Abstract:
:The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repeated CCl4 gavage for 30 weeks. The numbers of both altered liver cell foci and hepatocellular neoplasms in the hamsters given 0.1 ml CCl4, i.g. once every 2 weeks after the DMN were significantly higher than in the animals given DMN alone. PB or DDT (500 p.p.m. in the diet) after DMN did not produce a significantly higher incidence of altered foci or hepatocellular neoplasms compared to DMN alone. Thus, an enhancing effect of CCl4 on DMN-induced hepatocarcinogenesis in the hamster was demonstrated, but neither PB or DDT--both liver neoplasm promoters in rats and mice--displayed promoting activity under the conditions of study.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Tanaka T,Mori H,Williams GMdoi
10.1093/carcin/8.9.1171subject
Has Abstractpub_date
1987-09-01 00:00:00pages
1171-8issue
9eissn
0143-3334issn
1460-2180journal_volume
8pub_type
杂志文章相关文献
CARCINOGENESIS文献大全abstract::An antibody (anti-EH) specific for microsomal epoxide hydrolase (mEH) from rhesus monkey liver has been used to test the immunochemical relationship between human liver mEH and the serum EH levels in human patients with hepatocellular carcinoma (HCC). Immunoblots of separated rhesus monkey and human liver microsomal p...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/10.2.343
更新日期:1989-02-01 00:00:00
abstract::The N-hydroxylamine of the carcinogen 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) covalently bound to calf thymus DNA at pH 7, and the binding was 11% higher under acidic conditions (pH 5). The extent of N-hydroxy-IQ binding to single-stranded polynucleotides at neutral pH was in the following order: polyguanylic a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.6.1061
更新日期:1988-06-01 00:00:00
abstract::Metabolism and macromolecular interaction of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were studied in human buccal mucosa in vitro. Microautoradiographic analysis of [5-3H]NNK-exposed explant cultures demonstrated a uniform distribution of bound radioactivity in the mucosal ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.11.2383
更新日期:1993-11-01 00:00:00
abstract::In efforts to determine common and consistent morphological parameters of transformation in C3H/10T1/2 cells, 15 cell lines transformed by different carcinogens were examined with the scanning electron microscope (SEM) and compared to non-transformed cells. Cell lines were studied at different passages, at different c...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.7.885
更新日期:1984-07-01 00:00:00
abstract::AP-endonuclease (APE) plays a central role in the base excision repair process for oxidative and alkylation damage in DNA. The major human APE with 318 amino acid residues possesses transcriptional regulatory activities for which the N-terminal region was found to be essential. Systematic deletion studies of both amin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.3.525
更新日期:1998-03-01 00:00:00
abstract::We examined the effects of the aliphatic amides isopropyl-valeramide (IVA) and allylisopropylacetamide (AIA) on oncogenic transformation and sister chromatid exchanges (SCE) induced by cyclopenta[cd]pyrene (CPP) and benzo[a]pyrene (B[a]P) in C3H/10T1/2 cells and on B[a]Pdiol-epoxide (BPDE)-induced mutation at the HGPR...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.10.1647
更新日期:1986-10-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) are important regulators of angiogenesis. HIF-1 is composed of HIF-1alpha and HIF-1beta subunits, and regulates VEGF expression at transcriptional level. In this study, we demonstrated that insulin induced H2O2 production and p70S6K1 acti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgl085
更新日期:2007-01-01 00:00:00
abstract::In vivo incorporation of [3H] thymidine into DNA was determined in rats at 28 h after partial hepatectomy. Administration of nickel carbonyl (Ni(CO)4) at 2 or 4 h before sacrifice inhibited [3H] thymidine uptake into liver and kidney DNA. For example, in rats killed 4 h after i.v. injection of Ni(CO)4 (2 mg Ni/100 g),...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/1.4.297
