S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation levels in the liver of rats fed methapyrilene and analogs.

abstract：:Vinyl carbamate epoxide (VCO) was found to possess strong electrophilic, mutagenic and carcinogenic activities. It reacted with water at 37 degrees C and pH 7.4 (phosphate buffer) to form glycolaldehyde and several related reducing compounds; none of these products were mutagenic for Salmonella typhimurium TA1535. Und...

journal_title：Carcinogenesis

authors： Park KK,Liem A,Stewart BC,Miller JA

更新日期：1993-03-01 00:00:00

abstract：:Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...

journal_title：Carcinogenesis

authors： Gunter MJ,Probst-Hensch NM,Cortessis VK,Kulldorff M,Haile RW,Sinha R

更新日期：2005-03-01 00:00:00

abstract：:The kinetics of nuclear polyploidization in livers of CF-1 mice exposed to dieldrin were studied at concentrations of 0, 0.1, 1, 5 and 10 p.p.m. in the diet, in 'steady-state' situations (which are reached within a few weeks after initiation of treatment). Animals were killed at five time intervals (after 1.85, 3, 6, ...

journal_title：Carcinogenesis

authors： van Ravenzwaay B,Tennekes H,Stöhr M,Kunz W

更新日期：1987-02-01 00:00:00

abstract：:Glioblastoma (GBM) is amongst the most aggressive brain tumors with a dismal prognosis. Despite significant advances in the current multimodality therapy including surgery, postoperative radiotherapy (RT) and temozolomide (TMZ)-based concomitant and adjuvant chemotherapy (CT), tumor recurrence is nearly universal with...

journal_title：Carcinogenesis

authors： Vengoji R,Ponnusamy MP,Rachagani S,Mahapatra S,Batra SK,Shonka N,Macha MA

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:Variations in genetic mutations in pancreatic carcinoma between different geographical regions have not been studied extensively, especially in developing countries where pancreatic cancer is relatively rare. METHODS:We studied the molecular pathology of 54 pancreatic adenocarcinomas from Egyptian patients ...

journal_title：Carcinogenesis

authors： Soliman AS,Lo AC,Banerjee M,El-Ghawalby N,Khaled HM,Bayoumi S,Seifeldin IA,Abdel-Aziz A,Abbruzzese JL,Greenson JK,Hamilton SR

更新日期：2007-08-01 00:00:00

abstract：:Junctional adhesion molecule-A (JAM-A) is preferentially concentrated at tight junctions and influences epithelial cell morphology and migration. Epithelial-to-mesenchymal transition (EMT) is the conversion process of epithelial cells into mesenchymal cells, and it plays an important role in the invasiveness and metas...

journal_title：Carcinogenesis

authors： Tian Y,Tian Y,Zhang W,Wei F,Yang J,Luo X,Zhou T,Hou B,Qian S,Deng X,Qiu Y,Yao K

更新日期：2015-01-01 00:00:00

abstract：:O-Methylation of catecholestrogens catalyzed by catechol-O-methyltransferase provides a major route for the rapid metabolic clearance of these steroids. However, the metabolic clearance rate of 4-hydroxyestradiol (4-OH-E2) is considerably lower than that of 2-hydroxyestradiol, although 2- and 4-hydroxycatecholestrogen...

journal_title：Carcinogenesis

authors： Roy D,Weisz J,Liehr JG

更新日期：1990-03-01 00:00:00

abstract：:Treatment of human skin fibroblasts in early S-phase with (+-)7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE-I) results in more extensive modification of early replicating DNA than parental DNA. We have investigated the effects of benzamide (BZ) and 3-aminobenzamide (3-ABZ), i...

journal_title：Carcinogenesis

authors： Kurian P,Kumari HL,Milo GE

更新日期：1992-03-01 00:00:00

abstract：:Angiogenesis, the formation of new blood vessels, is critical to tumor growth and metastasis. Vascular endothelial growth factor (VEGF), an important angiogenic activator, is essential for angiogenesis. Our laboratory has used a rodent model of human esophageal squamous cell carcinoma (ESCC) to identify putative chemo...

