Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice.

abstract：:The E3 ubiquitin ligase EDD is overexpressed in recurrent, platinum-resistant ovarian cancers, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of the prosurvival pro...

journal_title：Carcinogenesis

authors： Bradley A,Zheng H,Ziebarth A,Sakati W,Branham-O'Connor M,Blumer JB,Liu Y,Kistner-Griffin E,Rodriguez-Aguayo C,Lopez-Berestein G,Sood AK,Landen CN Jr,Eblen ST

更新日期：2014-05-01 00:00:00

abstract：:Inflammatory tumor microenvironments play pivotal roles in the development of cancer. Inflammatory cytokines such as CXCL1/GROα exert cancer-promoting activities by increasing tumor angiogenesis. However, whether CXCL1/GROα also plays a role in the progression of prostate cancer, particularly in highly invasive castra...

journal_title：Carcinogenesis

authors： Kuo PL,Shen KH,Hung SH,Hsu YL

更新日期：2012-12-01 00:00:00

abstract：:The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p. administration of 100 mg/kg body wt N-diethyl-nitrosamine, 4 i.p. administrations of 20 mg/kg body wt N-methylnitrosourea, 4 s...

journal_title：Carcinogenesis

authors： Hirose M,Hoshiya T,Akagi K,Takahashi S,Hara Y,Ito N

更新日期：1993-08-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...

journal_title：Carcinogenesis

authors： Saad MI,McLeod L,Yu L,Ebi H,Ruwanpura S,Sagi I,Rose-John S,Jenkins BJ

更新日期：2020-06-17 00:00:00

abstract：:In the present study the role of two families of cytochrome P-450 proteins and the contribution of the cytosolic fraction in the activation of N-nitrosopiperidine to mutagens in the Ames test were investigated. The bioactivation of this nitrosamine was preferentially catalysed by the phenobarbitone-induced cytochromes...

journal_title：Carcinogenesis

authors： Ayrton AD,Smith JN,Ioannides C

更新日期：1987-11-01 00:00:00

abstract：:Normal human fibroblasts do not synthesize platelet-derived growth factor (PDGF), but they respond to its mitogenic action. In contrast, cells from several human fibrosarcomas have been shown to synthesize PDGF at significant levels. To investigate the possible role of PDGF expression in the development of tumors of m...

journal_title：Carcinogenesis

authors： Yang D,Kohler SK,Maher VM,McCormick JJ

更新日期：1994-10-01 00:00:00

abstract：:The influence of the enzymatic inducer beta-naphthoflavone (BNF) and of the inhibitors alpha-naphthoflavone (ANF) and 2-diethylaminoethyl-2,2-diphenylvalerate HCl (SKF 525-A) on the frequency of sister chromatid exchanges (SCE) induced by cyclophosphamide (CPA) was studied in vivo in C57BL/6J male mice. Neither induce...

journal_title：Carcinogenesis

authors： Dragani TA,Sozzi G,Della Porta G

更新日期：1983-01-01 00:00:00

abstract：:The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...

journal_title：Carcinogenesis

authors： Göttlicher M,Cikryt P

更新日期：1987-07-01 00:00:00

abstract：:The carcinogenicities of 1-nitropyrene (1-NP), 4-nitropyrene (4-NP), 1,3-dinitropyrene (1,3-DNP), 1,6-dinitropyrene (1,6-DNP), 1,8-dinitropyrene (1,8-DNP), 3-hydroxy-1-nitropyrene (3-OH-1-NP) and a mixture of 6- and 8-hydroxy-1-nitropyrene (6/8-OH-1-NP) were investigated in newborn female rats. Newborn female CD rats ...

journal_title：Carcinogenesis

authors： Imaida K,Lee MS,Land SJ,Wang CY,King CM

更新日期：1995-12-01 00:00:00

abstract：:Phosphorylation of proteins on serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase Pin1 and is a central signaling mechanism in cell proliferation and transformation. Although Pin1 is frequently overexpressed in hepatocellula...

journal_title：Carcinogenesis

authors： Lee NY,Choi HK,Shim JH,Kang KW,Dong Z,Choi HS

更新日期：2009-04-01 00:00:00

abstract：:Effects of tamoxifen (TAM) on development of uterine endometrial carcinogenesis were studied in intact and ovariectomized (OVX) mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG). In experiment I, animals were implanted with cholesterol (ChL, controls) or TAM (5% w/w) and/or 17beta-oestradiol (E(2), 0.5% w...

