Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity.

abstract：:The in vivo formation of specific 7,12-dimethylbenz[a]-anthracene (DMBA)-DNA adducts in the mammary gland of the female Sprague-Dawley rat was studied in response to dietary butylated hydroxytoluene (BHT). Dietary BHT concentrations of 0.4 and 0.8% significantly inhibited total DMBA-DNA binding by 41.5 and 35.6% respe...

journal_title：Carcinogenesis

authors： Singletary KW,Nelshoppen JM

更新日期：1991-10-01 00:00:00

abstract：:Malondialdehyde (MDA), a product of lipid peroxidation, causes mutations in bacterial and mammalian cells and cancer in rats. MDA reacts with deoxynucleosides in vitro and the monomeric adduct of MDA with deoxyguanosine (M1G-dR) is the major adduct. M1G-dR has been detected in rat and human liver. Random mutagenesis s...

journal_title：Carcinogenesis

authors： Chaudhary AK,Reddy GR,Blair IA,Marnett LJ

更新日期：1996-05-01 00:00:00

abstract：:LHX4 is a member of the LIM-homeobox family and plays a critical role in pituitary development and differentiation. Several lines of evidences have reported their aberrant expression in cancers. However, the exact roles of LHX4 in carcinogenesis remain unclear. In this study, LHX4 expression was analyzed in tumor and ...

journal_title：Carcinogenesis

authors： Hung TM,Hu RH,Ho CM,Chiu YL,Lee JL,Jeng YM,Shih DT,Lee PH

更新日期：2011-12-01 00:00:00

abstract：:Cytochrome P4501A1 (CYP1A1) has been implicated in the conversion of numerous polycyclic aromatic hydrocarbons into electrophilic species capable of binding covalently to DNA and has therefore been postulated to be involved in the initiation of carcinogenesis. The expression of CYP1A1 protein appears not to be constit...

journal_title：Carcinogenesis

authors： Drahushuk AT,McGarrigle BP,Larsen KE,Stegeman JJ,Olson JR

更新日期：1998-08-01 00:00:00

abstract：:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...

journal_title：Carcinogenesis

authors： Tanaka T,Mori H,Williams GM

更新日期：1987-09-01 00:00:00

abstract：:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for ...

journal_title：Carcinogenesis

authors： Stitzel KA,Horn PA,Ezra MF

更新日期：1990-12-01 00:00:00

abstract：:Ouabain resistance (ouar) and 6-thioguanine resistance (6-TGr) mutation frequencies were measured in Chinese hamster ovary cells after treatment with N-ethyl-N-nitrosourea (ENU) for varying periods of time. Maximal mutation frequency at the Na+/K+ ATPase gene locus (ouar mutations) was attained within 5 min of exposur...

journal_title：Carcinogenesis

authors： Dogliotti E,Vitelli A,Terlizzese M,Di Muccio A,Calcagnile A,Saffiotti U,Bignami M

更新日期：1987-01-01 00:00:00

abstract：:A growing body of evidence from human and animal cancer cytogenetics studies indicates that aneuploidy is an important chromosome change in carcinogenesis. To understand the role of this genetic phenomenon during the first steps of an experimental cancer model, molecular and cellular techniques were combined. A sequen...

journal_title：Carcinogenesis

authors： Van Goethem F,de Stoppelaar J,Hoebee B,Kirsch-Volders M

更新日期：1995-08-01 00:00:00

abstract：:The E3 ubiquitin ligase EDD is overexpressed in recurrent, platinum-resistant ovarian cancers, suggesting a role in tumor survival and/or platinum resistance. EDD knockdown by small interfering RNA (siRNA) induced apoptosis in A2780ip2, OVCAR5 and ES-2 ovarian cancer cells, correlating with loss of the prosurvival pro...

journal_title：Carcinogenesis

authors： Bradley A,Zheng H,Ziebarth A,Sakati W,Branham-O'Connor M,Blumer JB,Liu Y,Kistner-Griffin E,Rodriguez-Aguayo C,Lopez-Berestein G,Sood AK,Landen CN Jr,Eblen ST

更新日期：2014-05-01 00:00:00

abstract：:Genotoxic carcinogens, including 2-acetylaminofluorene (2-AAF), in addition to exerting their genotoxic effects, often cause a variety of non-genotoxic alterations in cells. It is believed that these non-genotoxic effects may be indispensable events in tumorigenesis; however, there is insufficient knowledge to clarify...

