Induction of gamma-glutamyl transpeptidase in primary cultures of normal rat hepatocytes by liver tumor promoters and structurally related compounds.

abstract：:To compare mutagenesis by O6-methylguanine (m6G), O4-methylthymine (m4T) and O6-ethylguanine (e6G), and assess their genotoxicity in Escherichia coli, double-stranded and gapped plasmids were constructed containing a single m6G, e6G or m4T in the initiation codon (ATG) of a lacZ' gene. Modified base induced mutations ...

journal_title：Carcinogenesis

authors： Pauly GT,Hughes SH,Moschel RC

更新日期：1998-03-01 00:00:00

abstract：:Prior work has demonstrated that food restriction of mice markedly suppresses 12-O-tetradecanoylphorbol-13-acetate (TPA) promotion of skin papillomas and adrenalectomy prior to initiating food restriction completely reverses the tumor inhibitory effect of underfeeding. In the present experiment the effect of food rest...

journal_title：Carcinogenesis

authors： Pashko LL,Schwartz AG

更新日期：1996-02-01 00:00:00

abstract：:The antihistamine methapyrilene (hydrochloride) and four close structural analogs, methaphenilene, methafurylene, thenyldiamine and clorothen, were given to rats at a concentration of 0.1% in drinking water for 34 weeks. Only methapyrilene produced notable histopathological changes in the liver, bile duct hyperplasia ...

journal_title：Carcinogenesis

authors： Hernandez L,Allen PT,Poirier LA,Lijinsky W

更新日期：1989-03-01 00:00:00

abstract：:We have compared liver, kidney and colon DNA damage, as single strand breaks, in mice with different strain-dependent susceptibility to the colon-specific carcinogen 1,2-dimethylhydrazine (DMH). The mouse strains studied were: AKR/J, DBA2 totally resistant; CD1, C57BL/6N moderately susceptible; SWR/J very susceptible ...

journal_title：Carcinogenesis

authors： Bolognesi C,Mariani MR,Boffa LC

更新日期：1988-08-01 00:00:00

abstract：:In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...

journal_title：Carcinogenesis

authors： van den Goorbergh JA,de Wit H,Tijdens RB,Mulder GJ,Meerman JH

更新日期：1987-02-01 00:00:00

abstract：:Rats received a choline-deficient diet containing 0.1% (w/w) DL-ethionine (CDE) for 4, 10, 14 or 22 weeks. A separate group was treated for 4 weeks with CDE and then received a normal diet for 4 weeks. The L and M2 isoenzymes of pyruvate kinase were immunocytochemically demonstrated in liver sections. L-PK expression ...

journal_title：Carcinogenesis

authors： Hacker HJ,Steinberg P,Bannasch P

更新日期：1998-01-01 00:00:00

abstract：:The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background pa...

journal_title：Carcinogenesis

authors： Tsuda H,Moore MA,Asamoto M,Inoue T,Ito N,Satoh K,Ichihara A,Nakamura T,Amelizad Z,Oesch F

更新日期：1988-04-01 00:00:00

abstract：:We have established a protocol that allows qualitative and quantitative determination of butadiene monoepoxide-DNA adducts formed as a result of inhalation exposure to 1,3-butadiene. We observed that in this particular case in vivo samples required extensive sample purification to facilitate a low background. Sample p...

journal_title：Carcinogenesis

authors： Koivisto P,Sorsa M,Pacchierotti F,Peltonen K

更新日期：1997-02-01 00:00:00

abstract：:N-Acetoxyarylamines are reactive metabolites that lead to arylamine adduct formation with biological macromolecules. A series of 7-substituted-N-hydroxy-2-acetylaminofluorenes were converted to reactive N-acetoxyarylamines by enzymatic N,O-acyltransfer in the presence of DNA. The N-arylhydroxamic acid substrates that ...

journal_title：Carcinogenesis

authors： Boteju LW,Hanna PE

更新日期：1993-08-01 00:00:00

abstract：:S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...

journal_title：Carcinogenesis

authors： Simile MM,Saviozzi M,De Miglio MR,Muroni MR,Nufris A,Pascale RM,Malvaldi G,Feo F

