Induction of liver cell tumours in IF mice by paracetamol.

abstract：:Hairless mice were given 5 topical applications of 470 nmol 20-methylcholanthrene (MCA) at one week intervals. In one experimental group the MCA was dissolved in reagent grade acetone alone, in another group it was dissolved in a mixture consisting of 50% acetone and 50% dimethyl sulfoxide (DMSO). A control group rece...

journal_title：Carcinogenesis

authors： Iversen OH,Thorud E,Volden G

更新日期：1981-01-01 00:00:00

abstract：:Multidrug resistance 2 (Mdr2), also called adenosine triphosphate-binding cassette B4 (ABCB4), is the transporter of phosphatidylcholine (PC) at the canalicular membrane of mouse hepatocytes, which plays an essential role for bile formation. Mutations in human homologue MDR3 are associated with several liver diseases....

journal_title：Carcinogenesis

authors： Tebbi A,Levillayer F,Jouvion G,Fiette L,Soubigou G,Varet H,Boudjadja N,Cairo S,Hashimoto K,Suzuki AM,Carninci P,Carissimo A,di Bernardo D,Wei Y

更新日期：2016-01-01 00:00:00

abstract：:FEZ1/LZTS1 is a tumor suppressor gene that is frequently altered in human cancers of different histotypes. We have reported previously that LZTS1 is downregulated in high-grade bladder cancer and that its restoration suppresses tumorigenicity in urothelial carcinoma cells. To further investigate the role of LZTS1 in t...

journal_title：Carcinogenesis

authors： Baffa R,Fassan M,Sevignani C,Vecchione A,Ishii H,Giarnieri E,Iozzo RV,Gomella LG,Croce CM

更新日期：2008-04-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) expression is elevated by tumor promoters in the mouse skin, but its role in tumor promotion has not been well defined. To investigate this, we have compared TGFbeta1+/+ and +/- mice in a two-stage skin chemical carcinogenesis protocol. Surprisingly, TGFbeta1+/- mice had few...

journal_title：Carcinogenesis

authors： Pérez-Lorenzo R,Markell LM,Hogan KA,Yuspa SH,Glick AB

更新日期：2010-06-01 00:00:00

abstract：:Human cancers are often associated with numerical and structural chromosomal instability. Structural chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBL) arise as consequences of direct DNA damage or due to replication on a damaged DNA template. In both cases, DNA repair is critical and inter-individual...

journal_title：Carcinogenesis

authors： Vodicka P,Musak L,Frank C,Kazimirova A,Vymetalkova V,Barancokova M,Smolkova B,Dzupinkova Z,Jiraskova K,Vodenkova S,Kroupa M,Osina O,Naccarati A,Palitti F,Försti A,Dusinska M,Vodickova L,Hemminki K

更新日期：2015-11-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB. NF-kappaB plays a complex role in the control of survival due to the influence of cellular factors acting downstream. We undertook a comparative investi...

journal_title：Carcinogenesis

authors： Tacchini L,De Ponti C,Matteucci E,Follis R,Desiderio MA

更新日期：2004-11-01 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00

abstract：:Several previous in vitro studies have indicated that ascorbate and glutathione are the major reductants of Cr(VI) in cells. In order to evaluate the in vivo effects of ascorbate and glutathione on Cr(VI)-induced carcinogenesis, Cr uptake and the formation of Cr(V), Cr-DNA adducts and 8-hydroxy-2'-deoxyguanosine (8-OH...

journal_title：Carcinogenesis

authors： Yuann JM,Liu KJ,Hamilton JW,Wetterhahn KE

更新日期：1999-07-01 00:00:00

abstract：:Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...

journal_title：Carcinogenesis

authors： Kato T,Ohgaki H,Hasegawa H,Sato S,Takayama S,Sugimura T

更新日期：1988-01-01 00:00:00

abstract：:Acrylamide is an alkylating agent which reacts very slowly in direct reactions with DNA and is negative in the Ames test, but is carcinogenic in mice and rats. In order to explain the cancer-initiating properties of acrylamide we have studied DNA adduct formation in vitro with a metabolizing system and in vivo in mice...