journal_title：Carcinogenesis

authors： Bagnyukova TV,Tryndyak VP,Montgomery B,Churchwell MI,Karpf AR,James SR,Muskhelishvili L,Beland FA,Pogribny IP

更新日期：2008-03-01 00:00:00

abstract：:The expression of human placental type glutathione S-transferase (GST-pi) was investigated in human cutaneous carcinoma in situ, that is, actinic keratosis and Bowen's disease, and compared with that in normal skin, using Northern blot and immunohistochemical analysis. In Northern blot examination, the expression of G...

journal_title：Carcinogenesis

authors： Shimizu K,Toriyama F,Zhang HM,Yoshida H

更新日期：1995-10-01 00:00:00

abstract：:Tumor suppression by insulin-like growth factor-binding protein-3 (IGFBP-3) has been demonstrated to occur via insulin-like growth factor-dependent and -independent mechanisms in vitro and in vivo. We have recently described IGFBP-3-induced mitochondrial translocation of the nuclear receptors RXRalpha/Nur77 in the ind...

journal_title：Carcinogenesis

authors： Lee KW,Cobb LJ,Paharkova-Vatchkova V,Liu B,Milbrandt J,Cohen P

更新日期：2007-08-01 00:00:00

abstract：:The expression of proteinase-activated receptor (PAR)(2) in human hepatocellular carcinoma (HCC) was established by reverse transcription-polymerase chain reaction, confocal immunofluorescence and electron microscopy in permanent cell lines, primary HCC cell cultures and HCC tumor tissue. Stimulation of HCC cells with...

journal_title：Carcinogenesis

authors： Kaufmann R,Oettel C,Horn A,Halbhuber KJ,Eitner A,Krieg R,Katenkamp K,Henklein P,Westermann M,Böhmer FD,Ramachandran R,Saifeddine M,Hollenberg MD,Settmacher U

更新日期：2009-09-01 00:00:00

abstract：:DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on DNA methylation, thereby modulating the susceptibility to lung cancer. To test this hypothesis, we investigated the ass...

journal_title：Carcinogenesis

authors： Lee SJ,Jeon HS,Jang JS,Park SH,Lee GY,Lee BH,Kim CH,Kang YM,Lee WK,Kam S,Park RW,Kim IS,Cho YL,Jung TH,Park JY

更新日期：2005-02-01 00:00:00

abstract：:We studied the modulating effects of caffeic acid and chlorogenic acid (two common coffee polyphenols) on the in vitro methylation of synthetic DNA substrates and also on the methylation status of the promoter region of a representative gene in two human cancer cells lines. Under conditions that were suitable for the ...

journal_title：Carcinogenesis

authors： Lee WJ,Zhu BT

更新日期：2006-02-01 00:00:00

abstract：:Exogenous chemical carcinogenesis is an extremely complex multifactorial process during which gene-environment interactions involving chronic exposure to exogenous chemical carcinogens (ECCs) and polymorphisms of cancer susceptibility genes add further complexity. We describe the properties and molecular mechanisms of...

journal_title：Carcinogenesis

authors： Irigaray P,Belpomme D

更新日期：2010-02-01 00:00:00

abstract：:The present study was aimed at verifying the occurrence, if any, of in vivo oxidative DNA damage in FA homozygotes, their parents and siblings. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) was measured, by HPLC/EC, in DNA from circulating blood leucocytes from FA homozygotes and their relatives and compared with a group of pa...

journal_title：Carcinogenesis

authors： Degan P,Bonassi S,De Caterina M,Korkina LG,Pinto L,Scopacasa F,Zatterale A,Calzone R,Pagano G

更新日期：1995-04-01 00:00:00

abstract：:The effect of co-administration of diethylnitrosamine (DEN) and Clophen A 50, a commercial mixture of polychlorinated biphenyls (PCB), on pre-neoplastic enzyme-altered islands in livers of female Sprague-Dawley rats was studied. The islands were identified by the loss of adenosine-5'-triphosphatase (ATPase), emergence...

journal_title：Carcinogenesis

authors： Deml E,Oesterle D

更新日期：1986-10-01 00:00:00

abstract：:Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide association studies have identified multiple susceptibility loci in Asi...

journal_title：Carcinogenesis

authors： Chen WC,Bye H,Matejcic M,Amar A,Govender D,Khew YW,Beynon V,Kerr R,Singh E,Prescott NJ,Lewis CM,Babb de Villiers C,Parker MI,Mathew CG