更新日期:1980-04-01 00:00:00
abstract::Carcinogenesis develops in stages that have been operationally defined as initiation, promotion and progression. Although morphological end points have been described for detection and quantitation of these stages, to date initiation has been assessed only in the context of clonal growth in response to certain promoti...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.11.2587
更新日期:1994-11-01 00:00:00
abstract::The faecal concentration of substances responding to the chemical test for N-nitroso compounds (apparent total N-nitroso compounds, ATNC) was investigated in human subjects consuming their normal free-choice diet. Concentrations ranged from 40 to 590 micrograms (N-NO)/kg faeces. To ascertain the likely relative contri...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.8.1395
更新日期:1991-08-01 00:00:00
abstract::Endocrine therapies, which inhibit estrogen receptor (ER)alpha signaling, are the most common and effective treatment for ERalpha-positive breast cancer. However, the use of these agents is limited by the frequent development of resistance. The cyclin-dependent kinase family member CRK7 (aka CRKRS) was identified from...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgp187
更新日期:2009-10-01 00:00:00
abstract::Childhood cancer is the leading cause of disease-related death in children aged 1-14 years in Canada and the USA and it has been hypothesized that transplacental exposure to environmental carcinogens such as benzene may contribute to the etiology of these cancers. Our objectives were to determine if transplacental ben...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgq074
更新日期:2010-06-01 00:00:00
abstract::The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM). A putative role of host-environmental interactions in the etiology of hereditary melanoma has been strengthened by the recent finding that fibroblasts deriv...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/4.7.911
更新日期:1983-01-01 00:00:00
abstract::Formation and removal of hepatic DNA adducts was studied in male Sprague-Dawley rats following single injections of two hepatocarcinogens, N-hydroxy-2-acetylaminofluorene (N-OH-AAF) and N-hydroxy-4-acetylaminobiphenyl (N-OH-AABP) and a nonhepatocarcinogen, N-hydroxy-2-acetylaminophenanthrene (N-OH-AAP) at 0.5 h, 1.5 h...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/5.3.343
更新日期:1984-03-01 00:00:00
abstract::Prostate cancer (CaP) is the second leading cause of cancer death in American men. Chronic inflammation has been one of several factors associated with the development of CaP. Single-nucleotide polymorphisms (SNPs) in cytokine genes have been associated with increased inflammation, increased cytokine production and po...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgm277
更新日期:2008-03-01 00:00:00
abstract::7-Hydroxymethylbenz[a]anthracene (7-HBA) showed potent mutagenicity towards Salmonella typhimurium TA 98 in the presence of untreated rat liver cytosol fortified with the PAPS-generating system, sodium sulphate and ATP. No mutagenic activity was observed either when the cytosol was boiled or when sodium sulphate or AT...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/7.2.207
更新日期:1986-02-01 00:00:00
abstract::The role of rat O6-alkylguanine-DNA alkyltransferase (AGT) in modulating mutagenesis by O6-substituted guanines in the rat H-ras gene was examined. Rat4 cells were transfected with vectors carrying O6-methyl-, O6-ethyl- or O6-benzylguanine residues in place of the normal guanines at either the first, second, or both t...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/14.4.593
更新日期:1993-04-01 00:00:00
abstract::Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolite can be rapidly hydrolyzed in acidic urine to undergo further metabolic activation and form DNA adducts in the urothelium. We conducted a large multicenter case-control study in Spain to explore the etiology of bladder cancer and evaluated the assoc...
