Increased formation of hepatic N2-ethylidene-2'-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol.

abstract：:Most cancer cells show resistance to ionizing radiation (IR)-induced cell death. Recently, Ki-Ras was reported to be responsible for the increased radioresistance. We report here that inhibition of IR-induced activaton of nuclear transcription factor kappa B (NF-kappaB) but not of either Akt or MAPK kinase (MEK), incr...

journal_title：Carcinogenesis

authors： Kim BY,Kim KA,Kwon O,Kim SO,Kim MS,Kim BS,Oh WK,Kim GD,Jung M,Ahn JS

更新日期：2005-08-01 00:00:00

abstract：:To establish a cell culture model for lung carcinogenesis, independent populations of the human papillomavirus 18-immortalized human bronchial epithelial cell line BEP2D were treated with high linear energy transfer radon-simulated alpha-particles, expanded and xenotransplanted into Nu/Nu mice. Six independent cell li...

journal_title：Carcinogenesis

authors： Weaver DA,Hei TK,Hukku B,McRaven JA,Willey JC

更新日期：1997-06-01 00:00:00

abstract：:The effect of transplantation of Yoshida sarcoma cells into rats on the concentrations of both the acute-phase proteins (APPs) in the serum and their mRNAs in the liver has been investigated. In rats that responded to transplantation by forming solid tumors, the serum APP levels increased with tumor size. Some of the ...

journal_title：Carcinogenesis

authors： Sevaljević L,Savovski K,Sekularac S

更新日期：1991-09-01 00:00:00

abstract：:The LEC rat spontaneously develops liver cancer after suffering chronic liver injury caused by abnormal copper accumulation in the liver, but the role of copper accumulation in the induction of liver cancer remains obscure. We histochemically and biochemically examined the content of copper and metallothionein (MT), a...

journal_title：Carcinogenesis

authors： Sawaki M,Enomoto K,Hattori A,Tsuzuki N,Sugawara N,Mori M

更新日期：1994-09-01 00:00:00

abstract：:BTG3/ANA/APRO4 has been reported to be a tumor suppressor gene in some malignancies. It constitutes important negative regulatory mechanism for Src-mediated signaling, a negative regulator of the cell cycle and inhibits transcription factor E2F1. We report that BTG3 is downregulated in renal cancer and that the mechan...

journal_title：Carcinogenesis

authors： Majid S,Dar AA,Ahmad AE,Hirata H,Kawakami K,Shahryari V,Saini S,Tanaka Y,Dahiya AV,Khatri G,Dahiya R

更新日期：2009-04-01 00:00:00

abstract：:The identification of primary molecular targets of cancer-preventive phytochemicals is essential for a comprehensive understanding of their mechanism of action. In the present study, we investigated the chemopreventive effects and molecular targets of acacetin, a flavonoid found in Robinia p seudoacacia, also known as...

journal_title：Carcinogenesis

authors： Jung SK,Kim JE,Lee SY,Lee MH,Byun S,Kim YA,Lim TG,Reddy K,Huang Z,Bode AM,Lee HJ,Lee KW,Dong Z

更新日期：2014-01-01 00:00:00

abstract：:Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxifica...

journal_title：Carcinogenesis

authors： Ciolino HP,MacDonald CJ,Memon OS,Bass SE,Yeh GC

更新日期：2006-08-01 00:00:00

abstract：:A simple method for detection of DNA single-strand breaks (DNA-SSB) in cultured cells is described, based on filtration of alkaline-lysed cells through microfilters. After exposure to potentially DNA damaging agents, the cells are transferred to 0.8 micron cellulose acetate filters mounted in microfilter devices where...

journal_title：Carcinogenesis

authors： Leanderson P,Wennerberg K,Tagesson C

更新日期：1994-01-01 00:00:00

abstract：:Precursor T-cell lymphoblastic neoplasms are aggressive malignancies in need for more effective and specific therapeutic treatments. A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeep...

journal_title：Carcinogenesis

authors： Gonzalez-Sanchez L,Cobos-Fernandez MA,Lopez-Nieva P,Villa-Morales M,Stamatakis K,Cuezva JM,Marin-Rubio JL,Vazquez-Dominguez I,Gonzalez-Vasconcellos I,Salido E,Llamas P,Lopez-Lorenzo JL,Santos J,Fernandez-Piqueras J

