Abstract:
:The effect of exposing mice to both a chemical carcinogen and leukemia virus with and without an inhibitor of DNA repair were compared. The data indicated that benzo[a]pyrene (BP) could exert a potentiating effect of Friend viral leukemogenesis in mice, which was dependent on the relative times of administration of the chemical and virus. The addition of caffeine as an inhibitor of DNA repair further enhanced the potentiating effect of BP on the leukemia, but in the absence of BP, caffeine showed no carcinogenic effect either when given alone or in conjunction with Friend leukemia virus.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Raikow RB,Okunewick JP,Buffo MJ,Jones DL,Brozovich BJ,Seeman PR,Koval TMdoi
10.1093/carcin/2.1.1subject
Has Abstractpub_date
1981-01-01 00:00:00pages
1-6issue
1eissn
0143-3334issn
1460-2180journal_volume
2pub_type
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