journal_title：Carcinogenesis

authors： Segerbäck D,Calleman CJ,Schroeder JL,Costa LG,Faustman EM

更新日期：1995-05-01 00:00:00

abstract：:The liver-derived human cell line, Hep G2, has high benzo[a]pyrene-metabolizing activity and converts benzo[a]pyrene to intermediates that are mutagenic and that bind to DNA. This cell line will be useful for studying metabolic activation of polycyclic aromatic hydrocarbons and other xenobiotics by human tissue and as...

journal_title：Carcinogenesis

authors： Diamond L,Kruszewski F,Aden DP,Knowles BB,Baird WM

更新日期：1980-01-01 00:00:00

abstract：:Occupational exposure to hydrocarbon solvents has been found to be associated with an increased risk of exocrine pancreatic cancer (EPC), the human tumor with the highest prevalence of K-ras mutations. Ras genes are critical DNA targets for chemical carcinogens. We analysed the relationship between past occupational e...

journal_title：Carcinogenesis

authors： Alguacil J,Porta M,Malats N,Kauppinen T,Kogevinas M,Benavides FG,Partanen T,Carrato A,PANKRAS II Study Group.

更新日期：2002-01-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a mutagen found in cooked meat, has been shown to induce mammary gland tumors in rats. Our laboratory recently observed that a high fat diet enhances the incidence and severity of PhIP-induced mammary gland cancer in rats. In the current study, reverse transcript...

journal_title：Carcinogenesis

authors： Davis CD,Snyderwine EG

更新日期：1995-12-01 00:00:00

abstract：:Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...

journal_title：Carcinogenesis

authors： Degen GH,Metzler M,Sivarajah KS

更新日期：1986-01-01 00:00:00

abstract：:The mutational specificity of the monofunctional alkylating agent N-propyl-N'-nitro-N-nitrosoguanidine (PNNG) has been determined through the DNA sequence characterization of 109 LacI- mutations of Escherichia coli. The predominant mutation induced was the G:C----A:T transition (73%), presumably the result of O6-propy...

journal_title：Carcinogenesis

authors： van der Vliet GM,Zielenska M,Anderson MW,Glickman BW

更新日期：1989-05-01 00:00:00

abstract：:The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of th...

journal_title：Carcinogenesis

authors： Raikow RB,Okunewick JP,Buffo MJ,Jones DL,Brozovich BJ,Seeman PR,Koval TM

更新日期：1981-01-01 00:00:00

abstract：:Base excision repair (BER) corrects DNA damage caused by oxidative stress and chronic inflammation, putative risk factors for cancer. To understand the relationship between genetic variation in BER genes and risk of biliary tract cancer and biliary stones, we examined non-synonymous polymorphisms in three key BER gene...

journal_title：Carcinogenesis

authors： Huang WY,Gao YT,Rashid A,Sakoda LC,Deng J,Shen MC,Wang BS,Han TQ,Zhang BH,Chen BE,Rosenberg PS,Chanock SJ,Hsing AW

更新日期：2008-01-01 00:00:00

abstract：:Resveratrol (RSVL) is a well-established chemopreventive agent in human breast cancer models. The molecular basis of its action is far less characterized. We investigated the effects of RSVL on activity of adenylate- and guanylate-cyclase (AC, GC) enzymes; two known cytostatic cascades in MCF-7 breast cancer cells. RS...

journal_title：Carcinogenesis

authors： El-Mowafy AM,Alkhalaf M

更新日期：2003-05-01 00:00:00

abstract：:Flow cytometric analysis of fibroblasts, normal breast epithelial cells and breast or other cancer cell lines identified variation in the abilities of cell lines to undergo cell cycle arrest as a response to hypoxia. Human mammary epithelial cells (HMEC), normal fibroblasts (Hs68 and WI38), HeLa cervical carcinoma and...

journal_title：Carcinogenesis

authors： Box AH,Demetrick DJ

更新日期：2004-12-01 00:00:00

abstract：:Ulcerative colitis is a dynamic, chronic inflammatory condition of the colon associated with an increased colon cancer risk. Ginkgo biloba is a putative antioxidant and has been used for thousands of years to treat a variety of ailments. The aim of this study was to test whether the standardized G.biloba extract, EGb ...

