Abstract:
:The Raji human lymphoma line is able to remove O6-methylguanine (O6MeG) lesions introduced by treatment of cells with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The reaction has a rapid phase in which approximately 40% of the O6MeG is removed in the first 10 min. The capacity of cells for rapid O6MeG removal is limited and is saturated at concentrations of MNNG which do not saturate the systems removing 3-methyladenine. Pretreatment of cells with MNNG inhibits their ability to remove O6MeG produced by a subsequent dose given after 2 h. Treatment with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) is effective in diminishing cellular capacity for O6MeG removal, and cells unable to remove O6MeG and sensitive to the cytotoxic effects of MNNG are also more sensitive to ENNG than their removal competent counterparts. Regeneration of the ability to remove O6MeG requires incubation of cells for periods greater than 24 h. The O6MeG removal system is similar to that found in adapted Escherichia coli although the capacity of the Raji lymphoma line much lower than that of the induced bacteria per unit of DNA.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Sklar R,Brady K,Strauss Bdoi
10.1093/carcin/2.12.1293subject
Has Abstractpub_date
1981-01-01 00:00:00pages
1293-8issue
12eissn
0143-3334issn
1460-2180journal_volume
2pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::The phosphoinositide 3-kinase (PI 3-kinase) signaling pathway has been shown to play a pivotal role in intracellular signal transduction pathways involved in cell growth, cellular transformation and tumorigenesis. Analysis of several colon adenocarcinoma cell lines indicates that the PI 3-kinase signaling pathway is u...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg195
更新日期:2004-02-01 00:00:00
abstract::Liver DNA, obtained at various time intervals from rats chronically fed a choline-devoid diet, was analysed for the presence of aromatic or alkyl adducts by the 32P-postlabeling assay. Alkyl adducts were not detected. Aromatic DNA adduct lesions were revealed, but only at levels (1 adduct per 0.5-3 X 10(9) nucleotides...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.1.187
更新日期:1987-01-01 00:00:00
abstract::The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg014
更新日期:2003-04-01 00:00:00
abstract::Recent studies have examined and demonstrated the potential cancer chemopreventive activity of freeze-dried berries including strawberries and black raspberries. Although ellagic acid, an abundant component in these berries, has been shown to inhibit carcinogenesis both in vivo and in vitro, several studies have repor...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/22.2.351
更新日期:2001-02-01 00:00:00
abstract::The effect of glucose on the formation of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) was studied in a model system. When a mixture of creatine (0.9 mmol), phenylalanine (0.9 mmol) and glucose (0.45 mmol) was heated in diethylene glycol and water (3 ml, 5:1) for 10 min at 180 or 225 degrees...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.12.2297
更新日期:1991-12-01 00:00:00
abstract::Many chemoradiation therapies cause DNA damage through oxidative stress. An important cellular mechanism that protects cells against oxidative stress involves DNA repair. One of the primary DNA repair mechanisms for oxidative DNA damage is base excision repair (BER). BER involves the tightly coordinated function of fo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm072
更新日期:2007-08-01 00:00:00
abstract::Syrian hamster embryo cells were treated with crocidolite asbestos at a dose (1 microgram/cm2) which was shown in previous studies to induce cell transformation and aneuploidy in these cells. Treatment of cells with asbestos induced a greater than 20-fold increase in the incidence of cells in anaphase with abnormaliti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.3.473
更新日期:1985-03-01 00:00:00
abstract::raf oncogenes have been implicated in hepatic carcinogenesis. We studied the effects of the v-raf of murine retrovirus 3611-MSV on the growth and differentiation of a simian virus 40 (SV40)-immortalized rat liver cell line (ALB-8) which maintained many of characteristics of differentiated hepatocytes. Cells were co-tr...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.4.669
更新日期:1993-04-01 00:00:00
abstract::Disulfiram (DSF) can considerably alter the organotropy of chemical carcinogens. For N-nitrosodimethylamine and for N-nitrosodiethylamine the organotropy is shifted from the liver to the nasal cavity or the oesophagus, respectively. Whereas the influence of DSF or its metabolites on enzyme systems has been studied, li...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/3.5.563
更新日期:1982-01-01 00:00:00
abstract::In order to detect any protective agent against tumor formation, we examined the anti-tumor-promoting effect of a Japanese traditional soybean fermented food, Natto. Dye transfer was employed as an assay method. When fluorescent dye was microinjected into cultured BALB/3T3 cells, the dye was transformed into the neigh...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.3.471
更新日期:1995-03-01 00:00:00
abstract::3,4-Epoxy-1-butene (EB) is the major mutagenic metabolite of butadiene (BD), an important industrial chemical classified as a probable human carcinogen. Although the mechanism of carcinogenicity of EB is not known, its reactions with nucleophilic sites of DNA giving pro-mutagenic lesions are likely to constitute the e...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.1.137
更新日期:1997-01-01 00:00:00
abstract::Cryptic deletions at chromosome 6q are common cytogenetic abnormalities in T-cell lymphoblastic leukemia/lymphoma (T-LBL), but the target genes have not been formally identified. Our results build on detection of specific chromosomal losses in a mouse model of γ-radiation-induced T-LBLs and provide interesting clues f...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr271
更新日期:2012-02-01 00:00:00
abstract::Resveratrol is a naturally occurring trihydroxyl-diphenylethylene compound that has been shown experimentally to have beneficial effects in the treatment of cancer and cardiovascular disease. Resveratrol induces programmed cell death (apoptosis) in these cells and activates important signal transducing proteins includ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq212
更新日期:2011-01-01 00:00:00
abstract::The dose and time dependence of the cellular phenotype in preneoplastic and neoplastic liver lesions was evaluated quantitatively in groups of male Sprague-Dawley rats exposed for 7 weeks to 0, 12 and 24 mg/kg body wt of N-nitrosomorpholine (NNM) and studied at different time points up to 80 weeks after withdrawal of ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.6.1227
更新日期:1994-06-01 00:00:00
abstract::Reactive oxygen species (ROS) have been implicated in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance of many cancers. We evaluated the role of peroxiredoxin (Prx) I in TRAIL resistance governed by coupling of nicotinamide adenosine dinucleotide phosphate oxidase (Nox)-derived ROS signaling ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp104
更新日期:2009-07-01 00:00:00
abstract::The ability to repair damaged DNA was determined in different cell populations of rabbit lung cells isolated by centrifugal elutriation. DNA excision repair, measured as unscheduled DNA synthesis, was examined in in vitro confluent primary cultures. A dose dependent level of DNA excision repair was observed in alveola...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.4.661
更新日期:1985-04-01 00:00:00
abstract::We have explored the induction of DNA repair synthesis in monocyte/B- and T-lymphocyte enriched cell fractions from 12 different human mononuclear blood cell populations. Unscheduled DNA synthesis was measured in monocyte/B- and T-cells after exposure to the DNA-damaging agents dimethylsulfate (DMS) and N-acetoxy-N-ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/13.7.1285
更新日期:1992-07-01 00:00:00
abstract::Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...
