Abstract:
:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined the effect of single-nucleotide polymorphisms (SNPs) in predicted miRNA target sites of six integrin genes (ITGA3, ITGA6, ITGAv, ITGB3, ITGB4 and ITGB5) on breast cancer (BC) risk and clinical outcome. Six SNPs were genotyped in 749 Swedish incident BC cases with detailed clinical data and up to 15 years of follow-up together with 1493 matched controls. We evaluated associations between genotypes and BC risk and clinical tumour characteristics. Survival probabilities were compared between different subgroups. As a novel finding, several SNPs seemed to associate with the hormone receptor status. The strongest association was observed between the A allele of the SNP rs743554 in the ITGB4 gene and oestrogen receptor-negative tumours [odds ratio 2.09, 95% confidence intervals (CIs) 1.19-3.67]. The same SNP was associated with survival. The A allele carriers had a worse survival compared with the wild-type genotype carriers (hazard ratio 2.11, 95% CIs 1.21-3.68). The poor survival was significantly associated with the aggressive tumour characteristics: high grade, lymph node metastasis and high stage. None of the SNPs was significantly associated with BC risk. As the ITGB4 SNP seems to influence tumour aggressiveness and survival, it may have prognostic value in the clinic.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti Adoi
10.1093/carcin/bgn126subject
Has Abstractpub_date
2008-07-01 00:00:00pages
1394-9issue
7eissn
0143-3334issn
1460-2180pii
bgn126journal_volume
29pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The effects of consumption of glucosinolate-containing Brussels sprouts on plasma and urinary glutathione S-transferase (GST) class-alpha and -pi were investigated. Five male and five female non-smoking volunteers were randomly assigned to two groups in a crossover design. Five persons started on a glucosinolate-free ...
journal_title:Carcinogenesis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/carcin/16.4.955
更新日期:1995-04-01 00:00:00
abstract::Metabolomic analysis of feces may provide insights on colorectal cancer (CRC) if assay performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls, and 48 masked quality control specimens, 1043 small molecules were detected with a commercial platform. Assay reproducibility was good for 52...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu131
更新日期:2014-09-01 00:00:00
abstract::Certain hexavalent chromium [Cr(VI)] compounds are implicated as occupational respiratory carcinogens. Cr(VI) induces a broad spectrum of DNA damage, but Cr(VI)-induced DNA double-strand breaks (DSBs) have not been reported. Previously we found that Cr(VI) activates the ataxia telangiectasia mutated (ATM) kinase. ATM ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh242
更新日期:2004-11-01 00:00:00
abstract::We have studied the influence of genetic polymorphisms in the xenobiotic-metabolizing genes GSTM1, GSTP1, GSTT1, EPHX1, NAT1 and NAT2 and the folate-metabolizing genes MTR and MTHFR on the frequencies of cells with chromosomal aberrations (CAs) in peripheral lymphocytes of Norwegian men. Log-linear Poisson regression ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq246
更新日期:2011-03-01 00:00:00
abstract::N-Acetoxyarylamines are reactive metabolites that lead to arylamine adduct formation with biological macromolecules. A series of 7-substituted-N-hydroxy-2-acetylaminofluorenes were converted to reactive N-acetoxyarylamines by enzymatic N,O-acyltransfer in the presence of DNA. The N-arylhydroxamic acid substrates that ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.8.1651
更新日期:1993-08-01 00:00:00
abstract::The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi175
更新日期:2006-01-01 00:00:00
abstract::Mammalian DNA contains bulky endogenous DNA modifications (I-compounds), which increase with age in unexposed animals, as shown by 32P-postlabeling. We have examined the perinatal formation of a subclass (type II) of I-compounds in rat liver, kidney, skin and lung. These I-compounds represent bulky oxidative DNA lesio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.12.2563
更新日期:1996-12-01 00:00:00
abstract::We previously reported a rapid production model for pancreatic carcinoma development in Syrian hamsters incorporating the principle of selection by resistance to cytotoxicity. In the present experiment, the efficacy of repeated augmentation pressure with regard to generation of pancreatic lesions in hamsters initiated...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.8.1457
更新日期:1989-08-01 00:00:00
abstract::The phylogenetically distant F344 and BN rat strains and their (BN x F344) F1 hybrids were compared for susceptibility to hepatocarcinogenesis using the 'resistant hepatocyte' model. Quantitative stereological analysis of frequency (number/liver) and size (mean volume and volume fraction) of placental form glutathione...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.8.1765
更新日期:1996-08-01 00:00:00
abstract::The repair kinetics and sensitivity to inhibitors of DNA strand breaks caused by superoxide anion, hydrogen peroxide, benzoyl peroxide and anthralin have been studied and compared with strand breaks caused by well-studied agents such as ionizing radiation and bleomycin. The latter two agents are generally believed to ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.9.1511
更新日期:1986-09-01 00:00:00
abstract::Hypoxia-inducible factors (HIFs), in particular HIF-1alpha, have been implicated in tumor biology. However, HIF target genes in the esophageal tumor microenvironment remain elusive. Gene expression profiling was performed upon hypoxia-exposed non-transformed immortalized human esophageal epithelial cells, EPC2-hTERT, ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp326
更新日期:2010-03-01 00:00:00
abstract::Pleomorphic adenoma gene like-2 (PLAGL2), a member of the PLAG gene family, is a C2H2 zinc finger transcriptional factor that is involved in cellular transformation and apoptosis. In this report, we show that PLAGL2 is associated with the organization of stress fibers and with small guanosine triphosphatase (GTPase) a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgu081
