Comparison of epidermal protein kinase C activity, ornithine decarboxylase induction and DNA synthesis stimulated by TPA or dioctanoylglycerol in mouse strains with differing susceptibility to TPA-induced tumor promotion.

abstract：:Capsaicin, a pungent ingredient of red chili peppers, has been reported to possess antitumor activities. Here, we show that subtoxic doses of capsaicin effectively sensitize multiple malignant glioma cell lines to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis. Although TRAIL alone m...

journal_title：Carcinogenesis

authors： Kim JY,Kim EH,Kim SU,Kwon TK,Choi KS

更新日期：2010-03-01 00:00:00

abstract：:The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...

journal_title：Carcinogenesis

authors： Jungert K,Buck A,Buchholz M,Wagner M,Adler G,Gress TM,Ellenrieder V

更新日期：2006-12-01 00:00:00

abstract：:Garcinol, a polyisoprenylated benzophenone, from the fruit rind of Garcinia spp., has been shown to have anti-inflammatory and anticarcinogenic activities. To study its mechanism of action, we analyzed the effects of garcinol and its derivatives, including cambogin, garcim-1 and garcim-2, on arachidonic acid metabolis...

journal_title：Carcinogenesis

authors： Hong J,Sang S,Park HJ,Kwon SJ,Suh N,Huang MT,Ho CT,Yang CS

更新日期：2006-02-01 00:00:00

abstract：:Diethylstilbestrol (DES), a synthetic stilbene estrogen, is a potent development toxin and carcinogen in humans and rodents. A number of 32P-postlabeling studies suggest that genotoxic effects of DES substantially contribute to these biological effects. The mechanisms involved in DES-mediated genotoxicity are not comp...

journal_title：Carcinogenesis

authors： Moorthy B,Liehr J,Randerath E,Randerath K

更新日期：1995-11-01 00:00:00

abstract：:We have tested the hypothesis that the inhibition by hydroxyurea of repair patch ligation and chromatin rearrangement during u.v.-induced DNA excision repair results from a reduction in cellular deoxyribonucleotide concentrations and not from a direct effect of hydroxyurea on the repair process. Using permeable human ...

journal_title：Carcinogenesis

authors： Hunting DJ,Dresler SL

更新日期：1985-10-01 00:00:00

abstract：:The Notch signaling pathway is evolutionarily conserved and responsible for cell fate determination in the developing embryo and mature tissue. At the molecular level, ligand binding activates Notch signaling by liberating the Notch intracellular domain, which then translocates into the nucleus and activates gene tran...

journal_title：Carcinogenesis

authors： Capaccione KM,Pine SR

更新日期：2013-07-01 00:00:00

abstract：:The HSP70 family of heat shock proteins consists of molecular chaperones of approximately 70kDa in size that serve critical roles in protein homeostasis. These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascent...

journal_title：Carcinogenesis

authors： Murphy ME

更新日期：2013-06-01 00:00:00

abstract：:Administration of 2-acetylaminofluorene (2-AAF) to rats increased mdr1b expression in Fischer, Wistar and Sprague-Dawley rat livers; however, the response was much smaller in Sprague-Dawley livers. To investigate the basis of this difference we further examined the regulation of the mdr1b gene in hepatocytes isolated ...

journal_title：Carcinogenesis

authors： Hill BA,Brown PC,Preisegger KH,Silverman JA

更新日期：1996-03-01 00:00:00

abstract：:Pardaxin, an antimicrobial peptide secreted by the Red Sea flatfish Pardachirus marmoratus, inhibits proliferation and induces apoptosis of human cancer cell lines. However, the underlying molecular mechanisms are only partially understood at present. In this study, we used proteomic approaches and network reconstruct...

journal_title：Carcinogenesis

authors： Huang TC,Chen JY

更新日期：2013-08-01 00:00:00

abstract：:We have examined both the initial nuclease sensitivity and subsequent nucleosome rearrangement of newly repaired regions of chromatin in human diploid fibroblasts treated with methyl methanesulfonate (MMS) and methylnitrosourea (MNU). We initially examined the effect of these two alkylating agents on DNA replicative s...

journal_title：Carcinogenesis

authors： Sidik K,Smerdon MJ

更新日期：1984-02-01 00:00:00

abstract：:The Wnt-beta-catenin pathway plays a central role in colorectal tumorigenesis. Frizzled-related protein (FRZB, also termed secreted frizzled-related protein 3, sFRP3) antagonizes the signaling of wingless (Wnt) ligands through the frizzled membrane-bound receptors, resulting in beta-catenin destabilization thereby sup...

