Frequent allelic imbalance on chromosome 6 and 17 correlate with radiation-induced neoplastic transformation of human breast epithelial cells.

abstract：:High intake of red meat is associated with an increased risk of colon cancer. It has been suggested that fat from red meat is responsible, because high fat intake increases the concentration of cytotoxic lipids in the colon. Experimental studies have not unequivocally supported such a role for fat, however. Recently, ...

journal_title：Carcinogenesis

authors： Sesink AL,Termont DS,Kleibeuker JH,Van Der Meer R

更新日期：2000-10-01 00:00:00

abstract：:Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...

journal_title：Carcinogenesis

authors： Hirose M,Inoue T,Masuda A,Tsuda H,Ito N

更新日期：1987-10-01 00:00:00

abstract：:Previous studies have shown that decorin expression is significantly reduced in colorectal cancer tissues and cancer cells, and genetic deletion of the decorin gene is sufficient to cause intestinal tumor formation in mice, resulting from a downregulation of p21, p27(kip1) and E-cadherin and an upregulation of β-caten...

journal_title：Carcinogenesis

authors： Bi X,Pohl NM,Qian Z,Yang GR,Gou Y,Guzman G,Kajdacsy-Balla A,Iozzo RV,Yang W

更新日期：2012-02-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Staurosporine (stsp) is a kinase inhibitor which induces cornified envelope assembly and terminal differentiation in normal and neoplastic mouse keratinocytes. In the tumorigenic cell lines 308 and SP-1 experiments were performed to determine if this effect was due only to activation of transglutaminases (TGases) alre...

journal_title：Carcinogenesis

authors： Stanwell C,Dlugosz AA,Yuspa SH

更新日期：1996-06-01 00:00:00

abstract：:Retroelements constitute a large part of the human genome. These sequences are mostly silenced in normal cells, but genome-wide DNA hypomethylation in cancers might lead to their re-expression. Whether this re-expression really occurs in human cancers is largely unkown. We therefore investigated expression and DNA met...

journal_title：Carcinogenesis

authors： Goering W,Ribarska T,Schulz WA

更新日期：2011-10-01 00:00:00

abstract：:CD133 is a pivotal marker of cancer stem cells (CSCs), which is involved in tumorigenesis and cancer progression. Recent studies have identified CD133 to be a prognostic factor for cancer rested with its expression and genetic variants. Here, we hypothesized that the single nuclear polymorphisms (SNPs) in CD133 may be...

journal_title：Carcinogenesis

authors： Cheng M,Yang L,Yang R,Yang X,Deng J,Yu B,Huang D,Zhang S,Wang H,Qiu F,Zhou Y,Lu J

更新日期：2013-10-01 00:00:00

abstract：:Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...

journal_title：Carcinogenesis

authors： Brendle A,Lei H,Brandt A,Johansson R,Enquist K,Henriksson R,Hemminki K,Lenner P,Försti A

更新日期：2008-07-01 00:00:00

abstract：:Inbred strains of mice with differential response to known tumor promoters were compared with respect to their susceptibility to modulation of hepatic antioxidant enzymes by long-term treatment with high fat diet (HF) and phenobarbital (PB). Mice of the C57BL/6J (C57), C3H/HeOuJ (C3H) and DBA/2J (DBA) strains were fed...

journal_title：Carcinogenesis

authors： Ahotupa M,Bereziat JC,Mäntylä E,Bartsch H

更新日期：1993-06-01 00:00:00

abstract：:The NIH3T3 cell line undergoes transformation when the cells are maintained at high densities for extended periods. In an effort to define the physiological status of the cells before and during the transformation process, they were seeded in medium containing 2, 5 or 10% calf serum (CS) and growth was monitored by me...

journal_title：Carcinogenesis

authors： Rubin AL,Ellison BJ

更新日期：1991-10-01 00:00:00

abstract：:Alterations in the pattern of epidermal cell differentiation and proliferation in mouse skin and benign skin tumors were studied by two-color immunofluorescence using monospecific antibodies. Replicating cells were identified by 5-bromo-deoxyuridine (BrdU) pulse-labeling and differentiating cells by keratins K1 and K1...