更新日期：2020-08-12 00:00:00

abstract：:The aim of the present study was to investigate the impact of four different lactobacillus (LB) strains, namely Lactobacillus bulgaricus 291, Streptococcus thermophilus F4, S.thermophilus V3 and Bifidobacterium longum BB536, which are used for the production of yogurt, on the DNA-damaging effects of heterocyclic aroma...

journal_title：Carcinogenesis

authors： Zsivkovits M,Fekadu K,Sontag G,Nabinger U,Huber WW,Kundi M,Chakraborty A,Foissy H,Knasmüller S

更新日期：2003-12-01 00:00:00

abstract：:The sensitivity of various mouse strains to skin carcinogenesis has been investigated in two ways; (i) by comparing carcinogenesis induced by treatments involving both the application of tumour promoters and the application of single or multiple doses of a carcinogen, and (ii) by comparing the binding characteristics ...

journal_title：Carcinogenesis

authors： Wheldrake JF,Marshall J,Ramli J,Murray AW

更新日期：1982-01-01 00:00:00

abstract：:Primary hepatocyte cultures from six human donors were established and their abilities to metabolize the polycyclic aromatic hydrocarbon carcinogen benzo[a]pyrene (B[a]P) were examined. Cells from each donor were plated at similar densities (1 X 10(7) cells/100 mm dish). All cultures metabolized B[a]P to a significant...

journal_title：Carcinogenesis

authors： Moore CJ,Gould MN

更新日期：1984-12-01 00:00:00

abstract：:Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...

journal_title：Carcinogenesis

authors： Kumar A,Pandurangan AK,Lu F,Fyrst H,Zhang M,Byun HS,Bittman R,Saba JD

更新日期：2012-09-01 00:00:00

abstract：:Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that GRHL2 also controls normal epithelial cell proliferation and differentiation. In this study, we investigated the role of GRHL2 in oral carcinogenesis and the underly...

journal_title：Carcinogenesis

authors： Chen W,Yi JK,Shimane T,Mehrazarin S,Lin YL,Shin KH,Kim RH,Park NH,Kang MK

更新日期：2016-05-01 00:00:00

abstract：:Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...

journal_title：Carcinogenesis

authors： Hirose M,Inoue T,Masuda A,Tsuda H,Ito N

更新日期：1987-10-01 00:00:00

abstract：:Two solid-phase extraction methods were developed for the determination of mutagenic heterocyclic aromatic amines in heated meat products. The copper phthalocyanine (CPC) tandem extraction was performed on coupled cartridges of diatomaceous earth and CPC-derivatized Sephasorb HP, followed by further clean-up on Sephas...

journal_title：Carcinogenesis

authors： Gross GA

更新日期：1990-09-01 00:00:00

abstract：:Barrett's esophagus (BE) and esophageal adenocarcinoma (ADC) is associated with reflux of duodenal contents. Cyclooxygenase (COX)-2 is over-expressed in BE and ADC, and supposedly contributes to esophageal carcinogenesis. The aim of this study is to investigate what effect a COX-2 inhibitor has on esophageal adenocarc...

journal_title：Carcinogenesis

authors： Oyama K,Fujimura T,Ninomiya I,Miyashita T,Kinami S,Fushida S,Ohta T,Koichi M

更新日期：2005-03-01 00:00:00

abstract：:The heterocyclic aromatic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) are formed during frying of meat. PhIP and 4,8-DiMeIQx have, after metabolic activation, been shown to form adducts with DNA at the C8 of guanine both in vitro and...

journal_title：Carcinogenesis

authors： Frandsen H

更新日期：1997-08-01 00:00:00

abstract：:Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...

journal_title：Carcinogenesis

authors： Popova NV,Teti KA,Wu KQ,Morris RJ

更新日期：2003-03-01 00:00:00

abstract：:[3H]Benzo[a]pyrene (B[a]P) was administered to male Sprague-Dawley rats via intratracheal instillation, and bile was collected over a period of 6 h. Conjugated metabolites of B[a]P in bile were separated by paper chromatography or reversed-phase ion-pair HPLC and quantified by liquid scintillation spectrometry. In pap...

