Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion.

abstract：:Whether single cells immunohistochemically positive for glutathione S-transferase P1-1 (GSTP1-1) induced in the female mouse liver by DEN (Hatayama et al., Carcinogenesis, 14, 537-538, 1993) are precursor initiated cells of preneoplastic foci, is of importance in chemical hepatocarcinogenesis. Nrf2 transactivates a wi...

journal_title：Carcinogenesis

authors： Satoh K,Itoh K,Yamamoto M,Tanaka M,Hayakari M,Ookawa K,Yamazaki T,Sato T,Tsuchida S,Hatayama I

更新日期：2002-03-01 00:00:00

abstract：:Following intraperitoneal administration of [3H] aflatoxin B1 (AFB1) to young adult male rats, there is rapid uptake of the carcinogen by the liver, the target organ for carcinogenesis, leading to DNA covalent binding. Acid hydrolysis of this DNA shows that after 2h, the major DNA adduct is trans 8,9-dihydro-8-(7-guan...

journal_title：Carcinogenesis

authors： Hertzog PJ,Lindsay Smith JR,Garner RC

更新日期：1980-09-01 00:00:00

abstract：:Liposarcoma (LS) is the most common soft-tissue sarcoma. Dedifferentiated liposarcoma (DDLS) shows more aggressive biological behavior than that of well-differentiated liposarcoma (WDLS), so advanced therapeutic agents based on molecular mechanism are urgently needed. Here we show that tissue inhibitors of metalloprot...

journal_title：Carcinogenesis

authors： Shrestha M,Ando T,Chea C,Sakamoto S,Nishisaka T,Ogawa I,Miyauchi M,Takata T

更新日期：2019-10-16 00:00:00

abstract：:S-Adenosyl-L-methionine (SAM) is a strong chemopreventive agent of rat liver carcinogenesis. Examination was made to determine whether inhibition by SAM of the development of preneoplastic liver lesions persists to SAM withdrawal in diethylnitrosamine-initiated F344 rats promoted with thiobenzamide (TB). The rats were...

journal_title：Carcinogenesis

authors： Simile MM,Saviozzi M,De Miglio MR,Muroni MR,Nufris A,Pascale RM,Malvaldi G,Feo F

更新日期：1996-07-01 00:00:00

abstract：:Synergistic effects of dysregulation of the WNT/CTNNB1 and phosphatidylinositol 3-kinase (PI3K)/AKT pathways are thought to be important for the development and progression of many forms of cancer, including the granulosa cell tumor of the ovary. Sustained WNT/CTNNB1 signaling in Sertoli cells causes testicular degene...

journal_title：Carcinogenesis

authors： Boyer A,Paquet M,Laguë MN,Hermo L,Boerboom D

更新日期：2009-05-01 00:00:00

abstract：:Formation of O6-ethylguanine (O6EG) in trachea DNA was measured 12 h after acute i.p. administration of 50, 100 and 200 mg diethylnitrosamine (DEN)/kg body wt to Syrian golden hamsters. Purine bases were fractionated by h.p.l.c., and ethylated guanines were quantified optically by fluorescence spectrophotometry. Signi...

journal_title：Carcinogenesis

authors： Fong AT,Rasmussen RE

更新日期：1986-09-01 00:00:00

abstract：:Several converging lines of evidence suggest that keratinocyte stem cells including those clonogenic in vitro, are the target cells in skin carcinogenesis. However, the mechanism of their involvement in carcinogenesis continues to be unknown. Recently, we have demonstrated that the number of keratinocyte clonogenic st...

journal_title：Carcinogenesis

authors： Popova NV,Teti KA,Wu KQ,Morris RJ

更新日期：2003-03-01 00:00:00

abstract：:An elevation in total MAP kinase activity and expression has been observed in breast cancer tissue. However, the mechanisms underlying these changes in kinase activity and regulation by growth factors are not well characterized. In these studies, the effect of the potent mammary mitogen, epidermal growth factor (EGF),...

journal_title：Carcinogenesis

authors： Xing C,Imagawa W

更新日期：1999-07-01 00:00:00

abstract：:Preparations of dietary fibre have an ability to bind potentially toxic compounds in vitro, but it is unclear how the measured binding properties are a reflection of either the relative affinity of such compounds for fibre or the saturation binding capacity of the fibre. Cooking and processing of foods and fermentatio...

journal_title：Carcinogenesis

authors： Ryden P,Robertson JA

更新日期：1995-02-01 00:00:00

abstract：:Male rats were treated with [ring-3H]N-acetyl-2-aminofluorene and sacrificed at different periods of time after a single i.p. dose. Chromatin was isolated from liver homogenates and treated with RNAse and proteinase K. The resulting crude DNA was purified as the N-hexadecyl-N-trimethylammonium salt. The amounts of 2-a...