journal_title:Carcinogenesis
pub_type: 杂志文章,多中心研究
doi:10.1093/carcin/bgr048
更新日期:2011-06-01 00:00:00
abstract::Dacarbazine (DTIC) is an antitumor agent, used for the treatment of metastatic melanoma. It is metabolized to an alkylating agent which reacts with DNA. A fast and simple method was developed in order to measure drug-induced DNA damage in lymphocytes isolated from frozen blood samples of treated patients. The level of...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/12.6.1153
更新日期:1991-06-01 00:00:00
abstract::In order to investigate specific DNA damage caused by nitric oxide (NO) induced lipid peroxidation, levels of promutagenic etheno adducts 1,N6-ethenodeoxyadenosine (epsilondA) and 3,N4-ethenodeoxycytidine (epsilondC) were measured in spleen DNA of SJL mice induced to produce high levels of NO by injection of RcsX (pre...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/19.12.2081
更新日期:1998-12-01 00:00:00
abstract::Long-Evans Cinnamon (LEC) rats, a model for human Wilson's disease, develop chronic hepatitis and liver tumors owing to accumulation of copper and induced oxidative stress. Lipid peroxidation (LPO)-induced etheno-DNA adducts in nuclear- and mitochondrial-DNA along with apoptosis was measured in LEC rat liver. Levels o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgi073
更新日期:2005-07-01 00:00:00
abstract::In order to address the hypothesis that 6-aminochrysene (6-AC) is converted to genotoxic products by cytochrome P450 enzymes via two activation pathways (N-hydroxylation and epoxidation), the activation of 6-AC and trans-1,2-dihydro-1,2-dihydroxy-6-aminochrysene (6-AC-diol) to genotoxic metabolites was examined in rat...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.3.465
更新日期:1994-03-01 00:00:00
abstract::The hepatitis B virus X protein (HBx) has pleiotropic biological effects, which underlies its potential role in cell transformation. However, its involvement in hepatic fibrosis remains unclear. In this study, we wanted to clarify, in vivo, the role of HBx protein in the development of liver fibrosis. Mice transgenic ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz109
更新日期:2020-05-14 00:00:00
abstract::Diallyl disulfide (DADS), a sulfur compound from garlic has been shown to exert many biological effects: induction of carcinogen detoxication, inhibition of tumor cell proliferation, etc. These effects are consistent with its anticarcinogenic properties in animal models and could account for garlic protective effects ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg182
更新日期:2004-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine ketone (NNK) is the most potent lung carcinogen. The ADAM17 protease is responsible for the ectodomain shedding of many pro-tumorigenic cytokines, growth factors and recept...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz123
更新日期:2020-06-17 00:00:00
abstract::Metastasis is the primary cause of treatment failures and mortality in most cancers. Triple-negative breast cancer (TNBC) is refractory to treatment and rapidly progresses to disseminated disease. We utilized an orthotopic mouse model that molecularly and phenotypically resembles human TNBC to study the effects of exo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgz172
更新日期:2020-05-14 00:00:00
abstract::The role of nitric oxide (NO) in colon cancer remains controversial. Inducible nitric oxide synthase (iNOS) has been reported to be up regulated and down regulated in colorectal cancer in both animal models and patient tissue samples. Cyclooxygenase-2 (COX-2) is important in colorectal carcinogenesis but its relations...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/bgg014
更新日期:2003-04-01 00:00:00
abstract::[14C]Benzo[a]pyrene (BP) was administered to male germfree rats. Urinary metabolites, constituting 9% of the administered radioactivity, were fractionated by lipophilic ion exchange chromatography. More than 80% of the urinary metabolites were conjugated, while neutral metabolites constituted 13-18%. The latter group ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/15.4.681
更新日期:1994-04-01 00:00:00
abstract::The heterocyclic aromatic amines, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx) are formed during frying of meat. PhIP and 4,8-DiMeIQx have, after metabolic activation, been shown to form adducts with DNA at the C8 of guanine both in vitro and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/18.8.1555
更新日期:1997-08-01 00:00:00
abstract::The hypolipidaemic drug nafenopin (NAF) has been shown to enhance the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine in rats. We have investigated whether the NAF-induced peroxisome proliferation in hepatocytes interferes with NDMA's metabolism and interaction with DNA. Adult male...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/6.9.1309
更新日期:1985-09-01 00:00:00