journal_title：Carcinogenesis

authors： Huitfeldt HS,Heyden A,Clausen OP,Thrane EV,Roop D,Yuspa SH

更新日期：1991-11-01 00:00:00

abstract：:Epidemiological investigations suggest that chronic lung inflammation increases lung cancer risk. Pharmacologic and genetic evidence in mouse models indicates that lipid mediators released during pulmonary inflammation enhance lung tumor formation. Cytosolic phospholipase A2 (cPLA2) catalyzes arachidonic acid (AA) rel...

journal_title：Carcinogenesis

authors： Meyer AM,Dwyer-Nield LD,Hurteau GJ,Keith RL,O'Leary E,You M,Bonventre JV,Nemenoff RA,Malkinson AM

更新日期：2004-08-01 00:00:00

abstract：:In China, esophageal cancer is the fourth leading cause of cancer death where essentially all cases are histologically esophageal squamous cell carcinoma (ESCC), in contrast to esophageal adenocarcinoma in the West. Globally, ESCC is 2.4 times more common among men than women and recently it has been suggested that se...

journal_title：Carcinogenesis

authors： Hyland PL,Freedman ND,Hu N,Tang ZZ,Wang L,Wang C,Ding T,Fan JH,Qiao YL,Golozar A,Wheeler W,Yu K,Yuenger J,Burdett L,Chanock SJ,Dawsey SM,Tucker MA,Goldstein AM,Abnet CC,Taylor PR

更新日期：2013-05-01 00:00:00

abstract：:Tumor induction with chronic feeding of methyl-donor-deficient diets has been well established; however, the biochemical and molecular mechanisms which predipose to tumorigenesis in this model are still not well understood. The purpose of the present investigation was to assess DNA damage and altered nucleotide metabo...

journal_title：Carcinogenesis

authors： James SJ,Yin L

更新日期：1989-07-01 00:00:00

abstract：:The possibility that long-term exposure to relatively weak power frequency magnetic fields (MFs) emanating from the generation, transmission and use of electricity could increase the risk of breast cancer is a matter of ongoing debate. Laboratory studies using well-defined exposure conditions are useful to examine whe...

journal_title：Carcinogenesis

authors： Fedrowitz M,Löscher W

更新日期：2008-01-01 00:00:00

abstract：:Capsaicin, a pungent ingredient of red chili peppers, has been reported to possess antitumor activities. Here, we show that subtoxic doses of capsaicin effectively sensitize multiple malignant glioma cell lines to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Although TRAIL alone m...

journal_title：Carcinogenesis

authors： Kim JY,Kim EH,Kim SU,Kwon TK,Choi KS

更新日期：2010-03-01 00:00:00

abstract：:The effect of glucose on the formation of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) was studied in a model system. When a mixture of creatine (0.9 mmol), phenylalanine (0.9 mmol) and glucose (0.45 mmol) was heated in diethylene glycol and water (3 ml, 5:1) for 10 min at 180 or 225 degrees...

journal_title：Carcinogenesis

authors： Skog K,Jägerstad M

更新日期：1991-12-01 00:00:00

abstract：:Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...

journal_title：Carcinogenesis

authors： Plna K,Segerbäck D,Schweda EK

更新日期：1996-07-01 00:00:00

abstract：:An iron chelate, ferric nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage, a consequence of iron-catalysed Fenton-like reactions, that finally leads to a high incidence of renal cell carcinoma (RCC) in rodents. Glutathione S-transferase (GST) is a family of enzymes that play an important role in detoxi...

journal_title：Carcinogenesis

authors： Tanaka T,Nishiyama Y,Okada K,Satoh K,Fukuda A,Uchida K,Osawa T,Hiai H,Toyokuni S

更新日期：1998-05-01 00:00:00

abstract：:In two separate in vivo studies, ethionine was evaluated for carcinogenic activity in mice. In the first study, DL-ethionine was fed in a chow diet at 0 (controls), 0.1 (low dose, LD) and 0.25% (high dose, HD) concentrations to the following groups of mice (30 animals/group): Swiss Webster CD-1 females, BALB/c males, ...