更新日期：1996-07-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that are involved in different biological processes by suppressing target gene expression. Altered expression of miR-30a-5p has been reported in colon carcinoma. To elucidate its potential biological role in colon cancer, miR-30a-5p was overexpressed via a lentiviral vector...

journal_title：Carcinogenesis

authors： Baraniskin A,Birkenkamp-Demtroder K,Maghnouj A,Zöllner H,Munding J,Klein-Scory S,Reinacher-Schick A,Schwarte-Waldhoff I,Schmiegel W,Hahn SA

更新日期：2012-04-01 00:00:00

abstract：:We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...

journal_title：Carcinogenesis

authors： Knudsen LE,Ryder LP,Wassermann K

更新日期：1992-07-01 00:00:00

abstract：:The mechanism(s) of tumour promotion in liver by estrogens is not well understood although growth stimulation is known to be one important element of their action. As a basis for studying mechanisms of growth control by estrogens, effects of both natural and synthetic estrogens on DNA synthesis and protooncogene c-fos...

journal_title：Carcinogenesis

authors： Lee CH,Edwards AM

更新日期：2001-09-01 00:00:00

abstract：:O6-Methylguanine (O6MeGua) is generally regarded as the most important premutagenic lesion formed from carcinogenic methylating agents, so its structure and mechanism of action have received considerable attention. Two conformations for the methyl group in O6MeGua are possible: in one the methyl group is syn with resp...

journal_title：Carcinogenesis

authors： Loechler EL

更新日期：1991-09-01 00:00:00

abstract：:IARC Monographs are globally-recognized assessments of carcinogenicity published by International Agency for Research on Cancer and directed to national authorities as a contribution to public health. Currently, though not constraining the scope of studies examined, Monographs are declared to involve only hazard ident...

journal_title：Carcinogenesis

authors： Stewart BW

更新日期：2020-12-01 00:00:00

abstract：:The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limi...

journal_title：Carcinogenesis

authors： Sklar R,Brady K,Strauss B

更新日期：1981-01-01 00:00:00

abstract：:Although the alternative splicing of various genes is a common event in human tumors, the mechanisms behind it have not been characterized. We hypothesized that the expression of splicing regulatory factors would be changed during cellular transformation. Gene expression of three splicing regulatory factors, alternati...

journal_title：Carcinogenesis

authors： Maeda T,Hiranuma H,Jikko A

更新日期：1999-12-01 00:00:00

abstract：:Sphingadienes (SDs) derived from soy and other natural sphingolipids are cytotoxic to colon cancer cells via an Akt-dependent mechanism and reduce adenoma formation in Apc(Min/+) mice. Wnt signaling is fundamental to colon carcinogenesis and is the basis for spontaneous tumorigenesis in Apc(Min/+) mice and patients wi...

journal_title：Carcinogenesis

authors： Kumar A,Pandurangan AK,Lu F,Fyrst H,Zhang M,Byun HS,Bittman R,Saba JD

更新日期：2012-09-01 00:00:00

abstract：:Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...

journal_title：Carcinogenesis

authors： Degen GH,Metzler M,Sivarajah KS

更新日期：1986-01-01 00:00:00

abstract：:The regulation of growth hormone 1 (GH1) and insulin-like-growth factor-1 (IGF-1) release is under the influence of three pituitary hormones [growth hormone releasing hormone (GHRH), ghrelin (GHRL) and somatostatin (SST)], which act in an autocrine/paracrine fashion in the breast. By binding to their respective recept...

journal_title：Carcinogenesis

authors： Wagner K,Hemminki K,Grzybowska E,Klaes R,Burwinkel B,Bugert P,Schmutzler RK,Wappenschmidt B,Butkiewicz D,Pamula J,Pekala W,Försti A

更新日期：2006-09-01 00:00:00

abstract：:Oncogenic pathogens can disturb tissue homeostasis and initiate immune responses for oncogenicity clearance and homeostasis restoration, while failed clearance and chronic inflammation may result in tumorigenesis. The primary tumor development will undergo a cancer immunoediting process, including three phases, termed...