journal_title：Carcinogenesis

authors： Visser A,Westra JG

更新日期：1981-01-01 00:00:00

abstract：:The mechanism of inactivation of the O6-methylguanine-DNA methyltransferase (MGMT), responsible for repair of mutagenic and cytotoxic O6-alkylguanine, in Mex- tumor cells, is not completely understood. We have examined the role of CpG methylation in the human MGMT promoter in a luciferase (luc) reporter plasmid and as...

journal_title：Carcinogenesis

authors： Bhakat KK,Mitra S

更新日期：2003-08-01 00:00:00

abstract：:The purpose of this study was to determine whether the level of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) (8-oxo-dG), a major mutagenic DNA oxidation product, is enhanced in newborn rat liver DNA as a consequence of oxidative stress incurred during the early postnatal period. 32P-postlabeling s...

journal_title：Carcinogenesis

authors： Randerath K,Zhou GD,Monk SA,Randerath E

更新日期：1997-07-01 00:00:00

abstract：:Comparative in vitro metabolic experiments with 7,8-benzoflavone using microsomes prepared from the livers of control Sprague-Dawley rats or from rats of the same strain treated with phenobarbitone, 3-methylcholanthrene, or Aroclor 1254 (known inducers of hepatic cytochrome P450 mixed function oxidases) disclose varia...

journal_title：Carcinogenesis

authors： Coombs MM

更新日期：1982-01-01 00:00:00

abstract：:The syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-6-methylchrysene (6-MeC-1,2-diol-3,4-epoxide) were synthesized and their mutagenic activities in Salmonella typhimurium were compared with those of the syn- and anti-isomers of 1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene (5-MeC-1,2...

journal_title：Carcinogenesis

authors： Amin S,Huie K,Hecht SS,Harvey RG

更新日期：1986-12-01 00:00:00

abstract：:An ongoing controversy exists on beneficial versus harmful effects of high beta-carotene (BC) intake, especially for the lung. To elucidate potential mechanisms, we studied effects of BC on lung gene expression. We used a beta-carotene 15,15'-monooxygenase 1 (Bcmo1) knockout mouse (Bcmo1(-/-)) model, unable to convert...

journal_title：Carcinogenesis

authors： van Helden YG,Godschalk RW,Heil SG,Bunschoten A,Hessel S,Amengual J,Bonet ML,von Lintig J,van Schooten FJ,Keijer J

更新日期：2010-08-01 00:00:00

abstract：:The major mammalian apurinic/apyrimidinic (AP) endonuclease (APE1) plays a central role in the DNA base excision repair pathway (BER) in two distinct ways. As an AP endonuclease, it initiates repair of AP sites in DNA produced either spontaneously or after removal of uracil and alkylated bases in DNA by monofunctional...

journal_title：Carcinogenesis

authors： Izumi T,Hazra TK,Boldogh I,Tomkinson AE,Park MS,Ikeda S,Mitra S

更新日期：2000-07-01 00:00:00

abstract：:Apolipoprotein E (apoE) plays a major role in the metabolism of bile acids, cholesterol and triglycerides, and has recently been proposed as being involved in the carcinogenic process. Given the potential role of bile acids in colorectal cancer etiology, it is reasonable that colorectal cancer risk might be modified b...

journal_title：Carcinogenesis

authors： Slattery ML,Sweeney C,Murtaugh M,Ma KN,Potter JD,Levin TR,Samowitz W,Wolff R

更新日期：2005-08-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs) have been described to play critical roles in initiation, progression and metastasis of various cancers. However, the involvement of CAFs in oral cancer (OC) has not been well addressed. In this study, we demonstrate that CAFs, when cocultured with OC cells (OCCs), produce high lev...

journal_title：Carcinogenesis

authors： Li X,Xu Q,Wu Y,Li J,Tang D,Han L,Fan Q

更新日期：2014-06-01 00:00:00

abstract：:Lipid peroxidation aldehydes of the 4-hydroxy-alpha, beta-unsaturated type, as well as the tobacco-smoke related alpha, beta-unsaturated aldehyde, acrolein, were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations. In com...

journal_title：Carcinogenesis

authors： Krokan H,Grafstrom RC,Sundqvist K,Esterbauer H,Harris CC

更新日期：1985-12-01 00:00:00

abstract：:E mu-pim-1 transgenic mice, which overexpress the pim-1 oncogene in lymphoid tissues, have shown increased susceptibility to induction of T cell lymphomas by N-ethyl-N-nitrosourea, a direct-acting chemical carcinogen (Nature, 340, 61-63, 1989). We sought to further evaluate E mu-pim-1 transgenic mice as a potential te...

