Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women.

abstract：:The epidermal growth factor receptor (EGFR) pathway has recently been appreciated as a central mediator of tumorigenesis and an important drug target; however, the influence of genetic variation in this pathway on bladder cancer is not understood. Pathway activation leads to cell proliferation, angiogenesis and is ant...

journal_title：Carcinogenesis

authors： Mason RA,Morlock EV,Karagas MR,Kelsey KT,Marsit CJ,Schned AR,Andrew AS

更新日期：2009-07-01 00:00:00

abstract：:Naturally occurring allyl isothiocyanate (AITC) was recently shown to be selectively delivered to bladder cancer tissue via urinary excretion and to inhibit bladder cancer growth and muscle invasion in an animal model. AITC is excreted in urine mainly as N-acetyl-S-(N-allylthiocarbamoyl)cysteine, more commonly known a...

journal_title：Carcinogenesis

authors： Bhattacharya A,Li Y,Geng F,Munday R,Zhang Y

更新日期：2012-02-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mammary gland carcinogen present in the human diet. Herein, the expression of estrogen receptor alpha (ERalpha), estrogen receptor beta (ER beta) and progesterone receptor (PR) was examined in mammary gland carcinomas induced by PhIP in female Sprague-Dawley ...

journal_title：Carcinogenesis

authors： Qiu C,Shan L,Yu M,Snyderwine EG

更新日期：2005-04-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), which is due to mutations in the ATM gene, is a rare autosomal recessive genomic instability syndrome characterized by radiosensitivity and predisposition to cancer. Epidemiological studies have suggested that relatives of A-T patients (A-T carriers) have increased risks of developing brea...

journal_title：Carcinogenesis

authors： Lu S,Shen K,Wang Y,Santner SJ,Chen J,Brooks SC,Wang YA

更新日期：2006-04-01 00:00:00

abstract：:In order to test the controversially discussed hypothesis that oval cells are part of a liver stem cell compartment and can give rise to cholangiocellular as well as hepatocellular carcinomas in the course of liver carcinogenesis, we transfected an oval cell line established in our laboratory with an oncogenically act...

journal_title：Carcinogenesis

authors： Becker R,Lüthgens B,Oesch F,Dienes HP,Steinberg P

更新日期：1996-12-01 00:00:00

abstract：:We have investigated the effect of the soybean isoflavone genistein on 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in calf thymus DNA exposed to either UV irradiation or the Fenton reaction system. Under the conditions used we observed that UV light and the Fenton reaction significantly increase 8-OHdG formation in...

journal_title：Carcinogenesis

authors： Wei H,Cai Q,Rahn RO

更新日期：1996-01-01 00:00:00

abstract：:Rat hepatocytes maintained for up to 6 days in primary culture were used to test a variety of xenobiotics and steroids for effects on the activity of gamma-glutamyltranspeptidase (GGT) in normal cells. In control cultures GGT activity was low and increased slowly with time. When added to cultures for 5 days, a variety...

journal_title：Carcinogenesis

authors： Edwards AM,Lucas CM

更新日期：1985-05-01 00:00:00

abstract：:17beta-estradiol (E2), estrone and diethylstilbestrol (DES) had no effect on nuclear and nucleolar RNA synthesis in vitro. However, after reacting with dimethyldioxirane (DMDO), a versatile epoxide-forming oxidant, these estrogens were able to inhibit and in a dose-dependent manner nuclear and nucleolar RNA synthesis ...

journal_title：Carcinogenesis

authors： Yu FL,Bender W

更新日期：1996-09-01 00:00:00

abstract：:To determine whether B or T lymphoid malignancies could be induced following the exposure of lymphoid cells within different lymphoid organs to a potential chemical carcinogen, 3-methylcholanthrene (3-MC) was directly injected into surgically exposed Peyer's patches (PP), mesenteric lymph nodes (MLN), axillary lymph n...

