The expression of placental-type glutathione S-transferase (GST-pi) in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, compared with normal human skin.

abstract：:The human XPBC/ERCC-3 DNA repair gene specifically corrects the repair defect of xeroderma pigmentosum (XP) complementation group B and rodent repair mutant cell lines of group 3. The gene encodes a presumed DNA- and chromatin-binding helicase involved in early steps of the excision repair pathway. To study the evolut...

journal_title：Carcinogenesis

authors： Weeda G,Ma L,van Ham RC,Bootsma D,van der Eb AJ,Hoeijmakers JH

更新日期：1991-12-01 00:00:00

abstract：:The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limi...

journal_title：Carcinogenesis

authors： Sklar R,Brady K,Strauss B

更新日期：1981-01-01 00:00:00

abstract：:Not all carcinogens are mutagens, and many mutagens are not carcinogens. Among related chemicals, small changes of structure can markedly influence carcinogenic potency. Many tumours are genetically unstable, but some, especially 'benign' types, rarely exhibit 'progression' or show other evidence of genetic instabilit...

journal_title：Carcinogenesis

authors： Bignold LP

更新日期：2004-03-01 00:00:00

abstract：:We previously demonstrated that a single dose of gamma-radiation (350 rads) was able to induce thymic lymphomas in C57BL mice when followed by promoting treatment with oral cyclosporine (CsA), a non-genotoxic immunosuppressant. We have now tested the efficacy of various doses of gamma-radiation as an initiator of CsA ...

journal_title：Carcinogenesis

authors： Yabu K,Warty VS,Gorelik E,Shinozuka H

更新日期：1991-01-01 00:00:00

abstract：:Base excision repair pathway may play an important role in repairing DNA damage related to Helicobacter pylori-induced inflammatory process. To evaluate the association between genetic polymorphisms of X-ray repair cross-complementing group 1 (XRCC1, Arg194Trp and Arg399Gln), adenosine diphosphate ribosyl transferase ...

journal_title：Carcinogenesis

authors： Li WQ,Zhang L,Ma JL,Zhang Y,Li JY,Pan KF,You WC

更新日期：2009-03-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved mechanism to protect the cells from unfavorable environmental conditions. Inhibition of autophagy has been contemplated as a novel strategy to enhance anticancer efficacy of existing chemotherapeutic agents. We previously reported that pulsatilla saponin D (PSD) was a potent au...

journal_title：Carcinogenesis

authors： Wang K,Tu Y,Wan JB,Chen M,He C

更新日期：2020-07-10 00:00:00

abstract：:Colorectal cancer is the second leading cause of cancer deaths worldwide with diet playing a prominent role in disease initiation and progression. Flavonoids are secondary plant compounds that are suggested as protective ingredients of a diet rich in fruits and vegetables. We here tested whether flavone, a flavonoid t...

journal_title：Carcinogenesis

authors： Winkelmann I,Diehl D,Oesterle D,Daniel H,Wenzel U

更新日期：2007-07-01 00:00:00

abstract：:Conjugated linoleic acid (CLA) is a class of commercially available fatty acids that have been associated with anticancer properties in rodent models of chemical carcinogenesis. We conducted a pilot study to examine the antitumor effect of dietary CLA in a polyoma virus-middle T antigen (PyMT) mouse model of invasive ...

journal_title：Carcinogenesis

authors： Flowers M,Schroeder JA,Borowsky AD,Besselsen DG,Thomson CA,Pandey R,Thompson PA

更新日期：2010-09-01 00:00:00

abstract：:In this case-control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In individual single nucleotide polymorphis...

journal_title：Carcinogenesis

authors： Pan J,Lin J,Izzo JG,Liu Y,Xing J,Huang M,Ajani JA,Wu X

更新日期：2009-05-01 00:00:00

abstract：:Ultraconserved elements (UCEs) are segments of >200 bp length showing absolute sequence identity between orthologous regions of human, rat and mouse genomes. The selection factors acting on these UCEs are still unknown. Recent studies have shown that UCEs function as long-range enhancers of flanking genes or are invol...

