Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamine-initiated rats.

abstract：:Eight different forms of cytochrome P-450 have been isolated from the liver microsomes of male Sprague-Dawley rats and compared with previously characterized forms on the basis of chromatographic behavior, absorption maximum of the carbon monooxide complex, apparent molecular weight upon SDS-disc gel electrophoresis, ...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW

更新日期：1985-01-01 00:00:00

abstract：:The effect of the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was studied using an immortalized human bronchial epithelial cell line, BEAS-2B, both in vivo and in vitro. The in vivo model consisted of tracheas reconstituted with an epithelium of BEAS-2B cells xenotransplanted into athymic nude mice. Int...

journal_title：Carcinogenesis

authors： Bonfil RD,Momiki S,Fridman R,Reich R,Reddel R,Harris CC,Klein-Szanto A

更新日期：1989-12-01 00:00:00

abstract：:Teflon tubing used in the isolated, ventilated and perfused lung apparatus (IVPL) was found to yield artifactually high values for nitrosamine formation after it had been exposed to nitrite. In contrast to an earlier report, we found that submilligram levels of nitrite do not react to form significant quantities of ni...

journal_title：Carcinogenesis

authors： Cooney RV,Ross PD,Bartolini GL

更新日期：1986-05-01 00:00:00

abstract：:Experiments were conducted to determine whether the natural estrogen and an environmental compound with estrogenic action, 4-n-octylphenol (4nOP), could modify tumor development in human c-Ha-ras proto-oncogene transgenic (Tg) rats which are highly susceptible to mammary and skin carcinogens. Female and male Tg and no...

journal_title：Carcinogenesis

authors： Han BS,Fukamachi K,Takasuka N,Ohnishi T,Maeda M,Yamasaki T,Tsuda H

更新日期：2002-07-01 00:00:00

abstract：:Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...

journal_title：Carcinogenesis

authors： Dragan YP,Campbell HA,Baker K,Vaughan J,Mass M,Pitot HC

更新日期：1994-11-01 00:00:00

abstract：:2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is a heterocyclic amine mutagen found in cooked meats and is carcinogenic in mice and rats at high doses (mg/kg body wt). Humans, however, are exposed to low amounts (p.p.b.) in the diet, and the effects caused by exposure to human equivalent doses of MeIQx have be...

journal_title：Carcinogenesis

authors： Frantz CE,Bangerter C,Fultz E,Mayer KM,Vogel JS,Turteltaub KW

更新日期：1995-02-01 00:00:00

abstract：:Male ICR Swiss mice, weighing 16-20 g, were fed ad libitum either a fat-free diet or a diet containing 10% corn oil. After three weeks on these diets, the rates of benzo[a]pyrene (B[a]P) metabolite formation and metabolism to products which covalently bind with macromolecules were compared using hepatic nuclei and mic...

journal_title：Carcinogenesis

authors： Baker MT,Karr SW,Wade AE

更新日期：1983-01-01 00:00:00

abstract：:The ability of cytosolic 3-methylcholanthrene binding proteins from rat liver to interact with DNA was studied using DNA-cellulose chromatography. Two DNA binding fractions, eluting in 0.15 M KCl (peak 1) and 0.33 M KCl (peak 2), were observed on salt elution from a denatured DNA-cellulose column which had been incuba...

journal_title：Carcinogenesis

authors： Weaver D,Amos A,Tierney B,Bresnick E

更新日期：1980-06-01 00:00:00

abstract：:Examination of p53 mutation spectra may provide clues to molecular mechanisms involved in different histologic types of gastric cancer. A total of 105 gastric cancer cases classified according to the Laurén's system were selected from a high-risk area around Florence, Italy. Exons 5-8 of the p53 gene were examined for...

journal_title：Carcinogenesis

authors： Shiao YH,Palli D,Buzard GS,Caporaso NE,Amorosi A,Saieva C,Fraumeni JF Jr,Anderson LM,Rice JM

更新日期：1998-12-01 00:00:00

abstract：:Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asi...

journal_title：Carcinogenesis

authors： Chen WC,Bye H,Matejcic M,Amar A,Govender D,Khew YW,Beynon V,Kerr R,Singh E,Prescott NJ,Lewis CM,Babb de Villiers C,Parker MI,Mathew CG

