Abstract:
:Prepubertal exposure to soy or its biologically active component genistein reduces later breast cancer risk in both animal models and human populations. We investigated whether that might be due to reported estrogenic properties of genistein. Our study indicated that daily prepubertal exposures between postnatal days 7 and 20 to 10 microg 17beta-estradiol (E2) reduced later risk of developing 7,12-dimethylbenz[a]anthracene (DMBA)-induced mammary tumors. Assessment of mammary gland morphology revealed that both prepubertal E2 and genistein (50 microg daily) exposures reduced the size of mammary epithelial area and number of terminal end buds (TEBs) and increased the density of lobulo-alveolar structures, suggesting that these exposures induced elimination of targets for malignant transformation by differentiation. Next, the mechanisms mediating the protective effects of E2 and genistein were investigated. E2 is shown to up-regulate BRCA1, a tumor suppressor gene that participates in DNA damage repair processes and cell differentiation and that down-regulates the activity of estrogen receptor (ER)-alpha. The expression of BRCA1 mRNA was up-regulated in the mammary glands of rats exposed to E2 or genistein during prepuberty, when determined at the ages of 3, 8 and 16 weeks. Prepubertal E2 exposure reduced ER-alpha levels in the mammary gland, while prepubertal genistein exposure had an opposite effect. Our results suggest that prepubertal estrogenic exposures may reduce later breast cancer risk by inducing a persistent up-regulation of BRCA1 in the mammary gland.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Cabanes A,Wang M,Olivo S,DeAssis S,Gustafsson JA,Khan G,Hilakivi-Clarke Ldoi
10.1093/carcin/bgh065keywords:
subject
Has Abstractpub_date
2004-05-01 00:00:00pages
741-8issue
5eissn
0143-3334issn
1460-2180pii
bgh065journal_volume
25pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::Apoptosis is a morphologically and biochemically distinct form of cell death which determines specific patterns of tissue size and shape and balances cell proliferation. In the present study, the sequence of cellular proliferative alterations in urinary bladder epithelium associated with uracil-induced reversible urin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.8.1485
更新日期:1997-08-01 00:00:00
abstract::An enhancement of the cellular cAMP level has been shown to protect against phorbol ester-induced inhibition of gap junctional intercellular communication (GJIC) and induction of morphological transformation in Syrian hamster embryo (SHE) cells. Cholera toxin, forskolin, 3-isobutyl-1-methylxanthine (IBMX) and theophyl...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.10.1803
更新日期:1992-10-01 00:00:00
abstract::Docosahexaenoic acid (DHA), a 22:6 n-3 polyunsaturated fatty acid, is the longest and most highly unsaturated fatty acid found in most membranes and has been shown to inhibit cancer cell growth in part by modifying cell signaling. In the current study, alterations to epidermal growth factor receptor (EGFR) signaling u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq111
更新日期:2010-09-01 00:00:00
abstract::Apurinic/apyrimidinic endonuclease/redox effector factor-1 (APE/Ref-1) is a multifunctional protein involved both in DNA base excision repair and redox regulation. Studies have suggested that abnormal Ref-1 levels and/or activities are associated with tumor progression and sensitivities to treatment, but no direct evi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm128
更新日期:2007-11-01 00:00:00
abstract::An electron microscope study was carried out on changes in the pancreatic acinar tissues of male Syrian hamsters during the course of induction of pancreatic neoplasia by lifetime weekly injections of N-nitroso-bis(2-hydroxypropyl)amine (BHP). The dominant process observed was a loss of differentiation of the acinar c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.5.485
更新日期:1982-01-01 00:00:00
abstract::We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.1.43
更新日期:1991-01-01 00:00:00
abstract::Inflammation is highly associated with colon carcinogenesis. Epigenetic mechanisms could play an important role in the initiation and progression of colon cancer. Curcumin, a dietary phytochemical, shows promising effects in suppressing colitis-associated colon cancer in azoxymethane-dextran sulfate sodium (AOM-DSS) m...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgy043