journal_title：Carcinogenesis

authors： Shanmugam KS,Brenner H,Hoffmeister M,Chang-Claude J,Burwinkel B

更新日期：2007-09-01 00:00:00

abstract：:Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...

journal_title：Carcinogenesis

authors： Rizzato C,Canzian F,Rudnai P,Gurzau E,Stein A,Koppova K,Hemminki K,Kumar R,Campa D

更新日期：2011-12-01 00:00:00

abstract：:Previously we have reported the development of a model in vitro system for the study of osteosarcoma. In this system, when chick periosteal explants are infected with Fujinami sarcoma virus (FSV), osteosarcoma-like tissue is formed. In the present study, a series of histopathologic parameters of neoplastic transformat...

journal_title：Carcinogenesis

authors： Birek C,Pawson T,McCulloch CA,Tenenbaum HC

更新日期：1988-10-01 00:00:00

abstract：:Cultured human epidermal cells which require no feeder layer were used to study metabolism of benzo[a]pyrene (BP) and DNA adduct formation. The cultures were prepared from a single cell suspension and maintained at a pH of 5.9--6.2. At 2 microM BP some cell toxicity was observed, and substantial cell death occurred at...

journal_title：Carcinogenesis

authors： Theall G,Eisinger M,Grunberger D

更新日期：1981-01-01 00:00:00

abstract：:Resistance to chemically-induced mammary tumors in the Copenhagen rat is well defined, but the mechanism of resistance has yet to be determined. We have tested whether or not Copenhagen rat resistance is dependent on T-cells, since several lines of evidence supported an involvement of the immune system. We crossed Cop...

journal_title：Carcinogenesis

authors： Korkola JE,Wood GA,Archer MC

更新日期：1997-01-01 00:00:00

abstract：:In Thailand, smoking of commercial cigarettes and of handmade cigarettes has drastically increased in recent decades. Cancer of the lung and of the upper aero-digestive tract have also increased in Thailand as they have in many other countries. It is our working hypothesis that the increase of primary cancer of the li...

journal_title：Carcinogenesis

authors： Mitacek EJ,Brunnemann KD,Hoffmann D,Limsila T,Suttajit M,Martin N,Caplan LS

更新日期：1999-01-01 00:00:00

abstract：:Although microRNAs (miRNA) have extensively been investigated in cancer research, less attention has been paid to their regulation by carcinogens and/or protective factors in early stages of the carcinogenesis process. The present study was designed to evaluate the modulation of mRNA expression as related to exposure ...

journal_title：Carcinogenesis

authors： Izzotti A,Larghero P,Cartiglia C,Longobardi M,Pfeffer U,Steele VE,De Flora S

更新日期：2010-05-01 00:00:00

abstract：:A number of drug-metabolizing systems were measured in hyperplastic noduli from the livers of rats receiving 2-acetyl-aminofluorene in their diet and compared with corresponding activities in control liver. The level of microsomal cytochrome P-450 is reduced 54% in the nodular tissue, while 5 activities catalyzed by t...

journal_title：Carcinogenesis

authors： Aström A,DePierre JW,Eriksson L

更新日期：1983-01-01 00:00:00

abstract：:Cyclin E is reported to be an important cell cycle regulator, and its dysregulation is implicated in tumorigenesis including esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) regulate gene expression at the posttranscriptional level and play important roles in tumor initiation and progression. However, the...

journal_title：Carcinogenesis

authors： Ding DP,Chen ZL,Zhao XH,Wang JW,Sun J,Wang Z,Tan FW,Tan XG,Li BZ,Zhou F,Shao K,Li N,Qiu B,He J

更新日期：2011-07-01 00:00:00

abstract：:The effect of glucose on the formation of the food mutagen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) was studied in a model system. When a mixture of creatine (0.9 mmol), phenylalanine (0.9 mmol) and glucose (0.45 mmol) was heated in diethylene glycol and water (3 ml, 5:1) for 10 min at 180 or 225 degrees...

journal_title：Carcinogenesis

authors： Skog K,Jägerstad M

更新日期：1991-12-01 00:00:00

abstract：:Hepatic microsomes of female F344 rats were capable of N,O-acyltransfer of N-hydroxy-N-acetyl-2-aminofluorene (N-OH-AAF) and N-hydroxy-N-formyl-2-aminofluorene (N-OH-FAF), N-deacetylation of N-OH-AAF and N-acetyl-2-aminofluorene (2-AAF), and O-deacetylation of 4-nitrophenyl acetate (NPA). The activity for N,O-acyltran...