更新日期：2019-06-10 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:The MDM2 protein negatively regulates p53 expression level in modulating DNA repair, cell-cycle control, cell growth and apoptosis. Polymorphisms in the promoter region of the MDM2 gene have been shown to alter protein expression and may, thus, play a role in carcinogenesis. To test our hypothesis that the MDM2 promot...

journal_title：Carcinogenesis

authors： Li G,Zhai X,Zhang Z,Chamberlain RM,Spitz MR,Wei Q

更新日期：2006-10-01 00:00:00

abstract：:A single i.p. injection of 12-O-tetradecanoylphorbol-13-acetate (TPA) induced a transient increase in the levels of rat liver putrescine, spermidine and spermine. These polyamine concentrations continuously increased until 6 h, immediately following administration of the tumor promoter. Phenobarbital (PB) induced an i...

journal_title：Carcinogenesis

authors： Van Rooijen LA,Derks HJ,Van Wijk R,Bisschop A

更新日期：1984-02-01 00:00:00

abstract：:Practical methods for the routine solid-phase synthesis of oligodeoxynucleotides containing O6-alkylguanine are described. It is shown that if the 2-amino group of the alkylated base is protected with a phenylacetyl group, and a mixture of nitrobenzaldoximate ions and ammonia used to remove the protecting groups from ...

journal_title：Carcinogenesis

authors： Smith CA,Xu YZ,Swann PF

更新日期：1990-05-01 00:00:00

abstract：:To test the hypothesis that aberrations of DNA repair contribute to susceptibility for the progression of gastroesophageal reflux disease (GERD) into Barrett esophagus (BE) and esophageal adenocarcinoma (EADC), we studied the frequency of polymorphisms of selected DNA repair genes in patients with GERD (n = 126), BE (...

journal_title：Carcinogenesis

authors： Casson AG,Zheng Z,Evans SC,Veugelers PJ,Porter GA,Guernsey DL

更新日期：2005-09-01 00:00:00

abstract：:To indicate how readily nitrosamines (NAms) diffuse into the esophagus, we measured diffusion rate (flux) through rat esophagus of dialkyl-NAms using side-by-side diffusion apparatuses. Mucosal and serosal flux at 37 degrees C of two NAms, each at 50 microM, was followed for 90 min by gas chromatography-thermal energy...

journal_title：Carcinogenesis

authors： Haorah J,Miller DW,Brand R,Smyrk TC,Wang X,Chen SC,Mirvish SS

更新日期：1999-05-01 00:00:00

abstract：:Excess consumption of trans-fatty acid (TFA), an unsaturated fatty acid containing trans double bonds, is a major risk factor for cardiovascular disease and metabolic syndrome. However, little is known about the link between TFA and hepatocellular carcinoma (HCC) despite it being a frequent form of cancer in humans. I...

journal_title：Carcinogenesis

authors： Hu X,Wang X,Jia F,Tanaka N,Kimura T,Nakajima T,Sato Y,Moriya K,Koike K,Gonzalez FJ,Nakayama J,Aoyama T

更新日期：2020-04-22 00:00:00

abstract：:The present study was aimed at verifying the occurrence, if any, of in vivo oxidative DNA damage in FA homozygotes, their parents and siblings. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured, by HPLC/EC, in DNA from circulating blood leucocytes from FA homozygotes and their relatives and compared with a group of pa...

journal_title：Carcinogenesis

authors： Degan P,Bonassi S,De Caterina M,Korkina LG,Pinto L,Scopacasa F,Zatterale A,Calzone R,Pagano G

更新日期：1995-04-01 00:00:00

abstract：:Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytos...

journal_title：Carcinogenesis

authors： Rice JC,Ozcelik H,Maxeiner P,Andrulis I,Futscher BW

更新日期：2000-09-01 00:00:00

abstract：:2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is formed in cooked meats and may be linked to dietary-associated colorectal, prostate and mammary cancers. Genotoxic N-oxidized metabolites of PhIP react with the Cys34 of albumin (Alb) to form a sulfinamide adduct, a biomarker of the biologically effective dose....

journal_title：Carcinogenesis

authors： Bellamri M,Wang Y,Yonemori K,White KK,Wilkens LR,Le Marchand L,Turesky RJ

更新日期：2018-12-31 00:00:00

abstract：:The nature of mutagenic burden due to occupational exposure to tobacco flakes and dust was determined among 20 female tobacco processors (TP) and 20 matched controls (C) by testing urinary mutagenicity in the Ames assay. In addition, urinary cotinine was estimated as a marker of tobacco absorption. Workers and control...