更新日期:2018-05-03 00:00:00
abstract::Phosphoinositide-specific phospholipase Cgamma (PLCgamma) is a key regulatory enzyme that binds to the phosphoryl-tyrosine residues in the cytoplasmic domain of certain activated receptors and catalyses the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] forming IP3 and diacylglycerol (DAG) in resp...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.1.177
更新日期:1998-01-01 00:00:00
abstract::Malondialdehyde (MDA), a product of lipid peroxidation, causes mutations in bacterial and mammalian cells and cancer in rats. MDA reacts with deoxynucleosides in vitro and the monomeric adduct of MDA with deoxyguanosine (M1G-dR) is the major adduct. M1G-dR has been detected in rat and human liver. Random mutagenesis s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.5.1167
更新日期:1996-05-01 00:00:00
abstract::To study the mechanisms of mutagenesis by the carcinogen N-acetyl-2-aminofluorene (AAF), we determined by DNA sequencing the spectrum of mutations in the Escherichia coli lacI gene induced by the ultimate metabolite N-acetoxy-N-acetyl-2-aminofluorene, using an E. coli derivative with increased permeability to this com...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.7.1087
更新日期:1990-07-01 00:00:00
abstract::We employed cDNA microarray analysis to identify, in mammary adenocarcinomas induced by 7,12-dimethylbenz[a] anthracene (DMBA) in the rat, target genes as potential biomarkers for cancer chemoprevention by 1,4-phenylenebis(methylene)selenocyanate (p-XSC). Confirmation of selected genes was conducted by reverse transcr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg103
更新日期:2003-09-01 00:00:00
abstract::Genetic variants in multiple cellular pathways have been associated with an altered risk of oesophageal cancer. In this study, eight genes previously associated with an altered risk of oesophageal squamous cell carcinoma (OSCC) in European or Asian populations were investigated in two South African populations. We gen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr211
更新日期:2011-12-01 00:00:00
abstract::Twist1 is an essential transcription factor required to initiate epithelial-mesenchymal transition (EMT) and promote tumor metastasis. PAQR3 is a newly found tumor suppressor that is frequently downregulated in many types of human cancers. Downregulation of PAQR3 is associated with accelerated metastasis and poor prog...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgw013
更新日期:2016-04-01 00:00:00
abstract::In addition to genetic changes, epigenetic aberrations also play important roles in radiation- and chemical-induced disorders and carcinogenesis. The present study investigated whether epigenetic therapy with a histone deacetylase (HDAC) inhibitor has dual benefits for radiation-induced oral mucositis and chemical-ind...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp079
更新日期:2009-08-01 00:00:00
abstract::The expression of human placental type glutathione S-transferase (GST-pi) was investigated in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, and compared with that in normal skin, using Northern blot and immunohistochemical analysis. In Northern blot examination, the expression of G...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.10.2327
更新日期:1995-10-01 00:00:00
abstract::Initiation with the carcinogen 7,12-dimethylbenz[a]anthracene followed by promotion with the hyperplasiogenic phorbol ester 12-O-tetradecanoylphorbol-13-acetate carried out on the dorsal skin of European hamsters (Cricetus cricetus L.) led to the formation of a broad spectrum of skin tumors in terms of a two-stage pri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.4.521
更新日期:1984-04-01 00:00:00
abstract::Dacarbazine (DTIC) is an antitumor agent, used for the treatment of metastatic melanoma. It is metabolized to an alkylating agent which reacts with DNA. A fast and simple method was developed in order to measure drug-induced DNA damage in lymphocytes isolated from frozen blood samples of treated patients. The level of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1153
更新日期:1991-06-01 00:00:00
abstract::Previous results in a number of laboratories have demonstrated that epidermal papillomas and carcinomas induced by the two-stage protocol of initiation and promotion contain a point mutation in the 61st codon of the c-Ha-ras oncogene when the initiating agent used is 7,12-dimethylbenz[a]anthracene (DMBA). In the prese...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.665