journal_title：Carcinogenesis

authors： Bost KL,Garrett LR,Cuchens MA

更新日期：1986-08-01 00:00:00

abstract：:It is widely believed that abnormal production of polypeptide growth factors, together with other molecular alterations, play an important role in neoplastic development. Transforming growth factor alpha (TGFalpha), hepatocyte growth factor (HGF) and acidic fibroblast growth factor (aFGF) are the three major growth fa...

journal_title：Carcinogenesis

authors： Hu Z,Evarts RP,Fujio K,Omori N,Omori M,Marsden ER,Thorgeirsson SS

更新日期：1996-05-01 00:00:00

abstract：:Antimutagenic effects of a novel lipophilic antioxidant, 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), and other known antioxidants against heterocyclic amine- or other mutagen-induced mutagenesis were examined in the Ames assay using Salmonella strain TA 98 to access the chemo-preventive effects of antioxidants on he...

journal_title：Carcinogenesis

authors： Hirose M,Iwata S,Ito E,Nihro Y,Takahashi S,Mizoguchi Y,Miki T,Satoh T,Ito N,Shirai T

更新日期：1995-09-01 00:00:00

abstract：:The reaction of deoxyadenosine with beta-propiolactone produces two derivatives. One is 1-(2-carboxyethyl)-2'-deoxyadenosine (CEdA) first described by Maté, et al. The proposed structure for the other is 3-(beta-D-2-deoxyribosyl)-7,8-dihydropyrimido-[2,l-i]purine-9-one (dDPP). Spectral characteristics of both compound...

journal_title：Carcinogenesis

authors： Chen R,Mieyal JJ,Goldthwait DA

更新日期：1981-01-01 00:00:00

abstract：:Eukaryotic 3'-end formation is a critical step for mRNA maturation and involves a requisite cleavage and polyadenylation event downstream of a polyadenylation signal. Recent discoveries suggest that in nearly 70% of human genes, cleavage and polyadenylation can occur at multiple locations through a process known as al...

journal_title：Carcinogenesis

authors： Masamha CP,Wagner EJ

更新日期：2018-01-12 00:00:00

abstract：:Gap junctions are composed of protein subunits, called connexins, and provide a pathway for the exchange of ions and small molecules between contacting cells. This transfer of molecules is thought to be an important pathway for direct cell communication, and is involved in tissue homeostasis, growth control and embryo...

journal_title：Carcinogenesis

authors： Evert M,Ott T,Temme A,Willecke K,Dombrowski F

更新日期：2002-05-01 00:00:00

abstract：:An increased neuroendocrine (NE) cell population in prostate cancer is associated with more aggressive disease and recurrence after androgen-deprivation therapy, although the mechanism responsible is unknown. In this study, we report that the treatment of LNCaP cells with epidermal growth factor (EGF) in the presence ...

journal_title：Carcinogenesis

authors： Cortés MA,Cariaga-Martinez AE,Lobo MV,Martín Orozco RM,Motiño O,Rodríguez-Ubreva FJ,Angulo J,López-Ruiz P,Colás B

更新日期：2012-06-01 00:00:00

abstract：:Grainyhead-like 2 (GRHL2) is one of the three mammalian homologues of Drosophila Grainyhead involved in epithelial morphogenesis. We recently showed that GRHL2 also controls normal epithelial cell proliferation and differentiation. In this study, we investigated the role of GRHL2 in oral carcinogenesis and the underly...

journal_title：Carcinogenesis

authors： Chen W,Yi JK,Shimane T,Mehrazarin S,Lin YL,Shin KH,Kim RH,Park NH,Kang MK

更新日期：2016-05-01 00:00:00

abstract：:Polyphenols have shown promising bioactivity in experimental in vitro and in vivo models for cancer chemoprevention. However, consumed orally, they are often transformed by gut microbes into new active principles with so far incompletely deciphered molecular mechanisms. Here, enterolacton, S-equol and urolithin A as r...

