Abstract:
:Iron exclusion has been used to identify foci of hepatocellular alteration (FHA) in rats exposed to known carcinogens. This study investigates whether basophilic FHA occurring spontaneously in aged female Fischer 344 rats also exclude iron. Female rats 514-544 days of age were given supplemental iron by injection for 2 weeks prior to being killed. Serial sections of the liver stained with hematoxylin and eosin or Gomori's stain were examined. Seventy-five basophilic FHA were identified; none excluded iron. It may be possible to differentiate spontaneous basophilic FHA from carcinogen-induced, iron-excluding FHA by the use of this staining method.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Stitzel KA,Horn PA,Ezra MFdoi
10.1093/carcin/11.12.2253subject
Has Abstractpub_date
1990-12-01 00:00:00pages
2253-4issue
12eissn
0143-3334issn
1460-2180journal_volume
11pub_type
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