journal_title：Carcinogenesis

authors： Yang R,Frank B,Hemminki K,Bartram CR,Wappenschmidt B,Sutter C,Kiechle M,Bugert P,Schmutzler RK,Arnold N,Weber BH,Niederacher D,Meindl A,Burwinkel B

更新日期：2008-02-01 00:00:00

abstract：:[3H]Benzo[a]pyrene (B[a]P) was administered to male Sprague-Dawley rats via intratracheal instillation, and bile was collected over a period of 6 h. Conjugated metabolites of B[a]P in bile were separated by paper chromatography or reversed-phase ion-pair HPLC and quantified by liquid scintillation spectrometry. In pap...

journal_title：Carcinogenesis

authors： Bevan DR,Sadler VM

更新日期：1992-03-01 00:00:00

abstract：:P-glycoprotein (P-gp) mediates the active transport of various substrates including xenobiotics, and it thus has a protective function in various cell types and tissues/organs including the intestinal epithelium. However, whether or not P-gp plays a positive role in the intestinal tumorigenesis is unclear. We have int...

journal_title：Carcinogenesis

authors： Mochida Y,Taguchi K,Taniguchi S,Tsuneyoshi M,Kuwano H,Tsuzuki T,Kuwano M,Wada M

更新日期：2003-07-01 00:00:00

abstract：:Skin is a major target of carcinogenic trivalent arsenic (arsenite, As3+). It has been thought that cell proliferation is one of the central events involved in the carcinogenic effect of arsenite. Cyclin D1, a nuclear protein playing a pivotal role in cell proliferation and cell cycle transition from G1 to S phases, h...

journal_title：Carcinogenesis

authors： Ouyang W,Li J,Ma Q,Huang C

更新日期：2006-04-01 00:00:00

abstract：:The modifying effects of the phenolic antioxidant catechol (CC) and its analogs hydroquinone (HQ) and resorcinol (RN) on pancreatic carcinogenesis were evaluated in 146 female Syrian golden hamsters. Groups of animals received either saline or 70 mg/kg body wt N-nitrosobis(2-oxopropyl)amine (BOP) s.c. injections, twic...

journal_title：Carcinogenesis

authors： Maruyama H,Amanuma T,Nakae D,Tsutsumi M,Kondo S,Tsujiuchi T,Denda A,Konishi Y

更新日期：1991-07-01 00:00:00

abstract：:Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...

journal_title：Carcinogenesis

authors： Kato T,Ohgaki H,Hasegawa H,Sato S,Takayama S,Sugimura T

更新日期：1988-01-01 00:00:00

abstract：:The objectives of this study were to isolate several rat liver epithelial cell clones containing the human bcl-2 and myc/bcl-2 genes in order to study their potential cooperative effect on neoplastic transformation and gap junction-mediated intercellular communication (GJIC) and to test the hypothesis that the loss of...

journal_title：Carcinogenesis

authors： DeoCampo ND,Wilson MR,Trosko JE

更新日期：2000-08-01 00:00:00

abstract：:Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...

journal_title：Carcinogenesis

authors： Kulkarni PS,Sundqvist K,Betsholtz C,Höglund P,Wiman KG,Zhivotovsky B,Bertolero F,Liu Y,Grafström RC

更新日期：1995-10-01 00:00:00

abstract：:We previously reported that quinacrine (QC) has anticancer activity against breast cancer cells. Here, we examine the mechanism of action of QC and its ability to inhibit Wnt-TCF signaling in two independent breast cancer cell lines. QC altered Wnt-TCF signaling components by increasing the levels of adenomatous polyp...

journal_title：Carcinogenesis

authors： Preet R,Mohapatra P,Das D,Satapathy SR,Choudhuri T,Wyatt MD,Kundu CN

更新日期：2013-02-01 00:00:00

abstract：:To test the hypothesis that polymorphic variants of antioxidant genes modify the risk of pancreatic cancer, we examined seven single-nucleotide polymorphisms (SNPs) of genes coding for superoxide dismutase (SOD) 2, glutathione S-transferase alpha 4 (GSTA4), catalase and glutathione peroxidase in 575 patients with panc...

