Abstract:
:Chrysoidine dyes are used by fishermen to colour bait and recent epidemiological evidence has suggested that this may explain why they are at increased risk of urothelial cancer. In recent years Bismark brown dyes have been used as chrysoidine substitutes. Previous mutagenicity studies on these azo-dyes have examined only one variety of dye and used only one type of activating enzyme. In this study six samples of chrysoidine and three samples of Bismark brown dye have been obtained from chemical suppliers and from angling sources. They have been analysed by n.m.r. spectroscopy to determine whether they contain ring methyl groups. The mutagenic potency of each dye has been assessed by the Salmonella typhimurium/mammalian microsomal mutagenicity assay utilizing the TA100 and TA98 stains. Those dyes with methyl substitutions have been found to be more potent mutagens than their non-methylated counterparts using either human or rat metabolic preparations and irrespective of whether the enzymes have been induced with phenobarbitone.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Sole GM,Chipman JKdoi
10.1093/carcin/7.11.1921subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1921-3issue
11eissn
0143-3334issn
1460-2180journal_volume
7pub_type
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