journal_title：Carcinogenesis

authors： Takahashi M,Shimomoto T,Miyajima K,Iizuka S,Watanabe T,Yoshida M,Kurokawa Y,Maekawa A

更新日期：2002-09-01 00:00:00

abstract：:3-Methyladenine is one of the major products formed by reaction of a large number of environmental methylating agents with DNA in vivo and in vitro. In spite of the rapid spontaneous depurination of this base an enzyme, 3-methyladenine DNA glycosylase, has been shown to catalyse its excision. The relevance of this enz...

journal_title：Carcinogenesis

authors： Craddock VM,Henderson AR

更新日期：1982-01-01 00:00:00

abstract：:Male and female strain A/J mice were exposed to a mixture of cigarette sidestream and mainstream smoke at a chamber concentration of total suspended particulates of 82.5 mg/m3. Exposure time was 6 h/day, 5 days/week for 5 months. The animals were allowed to recover for another 4 months in filtered air before sacrifice...

journal_title：Carcinogenesis

authors： Witschi H,Espiritu I,Yu M,Willits NH

更新日期：1998-10-01 00:00:00

abstract：:DNA mismatch repair defects in certain cell types confer resistance to the cytotoxic effects of alkylating agents, suggesting that a normally functioning DNA mismatch repair pathway can actually mediate alkylation-induced cell death. In eukaryotic cells this phenomenon is only observed in cells lacking adequate DNA me...

journal_title：Carcinogenesis

authors： Rasmussen LJ,Samson L

更新日期：1996-09-01 00:00:00

abstract：:Heterocyclic aromatics amines (HAAs), such as 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), are metabolically activated by cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2). We examined the relationship between CYP1A2 and NAT2 activity and the excretion of total unconjugated MeIQx in 66 healthy subje...

journal_title：Carcinogenesis

authors： Sinha R,Rothman N,Mark SD,Murray S,Brown ED,Levander OA,Davies DS,Lang NP,Kadlubar FF,Hoover RN

更新日期：1995-11-01 00:00:00

abstract：:The expression levels of miR-365 vary in different malignancies. Herein, we found that miR-365 was overexpressed in both cells and clinical specimens of cutaneous squamous cell carcinoma (SCC). We demonstrated that the HaCaT(pre-miR-365-2) cell line, which overexpressed miR-365, could induce subcutaneous tumors in viv...

journal_title：Carcinogenesis

authors： Zhou M,Liu W,Ma S,Cao H,Peng X,Guo L,Zhou X,Zheng L,Guo L,Wan M,Shi W,He Y,Lu C,Jiang L,Ou C,Guo Y,Ding Z

更新日期：2013-07-01 00:00:00

abstract：:The metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1), plays multifaceted roles in inhibiting oncogenic signaling and can suppress the epithelial mesenchymal transition (EMT), a key step in metastasis. In this investigation, NDRG1 inhibited the oncogenic effects of transforming growth factor-β (TGF-β) i...

journal_title：Carcinogenesis

authors： Menezes SV,Fouani L,Huang MLH,Geleta B,Maleki S,Richardson A,Richardson DR,Kovacevic Z

更新日期：2019-07-06 00:00:00

abstract：:Dietary-related indoles, isothiocyanates, and the allyl isothiocyanate glucosinolate, sinigrin, were administered to F344 rats in the diet for 2 weeks (chronic protocol) or by gavage 2 h before sacrifice (acute protocol) and the effects of these pretreatments on the alpha-hydroxylation of two carcinogenic nitrosamines...

journal_title：Carcinogenesis

authors： Chung FL,Wang MY,Hecht SS

更新日期：1985-04-01 00:00:00

abstract：:Alcohol is a major risk factor for oesophageal squamous cell carcinoma (OSCC), the most prevalent histological subtype of oesophageal cancer (OC) worldwide. The metabolism of alcohol is regulated by specific enzymes whose activity and expression is influenced by genetic polymorphisms. We conducted a systematic review ...

journal_title：Carcinogenesis

authors： Matejcic M,Gunter MJ,Ferrari P

更新日期：2017-09-01 00:00:00

abstract：:The effect of oral vitamin C supplementation on intragastric ascorbate levels and gastric mucosal DNA damage as measured by the 32P-postlabelling assay was assessed in 43 patients. In patients with normal gastric mucosa, treatment with vitamin C resulted in elevation of intragastric ascorbate levels in all cases. In t...