journal_title：Carcinogenesis

authors： Norden E,Heiss EH

更新日期：2019-03-12 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...

journal_title：Carcinogenesis

authors： Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

更新日期：1995-02-01 00:00:00

abstract：:MicroRNA deregulation and pathway alterations have been implicated in nasopharyngeal carcinoma (NPC), a highly invasive and metastatic cancer widely prevalent in Southern China. In this study, we report that miR-9 is commonly downregulated in NPC specimens and NPC cell lines with important functional consequences. The...

journal_title：Carcinogenesis

authors： Lu J,Luo H,Liu X,Peng Y,Zhang B,Wang L,Xu X,Peng X,Li G,Tian W,He ML,Kung H,Li XP

更新日期：2014-03-01 00:00:00

abstract：:Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...

journal_title：Carcinogenesis

authors： Visser A,Westra JG

更新日期：1981-01-01 00:00:00

abstract：:The addition of supplementary cytosolic fraction greatly enhances the activation of 2-acetylaminofluorene (AAF) by uninduced 9,000 x g supernatant fractions (S9) in the Ames test. Uninduced S9 is poor at activating AAF in the Ames test (although it is effective in the liquid based fluctuation test) probably because cy...

journal_title：Carcinogenesis

authors： Forster R,Green MH,Priestley A

更新日期：1981-01-01 00:00:00

abstract：:Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...

journal_title：Carcinogenesis

authors： Eckl PM,Meyer SA,Whitcombe WR,Jirtle RL

更新日期：1988-03-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:Resveratrol has elicited many provocative anticancer effects in laboratory animals and cultured cells, including reduced levels of oxidative DNA damage, inhibition of tumor initiation and progression and induction of apoptosis in tumor cells. Use of resveratrol as a cancer-preventive agent in humans will require that ...

journal_title：Carcinogenesis

authors： Denissova NG,Nasello CM,Yeung PL,Tischfield JA,Brenneman MA

更新日期：2012-01-01 00:00:00

abstract：:Semi-permeable magnetic polyethyleneimine (PEI) microcapsules have been developed to trap carcinogens and their metabolites in vivo and their time-dependent binding of a model carcinogen, [14C]benzo[a]pyrene [( 14C]BaP), is studied within the intestinal lumen. Overall, approximately 0.5% of an intragastric BaP dose wa...

journal_title：Carcinogenesis

authors： Povey AC,Brouet I,Bartsch H,O'Neill IK

更新日期：1987-06-01 00:00:00

abstract：:Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to study carcinogenesis. Therefore, if Cop rats are resistant to hepatocar...

journal_title：Carcinogenesis

authors： Wood GA,Korkola JE,Lee VM,Sarma DS,Archer MC

更新日期：1997-09-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Carnosol is a naturally occurring phytopolyphenol found in rosemary. Carnosol functions as antioxidant and anticarcinogen. In the present study, we compared the antioxidant activity of carnosol and other compounds extracted from rosemary. Carnosol showed potent antioxidative activity in alpha,alpha-diphenyl-beta-picry...

journal_title：Carcinogenesis

authors： Lo AH,Liang YC,Lin-Shiau SY,Ho CT,Lin JK

更新日期：2002-06-01 00:00:00

abstract：:We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...

journal_title：Carcinogenesis

authors： Ireland CM,Eastman A,Bresnick E

更新日期：1984-02-01 00:00:00

abstract：:2-3H-Labelled 4-acetoxyaminoquinoline-1-oxide (Ac-4 HAQO), the ultimate carcinogen model of 4-nitroquinoline-1-oxide, was reacted in vitro with native and denatured DNA. We found that Ac-4 HAQO is 2- to 3-fold more reactive than diAc-4 HAQO, another ultimate carcinogen model of 4 NQO which was previously studied [Gali...

journal_title：Carcinogenesis

authors： Galiègue-Zouitina S,Bailleul B,Loucheux-Lefebvre MH

更新日期：1983-01-01 00:00:00