journal_title:Carcinogenesis
pub_type: 杂志文章,评审
doi:10.1093/carcin/bgx067
更新日期:2017-09-01 00:00:00
abstract::Soy-based products consumed in Asian countries are minimally processed whereas in the USA many of the soy foods and soy ingredients are highly processed. Soy foods contain complex mixtures of bioactive compounds, which may interact with one another. The objective of this study was to evaluate the ability of various so...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgh178
更新日期:2004-09-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a significant risk factor for lung cancer. One potential mechanism through which COPD contributes to lung cancer development could be through generation of an immunosuppressive microenvironment that allows tumor formation and progression. In this study, we compared the s...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgaa059
更新日期:2020-11-13 00:00:00
abstract::The pulmonary adenoma susceptibility 1 (Pas1) gene affects susceptibility to the development of lung adenomas in mice with a subset of the adenomas progressing to adenocarcinoma (ADC). In this study, genotype distributions for 10 polymorphisms in the human counterparts for three mouse candidate Pas1 genes, KRAS, CASC1...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn048
更新日期:2008-05-01 00:00:00
abstract::Epidemiological evidence suggests a link between meat consumption and prostate cancer. In this study, benign prostatic hyperplasia tissues, obtained by transurethral resection or radical retropubic prostatectomy from UK-resident individuals (n = 18), were examined for CYP1 expression and for their ability, in short-te...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/21.9.1683
更新日期:2000-09-01 00:00:00
abstract::Serum-free cultures of normal human buccal epithelial cells were transfected with a plasmid containing the SV40 T-antigen (SV40T) gene. Two major lines developed that showed extended lifespans (between 30 and 40 weeks) as compared with the controls (approximately 6 weeks). Continued growth through one or two crises ge...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.10.2515
更新日期:1995-10-01 00:00:00
abstract::The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite of 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis of the frequency of sister chromatid exchanges (SCEs) induced by DEB in whol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.6.1261
更新日期:1995-06-01 00:00:00
abstract::Treatment of murine Swiss 3T3 fibroblasts and XB/2 keratinocytes with UV-B light (302 nm) resulted in a dose-dependent inhibition of [125I]epidermal growth factor (EGF) binding. The light dose required to achieve 50% inhibition of binding in both cell types was 80-85 J/m2. Decreased [125I]platelet-derived growth facto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/11.7.1223
更新日期:1990-07-01 00:00:00
abstract::N2-ethylidene-2'-deoxyguanosine (N2-ethylidene-dG) is a major DNA adduct induced by acetaldehyde. Although it is unstable in the nucleoside form, it is relatively stable when present in DNA. In this study, we analyzed three acetaldehyde-derived DNA adducts, N2-ethylidene-dG, N2-ethyl-2'-deoxyguanosine (N2-Et-dG) and a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm057
更新日期:2007-11-01 00:00:00
abstract::The Tsc-2 tumor suppressor gene encodes the protein tuberin, a multi-functional protein with sequence homology to the GTPase activating protein (GAP) for Rap1. Mutations in the Tsc-2 gene are associated with the development of renal tumors. The Eker rat (Tsc-2(EK/+)) bears a mutation in one allele of the Tsc-2 gene, w...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/24.3.573
更新日期:2003-03-01 00:00:00
abstract::The present study was aimed at verifying the occurrence, if any, of in vivo oxidative DNA damage in FA homozygotes, their parents and siblings. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured, by HPLC/EC, in DNA from circulating blood leucocytes from FA homozygotes and their relatives and compared with a group of pa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/16.4.735
更新日期:1995-04-01 00:00:00
abstract::Estrogens are major risk factors for the development of breast cancer; they can be metabolized to catechols, which are further oxidized to DNA-reactive quinones and semiquinones (SQs). These metabolites are mutagenic and may contribute to the carcinogenic activity of estrogens. Redox cycling of the SQs and subsequent ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgr109
更新日期:2011-08-01 00:00:00
abstract::Integrins control the cell attachment to the extracellular matrix and play an important role in mediating cell proliferation, migration and survival. A number of important cancer-associated integrin genes can be regulated by microRNAs (miRNAs) that bind to their target sites in the 3' untranslated regions. We examined...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgn126
更新日期:2008-07-01 00:00:00