journal_title：Carcinogenesis

authors： Kotakadi VS,Jin Y,Hofseth AB,Ying L,Cui X,Volate S,Chumanevich A,Wood PA,Price RL,McNeal A,Singh UP,Singh NP,Nagarkatti M,Nagarkatti PS,Matesic LE,Auclair K,Wargovich MJ,Hofseth LJ

更新日期：2008-09-01 00:00:00

abstract：:The Tsc-2 tumor suppressor gene encodes the protein tuberin, a multi-functional protein with sequence homology to the GTPase activating protein (GAP) for Rap1. Mutations in the Tsc-2 gene are associated with the development of renal tumors. The Eker rat (Tsc-2(EK/+)) bears a mutation in one allele of the Tsc-2 gene, w...

journal_title：Carcinogenesis

authors： Habib SL,Phan MN,Patel SK,Li D,Monks TJ,Lau SS

更新日期：2003-03-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:Sweet potato (Ipomoea batatas) leaves or greens, extensively consumed as a vegetable in Africa and Asia, are an excellent source of dietary polyphenols such as anthocyanins and phenolic acids. Here, we show that sweet potato greens extract (SPGE) has the maximum polyphenol content compared with several commercial vege...

journal_title：Carcinogenesis

authors： Karna P,Gundala SR,Gupta MV,Shamsi SA,Pace RD,Yates C,Narayan S,Aneja R

更新日期：2011-12-01 00:00:00

abstract：:One of the most widely studied ultimate carcinogens, 7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE-I), is fairly stable in organic solvents but hydrolyses rapidly in the presence of water. Routine use of BPDE-I stock solutions involves multiple cycles of warming to room temperature and return to f...

journal_title：Carcinogenesis

authors： MacLeod MC,Lew L

更新日期：1988-11-01 00:00:00

abstract：:A three-dimensional molecular template has been generated for substrates of human debrisoquine 4-hydroxylase cytochrome P450 (CYP2D6). This template defines the stereochemical requirements for CYP2D6 substrates in terms of the volume occupied and positions of key atoms. The modelling was based on the X-ray crystallogr...

journal_title：Carcinogenesis

authors： Islam SA,Wolf CR,Lennard MS,Sternberg MJ

更新日期：1991-12-01 00:00:00

abstract：:Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been shown experimentally to have beneficial effects in the treatment of cancer and cardiovascular disease. Resveratrol induces programmed cell death (apoptosis) in these cells and activates important signal transducing proteins includ...

journal_title：Carcinogenesis

authors： Lin C,Crawford DR,Lin S,Hwang J,Sebuyira A,Meng R,Westfall JE,Tang HY,Lin S,Yu PY,Davis PJ,Lin HY

更新日期：2011-01-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:The development of human breast cancer is a complex multi-step process that depends on various exogenous and endogenous factors that modulate the transformation of normal human breast epithelial cells into neoplastic ones. Using a spontaneously-immortalized human breast epithelial (MCF-10F) cell line, we have shown pr...

journal_title：Carcinogenesis

authors： Roy D,Calaf G,Hei TK

更新日期：2001-10-01 00:00:00

abstract：:The effect of whole body ionising radiation from a linear accelerator on rat tissue O6-methylguanine (O6-meG) methyltransferase (MT) activity has been assessed using an assay which measures the transfer of 3H-radioactivity from 3H-methylated substrate DNA to protein. The maximal effect occurred 2 days after a 1 krad d...

journal_title：Carcinogenesis

authors： Margison GP,Butler J,Hoey B

更新日期：1985-12-01 00:00:00

abstract：:Dehydroepiandrosterone sulfate (DHEAS) is the most abundant adrenal steroid with apparent anticarcinogenic properties. Given our recent observation of the dehydro-epiandrosterone-mediated inhibition of protein isoprenylation and the fact that 99% of the circulating dehydro-epiandrosterone is sulfated, with less than 1...

journal_title：Carcinogenesis

authors： Schulz S,Nyce JW

更新日期：1994-11-01 00:00:00