of 20 mg/kg body wt N-methylnitrosourea, 4 s...

journal_title：Carcinogenesis

authors： Hirose M,Hoshiya T,Akagi K,Takahashi S,Hara Y,Ito N

更新日期：1993-08-01 00:00:00