journal_title：Carcinogenesis

authors： Hoover KL,Hyde CL,Wenk ML,Poirier LA

更新日期：1986-07-01 00:00:00

abstract：:The suppression of apoptosis may contribute to the carcinogenicity of the peroxisome proliferators (PPs), a class of non-genotoxic rodent hepatocarcinogens. Our previous work demonstrated that the PP nafenopin suppressed both spontaneous and transforming growth factor beta1 (TGFbeta1)-induced hepatocyte apoptosis both...

journal_title：Carcinogenesis

authors： Gill JH,James NH,Roberts RA,Dive C

更新日期：1998-02-01 00:00:00

abstract：:The phospholipid (PL) content was 4-fold higher while the triacylglycerol (TG) content tended to be 65% lower in human breast cancer tissues as compared with non-cancerous reference parts from excised breast tissues. The variation in TG content among breast tissues was very large while that of PL was relatively small....

journal_title：Carcinogenesis

authors： Sakai K,Okuyama H,Yura J,Takeyama H,Shinagawa N,Tsuruga N,Kato K,Miura K,Kawase K,Tsujimura T

更新日期：1992-04-01 00:00:00

abstract：:In order to investigate the modulatory effect of the immune response induced by recurrent carcinogen exposure, anti-2-acetylaminofluorene (anti-2-AAF) IgG were elicited in Swiss mice before subsequent carcinogen administration. The immunization schedule consisted of three weekly i.p. injections of 2-acetylaminofluoren...

journal_title：Carcinogenesis

authors： Verdina A,Zito R,Cortese G,Leopardi P,Marcon F,Zijno A,Crebelli R

更新日期：1996-08-01 00:00:00

abstract：:The DNA double-strand breaks (DSBs) repair pathway has been implicated in maintaining genomic integrity via suppression of chromosomal rearrangements. DNA-dependent protein kinase (DNA-PK) has an important role with DNA DSBs repair. In this study, 93 of untreated cancer patients and 41 of cancer-free healthy volunteer...

journal_title：Carcinogenesis

authors： Someya M,Sakata K,Matsumoto Y,Yamamoto H,Monobe M,Ikeda H,Ando K,Hosoi Y,Suzuki N,Hareyama M

更新日期：2006-01-01 00:00:00

abstract：:The HBL100 cell line, established in vitro from milk of an apparently healthy woman, expresses SV40 large T antigen defective in some of its functions. Here we demonstrate that the HBL100 genomic DNA possesses transforming activity in NIH3T3 cells and that this activity is associated with the viral information. ...

journal_title：Carcinogenesis

authors： Vanhamme L,Szpirer C

更新日期：1988-04-01 00:00:00

abstract：:Overexpression of the helix-loop-helix protein Id-1 has been reported in over 20 types of cancer. While a number of factors have been demonstrated to regulate Id-1 gene transcription, little is known about the mechanisms responsible for its degradation. In this study, we have demonstrated that Id-1 protein stability w...

journal_title：Carcinogenesis

authors： Ling MT,Kwok WK,Fung MK,Xianghong W,Wong YC

更新日期：2006-02-01 00:00:00

abstract：:An antimutagenic compound was isolated from the leaves of Carmona retusa (Vahl) Masam. Its structure has been elucidated by spectral analysis to be 4-hydroxy-7,8,11,12,15,7',8',11',12',15'-decahydro-beta, psi-carotene. The results of the Micronucleus Test, an in vivo method, showed that the isolated antimutagenic comp...

journal_title：Carcinogenesis

authors： Villaseñor IM,Edu DA,Bremner JB

更新日期：1993-01-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:3,3'-Diindolylmethane (DIM), an indole derivative produced on consumption of broccoli and other cruciferous vegetables, has been shown to have multiple anticancer effects in both in vivo and in vitro models. The present study was carried out to clarify the mechanism of DIM's antiangiogenic activity. We found that DIM ...

journal_title：Carcinogenesis

authors： Chang X,Firestone GL,Bjeldanes LF

更新日期：2006-03-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00