更新日期:1988-04-01 00:00:00
abstract::We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.10.1727
更新日期:1988-10-01 00:00:00
abstract::Diacylglycerols (DAG) are lipid second messengers which are generated during phospholipase-catalyzed hydrolysis of phospholipids. The model DAG, sn-1,2-didecanoylglycerol (DIC10), is an effective topical tumor promoter in 7,12-dimethylbenz[a]anthracene (DMBA)-initiated mouse skin. We now report that 11/12 of DMBA-init...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.12.2645
更新日期:1993-12-01 00:00:00
abstract::Pardaxin, an antimicrobial peptide secreted by the Red Sea flatfish Pardachirus marmoratus, inhibits proliferation and induces apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are only partially understood at present. In this study, we used proteomic approaches and network reconstruct...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgt130
更新日期:2013-08-01 00:00:00
abstract::A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.8.1825
更新日期:1995-08-01 00:00:00
abstract::The antihistamine methapyrilene (hydrochloride) and four close structural analogs, methaphenilene, methafurylene, thenyldiamine and clorothen, were given to rats at a concentration of 0.1% in drinking water for 34 weeks. Only methapyrilene produced notable histopathological changes in the liver, bile duct hyperplasia ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.3.557
更新日期:1989-03-01 00:00:00
abstract::Naturally occurring antioxidants are extensively studied for their capacity to protect organisms and cells from damage induced by oxygen reactive species. In fact, oxidative stress is considered a cause of aging, degenerative disease and cancer. We have focused our attention on two agents, ascorbic acid and beta-carot...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.1.223
更新日期:1997-01-01 00:00:00
abstract::In this study we have investigated the relationship between the dose of 1,2-dimethylhydrazine (DMH) and the yield (and location) of tumours in a mouse strain susceptible to colon tumour induction. Female SWR mice were injected with 6.8 mg/kg DMH i.p. once a week for 1, 5, 10 and 20 weeks and the animals were followed ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/20.3.509
更新日期:1999-03-01 00:00:00
abstract::Administration of 2-acetylaminofluorene (2-AAF) to rats increased mdr1b expression in Fischer, Wistar and Sprague-Dawley rat livers; however, the response was much smaller in Sprague-Dawley livers. To investigate the basis of this difference we further examined the regulation of the mdr1b gene in hepatocytes isolated ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/17.3.451
更新日期:1996-03-01 00:00:00
abstract::Botryodiplodin induces DNA-protein cross-links (DPC) in mammalian cells in culture. Removal of the mycotoxin followed by incubation of cells in fresh medium leads to the gradual disappearance of DPC. The present experiments attempted to determine to what extent the repair mechanism acts through a system involving tran...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.10.1375
更新日期:1984-10-01 00:00:00
abstract::Neuroblastic tumors (NTs) include the neuroblastomas, ganglioneuroblastomas and ganglioneuromas. We have reported previously that the calcium-sensing receptor is expressed in differentiated, favorable NTs but almost undetectable in unfavorable neuroblastomas. We have now detected hypermethylation of a particular regio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgs338
更新日期:2013-02-01 00:00:00
abstract::N-nitrosopiperidine (NPIP) is a potent esophageal carcinogen in rats whereas structurally similar N-nitrosopyrrolidine (NPYR) induces liver, but not esophageal tumors. NPIP is a possible causative agent for human esophageal cancer. Our goal is to explain mechanistically these differing carcinogenic activities in the e...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.2.291
更新日期:2003-02-01 00:00:00
abstract::The PEA3/E1AF/ETV4 gene encodes an Ets-related transcription factor that is expressed in the epithelial cells of the mammary gland. Previous reports have shown that PEA3 can up-regulate promoter activities of many genes associated with tumorigenesis. A significant fraction of those encode matrix metalloproteinases (MM...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh024
更新日期:2004-03-01 00:00:00