journal_title：Carcinogenesis

authors： Dyke GW,Craven JL,Hall R,Garner RC

更新日期：1994-02-01 00:00:00

abstract：:Extracts of human urine were shown to contain substances that strongly inhibited the liver S9-mediated mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Salmonella typhimurium TA98 strain in a liquid incubation assay. The inhibitory effect was unrelated to cytotoxicity and was similar with urin...

journal_title：Carcinogenesis

authors： Malaveille C,Hautefeuille A,Brun G,Vineis P,Bartsch H

更新日期：1992-12-01 00:00:00

abstract：:Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes involving the transcription factor NF-kappaB. NF-kappaB plays a complex role in the control of survival due to the influence of cellular factors acting downstream. We undertook a comparative investi...

journal_title：Carcinogenesis

authors： Tacchini L,De Ponti C,Matteucci E,Follis R,Desiderio MA

更新日期：2004-11-01 00:00:00

abstract：:Recent studies have shown opposing effects of n-6 and n-3 fatty acids on the development of cancer and suggest a role for the ratio of n-6 to n-3 fatty acids in the control of cancer. However, whether an alteration in the n-6/n-3 fatty acid ratio of cancer cells affects their invasive potential has not been well inves...

journal_title：Carcinogenesis

authors： Xia SH,Wang J,Kang JX

更新日期：2005-04-01 00:00:00

abstract：:Circulating microRNAs (miRNAs) are potential biomarkers for cancer diagnosis, screening and prognosis. This study aimed to identify serum miRNAs as predictors of survival in patients with advanced non-small cell lung cancer (NSCLC). We profiled serum miRNAs in a pilot set of four patients with good survival (>24 month...

journal_title：Carcinogenesis

authors： Zhang Y,Roth JA,Yu H,Ye Y,Xie K,Zhao H,Chang DW,Huang M,Li H,Qu J,Wu X

更新日期：2019-07-04 00:00:00

abstract：:Serum selenium (Se) levels were measured before, during and after high-dose induction chemotherapy in 70 patients with acute non-lymphocytic leukemia (ANLL). Pre-treatment serum Se levels were lower in patients than in controls (0.082 +/- 0.033 micrograms/ml versus 0.097 +/- 0.035 micrograms/ml, P less than 0.01). Pre...

journal_title：Carcinogenesis

authors： Beguin Y,Bours V,Delbrouck JM,Robaye G,Roelandts I,Bury J,Fillet G,Weber G

更新日期：1989-11-01 00:00:00

abstract：:Apigenin, a flavonoid abundant in various vegetables and fruits, including parsley and onions, has been reported to possess anticarcinogenic effects. However, the direct molecular target of apigenin and its chemopreventive effect on ultraviolet (UV)-induced skin inflammation are not understood fully. Herein, we examin...

journal_title：Carcinogenesis

authors： Byun S,Park J,Lee E,Lim S,Yu JG,Lee SJ,Chen H,Dong Z,Lee KW,Lee HJ

更新日期：2013-02-01 00:00:00

abstract：:The present study was designed to compare the skin tumor promoting and epidermal ornithine decarboxylase (ODC) inducing activities of various structural analogs of anthralin (1,8-dihydroxy-9-anthrone) and chrysarobin (1,8-dihydroxy-3-methyl-9-anthrone). Groups of 30 SENCAR mice each were initiated with 7,12-dimethylbe...

journal_title：Carcinogenesis

authors： DiGiovanni J,Kruszewski FH,Coombs MM,Bhatt TS,Pezeshk A

更新日期：1988-08-01 00:00:00

abstract：:4,4'-Methylenediphenyl diisocyanate (MDI) is the most widely used isocyanate in the manufacture of polyurethanes. MDI has been implicated as one of the major causes of occupational asthma. Hydrolysis of MDI can yield 4,4'-methylenedianiline (MDA), which is a suspected human carcinogen. Thus the need to monitor occupat...

journal_title：Carcinogenesis

authors： Sepai O,Henschler D,Sabbioni G

更新日期：1995-10-01 00:00:00

abstract：:A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of acti...

journal_title：Carcinogenesis

authors： Chik F,Szyf M

更新日期：2011-02-01 00:00:00

abstract：:The broccoli constituent sulforaphane (1-isothiocyanate-4-methylsulfinylbutane) has previously been shown to protect rats against 9,10-dimethyl-1,2-benz[a]anthracene tumorigenesis, thought to be due, at least in part, to induction of phase II detoxification. We investigated the ability of sulforaphane to also inhibit ...

journal_title：Carcinogenesis

authors： Barcelo S,Gardiner JM,Gescher A,Chipman JK

更新日期：1996-02-01 00:00:00