journal_title：Carcinogenesis

authors： Storer RD,Cartwright ME,Cook WO,Soper KA,Nichols WW

更新日期：1995-02-01 00:00:00

abstract：:Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced oxidative stress. Lipid peroxidation (LPO)-induced etheno-DNA adducts in nuclear- and mitochondrial-DNA along with apoptosis was measured in LEC rat liver. Levels o...

journal_title：Carcinogenesis

authors： Nair J,Strand S,Frank N,Knauft J,Wesch H,Galle PR,Bartsch H

更新日期：2005-07-01 00:00:00

abstract：:Previous studies have shown that in addition to serving as a target for covalent adduct formation, purified DNA catalyzes the detoxification of (+/-)-7r,8t-dihydroxy-9t,10t-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE). To begin to relate these in vitro findings with the processes important in carcinogenesis in vivo, w...

journal_title：Carcinogenesis

authors： Dock L,MacLeod MC

更新日期：1986-04-01 00:00:00

abstract：:Cultured human epidermal cells which require no feeder layer were used to study metabolism of benzo[a]pyrene (BP) and DNA adduct formation. The cultures were prepared from a single cell suspension and maintained at a pH of 5.9--6.2. At 2 microM BP some cell toxicity was observed, and substantial cell death occurred at...

journal_title：Carcinogenesis

authors： Theall G,Eisinger M,Grunberger D

更新日期：1981-01-01 00:00:00

abstract：:The human guanylate-binding protein 1 (GBP-1) is among the proteins the most highly induced by interferon-γ (IFN-γ) in every cell type investigated as yet. In vivo, GBP-1 expression is associated with the presence of inflammation and has been observed in autoimmune diseases, inflammatory bowel diseases (IBD) and cance...

journal_title：Carcinogenesis

authors： Britzen-Laurent N,Lipnik K,Ocker M,Naschberger E,Schellerer VS,Croner RS,Vieth M,Waldner M,Steinberg P,Hohenadl C,Stürzl M

更新日期：2013-01-01 00:00:00

abstract：:The effect of daily parenteral administration of a long-acting analogue of somatostatin (SMS 201-995) on the development of intestinal tumours and the rate of crypt cell proliferation in azoxymethane-treated rats has been studied. SMS 201-995 had no significant effect on the number of colonic tumours induced. In the d...

journal_title：Carcinogenesis

authors： Savage AP,Matthews JL,Adrian TE,Ghatei MA,Cooke T,Bloom SR

更新日期：1987-04-01 00:00:00

abstract：:Reported habits of red meat consumption, particularly red meat that has been cooked to the degree termed 'well-done', is a positive risk factor for colorectal cancer. Under high, pyrolytic temperatures, heterocyclic amines (HCA) and benzo[a]pyrene (BP) molecules can form inside and on the surface of red meat, respecti...

journal_title：Carcinogenesis

authors： Gunter MJ,Probst-Hensch NM,Cortessis VK,Kulldorff M,Haile RW,Sinha R

更新日期：2005-03-01 00:00:00

abstract：:N-Nitrosobutyl(4-hydroxybutyl)amine (BBN) is a selective bladder carcinogen in rats. Its organ specificity may depend on several factors, including metabolic activation, DNA alkylation and repair within the target organ. Metabolic activation of BBN, which is asymmetrical, may result in butylating and 4-hydroxybutylati...

journal_title：Carcinogenesis

authors： Airoldi L,Magagnotti C,Bonfanti M,Chiappetta L,Lolli M,Medana C,De Gregorio G,Fanelli R

更新日期：1994-10-01 00:00:00

abstract：:Glycidyl ethers are reactive epoxides used as components of a variety of epoxy materials. These compounds are known to cause allergic reactions, but since they are generally also genotoxic it would be of interest to evaluate the risk for induction of such effects. Reaction products of allyl glycidyl ether with nucleic...

journal_title：Carcinogenesis

authors： Plna K,Segerbäck D,Schweda EK

更新日期：1996-07-01 00:00:00

abstract：:Methylation of the non-carcinogen 15,16-dihydrocyclopenta[a]phenanthren-17-one (CPP-17-one) at the bay region to form 11-CH3-CPP-17-one confers carcinogenic potential. In the present study we have investigated the in vitro metabolism and mutagenicity of the methylated compound by hepatic microsomal preparations from r...

journal_title：Carcinogenesis

authors： Boyd GW,Young RJ,Harvey RG,Coombs MM,Ioannides C

更新日期：1993-09-01 00:00:00

abstract：:7-Methylguanine (7-meG) could be a useful marker of recent past exposure to environmental methylating agents for use in epidemiological studies. A method is described that is appropriate for such an application. 7-meG was released from DNA by thermal hydrolysis under conditions (pH 9, 70 degrees C, 8 h) that preferent...

journal_title：Carcinogenesis

authors： Bianchini F,Montesano R,Shuker DE,Cuzick J,Wild CP

更新日期：1993-08-01 00:00:00