journal_title：Carcinogenesis

authors： Tang H,Dong X,Day RS,Hassan MM,Li D

更新日期：2010-04-01 00:00:00

abstract：:4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the most abundant and carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke. The major metabolic pathway for NNK is carbonyl reduction to form the (R) and (S) enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) which, like NNK, is...

journal_title：Carcinogenesis

authors： Ashmore JH,Luo S,Watson CJW,Lazarus P

更新日期：2018-07-30 00:00:00

abstract：:The mechanism of inactivation of the O6-methylguanine-DNA methyltransferase (MGMT), responsible for repair of mutagenic and cytotoxic O6-alkylguanine, in Mex- tumor cells, is not completely understood. We have examined the role of CpG methylation in the human MGMT promoter in a luciferase (luc) reporter plasmid and as...

journal_title：Carcinogenesis

authors： Bhakat KK,Mitra S

更新日期：2003-08-01 00:00:00

abstract：:A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...

journal_title：Carcinogenesis

authors： Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

更新日期：1995-08-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:We have investigated the activity of insoluble and soluble lead compounds in inducing mutagenesis, cell transformation and sister chromatid exchange in mammalian cells. Insoluble lead sulfide, readily phagocytized, was more than four times as toxic to V79 cells on a microM basis, than two moderately soluble lead compo...

journal_title：Carcinogenesis

authors： Zelikoff JT,Li JH,Hartwig A,Wang XW,Costa M,Rossman TG

更新日期：1988-10-01 00:00:00

abstract：:The effects of dietary Brussels sprouts and indole-3-carbinol (I3C) on xenobiotic-metabolizing enzyme activities and hepatic aflatoxin B1 (AFB1)-DNA binding were determined in rats. Animals were dosed intraperitoneally (i.p.) or intragastrically (i.g.) with [3H]AFB1 and killed 2 (i.p.) or 3 (i.g.) h later. Brussels sp...

journal_title：Carcinogenesis

authors： Salbe AD,Bjeldanes LF

更新日期：1989-04-01 00:00:00

abstract：:A growing number of studies indicate a link between oxidative stress and cancer. We previously developed a rat model of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Here, we performed a genome-wide analysis to study characteristics of genomic alteration and identify putative genes involved ...

journal_title：Carcinogenesis

authors： Zhong Y,Onuki J,Yamasaki T,Ogawa O,Akatsuka S,Toyokuni S

更新日期：2009-01-01 00:00:00

abstract：:In order to study the mechanism of cancer production by aflatoxin B1 (AFB1) in extrahepatic tissues which have relatively low cytochrome P450 monooxygenase (P450) activity, we have examined prostaglandin H synthase (PHS)-mediated AFB1 activation [( 3H]AFB1-DNA binding). [3H]AFB1 was activated by both purified PHS and ...

journal_title：Carcinogenesis

authors： Liu L,Daniels JM,Stewart RK,Massey TE

更新日期：1990-11-01 00:00:00

abstract：:Epidemiological studies have suggested that frequent olive oil consumption may be a protective factor against lung cancer formation. Squalene, a characteristic compound in olive oil, is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and has been proposed to inhibit the farnesylation of ras on...

journal_title：Carcinogenesis

authors： Smith TJ,Yang GY,Seril DN,Liao J,Kim S

更新日期：1998-04-01 00:00:00

abstract：:Chrysoidine dyes are used by fishermen to colour bait and recent epidemiological evidence has suggested that this may explain why they are at increased risk of urothelial cancer. In recent years Bismark brown dyes have been used as chrysoidine substitutes. Previous mutagenicity studies on these azo-dyes have examined ...

journal_title：Carcinogenesis

authors： Sole GM,Chipman JK

更新日期：1986-11-01 00:00:00

abstract：:Procarbazine hydrochloride (PCZ), a chemotherapeutic agent used extensively to treat Hodgkins disease and other tumors, induces leukemia, lymphoma, mammary gland and other solid tumors in rodents and non-human primates and is strongly implicated as a leukemogen in humans. Lipotrope (choline and methionine) deficiency ...

journal_title：Carcinogenesis

authors： Rogers AE,Akhtar R,Zeisel SH

更新日期：1990-09-01 00:00:00