Dehydroepiandrosterone and 16 alpha-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes.

abstract：:A defect in DNA repair coupled to anomalous DNA synthesis after induction of certain radiogenic DNA damage is suspected to underlie the radiosensitivity of cells from patients with ataxia-telangiectasia (A-T). The response of cultured skin fibroblasts from A-T patients and A-T heterozygotes to six agents inducing vari...

journal_title：Carcinogenesis

authors： Shiloh Y,Tabor E,Becker Y

更新日期：1983-10-01 00:00:00

abstract：:In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...

journal_title：Carcinogenesis

authors： van den Goorbergh JA,de Wit H,Tijdens RB,Mulder GJ,Meerman JH

更新日期：1987-02-01 00:00:00

abstract：:Current procedures for diagnosis and biomarker examination of colorectal cancer (CRC) are invasive and unpleasant. There is a great need to identify sensitive and specific biomarkers for early diagnosis of CRC. Circulating microRNAs (miRNAs) are promising molecular markers for CRC prediction. We performed a comprehens...

journal_title：Carcinogenesis

authors： Du M,Liu S,Gu D,Wang Q,Zhu L,Kang M,Shi D,Chu H,Tong N,Chen J,Adams TS,Zhang Z,Wang M

更新日期：2014-12-01 00:00:00

abstract：:Previously, we reported the identification of a novel immunoglobulin-like cell adhesion molecule hepaCAM that is frequently downregulated and inhibits cell growth in hepatocellular carcinoma. In this study, we show that the expression of hepaCAM is suppressed in diverse human cancers. Aiming to evaluate the biological...

journal_title：Carcinogenesis

authors： Moh MC,Zhang T,Lee LH,Shen S

更新日期：2008-12-01 00:00:00

abstract：:Autoradiography has been used to study the effect of 12-O-tetradecanoylphorbol-13-acetate (TPA), 4-O-methyl TPA, and phorbol on metabolic cooperation between human diploid fibroblasts. When the donors, hypoxanthine-guanine phosphoribosyl transferase+ (HGPRT+) cells, and recipients, HGPRT- cells, were plated together i...

journal_title：Carcinogenesis

authors： Mosser DD,Bols NC

更新日期：1982-01-01 00:00:00

abstract：:The tissue distribution and macromolecular binding of benzene was studied over a dose range spanning nine-orders of magnitude to determine the nature of the dose-response and to establish benzene's internal dosimetry at doses encompassing human environmental exposures. [14C]-Benzene was administered to B6C3F1 male mic...

journal_title：Carcinogenesis

authors： Creek MR,Mani C,Vogel JS,Turteltaub KW

更新日期：1997-12-01 00:00:00

abstract：:The effects of hyperoxia on lung tumor development were examined in mice and rats. In mice, exposure to 70% O2 prevented the development of urethan- or 3-methylcholanthrene-induced lung tumors. Dietary antioxidants [butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA)] were unable to prevent the inhibitio...

journal_title：Carcinogenesis

authors： Lindenschmidt RC,Margaretten N,Griesemer RA,Witschi HP

更新日期：1986-09-01 00:00:00

abstract：:Human papillomavirus (HPV) type 16 infection is an etiologic factor in a subset of head and neck squamous cell carcinomas (HNSCC). It is unknown if host genetic susceptibility modifies the HPV16-HNSCC association. DNA samples collected as part of a Boston area case-control study of HNSCC were genotyped for single-nucl...

journal_title：Carcinogenesis

authors： Chen AA,Marsit CJ,Christensen BC,Houseman EA,McClean MD,Smith JF,Bryan JT,Posner MR,Nelson HH,Kelsey KT

更新日期：2009-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer mortality worldwide. Despite progress in developing chemotherapeutics for the treatment of NSCLC, primary and secondary resistance limits therapeutic success. NSCLC cells exhibit multiple mutations in the epidermal growth factor receptor (EGFR), which c...

journal_title：Carcinogenesis

authors： Kim MO,Lee MH,Oi N,Kim SH,Bae KB,Huang Z,Kim DJ,Reddy K,Lee SY,Park SJ,Kim JY,Xie H,Kundu JK,Ryoo ZY,Bode AM,Surh YJ,Dong Z

更新日期：2014-03-01 00:00:00

abstract：:Analysis of 24 h urine samples of rats administered N-nitrosodipropylamine (NDPA), N-nitroso-2-hydroxypropylpropylamine (NHPPA) or N-nitroso-2-oxopropylpropylamine (NOPPA) showed that the major excretion product in each case was the beta-glucuronide of NHPPA. This conjugate was shown to be present at levels of about 5...