journal_title：Carcinogenesis

authors： Bagwe AN,Bhisey RA

更新日期：1995-05-01 00:00:00

abstract：:XB2 cells, a teratocarcinoma derived cell line of keratinocyte lineage, have been shown to proliferate and differentiate in low calcium medium (0.03 mM Ca2+) at a density of 500 cells/9.6 cm2 without the need for fibroblast feeder layers or conditioned medium. The degree of differentiation can be assessed by measureme...

journal_title：Carcinogenesis

authors： Hewitt SD,Duffy PA,Orton TC,Garner RC

更新日期：1990-03-01 00:00:00

abstract：:Glucoraphanin in Brassica vegetables breaks down to either sulforaphane or sulforaphane nitrile depending on the conditions, and sulforaphane can be further conjugated with glutathione. Using a high-throughput microtitre plate assay and TaqMan real time quantitative RT-PCR to measure mRNA, we show that sulforaphane an...

journal_title：Carcinogenesis

authors： Basten GP,Bao Y,Williamson G

更新日期：2002-08-01 00:00:00

abstract：:Aloe-emodin (AE), one of the main bioactive anthraquinones of Rheum palmatum, possesses potent antitumor properties. Our previous proteomic study revealed that AE-induced apoptosis was associated with oxidative stress and oxidation of many redox-sensitive proteins. In this study, we aimed to further dissect the cell d...

journal_title：Carcinogenesis

authors： Lu GD,Shen HM,Chung MC,Ong CN

更新日期：2007-09-01 00:00:00

abstract：:In Saccharomyces cerevisiae a number of chemical agents induce synthesis of cytochrome P450. A cytochrome P450 gene has been well characterized in this yeast: CYP51, which codes for a constitutive enzyme involved in the 14 alpha-demethylation of lanosterol, a key step in the biosynthesis of ergosterol. In this work, w...

journal_title：Carcinogenesis

authors： Del Carratore R,Morichetti E,Cecchini E,Bronzetti G,Gallo E,Galeotti CL

更新日期：1992-11-01 00:00:00

abstract：:Although the human O6-alkylguanine-DNA alkyltransferase (AGT) is very sensitive to inactivation by O6-benzylguanine (BG) or 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine (5-nitroso-BP), the equivalent protein formed by the carboxyl terminal domain of the product of the Escherichia coli ada gene (Ada-C) is unaffected by ...

journal_title：Carcinogenesis

authors： Crone TM,Kanugula S,Pegg AE

更新日期：1995-08-01 00:00:00

abstract：:Expression of the human placental form of glutathione S-transferase (GST-pi), an enzyme proposed as a marker for human and experimental neoplasia, was immunohistochemically evaluated in 51 samples of 'normal' and diseased adult human uterine cervix. Five fetal uteri were also studied. GST-pi positivity was detected in...

journal_title：Carcinogenesis

authors： de Camargo JL,Tsuda H,Tatematsu M,Rodrigues MA,Yamada M,Tzuji K,Ito N

更新日期：1989-12-01 00:00:00

abstract：:Incubation of 3-[3H]fluoranthene with a rat liver microsomal activation system in the presence of calf thymus DNA resulted in radioactivity bound to the DNA. The fluoranthene-modified DNA was enzymatically digested and a DNA adduct elution profile developed using h.p.l.c. The fraction containing the major fluoranthene...

journal_title：Carcinogenesis

authors： Babson JR,Russo-Rodriguez SE,Rastetter WH,Wogan GN

更新日期：1986-06-01 00:00:00

abstract：:Previous studies demonstrate that the heavy metal cadmium and the metalloid arsenite activate estrogen receptor-alpha in breast cancer cells by forming a high-affinity complex with the ligand-binding domain of the receptor and that environmentally relevant doses of cadmium have estrogen-like activity in vivo. The pres...

journal_title：Carcinogenesis

authors： Divekar SD,Li HH,Parodi DA,Ghafouri TB,Chen R,Cyrus K,Foxworth AE,Fornace AJ,Byrne C,Martin MB

更新日期：2020-07-14 00:00:00

abstract：:Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly ...

journal_title：Carcinogenesis

authors： Eimoto H,Tsutsumi M,Nakajima A,Yamamoto K,Takashima Y,Maruyama H,Konishi Y

更新日期：1988-12-01 00:00:00