journal_title：Carcinogenesis

authors： Chen T,Rose ME,Hwang H,Nines RG,Stoner GD

更新日期：2006-11-01 00:00:00

abstract：:Basic in vitro systems can be used to model and assess complex diseases, such as cancer. Recent advances in this field include the incorporation of multiple cell types and extracellular matrix proteins into three-dimensional (3D) models to recapitulate the structure, organization and functionality of live tissue in si...

journal_title：Carcinogenesis

authors： Herrmann D,Conway JR,Vennin C,Magenau A,Hughes WE,Morton JP,Timpson P

更新日期：2014-08-01 00:00:00

abstract：:An iron chelate, ferric ethylenediamine-N,N'-diacetate [Fe(III)-EDDA], was found to produce hydroxyl radicals with hydrogen peroxide, as determined by both a deoxyribose degradation test and electron spin resonance. Hydroxyl radical production was inhibited not only by adding hydroxyl radical scavengers and catalase, ...

journal_title：Carcinogenesis

authors： Liu M,Okada S

更新日期：1994-12-01 00:00:00

abstract：:The repair of u.v.-induced damage in human and rodent cells was investigated at the level of DNA loops attached to the nuclear matrix. After 2 h post-u.v. incubation, DNase I digestion studies revealed a 3- to 4-fold enrichment of repair-labeled DNA at the nuclear matrix in four xeroderma pigmentosum cell strains belo...

journal_title：Carcinogenesis

authors： Mullenders LH,van Kesteren AC,Bussmann CJ,van Zeeland AA,Natarajan AT

更新日期：1986-06-01 00:00:00

abstract：:Recent studies have demonstrated that K-ras mutations in lung epithelial cells elicit inflammation that promotes carcinogenesis in mice (intrinsic inflammation). The finding that patients with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer after...

journal_title：Carcinogenesis

authors： Moghaddam SJ,Barta P,Mirabolfathinejad SG,Ammar-Aouchiche Z,Garza NT,Vo TT,Newman RA,Aggarwal BB,Evans CM,Tuvim MJ,Lotan R,Dickey BF

更新日期：2009-11-01 00:00:00

abstract：:The activity levels of L-ornithine carboxy-lyase (ODC) (E.C. 4.1.1.17) and S-adenosyl-L-methionine carboxy-lyase (SAM-D) (E.C.4.1.1.50) were determined in individual papillomas induced in mouse skin by a two-stage technique, and in normal mouse epidermis. Cycloheximide treatment abolished both enzyme activities. In no...

journal_title：Carcinogenesis

authors： Astrup EG,Boutwell RK

更新日期：1982-01-01 00:00:00

abstract：:Intratumor heterogeneity (ITH) plays an important role in tumor development, metastases, recurrence and has impact on clinical diagnosis, therapeutic responses. In this study, we used mutant-allele tumor heterogeneity (MATH) through whole-exome sequencing data to evaluate ITH in early stage diffuse large B-cell lympho...

journal_title：Carcinogenesis

authors： Wang Y,Feng W,Liu P

更新日期：2019-11-25 00:00:00

abstract：:The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...

journal_title：Carcinogenesis

authors： Capp JP,Boudsocq F,Bergoglio V,Trouche D,Cazaux C,Blanco L,Hoffmann JS,Canitrot Y

更新日期：2010-10-01 00:00:00

abstract：:7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...

journal_title：Carcinogenesis

authors： Watabe T,Hakamata Y,Hiratsuka A,Ogura K

更新日期：1986-02-01 00:00:00

abstract：:N-Hydroxy-2-acetylaminofluorene (N-OH-AAF), N-hydroxy-4'-fluoro-4-acetylaminobiphenyl (N-OH-FAABP) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) were compared for their initiation and promotion activity in the rat liver using a modified Solt-Farber system. N-OH-AAF, N-OH-FAABP and N-OH-AABP showed comparable initiat...

journal_title：Carcinogenesis

authors： van de Poll ML,van der Hulst DA,Tates AD,Meerman JH

更新日期：1990-02-01 00:00:00

abstract：:The variation in colorectal cancer (CRC) incidence worldwide strongly suggests a role for dietary influences. Based on epidemiological data, protective effects of vegetables and fruit intake on CRC are widely claimed, while other data indicate a possible increased CRC risk from (higher) dietary fat intake. Therefore, ...