journal_title：Carcinogenesis

authors： Leung KH,Archer MC

更新日期：1981-01-01 00:00:00

abstract：:Use of supercritical carbon dioxide extraction in the analysis of smokeless tobacco for tobacco-specific N-nitrosamines revealed the presence of higher levels of 4-(methylnitros-amino)-1-(3-pyridyl)-1-butanone (NNK) than had been determined with conventional methods. Whether human saliva may be similarly capable of re...

journal_title：Carcinogenesis

authors： Prokopczyk B,Wu M,Cox JE,Hoffmann D

更新日期：1992-05-01 00:00:00

abstract：:We have previously shown that addition of short chain fructo-oligosaccharides (indigestible carbohydrates) to food prevented colon tumors in C57BL/6-Apc(Min/+) mice, a model for human colon cancer. As gut-associated lymphoid tissue was concomitantly developed, we suggested that the immune response generated by this fo...

journal_title：Carcinogenesis

authors： Pierre F,Perrin P,Bassonga E,Bornet F,Meflah K,Menanteau J

更新日期：1999-10-01 00:00:00

abstract：:Resistance to chemically-induced mammary tumors in the Copenhagen rat is well defined, but the mechanism of resistance has yet to be determined. We have tested whether or not Copenhagen rat resistance is dependent on T-cells, since several lines of evidence supported an involvement of the immune system. We crossed Cop...

journal_title：Carcinogenesis

authors： Korkola JE,Wood GA,Archer MC

更新日期：1997-01-01 00:00:00

abstract：:Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the Western world. Inflammation may result in oxidative stress and contribute to promotion and progression of tumors, including BCC. The role of cytokines, which are inflammatory modulators, in the biology of tumors ha...

journal_title：Carcinogenesis

authors： Rizzato C,Canzian F,Rudnai P,Gurzau E,Stein A,Koppova K,Hemminki K,Kumar R,Campa D

更新日期：2011-12-01 00:00:00

abstract：:To better understand the mechanisms of mutagenesis by the carcinogen, methylene chloride (DCM), we have determined the nature and distribution of forward mutations induced by DCM in the N-terminal region of the lacI gene of Escherichia coli. A total of 116 lacI-d mutations (50 from Uvr+, 66 from UvrB- strain) were cha...

journal_title：Carcinogenesis

authors： Zielenska M,Ahmed A,Pienkowska M,Anderson M,Glickman BW

更新日期：1993-05-01 00:00:00

abstract：:p90 Ribosomal S6 kinase (RSK) 4 is a serine-threonine kinase that belongs to the p90RSK family. RSK4 has been proposed as a tumor suppressor gene, related with anti-invasive activity, inhibition of the RAS-mitogen-activated protein kinase (MAPK) pathway and induction of senescence. Despite the related findings, little...

journal_title：Carcinogenesis

authors： López-Vicente L,Pons B,Coch L,Teixidó C,Hernández-Losa J,Armengol G,Ramon Y Cajal S

更新日期：2011-04-01 00:00:00

abstract：:The purpose of this study was to examine the activity and associated kinetic parameters of epidermal protein kinase C (PKC) following stimulation by sn-1,2-dioctanoylglycerol (DIC8) or 12-O-tetradecanoylphorbol-13-acetate (TPA) and to examine the relationship between levels of epidermal PKC activity and the induction ...

journal_title：Carcinogenesis

authors： Mills KJ,Smart RC

更新日期：1989-05-01 00:00:00

abstract：:Several studies have indicated a correlation between the presence of inflammation and the development of cancer. The aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (B[a]P-7,8-diol), to an ultimate carcin...

journal_title：Carcinogenesis

authors： Petruska JM,Mosebrook DR,Jakab GJ,Trush MA

更新日期：1992-07-01 00:00:00

abstract：:Teleocidin, a new tumor promoter, increased incorporation of radioactive inorganic phosphate (32Pi) into phospholipids in HeLa cells. This effect was detected within 1 h on incubation of the cells in medium containing teleocidin. The half-maximum effective dose of teleocidin was approximately 10 ng/ml. The main effect...

journal_title：Carcinogenesis

authors： Nishino H,Fujiki H,Terada M,Sato S

更新日期：1983-01-01 00:00:00

abstract：:A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappeared when the choline-deficient diet was replaced by a choline-supplemente...

journal_title：Carcinogenesis

authors： Rushmore TH,Farber E,Ghoshal AK,Parodi S,Pala M,Taningher M

更新日期：1986-10-01 00:00:00

abstract：:Nitric oxide donating aspirin (NO-ASA), consisting of a traditional ASA to which a NO-releasing moiety is covalently attached, is a promising chemopreventive agent against colon cancer. Its mechanism of action is not fully delineated. Here we examined its effect on the expression of the nuclear receptor PPARdelta, who...