journal_title：Carcinogenesis

authors： Wang CY,Zukowski K,Lee MS,Sone T

更新日期：1992-11-01 00:00:00

abstract：:The Bowman-Birk protease inhibitor (BBI) is a legume-derived inhibitor of chymotrypsin and trypsin that has been shown to suppress cellular transformation and tumorigenesis. In the present investigation the effects of various BBI administration schedules were evaluated for suppression of 3-methylcholanthrene (3-MCA)-i...

journal_title：Carcinogenesis

authors： St Clair WH

更新日期：1991-05-01 00:00:00

abstract：:Previous epidemiological and laboratory studies have indicated an association between the ingestion of opium pyrolysates, dietary deficiencies and the high incidence of oesophageal cancer in subjects in north-east Iran. Pyrolysates of opium, and particularly of morphine, a major opium alkaloid, were both shown to cont...

journal_title：Carcinogenesis

authors： Friesen M,O'Neill IK,Malaveille C,Garren L,Hautefeuille A,Bartsch H

更新日期：1987-10-01 00:00:00

abstract：:The experiments reported in this study were designed to examine the question of whether a mammary epithelial cell's independence from hormonal requirements is established at the time of carcinogenic initiation, or whether the emergence of hormone independence is associated with the process of tumor progression. A newl...

journal_title：Carcinogenesis

authors： Thompson HJ,McGinley J,Rothhammer K,Singh M

更新日期：1998-03-01 00:00:00

abstract：:The association between prostate cancer risk and dietary fat consumption is well documented and explained partly by accelerated lipid peroxidation. We explored the possible effects of high dietary cholesterol on carcinogenesis and oxidative stress in the prostate of ACI/Seg rats. The rats develop prostate cancer spont...

journal_title：Carcinogenesis

authors： Homma Y,Kondo Y,Kaneko M,Kitamura T,Nyou WT,Yanagisawa M,Yamamoto Y,Kakizoe T

更新日期：2004-06-01 00:00:00

abstract：:Cell motility is partially dependent on interactions between the integrins and the extracellular matrix. Our previous studies have identified synthetic D-amino acid cell adhesion peptides using a combinatorial screening approach. In this study, we demonstrate that HYD1 (kikmviswkg) completely blocks random haptotactic...

journal_title：Carcinogenesis

authors： Sroka TC,Pennington ME,Cress AE

更新日期：2006-09-01 00:00:00

abstract：:The dorsal skins of 6-8 week old female SENCAR mice were initiated with a single application of 10 nmol of 7,12-dimethylbenz[a]anthracene (DMBA) and subsequently promoted twice/week with topical applications of vitamin E (dl-alpha-tocopherol, 80 mumol/treatment). Vitamin E from two separate commercial suppliers was te...

journal_title：Carcinogenesis

authors： Mitchel RE,McCann R

更新日期：1993-04-01 00:00:00

abstract：:Modulation of cellular thiols has been used to ameliorate the toxic side effects associated with cancer chemotherapy and is currently being investigated as a novel therapeutic strategy in cancer treatment. One of the most extensively studied modulators of thiol levels is N-acetylcysteine (NAC), a cytoprotective drug w...

journal_title：Carcinogenesis

authors： McLellan LI,Lewis AD,Hall DJ,Ansell JD,Wolf CR

更新日期：1995-09-01 00:00:00

abstract：:Celastrol is an anti-inflammatory natural triterpenoid, isolated from the herb Tripterygium wilfordii or thunder god vine. Here, we define mechanisms mediating anti-inflammatory activity of celastrol and demonstrate efficacy of a dietary celastrol supplement for chemoprevention of inflammation-driven carcinogenesis in...

journal_title：Carcinogenesis

authors： Barker EC,Kim BG,Yoon JH,Tochtrop GP,Letterio JJ,Choi SH

更新日期：2018-01-12 00:00:00

abstract：:Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg 3'-hydroxymethyl-N,N-dimethyl-4-aminoazobenzene (3'-CH2OH-DAB) for a period of 1 or 3 months. (This is the molar equivalent of 0.06% 3'-Me-DAB in the diet). The oral administration of 3'-CH2OH-DAB for 3 months resulted in a high incidence of liver t...

journal_title：Carcinogenesis

authors： Mori Y,Niwa T,Toyoshi K,Nagai H,Koda A,Kawada K,Ojima A,Takahashi Y

更新日期：1980-06-01 00:00:00