journal_title：Carcinogenesis

authors： Bevan DR,Sadler VM

更新日期：1992-03-01 00:00:00

abstract：:Purified human alpha-thrombin stimulates phosphoinositide turnover as a necessary step in its stimulation of fibroblast cell proliferation. Since phosphoinositide turnover releases diacylglycerol, which activates protein kinase C, we postulated that long-term exposure to thrombin might promote cellular transformation ...

journal_title：Carcinogenesis

authors： Morris DL,Ward JB Jr,Nechay P,Whorton EB Jr,Fenton JW 2nd,Carney DH

更新日期：1992-01-01 00:00:00

abstract：:Abl interactor 1 (Abi1) is a key regulator of actin polymerization/depolymerization. The involvement of Abi1 in the development of abnormal cytoskeletal functions of cancer cells has recently been reported. It remains unclear, however, how Abi1 exerts its effects in tumor cells and whether it contributes to tumor prog...

journal_title：Carcinogenesis

authors： Sun X,Li C,Zhuang C,Gilmore WC,Cobos E,Tao Y,Dai Z

更新日期：2009-12-01 00:00:00

abstract：:Breast cancer is the most common cancer and the second most frequent cause of cancer death in women. Despite extensive research, the precise mechanisms of breast carcinogenesis remain unclear. One of the reasons for this is due, at least in part, to a lack of a suitable animal model which can closely mimic the breast ...

journal_title：Carcinogenesis

authors： Xie B,Tsao SW,Wong YC

更新日期：1999-06-01 00:00:00

abstract：:Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...

journal_title：Carcinogenesis

authors： Fussell KC,Udasin RG,Smith PJ,Gallo MA,Laskin JD

更新日期：2011-08-01 00:00:00

abstract：:The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limi...

journal_title：Carcinogenesis

authors： Sklar R,Brady K,Strauss B

更新日期：1981-01-01 00:00:00

abstract：:Transgenic mice containing one copy of hepatitis B virus (HBV) genome without the core gene and expressing hepatitis B surface antigen (HBsAg) were crossed with C3H/He mice. The F1 hybrids (approximately 50% HBV positive and approximately 50% HBV negative) were treated with a single dose of diethylnitrosamine (NDEA) o...

journal_title：Carcinogenesis

authors： Dragani TA,Manenti G,Farza H,Della Porta G,Tiollais P,Pourcel C

更新日期：1990-06-01 00:00:00

abstract：:The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...

journal_title：Carcinogenesis

authors： Capp JP,Boudsocq F,Bergoglio V,Trouche D,Cazaux C,Blanco L,Hoffmann JS,Canitrot Y

更新日期：2010-10-01 00:00:00

abstract：:In a previous study a high first-pass metabolism of N-nitrosodi-[1-14C]amylamine (NDAA, 0.59-350 microM) has been shown in isolated perfused rat small intestinal segments. In the present work the identification of metabolites in samples of perfusate and absorbed fluid (absorbate) is reported. After HPLC enrichment and...

journal_title：Carcinogenesis

authors： Richter E,Lorck C,Wiessler M

更新日期：1988-03-01 00:00:00

abstract：:Alkylation of DNA and hemoglobin was compared in male F344 rats given a single s.c. injection of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), or its major metabolite formed by carbonyl reduction, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). In hepatic DNA, levels of 7...

journal_title：Carcinogenesis

authors： Hecht SS,Trushin N

更新日期：1988-09-01 00:00:00

abstract：:Pharmacological inhibitors of the transforming growth factor β (TGFβ) type I receptor (ALK5) have shown promise in blocking growth of xenotransplanted cancer cell lines but the effect on a multistage cancer model is not known. To test this, we treated mouse skin with SB431542 (SB), a well-characterized ALK5 inhibitor,...

journal_title：Carcinogenesis

authors： Mordasky Markell L,Pérez-Lorenzo R,Masiuk KE,Kennett MJ,Glick AB

更新日期：2010-12-01 00:00:00