journal_title：Carcinogenesis

authors： Ouyang N,Williams JL,Rigas B

更新日期：2006-02-01 00:00:00

abstract：:Functional inactivation of BRCA1 is an important mechanism involved in breast cancer pathogenesis. Mutation is often responsible for BRCA1 inactivation in familial breast cancer, but is not responsible for the decreased levels of BRCA1 seen in a subset of sporadic breast cancer patients. To determine if aberrant cytos...

journal_title：Carcinogenesis

authors： Rice JC,Ozcelik H,Maxeiner P,Andrulis I,Futscher BW

更新日期：2000-09-01 00:00:00

abstract：:Bile acids have been implicated in the aetiology of colon cancer. We have previously found, using 32P-postlabelling, that bile from control patients and from patients with familial adenomatous polyposis (FAP) produces DNA adducts when incubated with salmon sperm DNA in vitro. In the present study we have incubated the...

journal_title：Carcinogenesis

authors： Scates DK,Spigelman AD,Venitt S

更新日期：1994-12-01 00:00:00

abstract：:The lymphocyte response to u.v. radiation (254 nm) was investigated by two different methods in 29 unselected patients with multiple epidermal cancer. The u.v.-induced DNA synthesis was determined as the increase in incorporation of [3H]thymidine in irradiated cells compared with nonirradiated cells after incubation f...

journal_title：Carcinogenesis

authors： Munch-Petersen B,Frentz G,Squire B,Wallevik K,Horn CC,Reymann F,Faber M

更新日期：1985-06-01 00:00:00

abstract：:We investigated, in a cloned hamster tracheal epithelial cell line HTE-B, the effects of inhibitors of DNA topoisomerase, novobiocin and nalidixic acid; of DNA polymerase, 1-beta-arabinofuranosylcytosine (ara-C) and 2',3'-dideoxythymidine; of ribonucleotide reductase, hydroxyurea; and of poly(ADP-ribose)synthetase, 3-...

journal_title：Carcinogenesis

authors： Ireland CM,Eastman A,Bresnick E

更新日期：1984-02-01 00:00:00

abstract：:The transcription factor Sp1 has been implicated in cell-type-specific activation of transforming growth factor-beta (TGFbeta) target genes in normal epithelial cells as well as in aberrant gene activation by TGFbeta in epithelial tumor cells. Here, we have examined the interaction of Sp1 with components of the Smad s...

journal_title：Carcinogenesis

authors： Jungert K,Buck A,Buchholz M,Wagner M,Adler G,Gress TM,Ellenrieder V

更新日期：2006-12-01 00:00:00

abstract：:Carcinogen treatment of cultured mammalian cells prior to infection with u.v.-irradiated virus results in enhanced virus survival and mutagenesis suggesting the induction of SOS-type processes. In this paper, we report the development of a primary rat hepatocyte culture system to investigate cellular responses to DNA ...

journal_title：Carcinogenesis

authors： Zurlo J,Yager JD

更新日期：1984-04-01 00:00:00

abstract：:Sulfur-containing substances derived from garlic and onion have been shown to prevent experimental carcinogenesis. One of the hypotheses explaining the mechanisms of the chemopreventive activity of these substances is that they activate detoxification systems such as glutathione S-transferase (GST). In this study the ...

journal_title：Carcinogenesis

authors： Hatono S,Jimenez A,Wargovich MJ

更新日期：1996-05-01 00:00:00

abstract：:Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants with high carcinogenic potencies that have been linked to the etiology of human cancers through their presence in cigarette smoke and environmental mixtures. They are metabolically activated in cells by cytochrome P450 enzymes and/or perox...

journal_title：Carcinogenesis

authors： Melendez-Colon VJ,Luch A,Seidel A,Baird WM

更新日期：1999-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous non-coding RNAs, which play an essential role in the regulation of gene expression during carcinogenesis. The role of miRNAs in breast cancer has been thoroughly investigated, and although many miRNAs are identified as cancer related, little is known about their involvement in benign ...

journal_title：Carcinogenesis

authors： Tahiri A,Leivonen SK,Lüders T,Steinfeld I,Ragle Aure M,Geisler J,Mäkelä R,Nord S,Riis ML,Yakhini Z,Kleivi Sahlberg K,Børresen-Dale AL,Perälä M,Bukholm IR,Kristensen VN

更新日期：2014-01-01 00:00:00