更新日期:2014-09-01 00:00:00
abstract::Maternal nutrition during pregnancy influences the development and metabolism of the fetus. Recent studies suggest that the cancer risk of offspring later in life is associated with maternal diet, but little is known about the effect of a maternal diet high in methyl nutrients on breast cancer risk. Lipotropes are met...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs125
更新日期:2012-05-01 00:00:00
abstract::To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.8.1257
更新日期:1986-08-01 00:00:00
abstract::The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl047
更新日期:2006-10-01 00:00:00
abstract::Patients with familial adenomatous polyposis (FAP) have a high risk of developing duodenal adenomas and carcinomas. The distribution of these neoplasms resembles mucosal exposure to bile, suggesting that bile may play a role in adenoma development. Our previous results, using DNA adducts detected by 32P-postlabelling ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.6.1107
更新日期:1993-06-01 00:00:00
abstract::The chemopreventive effects of phenethyl isothiocyanate (PEITC) were investigated in N-nitrosobis(2-oxopropyl)-amine (BOP)-treated hamsters. Female 5-week-old Syrian golden hamsters were divided into six groups. Animals in groups 1-3, each consisting of 30 hamsters, were given BOP by two subcutaneous injections 7 days...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.6.1381
更新日期:1996-06-01 00:00:00
abstract::Despite advances in detection and treatment for breast cancer (BC), recurrence and death rates remain unacceptably high. Therefore, more convenient diagnostic and prognostic methods still required to optimize treatments among the patients. Here, we report the clinical significance of the serum cathepsin E (CatE) activ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt373
更新日期:2014-03-01 00:00:00
abstract::Although the alternative splicing of various genes is a common event in human tumors, the mechanisms behind it have not been characterized. We hypothesized that the expression of splicing regulatory factors would be changed during cellular transformation. Gene expression of three splicing regulatory factors, alternati...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.12.2341
更新日期:1999-12-01 00:00:00
abstract::Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of TIPE1 is observed in cervical cancer cell lines and tissues, indicating it might exert a distinctive role in cervical cancer. Cell and xenograft tumorigenicity assays showed that TIPE...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy163
更新日期:2019-06-10 00:00:00
abstract::Using an 18 week two-stage protocol we have compared the tumour-promoting properties of a range of phorbol and daphnane esters on female CD-1 mice. The induction of epidermal hyperplasia in this mouse strain by these compounds has also been assessed by comparison with the standard phorbol ester, 12-O-tetradecanoylphor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.283
更新日期:1989-02-01 00:00:00
abstract::The relationship between urinary metabolites and DNA damage in the urinary bladder epithelium of male and female rats was tested by alkaline elution assay after an intravesical injection of OPP or its urinary metabolites. 2-Phenyl-1,4-benzoquinone (PBQ) revealed a weak DNA-damaging activity in both sexes at 0.05-0.1%....
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.10.1823
更新日期:1989-10-01 00:00:00
abstract::3-tert-Butyl-4-hydroxyanisole (3-BHA) and its metabolites, tert-butyl-1,4-benzoquinone (BQ) and 3-tert-butyl-5-methoxy-1,2-benzoquinone (BHAoQ), were tested for initiating activity in a two-stage transformation assay using BALB/3T3 cells. Cells were treated first with a test chemical and then with the tumor promoter 1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.11.1985
更新日期:1990-11-01 00:00:00
abstract::Peroxisome proliferator-activated receptor (PPAR) gamma is a ligand-activated nuclear receptor that plays a key role in adipogenesis and adipocyte gene expression, and has recently been linked with possible antineoplastic effects in colonic carcinogenesis. PPARgamma2 and gamma3 are two transcripts arising from the PPA...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl001
更新日期:2006-09-01 00:00:00
abstract::The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.5.949
更新日期:1989-05-01 00:00:00
abstract::Teleocidin, a new tumor promoter, increased incorporation of radioactive inorganic phosphate (32Pi) into phospholipids in HeLa cells. This effect was detected within 1 h on incubation of the cells in medium containing teleocidin. The half-maximum effective dose of teleocidin was approximately 10 ng/ml. The main effect...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.1.107
更新日期:1983-01-01 00:00:00
abstract::The purpose of this study was to determine if decreasing dietary protein from 24% (high protein) to 5% casein (low protein), substituting sucrose and cornstarch isocalorifically for casein, would modify the activity of protein kinase C (PKC) alpha and beta isoenzymes, as well as the expression of PKC alpha, beta, delt...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.5.1233
更新日期:1995-05-01 00:00:00
abstract::Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most r...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq252
更新日期:2011-03-01 00:00:00
abstract::The crosstalk between microRNAs (miRNAs) and other epigenetic factors may lead to novel hypotheses about carcinogenesis identifying new targets for research. Because a single miRNA can regulate multiple downstream target genes, its altered expression may potentially be a sensitive biomarker to detect early malignant t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgv102
更新日期:2015-10-01 00:00:00
abstract::Administration of 2-acetylaminofluorene (2-AAF) to rats increased mdr1b expression in Fischer, Wistar and Sprague-Dawley rat livers; however, the response was much smaller in Sprague-Dawley livers. To investigate the basis of this difference we further examined the regulation of the mdr1b gene in hepatocytes isolated ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.3.451
更新日期:1996-03-01 00:00:00