journal_title：Carcinogenesis

authors： van Kranen HJ,van Iersel PW,Rijnkels JM,Beems DB,Alink GM,van Kreijl CF

更新日期：1998-09-01 00:00:00

abstract：:Yeasts were isolated from 12 cases of oral precancerous lesions (leukoplakia and erythroleukoplakia) by sampling the lesion as well as normal mucosa of each patient, yielding 21 strains of Candida albicans belonging to 15 biotypes, two strains of C. tropicalis, one strain of C. parapsilosis and two strains of Torulops...

journal_title：Carcinogenesis

authors： Krogh P,Hald B,Holmstrup P

更新日期：1987-10-01 00:00:00

abstract：:Cancer of the stomach is one of the most commonly diagnosed malignancies and remains an important cause of mortality world wide. This type of cancer is not uniformly distributed among populations but shows a marked variation in both incidence and mortality. Although gastric cancer is declining in many parts of the wor...

journal_title：Carcinogenesis

authors： Stadtländer CT,Waterbor JW

更新日期：1999-12-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:Epidemiological studies indicate that N-nitroso compounds (NOC) are causally linked to colorectal cancer (CRC). NOC induce DNA alkylations, including O (6)-methylguanine (O (6)-MeG) and N-methylated purines, which are repaired by O (6)-MeG-DNA methyltransferase (MGMT) and N-alkyladenine-DNA glycosylase (AAG)-initiated...

journal_title：Carcinogenesis

authors： Fahrer J,Frisch J,Nagel G,Kraus A,Dörsam B,Thomas AD,Reißig S,Waisman A,Kaina B

更新日期：2015-10-01 00:00:00

abstract：:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...

journal_title：Carcinogenesis

authors： Cosma GN,Marchok AC

更新日期：1987-12-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Metabolomic analysis of feces may provide insights on colorectal cancer (CRC) if assay performance is satisfactory. In lyophilized feces from 48 CRC cases, 102 matched controls, and 48 masked quality control specimens, 1043 small molecules were detected with a commercial platform. Assay reproducibility was good for 52...

journal_title：Carcinogenesis

authors： Goedert JJ,Sampson JN,Moore SC,Xiao Q,Xiong X,Hayes RB,Ahn J,Shi J,Sinha R

更新日期：2014-09-01 00:00:00

abstract：:The nasal passages are a common portal of entry and are a prime site for toxicant-induced pathology. Sustained increases in regenerative cell proliferation can be a significant driving force in chemical carcinogenesis. The atmosphere in Mexico City contains a complex mixture of air pollutants and its residents are exp...

journal_title：Carcinogenesis

authors： Calderón-Garcidueñas L,Rodriguez-Alcaraz A,Garcia R,Barragan G,Villarreal-Calderón A,Madden MC

更新日期：1999-03-01 00:00:00

abstract：:Prostate stromal and epithelial cell communication is important in prostate functioning and cancer development. Primary human stromal cells from normal prostate stromal cells (PRSC) maintain a smooth muscle phenotype, whereas those from prostate cancer (6S) display reactive and fibroblastic characteristics. Dihydrotes...

journal_title：Carcinogenesis

authors： Liu X,Allen JD,Arnold JT,Blackman MR

更新日期：2008-04-01 00:00:00

abstract：:Gap junctions are composed of protein subunits, called connexins, and provide a pathway for the exchange of ions and small molecules between contacting cells. This transfer of molecules is thought to be an important pathway for direct cell communication, and is involved in tissue homeostasis, growth control and embryo...

journal_title：Carcinogenesis

authors： Evert M,Ott T,Temme A,Willecke K,Dombrowski F

更新日期：2002-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the leading causes for cancer related mortality worldwide. Poor prognosis of HCC patients is mainly due to frequent metastasis and recurrence. Deregulation of metastasis suppressors in malignant cells plays critical roles during cancer metastasis. Thus, novel metastasis suppres...

journal_title：Carcinogenesis

authors： Luo Q,Wang C,Jin G,Gu D,Wang N,Song J,Jin H,Hu F,Zhang Y,Ge T,Huo X,Chu W,Shu H,Fang J,Yao M,Gu J,Cong W,Qin W

更新日期：2015-10-01 00:00:00