更新日期：2019-06-10 00:00:00

abstract：:Structural analogs of diethylstilbestrol (DES) with at least one phenolic hydroxyl group are metabolized by prostaglandin H synthase (PHS) from ram seminal vesicle microsomes (RSVM) in vitro in the presence of arachidonic acid (20:4). U.v. spectroscopy revealed the formation of p-quinoid intermediates in incubations o...

journal_title：Carcinogenesis

authors： Degen GH,Metzler M,Sivarajah KS

更新日期：1986-01-01 00:00:00

abstract：:The human DNA polymerase lambda (Polλ) is a DNA repair polymerase, which is believed not only to play a role in base excision repair but also to contribute to DNA double-strand break repair by non-homologous end joining. We described here that cellular expression of the recently described natural polymorphic variant o...

journal_title：Carcinogenesis

authors： Capp JP,Boudsocq F,Bergoglio V,Trouche D,Cazaux C,Blanco L,Hoffmann JS,Canitrot Y

更新日期：2010-10-01 00:00:00

abstract：:A hallmark of cancer is aberrant DNA methylation, consisting of global hypomethylation and regional hypermethylation of tumor suppressor genes. DNA methyltransferase inhibitors have been recognized as promising candidate anticancer drugs. Drug development has focused on DNA methylation inhibitors with the goal of acti...

journal_title：Carcinogenesis

authors： Chik F,Szyf M

更新日期：2011-02-01 00:00:00

abstract：:We have shown previously that (NOHA) an intermediate in the nitric oxide (NO) synthetic pathway and an inhibitor of arginase significantly reduced intracellular polyamines, activated caspase-3 and induced apoptosis in the human breast cancer cell line MDA-MB-468. These actions of NOHA were abolished in the presence of...

journal_title：Carcinogenesis

authors： Singh R,Pervin S,Wu G,Chaudhuri G

更新日期：2001-11-01 00:00:00

abstract：:Cigarette smoke (CS) contains hundreds of carcinogens and is a potent inducer of oxidative and bulky DNA damage, which when insufficiently repaired leads to activation of DNA damage response and possibly mutations. The DNA repair protein xeroderma pigmentosum group C (XPC) is primed to play an important role in CS-ind...

journal_title：Carcinogenesis

authors： Zhou H,Saliba J,Sandusky GE,Sears CR

更新日期：2019-05-14 00:00:00

abstract：:Okadaic acid is both a potent inhibitor of protein serine/threonine phosphatases and a tumor promoter in the mouse skin model. We have previously shown that at non-toxic nanomolar concentrations okadaic acid reversibly inhibits induction (promotion) by PDGF of transformed cells by the 'complete' and 'two-stage' protoc...

journal_title：Carcinogenesis

authors： Dean NM,Mordan LJ,Tse K,Mooberry SL,Boynton AL

更新日期：1991-04-01 00:00:00

abstract：:Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...

journal_title：Carcinogenesis

authors： Gupta RC,Dighe NR

更新日期：1984-03-01 00:00:00

abstract：:The expression of CYP1B1 in human mammary fibroblasts (HMFs) was characterized as a potential modulator of their individual function as well as effects on adjacent mammary epithelia. We have used these characteristics to explore the diversity of fibroblast cells isolated from reduction mammoplasty patients and from di...

journal_title：Carcinogenesis

authors： Eltom SE,Larsen MC,Jefcoate CR

更新日期：1998-08-01 00:00:00

abstract：:Food-derived aminoimidazoazarenes have been shown to be mutagenic and carcinogenic and to form covalent DNA adducts. 32P-Post-labelling analysis of DNA modified with these heterocyclic amines (HA), including 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-...

journal_title：Carcinogenesis

authors： Pfau W,Brockstedt U,Söhren KD,Marquardt H

更新日期：1994-05-01 00:00:00

abstract：:Two samples of 4-amino-2-nitrophenol were tested for mutagenicity in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100. Significant mutagenic activity was detected with a sample of this compound obtained from Aldrich (technical grade (Aldrich), TGA) both in the presence and in the absence of a rat...

journal_title：Carcinogenesis

authors： Shahin MM,Bugaut A,Junino A,Kalopissis G

更新日期：1982-01-01 00:00:00

abstract：:Cyclic 1,N2-propanodeoxyguanosine adducts are formed in vitro in DNA treated with alpha-acetoxy-N-nitrosopyrrolidine or its metabolite, crotonaldehyde. However, the in vivo formation of these cyclic adducts in DNA has not been demonstrated due to the lack of a sensitive detection method. In this study, a 32P-postlabel...

journal_title：Carcinogenesis

authors： Chung FL,Young R,Hecht SS

更新日期：1989-07-01 00:00:00