journal_title：Carcinogenesis

authors： Tao Y,Shen H,Liu Y,Li G,Huang Z,Liu Y

更新日期：2020-06-12 00:00:00

abstract：:A growing number of studies indicate a link between oxidative stress and cancer. We previously developed a rat model of renal cell carcinoma (RCC) induced by ferric nitrilotriacetate (Fe-NTA). Here, we performed a genome-wide analysis to study characteristics of genomic alteration and identify putative genes involved ...

journal_title：Carcinogenesis

authors： Zhong Y,Onuki J,Yamasaki T,Ogawa O,Akatsuka S,Toyokuni S

更新日期：2009-01-01 00:00:00

abstract：:The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...

journal_title：Carcinogenesis

authors： Liu Q,Chan ST,Mahendran R

更新日期：2003-04-01 00:00:00

abstract：:We have measured the levels of thymine glycol (TG) and thymidine glycol (dTG) in human urine, using an HPLC method. The results show that all 30 specimens examined (including 10 non-neoplastic and 20 neoplastic human urines) contained significant amounts of TG and dTG, average levels (mean +/- SEM) were 0.376 +/- 0.02...

journal_title：Carcinogenesis

authors： Cao EH,Wang JJ

更新日期：1993-07-01 00:00:00

abstract：:The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis of the frequency of sister chromatid exchanges (SCEs) induced by DEB in whol...

journal_title：Carcinogenesis

authors： Norppa H,Hirvonen A,Järventaus H,Uusküla M,Tasa G,Ojajärvi A,Sorsa M

更新日期：1995-06-01 00:00:00

abstract：:In this report we describe results showing that both arachidonic acid (20:4) release and prostaglandin (PG) synthesis in herpes simplex virus type 2 (HSV-2)-transformed tumor-derived rat fibrosarcoma (RFS) cells are inhibited by indomethacin (cyclooxygenase inhibitor). These data suggest that cyclooxygenase (prostagla...

journal_title：Carcinogenesis

authors： Heitman CR,Waite M,Kucera LS

更新日期：1989-11-01 00:00:00

abstract：:The rat liver 9000 g supernatant mediated metabolism of the carcinogenic aristolochic acid, which consists of aristolochic acid I (AAI) and aristolochic acid II (AAII), was investigated. Under anaerobic conditions the major metabolites were the corresponding aristolactams for both AAI and AAII. In contrast under aerob...

journal_title：Carcinogenesis

authors： Schmeiser HH,Pool BL,Wiessler M

更新日期：1986-01-01 00:00:00

abstract：:Epidemiological evidence suggests that the presence of human papillomaviruses (HPV), when combined with smoking behaviors, considerably enhances the risk of developing oral, cervical, vulvar, and/or anal carcinomas. It is well established that the cytochrome P450 (CYP), microsomal epoxide hydrolase (mEH), and other bi...

journal_title：Carcinogenesis

authors： Farin FM,Bigler LG,Oda D,McDougall JK,Omiecinski CJ

更新日期：1995-06-01 00:00:00

abstract：:O6-Methylguanine-DNA methyltransferase (O6-MT) has been described as a DNA repair enzyme that reverses alkylation damage at the O6 position of guanine in DNA. We demonstrate that the concentration of this protein decreases immediately prior to DNA synthesis in cultured chick hepatocytes. If intracellular levels are ex...

journal_title：Carcinogenesis

authors： Dutta-Choudhury TA,Couri D,Stephens RE

更新日期：1992-01-01 00:00:00

abstract：:In order to determine the nature of the cytotoxic lesion(s) formed by the antitumour drugs cisplatin and carboplatin, a comparative study was made of bifunctional DNA-adduct formation by these drugs. The kinetics of bifunctional cisplatin adduct formation were studied with DNA in vitro and in cultured Chinese hamster ...

journal_title：Carcinogenesis

authors： Fichtinger-Schepman AM,van Dijk-Knijnenburg HC,van der Velde-Visser SD,Berends F,Baan RA

更新日期：1995-10-01 00:00:00